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README.md
auth.nih.gov
CertAuthV3/forms
mfa
Help.html
passwordlinks.html
certauthv3/forms/help
NIHLoginPolicies.html
bioinformatics.ccr.cancer.gov
index.html
chernobyltissuebank.cancer.gov
index.html
chornobyltissuebank.cancer.gov
about
index.html
account/login
index.html
accounts
password/reset
index.html
signup
index.html
privacy
index.html
research
index.html
research_projects
index.html
search_facility/dashboard
index.html
datascience.cancer.gov/about
application-supportcbiit-directorcontactnci-cio
organization
index.htmlinformatics-data-science-program-idsoffice-data-sharing-ods
staff-directory
abigail-joycealex-nordanallen-dearryallison-dennisblaise-czekalskibrandon-wrightbrenda-dugganbrent-reynoldsbrian-capaldocarl-mccabechristopher-knillchristopher-siwychunhua-yancliff-wongcraig-hayncu-nguyendanny-rebolledodaoud-meerzamandenise-warzeldianna-kellydonald-halldoug-hosieremi-casas-silvaemily-bojaemily-greenspaneric-williamserika-kwonerin-beckfatma-onmusfreddie-pruittgilberto-fragosogranger-suttonheather-basehoreheather-creasyian-foreina-felaujane-pollackjanelle-cortnerjavis-brownjay-spencerjennifer-kwokjill-barnholtz-sloanjim-racheffjoe-flores-torojoe-longokanakadurga-durga-addepallikaren-friendkeyvan-farahanikrish-seshadrilawrence-larry-bremlyubov-remennikmarcos-munozramosmaurice-edmondsmelissa-nisongermousumi-ghoshnathan-boydnelya-guninapatty-fersonpaul-von-steinpreston-woodqingrong-chenrachel-lefflerrobinette-rennerryan-hashshan-liangshannon-silkensenshea-manleysichen-liusimona-popa-cotarlastephanie-hallingsubhashini-jagusue-pansylvia-gayletanja-davidsentanna-nelsonumit-topalogluute-reichlingying-huying-huang
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Cancer.Gov
==========
Public data archives from [cancer.gov](https://www.cancer.gov).

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<!DOCTYPE html>
<html lang="en">
<head>
<title>Login Help - NIH Login</title>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width">
<meta http-equiv="X-UA-Compatible" content="IE=edge" />
<link rel="stylesheet" href="/certauthv3/forms/index.css">
<link rel="shortcut icon" href="https://www.nih.gov/favicon.ico" type="image/vnd.microsoft.icon">
<link href="https://fonts.googleapis.com/css2?family=Roboto:wght@300;400;500&display=swap" rel="stylesheet">
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/4.4.1/js/bootstrap.bundle.js" integrity="sha256-Z1t+wxZ7Eh5T1sK6aePWMhEQOghR4jZVLwjwrUZAReE=" crossorigin="anonymous"></script>
</head>
<body>
<header class="nih-header d-flex align-items-center">
<div class="container">
<div class="row justify-content-left">
<div class="col col-10 offset-xl-1">
<img src="/certauthv3/forms/images/NIHLogo.png" alt="National Institutes of Health" class="header-logo">
</div>
</div>
</div>
</header>
<div class="container">
<div class="row">
<div class="col-xl-10 offset-xl-1">
<main class="nih-login-content">
<div class="col">
<h1>Login Help</h1><br>
<div class="panel-group" id="accordion">
<div class="panel panel-default">
<div class="panel-heading">
<h4 class="panel-title">
<a href="https://ocio.nih.gov/Smartcard/Pages/default.aspx">Trouble with your PIV card?</a>
</h4>
</div>
<div id="help1" class="collapse">
<div class="panel-body"><a href="https://ocio.nih.gov/Smartcard/Pages/PIV_faq.aspx">PIV FAQs</a> - Find answers to frequently asked PIV-related questions.<br>Smart Card Help <a href="https://ocio.nih.gov/Smartcard/Pages/default.aspx">Documentation</a> - Help materials covering a range of topics, includinng PIV certificates, email encryption, PIN resets, badge replacement, and more.<br><a href="http://testmysmartcard.nih.gov/">NIH Smart Card Validation</a> - Confirm your PIV card is working properly (note:must be behind the firewall to access).<br><a href="https://myitsm.nih.gov/selfservice/">Search Knowledge Base Articles</a> for more help(note: must be behind the firewall to access).</div>
</div>
</div>
<div class="panel panel-default">
<div class="panel-heading">
<br>
<h4 class="panel-title">
<a href="https://iforgotmypassword.nih.gov/">Need to reset your password?</a>
</h4>
</div>
<div id="help2" class="collapse">
<div class="panel-body"><b>For NIH, HRSA, or NIH External Accounts</b><br><a href="https://iforgotmypassword.nih.gov/">Password Self Service (PSS)</a> - This link can be used if you need to register or if you are already registered. For additional assistance, call the NIH IT Service Desk at 301-496-4357(6-HELP) or 866-319-4357(toll-free)<br><b>Other Account Types<br>eRA Commons</b> - <a href="https://public.era.nih.gov/commons/public/dispatcher?action=resetPassword">eRA Password Reset [info]</a><br><b>HHS OPDIVs</b> - <a href="https://ams.hhs.gov/amsLogin/help/LoginHelp.html">HHS AMS Login Help</a><br><b>OpenID</b> - Use the password reset options from your OpenID provider (e.g.,<a href="https://support.google.com/mail/answer/41078">Google</a> or <a href="https://account.live.com/password/reset">Microsoft</a>)<br><b>InCommon</b> - Contact the support team for your affiliated organization.</div>
</div>
</div>
<div class="panel panel-default">
<div class="panel-heading">
<br>
<h4 class="panel-title">
<a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">Trouble with Authenticator App?</a>
</h4>
</div>
<div id="help3" class="collapse">
<div class="panel-body">If you are not using a PIV card to sign in with your NIH credentials, you may register for the Authenticator App.<br><a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">Need to Register?</a> - Please follow <a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">these instructions</a> to register for the Authenticator App.<br><a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">New Phone?</a> - Please follow <a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">these instructions</a> to reset your Authenticator App.<br><a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">No internet on your phone?</a> - Please refer to <a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">these instructions</a> to view and/or change your default method to One-time Password (OTP) (OTP does not require internet).</div>
</div>
</div>
<div class="panel panel-default">
<div class="panel-heading">
<h4 class="panel-title">
<a href="https://myitsm.nih.gov/kb_view_customer.do?sysparm_article=KB0018369">Can't sign in and don't know why?</a>
</h4>
</div>
<div id="help4" class="collapse">
<div class="panel-body">If you are sure you entered the correct credentials but you're still unable to sign in: Check your phone. Did you get a push notification from the Authenticator App? If so, click the notification and select "Approve".</div>
</div>
</div>
</div>
</main>
</div>
</div>
<aside role="doc-notice" class="container nih-warning-content no-gutters">
<div class="col-xl-10 offset-xl-1">
<h2 class="warning-header">WARNING NOTICE:</h2>
<p class="warning-text">
For public facing web pages to which the public has privileged access, e.g., clinical trial or adverse effects systems where users/patients are logging in to enter PII/PHI: You are accessing a U.S. Government web site which may contain information that must be protected under the U.S. Privacy Act or other sensitive information and is intended for Government authorized use only. Unauthorized attempts to upload information, change information, or use of this web site may result in disciplinary action, civil, and/or criminal penalties. Unauthorized users of this web site should have no expectation of privacy regarding any communications or data processed by this web site. Anyone accessing this web site expressly consents to monitoring of their actions and all communication or data transitioning or stored on or related to this web site and is advised that if such monitoring reveals possible evidence of criminal activity, NIH may provide that evidence to law enforcement officials.
</p>
</div>
</aside>
</div>
<footer class="nih-footer">
<p>For assistance, call the NIH IT Service Desk at <br><span class="text-nowrap text-break"><a href="tel:301-496-4357">301-496-4357</a> (6-HELP)</span> or <span class="text-nowrap"><a href="tel:866-319-4357">866-319-4357</a> (toll-free)</span></p>
<img src="/certauthv3/forms/images/HHSLogo.svg" class="footer-logo-hhs" alt="HHS">
<img src="/certauthv3/forms/images/NIHLogo.png" alt="NIH" class="footer-logo-nih-small">
</footer>
</body>
</html>

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<!doctype html>
<html lang="en"><head>
<title>Login Help - NIH Login</title>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<link rel="stylesheet" href="/certauthv3/forms/index.css">
<link rel="shortcut icon" href="https://www.nih.gov/favicon.ico" type="image/vnd.microsoft.icon">
</head>
<body>
<header class="nih-header d-flex align-items-center">
<div class="container">
<div class="row justify-content-left">
<div class="col col-10 offset-xl-1">
<img src="/certauthv3/forms/images/NIHLogo.png" alt="National Institutes of Health" class="header-logo">
</div>
</div>
</div>
</header>
<div class="container main-container">
<div class="row">
<div class="col-xl-10 offset-xl-1 main-container-columns">
<main class="nih-login-content">
<h1>Login Help</h1>
<div class="row">
<div class="col-md-6 col-12 vertical-spaced-mid">
<h2>Password Reset Guidance</h2>
<h3>NIH, HRSA, and NIH External Accounts</h3>
<p>
<a href="https://iForgotMyPassword.NIH.GOV" target="_blank" rel="noreferrer">
<strong>Password Self Service (PSS)</strong>
</a> - This link can be used if you need to register or if you are already registered. </p><p class="vertical-spaced-mid">For additional assistance, call the NIH IT Service Desk at <span class="text-nowrap text-break"><a href="tel:301-496-4357">301-496-4357</a> (6-HELP)</span> or <span class="text-nowrap"><a href="tel:866-319-4357">866-319-4357</a> (toll-free)</span></p>
<h3 class="vertical-spaced-mid">Other Account Types</h3><p><span class="heavy">eRA Commons</span> - <a href="https://public.era.nih.gov/ams/public/accounts/password/reset.era" target="_blank" rel="noreferrer" title="eRA Commons Forgot Password">eRA Password Reset</a>
<a href="http://era.nih.gov/erahelp/commons/Default.htm#cshid=111" target="_blank" rel="noreferrer" style="font-size: small;">[info]</a>
</p>
<p class="vertical-spaced-mid"><span class="heavy">HHS OPDIVs</span> - <a href="https://ams.hhs.gov/amsLogin/help/LoginHelp.html" target="_blank" rel="noreferrer">HHS AMS Login Help</a></p>
<p class="vertical-spaced-mid"><span class="heavy">OpenID</span> - Use the password reset options from your OpenID provider (e.g., <a href="https://support.google.com/mail/answer/41078" target="_blank" rel="noreferrer">Google</a> or <a href="https://account.live.com/password/reset" target="_blank" rel="noreferrer">Microsoft</a>).
</p>
<p class="vertical-spaced-mid"><span class="heavy">InCommon</span> - Contact the support team for your <a href="https://www.incommon.org/federation/incommon-federation-participants/" target="_blank" rel="noreferrer">affiliated organization</a>.</p>
<p class="vertical-spaced-mid"><span class="heavy">Login.Gov</span> - <a href="https://www.login.gov/help/trouble-signing-in/overview/" target="_blank" rel="noreferrer">Login.Gov Help</a></p>
</div>
<div class="col-md-6 col-12 vertical-spaced-mid">
<h2>Smart Card Guidance</h2>
<p><a href="https://ocio.nih.gov/Smartcard/Pages/PIV_faq.aspx">PIV FAQs</a> - Find answers to frequently asked PIV-related questions.</p>
<p class="vertical-spaced-mid"><a href="https://ocio.nih.gov/Smartcard/Pages/default.aspx">Smart Card Help Documentation</a> - Help materials covering a range of topics, including PIV certificates, email encryption, PIN resets, badge replacement, and more.</p>
<p class="vertical-spaced-mid"><a href="http://testmysmartcard.nih.gov/">NIH Smart Card Validation</a> - Confirm your PIV card is working properly (note: must be behind the firewall to access).</p>
<p class="vertical-spaced-mid"><a href="https://myitsm.nih.gov/selfservice/">Search Knowledge Base articles</a> for more help (note: must be behind the firewall to access).</p>
</div>
</div>
</main>
</div>
</div>
<aside
role="doc-notice"
class="container nih-warning-content no-gutters"
>
<div class="col-xl-10 offset-xl-1">
<h2 class="warning-header">WARNING NOTICE:</h2>
<p class="warning-text">For public facing web pages to which the public has privileged access, e.g., clinical trial or adverse effects systems where users/patients are logging in to enter PII/PHI: You are accessing a U.S. Government web site which may contain information that must be protected under the U.S. Privacy Act or other sensitive information and is intended for Government authorized use only. Unauthorized attempts to upload information, change information, or use of this web site may result in disciplinary action, civil, and/or criminal penalties. Unauthorized users of this web site should have no expectation of privacy regarding any communications or data processed by this web site. Anyone accessing this web site expressly consents to monitoring of their actions and all communication or data transitioning or stored on or related to this web site and is advised that if such monitoring reveals possible evidence of criminal activity, NIH may provide that evidence to law enforcement officials.</p><p class="warning-text"><a href="https://www.nih.gov/web-policies-notices">NIH Web Policies and Notices</a></p>
<p class="warning-text"><a href="/certauthv3/forms/help/NIHLoginPolicies.html">NIH Login Service Privacy Policy</a></p>
<p class="warning-text"><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a></p>
</div>
</aside>
</div>
<footer class="nih-footer">
<p>For assistance, call the NIH IT Service Desk at <br><span class="text-nowrap text-break"><a href="tel:301-496-4357">301-496-4357</a> (6-HELP)</span> or <span class="text-nowrap"><a href="tel:866-319-4357">866-319-4357</a> (toll-free)</span></p>
<img src="/certauthv3/forms/images/HHSLogo.svg" class="footer-logo-hhs" alt="HHS">
<img src="/certauthv3/forms/images/NIHLogo.png" alt="NIH" class="footer-logo-nih-small">
</footer>
</body></html>

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<!DOCTYPE html>
<html lang="en">
<head>
<title>Web Policies and Notices</title>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width">
<meta http-equiv="X-UA-Compatible" content="IE=edge" />
<link rel="stylesheet" href="index.css">
<link rel="shortcut icon" href="https://www.nih.gov/favicon.ico" type="image/vnd.microsoft.icon">
<link href="https://fonts.googleapis.com/css2?family=Roboto:wght@300;400;500&display=swap" rel="stylesheet">
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.7.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/4.4.1/js/bootstrap.bundle.js" integrity="sha256-Z1t+wxZ7Eh5T1sK6aePWMhEQOghR4jZVLwjwrUZAReE=" crossorigin="anonymous"></script>
<script>
function searchText(srnum, tabnum) {
var input, filter, table, tr, td, i, txtValue;
input = document.getElementById(srnum);
filter = input.value.toUpperCase();
table = document.getElementById(tabnum);
tr = table.getElementsByTagName("tr");
for (i = 0; i < tr.length; i++) {
td = tr[i].getElementsByTagName("td")[0];
if (td) {
txtValue = td.textContent || td.innerText;
if (txtValue.toUpperCase().indexOf(filter) > -1) {
tr[i].style.display = "";
} else {
tr[i].style.display = "none";
}
}
}
}
</script>
</head>
<body>
<header class="nih-header d-flex align-items-center">
<div class="container">
<div class="row justify-content-left">
<div class="col col-10 offset-xl-1">
<img src="images/NIHLogo.png" alt="National Institutes of Health" class="header-logo">
</div>
</div>
</div>
</header>
<div class="container">
<div class="row">
<div class="col-xl-10 offset-xl-1">
<main class="nih-login-content">
<div class="col">
<h1><b>NIH Login Service Privacy Policy</b></h1><br>
<div class="panel-group" id="accordion">
<div class="panel-body">The <a href="https://auth.nih.gov/CertAuthV3/forms/hrsl/Login.aspx?TYPE=33554433&REALMOID=06-0a45fa03-3e11-40ce-b135-0196d9c4df35&GUID=&SMAUTHREASON=0&METHOD=GET&SMAGENTNAME=nihwamwebagent&TARGET=-SM-HTTPS%3a%2f%2fauth%2enih%2egov%2fiTrust%2fLoginHeaders%2easp%3fFED">NIH Login Service (NIH Login)</a> facilitates access by National Institutes of Health (NIH) staff and registered external collaborators to NIH operated websites, applications, and services that require a log in. Protecting your privacy is very important to us. NIH never collects information for commercial marketing or any purpose unrelated to the NIH’s mission and goals. Therefore, NIH Login will never sell your information to anyone, and we will only use it to provide secure access to the NIH websites and systems you log in to. Remember that once you leave the NIH Login screen, you will be subject to the privacy policies for the site(s) you are visiting.
</div>
<div class="panel-heading">
<h4 class="panel-title">
<a href="https://www.nih.gov/web-policies-notices">Types of Information Collected</a>
</h4>
</div>
<div class="panel-body">NIH Login automatically collects and retains a limited set of information about you when you use the service. We collect different information for badged NIH staff and non-NIH external collaborators:
<br><ul>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<li>NIH Staff: first name, last name, email address, and HHS identification number (HHSID); and</li>
<li>Non-NIH External Collaborators: first name, last name, email address, and persistent identifier from the external identity provider (the owner of the account you used to log in).</li>
</ul>
<br>The NIH Login Service only allows you to provide the information indicated above. You cannot provide information we do not automatically request from the identity provider (the owner of the account you used to log in).
</div>
<div class="panel-heading">
<h4 class="panel-title" color="blue">
<a href="https://www.nih.gov/web-policies-notices">How NIH Login Collects Information</a>
</h4>
</div>
<div class="panel-body">After you log in, NIH Login asks the identity provider (the owner of the account you used to log in) to send the information listed in the Types of Information Collected section. </div>
<div class="panel-heading">
<h4 class="panel-title" color="blue">
<a href="https://www.nih.gov/web-policies-notices">How NIH Login Uses Cookies</a>
</h4>
</div>
<div class="panel-body">When you visit any website, its server may generate a piece of text known as a "cookie" to place on your computer. The cookie allows the server to "remember" specific information about your visit while you are connected. The cookie makes it easier for you to use the dynamic features of webpages.</div>
<div class="panel-body">There are two types of cookies, single session (temporary), and multi-session (persistent). Session cookies last only as long as your web browser is open. Once you close your browser, the session cookie disappears. Persistent cookies are stored on your computer for longer periods.</div>
<div class="panel-body">The Office of Management and Budget <a href="https://www.nih.gov/sites/default/files/misc/m10-22.pdf">M-10-22, Guidance for Online Use of Web Measurement and Customization Technologies</a> allows Federal agencies to use both session and persistent cookies. The NIH Login Service uses session cookies to facilitate your secure access to NIH applications and websites. These session cookies contain only information about your browser’s visit to the site; they do not contain any personal information about you. NIH Login does not use persistent cookies.</div>
<div class="panel-heading">
<h4 class="panel-title">
<a href="https://www.nih.gov/web-policies-notices">How to Disable Cookies</a>
</h4>
</div>
<div class="panel-body">If you do not wish to allow the NIH Login Service to place session cookies on your computer, you can disable in your web browser. You can find instructions to disable cookies in the most popular browsers at <a href="https://www.usa.gov/optout-instructions">https://www.usa.gov/optout-instructions</a>.</div>
<div class="panel-body">Notes:<br><ul><li>If you choose to disable cookies, you will experience issues accessing information and resources at sites and applications that rely on the NIH Login service.</li>
<li>Configuring your browser to disable cookies will disable cookies for all websites, not just NIH sites that rely on NIH Login services.</li>
</ul>
</div>
<div class="panel-heading">
<h4 class="panel-title" color="blue">
<a href="https://www.nih.gov/web-policies-notices">Your Right to Correct Your Personal Information at NIH</a>
</h4>
</div>
<div class="panel-body">Your right to request corrections to errors in your personal information used by the NIH Login Service is specified in the published NIH System of Records Notice (SORN) <a href="https://www.hhs.gov/foia/privacy/sorns/nih-sorns.html">09-25-0216</a>.</div>
<div class="panel-heading">
NIH Staff
</div>
<div class="panel-body">For NIH staff, the NIH Login Service uses information from the NIH Enterprise Directory (NED). You may update your personal information in NED via the <a href="https://nedportal.nih.gov/ProcessPortal/dashboards/SYSRP/2657">NED self-service portal</a>. You may also contact the <a href="https://itservicedesk.nih.gov/">NIH IT Service Desk</a> if you need help.</div>
<div class="panel-heading">
Non-NIH Individuals
</div>
<div class="panel-body">NIH does not have a process in place for non-NIH individuals to correct your personal information used by NIH Login because the information is sent directly to the NIH Login Service by the identity provider (the owner of the account you used to log in) when you log in. To correct your personal information, you will need to contact the owner of the account you used to log in. For example, if you work at a research institution and use your institution’s credentials to log in via NIH Login, you must contact your research institution’s information technology (IT) department.</div>
<div class="panel-heading">
<h4 class="panel-title" color="blue">
<a href="https://www.nih.gov/web-policies-notices">How NIH Login Protects Your Personal Information</a>
</h4>
</div>
<div class="panel-body">NIH Login has implemented administrative, technical, and physical controls to protect your personal information that we collect.</div>
<div class="panel-heading">
Administrative
</div>
<div class="panel-body">NIH Login assigns specific roles on a case-by-case basis to qualified, vetted, and authorized NIH staff. Through those role assignments, authorized NIH staff get the system permissions they need to perform various job functions. NIH Login regularly reviews role assignments, and revokes role assignments when they are no longer required or appropriate.</div>
<div class="panel-heading">
Technical
</div>
<div class="panel-body">NIH Login segregates IT hardware and software from the internet to prevent unauthorized or malicious access. NIH Login maintains and monitors access control lists and event logs to detect unauthorized, suspicious, or malicious activity. Only authorized NIH IT technical staff have access to these logs and access lists, and they must use multi-factor authentication to access the information. In addition, NIH Login uses an array of tools to monitor and audit file and system integrity.</div>
<div class="panel-heading">
Physical
</div>
<div class="panel-body">NIH Login limits physical access to NIH Login servers that are all located in a secured facility or cloud environment. Security personnel are stationed at the main entrance of the complex, 24 hours a day, seven days a week. Anyone entering the facility must be pre-authorized and must display a valid government identification (ID) showing a current identification photo. All entrance doors to the data centers are controlled by card-activated locks that restrict access 24 hours a day, seven days a week.</div>
<div class="panel-heading">
<h4 class="panel-title" color="blue">
<a href="https://www.nih.gov/web-policies-notices">Data Safeguarding and Privacy</a>
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<h3 class="pt-3">About the CTB</h3>
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The Chernobyl (Chornobyl in Ukrainian) Tissue Bank (CTB) is a repository of biological material
and data from patients with thyroid tumors who were exposed as children or adolescents to
radioactive fallout from the April 26, 1986, accident at the Chernobyl nuclear power plant in
Ukraine. The CTB also houses a digital collection of data derived by researchers using our
samples.
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<div class="mt-3">Since CTB was found in October 1998, the project has been supported by a number of
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Cancer Institute (NCI), and the Sasakawa Health Foundation of Japan (SHF). At the time of its
founding, the CTB established a Coordinating Center at Imperial College, London, UK. In 2023,
the Coordinating Center moved to the Division of Cancer Epidemiology and Genetics at the NCI,
part of the National Institutes of Health, which now funds and coordinates the CTB in
collaboration with the V.P. Komisarenko Institute of Endocrinology (IEM) and Metabolism of the
National Academy of Medical Sciences of Ukraine in Kiev, with the full support of the Government
of Ukraine. Initially, Belarus and Russia were included in the project, but those collaborations
are currently suspended for political reasons.
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The objective of the CTB is to provide a research resource for studies of the health
consequences of the Chernobyl accident. It aims to:
<ul>
<li>Ensure that specimens of thyroid cancer removed on or after October 1, 1998, are
consistently described and sampled; that the materials (extracted tumor and normal
DNA/RNA, blood samples, and in some cases fixed tissue sections) along with the
demographic, clinical and pathological information, are available for appropriate
research studies; and that all specimens and data are collected and shared with
appropriate informed consent.
</li>
<li>Review tumor specimens and provide a consensus diagnosis by an international committee
of expert pathologists for all cases. Diagnostic information is available to research
groups carrying out molecular biological, therapeutic, epidemiological, and other
studies.
</li>
<li>Maximize the amount of information obtained from small pieces of tumor and promote
collaborative, rather than competitive, research on a limited biological resource.
</li>
<li>Ensure that knowledge pertaining to the consequences of this accident may benefit the
patients affected and be of value in responding to future nuclear accidents as well as
in understanding and treating thyroid tumors more generally.
</li>
</ul>
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The tissue bank is located at the V.P. Komisarenko Institute of Endocrinology and Metabolism
(IEM) in Kiev, Ukraine. The staff of the CTB obtains informed consent from patients and prepares
and stores their donated materials. (Historically, a separate tissue bank was also maintained in
Russia.) The CTB maintains a database of samples and data that are shared via an integrated
database managed by the coordinating center. The CTB staff work closely with the coordinating
center staff who make key information available to researchers wishing to access the material.
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<h3 class="pt-5">Informed Consent and Privacy Protection</h3>
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The CTB obtains informed consent for each sample collected and ensures proper description,
sampling, and preservation of donated materials (frozen tissue, fixed tissue sections, extracted
DNA/RNA and blood samples). The CTB has in place a robust security system to protect patient
privacy while ensuring their valuable information is available for research studies.
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Each specimen is given a unique identifier. The age, sex, age at operation, oblast, and a
measured or calculated dose received are recorded. All data accessible by researchers are
anonymized. Standard operating procedures, approved by relevant authorities for each country
involved, are followed to ensure privacy.
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<h3 class="pt-5">Description of Available Samples and Sample Access</h3>
<div class="mt-3">
The CTB currently includes material and information from patients with thyroid carcinomas and
cellular follicular adenomas from the contaminated oblasts of Ukraine (Kiev, Kiev city,
Cherkasse, Chernigov, Rovno, Zhitomyr and Sumy) who were born after April 26, 1967, (i.e.,
younger than 19 years of age at the time of the Chernobyl accident), were treated with surgery
on or after October 1,1998, at the Institute of Endocrinology and Metabolism in Kiev, Ukraine,
and who consent to donate to the project. The CTB also includes patients who were born after the
accident, and thus were not exposed to radioactive iodine, as a comparison.
</div>
<div class="mt-3">The CTB collects a variety of biospecimen from patients undergoing operations for
thyroid
cancer or adenoma. Tissue collection follows an approved standard operating procedure (SOP) and
is snap frozen whenever possible; the presence or absence of tumor is verified by frozen
section. A representative paraffin block is also obtained for each case. Where appropriate, the
CTB also collects fresh and paraffin-embedded tissue from loco-regional metastases.
</div>
<div class="mt-3">Histological slides from all tumors are reviewed by the CTB Pathology Panel, an
international
group of expert thyroid pathologists, and a consensus diagnosis agreed before any materials are
released to researchers.
</div>
<div class="mt-3">Available samples include frozen aliquots of DNA and RNA extracted from normal and
neoplastic
thyroid tissue and DNA extracted from blood. A frozen section is taken from each portion of
tissue before extraction to verify its nature. Quality control is performed on nucleic acid
extracted from all tissues and blood samples. In addition, paraffin sections and tissue
microarrays are available. Researchers who <a href="/research/">request access</a> to
samples are provided with extracted
nucleic acid from thyroid tissue, rather than a small piece of tissue. This maximizes the amount
of data that can potentially be obtained from a single specimen and enables multiple molecular
biological studies to be carried out for each case. Aliquots of serum are also available.
</div>
<div class="mt-3">The CTB website is equipped with a robust search function that allows researchers
wishing to
access biomaterials to select cases from which they would wish to receive samples. The search
function returns information on specimen type, patient characteristics, tumor characteristics,
and, for certain tumor specimens, the driver mutation(s) identified to date.
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<h3 class="pt-5">Maintaining an Archive of Findings</h3>
<div class="mt-3">All data generated with samples from the CTB are collected and maintained in an
online
archive that can be accessed for future studies. Researchers who obtain material from the CTB
agree
to provide the results of their investigation on a case-by-case basis. This information will not
be
available until after publication of their findings.
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<h3 class="pt-5">Contact CTB</h3>
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