From 8c20e7076a30b83e5f18f315bb0ed339b69c6c99 Mon Sep 17 00:00:00 2001 From: Scott Williams Date: Tue, 25 Feb 2025 20:59:21 -0500 Subject: [PATCH] Initial commit --- README.md | 5 + auth.nih.gov/CertAuthV3/forms/mfa/Help.html | 93 + .../CertAuthV3/forms/passwordlinks.html | 87 + .../forms/help/NIHLoginPolicies.html | 193 + bioinformatics.ccr.cancer.gov/index.html | 135 + chernobyltissuebank.cancer.gov/index.html | 473 + .../about/index.html | 532 + .../account/login/index.html | 430 + .../accounts/password/reset/index.html | 396 + .../accounts/signup/index.html | 423 + .../privacy/index.html | 570 + .../research/index.html | 543 + .../research/research_projects/index.html | 2308 + .../search_facility/dashboard/index.html | 430 + .../about/application-support | 1265 + datascience.cancer.gov/about/cbiit-director | 1444 + datascience.cancer.gov/about/contact | 1265 + datascience.cancer.gov/about/nci-cio | 1373 + .../about/organization/index.html | 1266 + 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For NIH staff, the NIH Login Service uses information from the NIH Enterprise Directory (NED). You may update your personal information in NED via the NED self-service portal. You may also contact the NIH IT Service Desk if you need help.
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+ + Non-NIH Individuals + +
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NIH does not have a process in place for non-NIH individuals to correct your personal information used by NIH Login because the information is sent directly to the NIH Login Service by the identity provider (the owner of the account you used to log in) when you log in. To correct your personal information, you will need to contact the owner of the account you used to log in. For example, if you work at a research institution and use your institution’s credentials to log in via NIH Login, you must contact your research institution’s information technology (IT) department.
+ + + +
NIH Login has implemented administrative, technical, and physical controls to protect your personal information that we collect.
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+ Administrative +
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NIH Login assigns specific roles on a case-by-case basis to qualified, vetted, and authorized NIH staff. Through those role assignments, authorized NIH staff get the system permissions they need to perform various job functions. NIH Login regularly reviews role assignments, and revokes role assignments when they are no longer required or appropriate.
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+ + Technical + +
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NIH Login segregates IT hardware and software from the internet to prevent unauthorized or malicious access. NIH Login maintains and monitors access control lists and event logs to detect unauthorized, suspicious, or malicious activity. Only authorized NIH IT technical staff have access to these logs and access lists, and they must use multi-factor authentication to access the information. In addition, NIH Login uses an array of tools to monitor and audit file and system integrity.
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+ + Physical + +
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NIH Login limits physical access to NIH Login servers that are all located in a secured facility or cloud environment. Security personnel are stationed at the main entrance of the complex, 24 hours a day, seven days a week. Anyone entering the facility must be pre-authorized and must display a valid government identification (ID) showing a current identification photo. All entrance doors to the data centers are controlled by card-activated locks that restrict access 24 hours a day, seven days a week.
+ + +
The session cookies used by NIH Login are considered web measurement and customization technologies. These technologies comply with existing Federal and NIH policies with respect to privacy and data safeguarding standards.
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NIH conducts and publishes a Privacy Impact Assessment (PIA) for each use of an IT system or third-party website application (TPWA) because each application or site may have different functionality or practices. PIAs are stored with the NIH Privacy Office and TPWAs are posted for public view on DHHS’ Third Party Websites and Applications web site.
+
Because NIH Login relies on groups of records that are designed to be retrieved by an individual’s name or other personal identifier linked to the individual, NIH Login is covered by the Privacy Act of 1974, as amended (5 U.S.C. Section 552a). NIH System of Records Notices are published in the Federal Register and posted on the HHS System of Records Notices Website.
+ + + +
NIH Login retains records for NIH users until business use ceases, or for six (6) years after their password is altered or user account is terminated, but longer retention is authorized if required for business use. Records are destroyed six years after cutoff, unless continuation is requested by the NIH, in accordance with the National Archives and Records Administration (NARA) approved disposition schedule #s DAA-GRS-2013-0006-0003 and DAA-GRS-2013-0006-0004. NIH Login retains a limited set of information for non-NIH individuals only for the short duration of time when they are using the service.
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NIH Login employs the principles of least privilege and need to know, allowing only authorized accesses for NIH staff where access is required to perform primary job responsibilities in accordance with organizational missions and business functions. Information collected by the NIH Login Service is available only to NIH Login System Administrators, and other designated NIH staff who require this information to perform their duties.
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For further information about NIH privacy policy, please contact the NIH Senior Official for Privacy at privacy@mail.nih.gov ; call 301-496-4606 or visit the NIH Privacy Program web page.
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+ + + + + + diff --git a/bioinformatics.ccr.cancer.gov/index.html b/bioinformatics.ccr.cancer.gov/index.html new file mode 100644 index 000000000..feab11c7a --- /dev/null +++ b/bioinformatics.ccr.cancer.gov/index.html @@ -0,0 +1,135 @@ + + + + + + + + + Bioinformatics + + + + + + + + + +
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Bioinformatics Training & Education Program
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The goal of BTEP is to increase the awareness and understanding of bioinformatics techniques and processes among CCR scientists.

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CCR Collaborative Bioinformatics Resource
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CCBR is a resource group which provides a mechanism for CCR researchers to obtain many different types of bioinformatics assistance to further their research goals.

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Genome Analysis Unit
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GAU provides bioinformatics assistance to CCR investigators by engaging in long-term collaborative projects, and by developing custom tools and pipelines to address specific novel challenges.

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NCI Bioinformatics Community
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NCI BC is an environment that aims to promote interdisciplinary collaboration on tool, algorithm, workflow, and pipeline development benefiting the larger bioinformatics community.

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+ + + diff --git a/chernobyltissuebank.cancer.gov/index.html b/chernobyltissuebank.cancer.gov/index.html new file mode 100644 index 000000000..d09910df9 --- /dev/null +++ b/chernobyltissuebank.cancer.gov/index.html @@ -0,0 +1,473 @@ + + + + + + + + + + + Chernobyl Tissue Bank + + + + + + + + + + + + + + + + + + + + + + + + + +
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+ Chernobyl Tissue Bank +

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+ The Chernobyl (Chornobyl in Ukrainian) Tissue Bank (CTB) is + a repository of samples donated by patients with thyroid tumors who live in the areas + affected by the accident at the Chernobyl Nuclear Power Plant. The purpose of the CTB is to + collect, document, and store these materials, and to facilitate access to these unique + resources by bona fide researchers. +
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The CTB website is hosted by the U.S. National Cancer Institute (NCI), Division of Cancer + Epidemiology and Genetics. +
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+ Chernobyl Tissue Bank +

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+ The Chernobyl (Chornobyl in Ukrainian) Tissue Bank (CTB) is + a repository of samples donated by patients with thyroid tumors who live in the areas + affected by the accident at the Chernobyl Nuclear Power Plant. The purpose of the CTB is to + collect, document, and store these materials, and to facilitate access to these unique + resources by bona fide researchers. +
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+ The CTB website is hosted by the U.S. National Cancer Institute (NCI), Division of Cancer + Epidemiology and Genetics. +
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About the CTB

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+ The Chernobyl (Chornobyl in Ukrainian) Tissue Bank (CTB) is a repository of biological material + and data from patients with thyroid tumors who were exposed as children or adolescents to + radioactive fallout from the April 26, 1986, accident at the Chernobyl nuclear power plant in + Ukraine. The CTB also houses a digital collection of data derived by researchers using our + samples. +
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History, Funding, and Organization

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Since CTB was found in October 1998, the project has been supported by a number of + sponsors including the European Commission, the World Health Organization, the U.S. National + Cancer Institute (NCI), and the Sasakawa Health Foundation of Japan (SHF). At the time of its + founding, the CTB established a Coordinating Center at Imperial College, London, UK. In 2023, + the Coordinating Center moved to the Division of Cancer Epidemiology and Genetics at the NCI, + part of the National Institutes of Health, which now funds and coordinates the CTB in + collaboration with the V.P. Komisarenko Institute of Endocrinology (IEM) and Metabolism of the + National Academy of Medical Sciences of Ukraine in Kiev, with the full support of the Government + of Ukraine. Initially, Belarus and Russia were included in the project, but those collaborations + are currently suspended for political reasons. +
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+
+

Purpose of the CTB

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+ The objective of the CTB is to provide a research resource for studies of the health + consequences of the Chernobyl accident. It aims to: +
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  • Ensure that specimens of thyroid cancer removed on or after October 1, 1998, are + consistently described and sampled; that the materials (extracted tumor and normal + DNA/RNA, blood samples, and in some cases fixed tissue sections) along with the + demographic, clinical and pathological information, are available for appropriate + research studies; and that all specimens and data are collected and shared with + appropriate informed consent. +
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  • Review tumor specimens and provide a consensus diagnosis by an international committee + of expert pathologists for all cases. Diagnostic information is available to research + groups carrying out molecular biological, therapeutic, epidemiological, and other + studies. +
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  • Maximize the amount of information obtained from small pieces of tumor and promote + collaborative, rather than competitive, research on a limited biological resource. +
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  • Ensure that knowledge pertaining to the consequences of this accident may benefit the + patients affected and be of value in responding to future nuclear accidents as well as + in understanding and treating thyroid tumors more generally. +
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CTB Location

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+ The tissue bank is located at the V.P. Komisarenko Institute of Endocrinology and Metabolism + (IEM) in Kiev, Ukraine. The staff of the CTB obtains informed consent from patients and prepares + and stores their donated materials. (Historically, a separate tissue bank was also maintained in + Russia.) The CTB maintains a database of samples and data that are shared via an integrated + database managed by the coordinating center. The CTB staff work closely with the coordinating + center staff who make key information available to researchers wishing to access the material. +
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Description of Available Samples and Sample Access

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+ The CTB currently includes material and information from patients with thyroid carcinomas and + cellular follicular adenomas from the contaminated oblasts of Ukraine (Kiev, Kiev city, + Cherkasse, Chernigov, Rovno, Zhitomyr and Sumy) who were born after April 26, 1967, (i.e., + younger than 19 years of age at the time of the Chernobyl accident), were treated with surgery + on or after October 1,1998, at the Institute of Endocrinology and Metabolism in Kiev, Ukraine, + and who consent to donate to the project. The CTB also includes patients who were born after the + accident, and thus were not exposed to radioactive iodine, as a comparison. +
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The CTB collects a variety of biospecimen from patients undergoing operations for + thyroid + cancer or adenoma. Tissue collection follows an approved standard operating procedure (SOP) and + is snap frozen whenever possible; the presence or absence of tumor is verified by frozen + section. A representative paraffin block is also obtained for each case. Where appropriate, the + CTB also collects fresh and paraffin-embedded tissue from loco-regional metastases. +
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Histological slides from all tumors are reviewed by the CTB Pathology Panel, an + international + group of expert thyroid pathologists, and a consensus diagnosis agreed before any materials are + released to researchers. +
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Available samples include frozen aliquots of DNA and RNA extracted from normal and + neoplastic + thyroid tissue and DNA extracted from blood. A frozen section is taken from each portion of + tissue before extraction to verify its nature. Quality control is performed on nucleic acid + extracted from all tissues and blood samples. In addition, paraffin sections and tissue + microarrays are available. Researchers who request access to + samples are provided with extracted + nucleic acid from thyroid tissue, rather than a small piece of tissue. This maximizes the amount + of data that can potentially be obtained from a single specimen and enables multiple molecular + biological studies to be carried out for each case. Aliquots of serum are also available. +
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The CTB website is equipped with a robust search function that allows researchers + wishing to + access biomaterials to select cases from which they would wish to receive samples. The search + function returns information on specimen type, patient characteristics, tumor characteristics, + and, for certain tumor specimens, the driver mutation(s) identified to date. +
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Maintaining an Archive of Findings

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All data generated with samples from the CTB are collected and maintained in an + online + archive that can be accessed for future studies. Researchers who obtain material from the CTB + agree + to provide the results of their investigation on a case-by-case basis. This information will not + be + available until after publication of their findings. +
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Contact CTB

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For queries regarding the Chernobyl Tissue Bank:
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For questions on the operation of the CTB website:
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For more information, please visit:
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Password Reset

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Forgot your password? Enter your email address below to reset it.

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Privacy Policy

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+

+ Protecting your privacy is very important to us. Our Web site links to other National Institutes of + Health (NIH) sites, + federal agency sites, and private organizations. Once you leave the primary CTB site, you are + subject to the privacy + policy for the site(s) you are visiting. In addition to name and email address, we collect some data + about your visit to + our Web site to help us better understand how the public uses the site and how to make it more + helpful. We collect + information from visitors who read, browse, and/or download information from our Web site. We never + collect information + for commercial marketing or any purpose unrelated to the CTB mission and goals. +

+ +
Types of Information Collected
+

+ When you browse through any Web site, certain information about your visit can be collected. We + automatically collect and + store the following type of information about your visit: +

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  • Domain from which you access the Internet
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  • IP address (an IP address is a number that is automatically assigned to a computer when surfing + the Web) +
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  • Operating system and information about the browser used when visiting the site
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  • Date and time of your visit
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  • Pages you visited
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  • Address of the Web site that connected you to the CTB site (such as google.com or bing.com)
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  • Email address associated to your Google Account
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  • Name (as available in your Google Account profile)
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  • Information about what datasets are visited, linked to the IP address used to visit it
  • +
  • Information about the datasets that were accessed from Google Cloud Storage requester pays, and + the associated IP address, and Collection ID +
  • +
+

+ We use this information to measure the number of visitors to our site and its various sections and + datasets to help make our site more useful to visitors. +

+ +
How CTB Collects Information
+

+ CTB uses Google Analytics, Google Cloud Platform StackDriver Logging, and the CTB login process to + collect + the information in the bulleted list in the Types of Information Collected section above. Google + Analytics and + StackDriver gather information automatically and continuously. No Personally Identifiable + Information (PII) is + collected from these two systems. When you log in to our CTB site using a Google Account or a + personal email, + we collect your email address and name (as stored in your Google Account profile if applicable). CTB + staff + conducts analyses and reports on the aggregated data, and those reports are only available to the + NCI and NIH. +

+

+ CTB retains the data from Google Analytics, StackDriver, and the login process as long as needed to + support + the mission of the CTB website and the NCI. +

+ +
How CTB Uses Cookies
+

+ The Office of Management and Budget Memo + + M-10-22, Guidance for Online Use of Web Measurement and Customization Technologies (link is + external) allows + Federal agencies to use session and persistent cookies. +

+ +

+ When you visit any Web site, its server may generate a piece of text known as a "cookie" to place on + your + computer. The cookie allows the server to "remember" specific information about your visit while you + are + connected. +

+

+ The cookie makes it easier for you to use the dynamic features of Web pages. Cookies from CTB pages + only + collect information about your browser’s visit to the site; they do not collect personal information + about you. +

+

+ There are two types of cookies, single session (temporary), and multi-session (persistent). Session + cookies last + only as long as your Web browser is open. Once you close your browser, the cookie disappears. + Persistent cookies + are stored on your computer for longer periods. +

+ +

Session Cookies

+

+ CTB uses session cookies for technical purposes such as to enable better navigation through our + site. These + cookies let our server know that you are continuing a visit to our site. The OMB Memo 10-22 Guidance + defines our + use of session cookies as "Usage Tier 1 — Single Session.” The policy says, "This tier encompasses + any use of + single session web measurement and customization technologies." +

+ +

Persistent Cookies

+

+ CTB uses persistent cookies to enable Google Analytics to differentiate between new and returning + CTB + visitors. Persistent cookies remain on your computer between visits to CTB until they expire. The + OMB Memo + 10-22 Guidance defines our use of persistent cookies as "Usage Tier 2 — Multi-session without + Personally + Identifiable Information (PII).” The policy says, "This tier encompasses any use of multi-session + Web + measurement and customization technologies when no PII is collected." +

+ +
How Personal Information Is Protected
+

+ If you choose to log in to our site with your Google Account we will receive your email address and + name as + listed in your Google Account profile. If you choose to make an account on our site using a personal + email + address, we will receive only that email address; any other profile information is optional and must + be entered + by you. We will maintain this information for security purposes only. We will safeguard the + information you + provide to us in accordance with the Privacy Act of 1974, as amended (5 U.S.C. Section 552a). +

+ +
Data Safeguarding and Privacy
+ +

+ CTB uses web measurement and customization technologies to help our Web sites function better for + visitors + and to better understand how the public uses the online resources we provide. All uses of web-based + technologies + comply with existing policies with respect to privacy and data safeguarding standards. Information + Technology + (IT) systems operated by CTB are assessed using Privacy Impact Assessments (PIAs) posted for public + view on + the Department of Health + and Human Services (DHHS) Web site + (link is external). CTB conducts and publishes a PIA for each use of a third-party website and + application + (TPWA) as they may have a different functionality or practice. TPWA PIAs are posted for public view + on the + DHHS Web + site (link is external). +

+ +

+ Groups of records that contain information about an individual and are designed to be retrieved by + the + individual’s name or other personal identifier linked to the individual are covered by the Privacy + Act of 1974, + as amended (5 U.S.C. Section 552a). For these records, NIH Systems of Record Notices are published + in the + Federal Register and posted on the + NIH Senior Official for Privacy Website (link is external). When web measurement and + customization + technologies are used, the Privacy Policy/Notice must provide: +

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  • Purpose of the web measurement and/or customization technology
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  • Usage tier, session type, and technology used
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  • Nature of the information collected
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  • Purpose and use of the information
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  • Whether and to whom the information will be disclosed
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  • Privacy safeguards applied to the information
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  • Data retention policy for the information
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  • Whether the technology is enabled by default or not and why
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  • Statement that opting-out still permits users to access comparable information or services
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  • Identities of all third-party vendors involved in the measurement and customization process
  • +
+ +
Data Retention and Access Limits
+

+ CTB will retain data collected using the following technologies long enough to achieve the specified + objective for which they were collected. The data generated from these activities falls under the + National + Archives and Records Administration (NARA) General Records Schedule (GRS) 20-item IC 'Electronic + Records,' and + will be handled per the + requirements of that schedule (link is external). +

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Research and CTB Data Access

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+ Researchers interested in using material, information, or data for research purposes must submit + a proposal via the online application system, accessed through the search function. Researchers + can refine their search by sample type and/or data required and obtain an instant report on the + availability of samples and data that match the search criteria. Interested researchers can + submit a request for data and materials using an application form and enter key information + on the research question, study design, laboratory and analytic methods, as well as researcher + qualifications. +
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The CTB will communicate with researchers who submit a request, if the questions + in their proposal have been addressed by previous projects or questions or is likely to produce + results that complement other studies.
List of + projects which have used or are using CTB materials +
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The CTB does not provide funding for research projects.
+ +
+
+

Evaluation of Applications

+
Applications are evaluated for scientific merit and appropriate use of CTB + resources by a Review Panel comprised of scientists from the centers contributing samples + (currently V.P. Komisarenko Institute of Endocrinology and Metabolism), the coordinating center, + managed by the NCI, and other independent, multi-disciplinary senior researchers in the fields + of thyroid cancer and radiobiological research. +
+
Projects may be submitted at any time and the review procedures are, in most + cases, completed by email. After evaluating applications according to the criteria below, each + application will be: 1) approved for access, 2) returned with comments and reconsidered after + the Principal Investigator responses to reviewers, or 3) rejected. +
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+
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Criteria for Evaluation

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+ Researchers applying for CTB samples and data must provide evidence that the following criteria + are satisfied: +
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  • The research question is of considerable scientific and/or medical interest. +
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  • + The study design is appropriate to address the question. +
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  • + The requested sample size is sufficient to provide a good chance of answering the + question. +
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  • + The researcher and research team have appropriate qualifications and experience to + conduct the study, including fluency with the accepted standards and quality control + relevant to necessary laboratory analytical procedures as well as appropriate + permissions from human subjects’ research and/or research ethics committees. +
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  • + The researchers demonstrate familiarity with the relevant literature. +
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  • + The proposed work cannot be undertaken without the data and/or materials of the type + available through the CTB. +
  • +
  • + If case information other than the standard data set (date of birth, date of operation, + sex, oblast of residence, calculated dose, and international Pathology Panel review + diagnosis) are required, the costs of obtaining these data and ethical and consent + should be adequately addressed. +
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  • + The researchers can cover the costs of shipping the material. +
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  • + The amounts of material requested are appropriate for the specified study, and not + excessive, given the limited availability of material. +
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  • + The research can be undertaken within the time consistent with the researchers funding + and the availability of the necessary data and materials. +
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  • + The researchers agree to share immediately with the CTB coordinating center any data + that may be clinically relevant uncovered during the course of the study. +
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  • The researchers agree to provide within three months of the completion of their project + a brief report on their work, including the results of their investigations on each + sample studied, using the CTB sample code number. This report will not be disseminated + beyond the CTB without the agreement of the Principal Investigator. The aim of the CTB + is to maximize the value of the research data derived from the unique tissue collection + and researchers are therefore required to submit their research data back to the CTB. +
  • +
  • The researchers will inform the CTB coordinating center if any material has not been + used in the performance of their study and will return this material, if requested, to + the CTB coordinating center. +
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+ The researchers agree not to use the material for any purpose other than those explicitly + proposed in their approved project, or to pass any material supplied by the CTB to third parties + without the explicit permission of the CTB coordinating center. +
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Procedures for Approved Projects

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+ Once approved, researchers will sign a Material and Data Transfer Agreement with the CTB + Coordinating Center, then biospecimens and data will be sent to the researcher. Samples are + provided free of charge, but shipping costs will be covered by the researchers. Where possible, + material for a given project will be provided in one batch, however, in some cases, materials + may be sent in stages. +
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+ Each sample will be accompanied by a minimum data set comprising the following information: +
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  • + Age at accident - complying with HIPAA regulations +
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  • + Age at surgical treatment - complying with HIPAA regulations +
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  • + Sex +
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  • + Oblast of residence +
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  • + International Pathology Review Panel diagnosis +
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  • + Estimated thyroid radiation dose (if requested) +
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+ Access to additional research data, if requested, may be made available. Additional clinical + information may require collaboration with IEM and NCI. +
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+ Researchers are strongly encouraged to publish their data and are asked to ensure that the CTB + is acknowledged in any publications arising from their study. +
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+ Principal Investigators who receive materials are required to: +
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  1. + Agree to conform to the conditions set out in the Material and Data Transfer Agreement +
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  3. + Notify the CTB coordinating center of any proposed modification of the number and size + of samples required (modification dependent on approval and the availability of the + material). +
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Research Projects Using CTB Materials

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Please select one of the sections below to view a breakdown of the research projects:

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  • [001/2001] Expression profiling of tyrosine kinase genes in malignant + tumors of the thyroid gland. +
    Heinz-Ulrich Weier, LBNL, + University of California, Berkeley Email +
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    + Abnormal + expression of tyrosine kinase (tk) + genes is a common phenomenon in papillary thyroid carcinomas + (PTCs), + where it is believed to alter + cell growth and response to external signals such as growth + factors, + hormones etc. While the + pathogenesis of radiation-induced PTC remains unclear, there is + evidence + that tk genes such as the + receptor tyrosine kinases ret and NTRK-1 are abnormally + expressed, + and + that the overexpression of + some tk genes due to gene amplification or changes in gene + regulation in + the absence of structural + alterations may lead to oncogenic transformation of cells. Using + a + DNA + microarray based technique, + we have identified several tk genes with abnormal expression in + human + tumor cell lines. We now + propose to apply the technique to measure the relative + expression + levels + of more than 50 tk genes in + the PTC's that arose after the Chernobyl nuclear accident and to + compare + these expression profiles + with the gene expression pattern found in sporadic PTC cases and + tumors + that arose following low + level therapeutic irradiation of the thyroid. Results from this + study + may allow the identification + of molecular markers that can be used to facilitate tumor + diagnosis + and + staging, and, eventually, + provide targets for therapeutic intervention.

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  • +
  • [002/2001] Chernobyl, an Integrated Pan-European Study, morphology, + oncogenes, + DNA repair and outcome in radiation carcinogenesis. +
    + GA Thomas, South West Wales Cancer Institute, University of Wales, Swansea, + UK. Email +
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    + +

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    + The objective of this study is to + investigate the link between exposure of children to radiation, + the + subsequent development of + tumors and how their morphology, molecular and cell biology + influence + clinical outcome. The project + is an integrated approach involving 5 leading European centers. + Samples + of the same tumors will be + studied by the 5 different centers to determibe tumor morphology + and + type; the degree of variation + within the tumor, including the variation of the proportion of + cells + in + cycle using antibodies to + novel DNA replication associated peptides; the gene involved in + the + carcinogenic process, using DNA + chip technology; specific studies of the pathways associated + with + one + oncogene (ret) known to be + linked to the tumor type involved; and studies of novel gene + rearrangements using FISH technology. + By using the same tumor/normal pairs in these studies, + integrating + the + results from the different + centers and studies and correlating these with detailed + morphological + analysis and patient details + including evidence on tumor aggressiveness and recurrence, we + will + increase our understanding of + the link between radiation exposure and cancer development, and + provide + evidence which will inform + decisions on radiation protection and on clinical management of + patients + with radiation associated + cancers.

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  • +
  • [004/2001] RET proto-oncogene rearrangements and tyrosine kinase gene + expression + in radiation induced papillary thyroid carcinomas developed after the + Chernobyl + accident. +
    + Horst Zitzelsberger, GSF, Munich, Germany + Email +
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    + The papillary thyroid + carcinoma oncogene (RET/PTC) is a rearranged version of the + tyrosine + kinase RET. It is know that the + incidence of RET/PTC activation is increased in + radiation-induced + papillary thyroid carcinomas + compared to papillary thyroid carcinomas without a radiation + history. + The prognostic value of + RET/PTC rearrangements and its importance as a + radiation-specific + marker + is still unclear. It is + proposed to screen 70 childhood cases from Belarus and Ukraine + with + interphase FISH in conjunction + with RT-PCR to confirm the presence and type of the chimeric + transcripts. Cases with indications for + atypical RET/PTC rearrangements will be further investigated + using + 5'RACE for the presence of novel + types of alteration. For this part of the proposal RNA samples + as + well + as a limited number of + paraffin-embedded sections would be needed. The RNA samples will + be + further investigated for + expression profiles of other tyrosine kinase genes to identify + other + gene rearrangements which may + occur as a sole abnormality or in addition to RET/PTC + rearrangements.

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  • +
  • [005/2001] Mitochondrial DNA deletions and mutations in post Chernobyl + thyroid + tumors and in the respective normal thyroid parenchyma. +
    + Manuel Sobrinho-Simoes, IPATIMUP, Porto, Portugal + Email +
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    + Mittochondrial DNA (mtDNA) is a likely hotspot for mutation in + cancer as + it is preferentially modified by many carcinogens. We have + previously + shown that there is a specific association between sequence + variants + of + Complex I genes and ATPase6, one of the two mitochondrial genes + of + Complex V, and the occurrence of malignancy and of oxyphil + features + in + thyroid tumors. We have also found a significant association + between + mitochondrial sequence variants and the occurrence (and degree) + of + the + so-called mitochondrial common deletion. In an attempt to + elucidate + the + role of post-Chernobyl irradiation in mtDNA alterations and to + find + out + whether or not such alterations are involved in the + etiopathogenesis + of + thyroid tumors we will search for the mtDNA common deletion and + for + somatic mutations and sequence variants in the D-loop region, in + the + 13 + coding genes and in the 22 tRNAs genes of cases from which there + are + RNA + and DNA samples extracted from blood (set without radiation), + normal + thyroid (set irradiation) and tumors (set irradiation and + tumorigenesis). In a first step, we will study exhaustively 20 + cases. + The results obtained in this first part will be used together + with + the + data we and others have previously obtained to decide the most + appropriate targets for the second part of the study. If + possible we + would like to correlate the results of our study on mtDNA + deletions + and + mutations with those on ret oncogene. In case there are also + clinico-pathyological data available, we would like to + collaborate + with + the pathologists who have studied the cases in order to clarify + the + putative clinical significance of the mtDNA alterations.

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  • [007/2001] Expression of the RET proto-oncogene in post-Chernobyl thyroid + tumors + and unirradiated controls: analysis of RET/PTC rearrangements, RET wild type + and + RET-TK domain, with quantitative assessment of mRNA and protein expression. +
    + Aldo Pinchera, University of Pisa, Italy + Email +
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    + Genetic alterations of the ret proto-oncogene play a critical + role + in + the pathogenesis of papillary thyroid carcinomas both naturally + occurring and radiation induced. We have recently found that + classical + RET/PTC rearrangements are present also in benign thyroid + nodular + disease. Furthermore, in several cases the independent + expression of + tyrosine kinase (TK) and extracellular (EC) domains of RET was + found. + This finding may be interpreted as RET wild type gene + expression. In + other cases, especially radiation exposed, the TK domain in the + absence + of EC was found and was interpreted as unknown RET/PTC + rearrangements + (PTCX). Aim of this project is to clarify the modality of + expression + of + RET protooncogene in nodular thyroid diseases. In cases with EC + and + TK + expression, we will search for RET wild type by an extralong PCR + encompassing the TK and EC domains, followed by sequencing of + the + PCR + product. In cases of TK positive expression only (but not + classical + PTC1, PTC2 and PTC3) we will identify the 5' domain rearranged + with + the + TK domain. As for other unknown RET/PTC rearrangements will use + the + 5'race approach.

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    + All samples positive for TK expression will be submitted to + quantitative PCR (ABI Prism 7700 sequence detector, Perkin + Elmer) + for TK + mRNA. The TK mRNA expression will be correlated with the + histological + characteristics of the analysed tissues, and the + immunohistochemical + pattern of RET protein expression, using an antibody to + recognize + the TK + domain.

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  • +
  • [001/2002] Analysis of RET/PTC transforming ability in Thyroid cells using + Oligonucleotide DNA Micro Array. + +
    + Giuliana Salvatore, University of Naples, Italy + Email +
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    + The expression of RET/PTC oncogenes in thyroid PC Cl 3 cells induces + a + complex phenotype with a block of the differentiation program, + hormone-independent proliferation and increased apoptotic rate. + Oligonucleotide GeneChips were used to analyse gene expression + profiles + of PC Cl 3 cells expressing either RET/PTC1 or RET/PTC3 oncogenes in + comparison to parental cells. About 2,000 genes showing at least + two-fold increase and 2,000 genes showing at least two-fold decrease + were identified in RET/PTC-expressing thyrocytes. Virtually all the + genes up-regulated by more than 5-folds (about 100) were confirmed + by + RT-PCR and some of them by immunoblot. Genes upregulated by RET/PTC + could be functionally divided in genes involved in proliferation + (such + as D-type cyclins), apoptosis, proteolysis, inflammation, and + metabolism. We plan to extend these studies on the identified genes + up + and on the downregulated by analyzing their expression in human + thyroid + tumors of different histotypes. We propose to study their expression + by + semiquantitative reverse transcriptase PCR and for selected genes by + real time quantitative PCR. Immunohistochemical analysis will be use + to + verify protein expression. +
    +
    + The findings of these studies can reveal clues to the molecular + pathways + involved in papillary thyroid carcinoma and may provide biomarkers + for + clinical use. +
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  • +
  • [002/2002] A Comprehensive Molecular Profile of ChildhoodRadiation Induced + Papillary Thyroid Tumors Compared to Adult Sporadic Papillary Tumors. + +
    + Lesleyann Hawthorn, Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York, USA + Email +
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    + +

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    + Papillary thyroid carcinoma (PTC) accounts for 80% of all thyroid + malignancies. It has a variable disease course and to date no + pathways + or specific genes have been implicated as causative in this tumor. + RET + activation, through translocations involving several genes, have + been + noted in a high incidence of PTCs. However, the activation of this + oncogene is found at all stages from benign through + well-differentiated + to undifferentiated carcinoma. This suggests that it represents an + early + event and that this defect is not in itself sufficient for + carcinogenesis. It may also suggest that the classification of PTC + covers more than one tumor subtype. The relationship between + radiation + exposure and PTC is well established. We plan to perform a genome + wide + scan using microarray analysis for alterations in tumors from + children + exposed to radiation and compare them to sporadic adult tumors to + identify which genes are commonly altered and which genes are + display + differential alteration expression patterns. We plan to extend this + study using high-resolution BAC-CGH to define a molecular pattern + for + these tumors and evaluate this approach for diagnostic applications. + The + study of molecular alterations which cause thyroid carcinoma is of + importance since the identification of causative factors could lead + to + new approaches for treatment. +
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  • [001/2003] A comprehensive analysis to find out molecular biomarker(s) of + radiation exposure and grade of malignancy in human post-Chernobyl PTC +
    + Hiroyuki Namba, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan + Email +
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    + +

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    + Development of papillary thyroid cancer (PTC), similarly to that of + most + of other human malignancies, is likely to comprise a multistep and + multihit process. It is quite probable that mutational events + initiating, promoting and/or driving the tumor progression are quite + similar in the sporadic and radiation-induced PTC. Along with this, + one + may expect there may be unidentified to date molecular distinctive + features peculiar to thyroid cancers of different etiology. Thus, a + comparative study of various molecular characteristics in the two + groups + of PTC may provide additional information for the determination of + the + molecular signature of radiation-induced thyroid cancerogenesis. +

    + In the proposed project we intend to study the following molecular + characteristics of the DNA extractedfrom normal and tumor tissue of + radiation-induced PTCs: i) relative content of mtDNA and number of + large-scale deletions in mtDNA; ii) prevalence of gene mutations of + MAPK + signal molecules, including the Ras,BRAF, Raf-1 and MEK genes; and + iii) + distribution of the codon 72 allelic variants of theTP53. +

    + After the data are obtained, we will perform a comprehensive + univariate + and multivariate statistical analysis against already available + results + of examination of sporadic PTC in order to identify molecular + parameter(s) specific to radiation-induced PTC. + +
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  • [002/2003] Molecular Change and Thyroid Cancer Risk after Chernobyl +
    + Scott Davis, Fred Hutchinson Cancer Centre, Seattle, USA + Email +
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    + +

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    + This study investigates the occurrence and molecular characteristics + of + thyroid cancer in residents of the Bryansk Oblast of the Russian + Federation, who were 0-50 years of age at the time of exposure to + radiation from the Chernobyl Power Station accident (ATA) on April + 26, + 1986. The study has three primary purposes: 1) to characterize cases + of + thyroid cancer according to specific molecular markers of genetic + change, and investigate whether the presence of such markers is + associated with individual thyroid radiation dose from the Chernobyl + accident; 2) to investigate whether age-at-exposure dependent + radiation + dose response for thyroid cancer differs between cancers that are + positive versus negative for the molecular markers investigated; and + 3) + to investigate whether the presence of these same molecular markers + is + associated with clinical outcomes. Included will be thyroid cancer + cases + diagnosed between April 1, 2001 and March 31, 2006 and confirmed by + a + panel of expert thyroid pathologists. An equal number of controls + will + be individually matched to cases by sex, age, type of settlement and + raion of residence on April 26, 1986. Data collected will include + in-person interviews for all participants, and for cases only, + paraffin + embedded tissue or fresh frozen tissue, clinical history and outcome + information. + +
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  • [001/2004] Analysis of Genetic and Epigenetic Abnormalities in + Radiation-induced + Thyroid Cancers +
    + Michael M Xing, John Hopkins University School of Medicine, Baltimore USA + Email +
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    + Thyroid cancers are the most common endocrine malignancies and the + vast + majority of them are papillary thyroid cancers (PTC). Several + genetic + abnormalities, including Ras mutations and RET/PTC rearrangements + have + been well characterized in these cancers. Recently, we and several + other + groups have reported the BRAF mutation in PTC with a high + prevalence. We + have also characterized aberrant DNA methylation in several genes in + thyroid cancers, including novel tumor suppressor genes and some + thyroid-specific genes. Except for the RET/PCT rearrangements, these + genetic and epigenetic abnormalities have been studied mainly in + sporadic thyroid cancers, and their role is unknown in the special + group + of thyroid cancers induced by radiation, the most common and + well-established environmental risk factor for thyroid cancer. + Chernobyl + nuclear accident has been associated with a significant increase in + the + incidence of PTC, which represent an ideal thyroid tumor model for + the + study of radiation-induced thyroid tumorigenesis. In the present + project, we propose to use such special thyroid cancer samples to + study + novel genetic and epigenetic abnormalities, their relationship, and + their effects on the expression of key thyroid genes. + Well-established + experimental protocols and techniques, including RT-PCR, + methylation-specific PCR, real-time quantitative PCR, and a recently + established colorimetric mutation detection method will be used. The + study is expected to result in important insights into + radiation-induced + thyroid tumorigenesis and provide novel clinical implications for + this + special group of thyroid cancers. + +
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  • [002/2004] Investigation of molecular genetic abnormalities associated with + progression of human thyroid follicular neoplasms +
    + D Wynford-Thomas, University of Wales College of Medicine, Cardiff UK + Email +
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    + Thyroid follicular carcinomas frequently exhibit RAS mutation, and + closely resemble benign follicular adenomas with respect to + morphology + and differentiation. Cell culture studies suggest that at least one + requirement for progression from an adenoma to a carcinoma is + failure of + an intrinsic mechanism that normally limits the proliferative + lifespan + of RAS-induced cell clones. One current candidate for over-riding + the + mechanism is the tumor suppressor gene p16 INK4a. +

    + There is great clinical interest in this area, as currently there is + no + marker to distinguish between thyroid follicular adenoma and + carcinoma + when evaluating fine needle aspirates and biopsies of thyroid + glands. + This means that many people have unnecessary operations on the basis + of + presumed malignancy. We now therefore wish to carry out a + comprehensive + comparison between thyroid carcinoma and adenoma cells to identify + differences that may confer an extended proliferative lifespan on + carcinoma cells. +
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  • [003/2004] Molecular Definition of Gene Expression in Chernobyl Thyroid + Cancers +
    + Carine Maenhaut, ULB, Brussels + Email +
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    + Chernobyl thyroid cancers represent a unique resource in + oncology + and radiation biology. They appear in a cohort of patients + irradiated at the same time and in which there is no doubt that + the + cancer originated from radiation exposure. The precise timing of + the + course allows to follow precisely the kinetics of appearance of + the + cancers. On the other hand study of the gene expression pattern + of + cancers by microarrays allows a precise molecular definition of + each + cancer. Using this methodology we were able to show that the + clustering of gene patterns of Chernobyl cancers of the first + wave + and European and US sporadic cases could not separate them. This + work should now be extended to a larger series of cases. +

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    1. + to try to distinguish subtypes of Chernobyl and sporadic + papillary carcinomas and their signature. +
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    3. + to relate patterns of gene expression with clinical + variables + such as the duration of the incubation period and with the + genetic diagnosis. +
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    5. + to validate data at the RNA level by PCR and at the protein + level by Western and to define potential diagnostic markers + and + therapeutic targets. +
    6. +
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  • [001/2005] Genomic Analysis of Gene Copy Number in Thyroid Cancer. +
    + PE Neiman, FHCRC, Seattle, USA + Email +
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    + High copy-number gene amplification is known to take place at a + few + genomic loci in numerous human cancers, but widespread low-level + copy-number changes in genomic DNA have not been described. cDNA + microarray-based comparative genome hybridization yields + high-resolution copy-number profiles that enable the detection + of + low-level amplification events at individual gene loci. We have + shown in a small pilot study that pediatric thyroid carcinoma in + residents of a region contaminated by 131I from the Chernobyl + accident (the Bryansk Oblast) exhibits gene amplification at a + higher frequency than that seen in pediatric thyroid carcinoma + in US + children with no history of radiation exposure. This result + suggests + that exposure to ionizing radiation from the environment may be + associated with an increased rate of gene amplification in a + human + cancer. The consistent amplification of many genes among cases + of + post-Chernobyl thyroid carcinoma from Bryansk suggests the + existence + of a target pool of radiation-sensitive genomic loci that + respond to + exposure by initiating local amplification events. The pattern + of + gene amplification may represent a radiation signature that + could be + used to map amplicons likely to harbor participating oncogenes. +

    + Based upon these differences observed in the pilot study in + apparent + gene amplification between post-Chernobyl and spontaneous + pediatric + papillary thyroid carcinoma (PTC), we hypothesize that radiation + exposure leaves a measurable genomic signature in the form of + stable + changes in gene amplification. Some chromosomal regions + identified + by this method are likely to harbor participating oncogenes, but + it + is unreasonable to expect that so many genes be directly + involved in + oncogenesis. We hypothesize the presence of genomic hot spots in + human DNA that are susceptible to radiation-induced + amplification. + These genomic targets are unlikely to be saturated by the doses + of + radiation delivered to these patients. The number of targets hit + in + each case should therefore be directly proportional to radiation + dose. +

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  • [002/2005] The influence of genetic variation in DNA repair pathways on + cancer + risk following exposure to ionising radiation. +
    + S Forbes-Robertson, Swansea Medical School, Swansea UK + Email +
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    + Genetic damage following radiation exposure is subject to + correction + by the caretaker systems of DNA repair. Our interest is in the + role + that these systems may play in the molecular pathogenesis of + cancer. + We propose a pilot project to assess the influence of genetic + variation on cancer risk following exposure to ionising + radiation. + This will be achieved by investigation of variation in the genes + involved in the DNA repair pathways, in DNA derived from blood + samples or normal tissue samples from patients with thyroid + tumors + of radiation-associated and non-radiation-associated etiology. + There + are two main justifications for such a study, first to identify + SNPs + which indicate possession of an at risk genotype, and secondly, + to + identify the genes in which genetic variation is a significant + modulator of cancer risk. This has particular and wider + relevance to + the involvement of DNA repair-associated factors in the + pathology of + other cancers as well, such as breast cancer. +

    + Genotyping of genes involved in double-strand break repair will + be + performed using a mass spectrometry-based SNPing platform which + has + been developed by our group at the University of Wales, Swansea. + Data will be provided to the Chernobyl Tissue Bank for + correlation + with pathology and expression of oncogenes such as ret and BRAF. +

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  • [001/2007] Array CGH analysis of RET/PTC-positive and RET/PTC-negative + post-Chernobyl thyroid tumors. +
    + H Zitzelsberger, Helmholtz Zentrum München, Neuherberg, Germany + Email +
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    + It is proposed to study chromosomal imbalances in post-Chernobyl + papillary thyroid carcinomas (PTC) by means of array CGH using + 1Mb + BAC arrays. As derived from interphase FISH experiments RET/PTC + rearrangements are heterogeneously distributed within tumor + tissues + leading to the assumption that additional gene alterations may + play + an important role in these tumors. To address this question + post-Chernobyl PTC, with and without RET/PTC rearrangements, + will be + analysed by array CGH. Altered candidate genes will be derived + from + recurrent regions of amplifications and deletions and will be + confirmed by interphase FISH on paraffin sections and further + studies by PCR-based approaches to investigate expression of + these + genes. In a first pilot study it is intended to compare 10 + RET/PTC-positive (RET/PTC3) and 10 RET/PTC-negative cases with + similar histological features, a comparable age range of + patients at + time of exposure and a similar latency after exposure is a first + study. The pilot study will use cases from the age-matched + series + with known RET/PTC status. If successful this study will be + extended + to a larger series of cases linked to the GENRISK-T project. +

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  • +
  • [002/2007] Expression profiling of childhood thyroid cancer: a comparison of + those exposed to radioiodine and those exposed to low level radiocaesium. +
    + Carine Maenhaut, University of Brussels School of Medicine, Brussels, Belgium + Email +
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    + +

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    + The aim of this study is to investigate whether different + transcriptomic profiles can be related to exposure to + radioiodine in + fallout from the Chernobyl accident and to lower level + radiocaesium + exposure present in the contaminated environment. We will use + Affymetrix microarray technology to define transcriptomic + profiles + in two cohorts of children, matched on age, oblast and + pathological + type of tumor. The research will be carried out in two separate + laboratories and cross-validated. This project is one of a + series of + projects that will study the transcriptomic and genetic profile + of + two well-defined cohorts to investigate the relative effects of + radioiodine and radiocaesium exposure on the development of + thyroid + cancer. +

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  • [003/2007] Gene expression in normal and cancerous tissue in relation to + I-131 + exposure. +
    + M Abend, Bundeswehr Institute of Radiobiology, Munich, Germany + Email +
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    + Gene expression has received less attention than the role of + germline polymorphisms or somatic mutations in studies of + radiation + and thyroid cancer. The increase in papillary thyroid cancers + (PTC) + in exposed children following the Chernobyl nuclear accident + presents an opportunity to pursue the role of gene expression + further. Recently, we reported on expression of seven genes, + each of + which was able to distinguish post-Chernobyl PTCs from sporadic + PTCs + (Port et al 2007). Our approach involved (i) a whole genome + microarray used for screening purposes; and (ii) quantitative + examination of the 92 target genes with a high throughput + RTQ-PCR + technique (LDA). The study had some limitations such as the + origin + of sporadic PTCs (Eastern Germany), their different age at + diagnosis + and a small number of cases (n=11). Subsequently another group + has + reported on expression of thirteen genes involved in homologous + recombination suggesting a distinct radiation pattern of + post-Chernobyl PTCs (Detours et al 2007). Using the already + established 2-stage design, the purpose of the present + application + is to overcome limitations in the previous study and extend the + findings (Port et al 1007) by evaluating a dose-dependent gene + expression pattern in 74 post-Chernobyl PTCs with individual + I-131 + dose estimates. +

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  • [004/2007] Genetic predisposition to radiation-induced carcinogenesis and to + specific genetic alterations in post-Chernobyl thyroid cancer. +
    + Y Nikiforov, University of Pittsburgh School of Medicine, Pittsburgh, USA + Email +
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    + +

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    + Radiation exposure is a well established risk factor for thyroid + cancer. Ionising radiation is known to cause extensive DNA + damage + including double strand breaks, which may lead to the generation + of + somatic mutations in thyroid cells and cancer initiation. + However, + environmental triggers cannot fully explain the inter-patient + heterogeneity in the individual response to exposure to + radiation, + which points to the existence of genetic variations that define + the + individual susceptibility to radiation-related cancer. We + propose to + analyse several candidate DNA repair genes and perform a + genome-wide + analysis of single nucleotide polymorphisms (SNPs) in Ukrainian + patients who developed thyroid cancer after Chernobyl and in + control + cancer-free individuals to identify mutations and SNPs that are + involved in genetic predisposition and to identify the genes + that + are affected. We will then perform functional analysis to find + whether these genetic variations alter gene function. We will + also + study the link between specific SNPs and known or new mutations + found in these tumors. The overall goal of this study is to + identify + genes involved in genetic predisposition to radiation-associated + thyroid carcinogenesis and a pattern of SNPs that can detect it. +

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  • +
  • [001/2008] Genrisk-T - defining the risk of low dose radiation for thyroid + cancer - the role of germline SNPs. +
    + GA Thomas, Imperial College London, Hammersmith Hospital, London + Email +
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    + +

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    + Cancer of the non-medullary (follicular epithelium) component of + the + thyroid is induced by external irradiation and by radionuclides + deposited within the thyroid tissue. Estimates of the + radiological + risk of developing thyroid cancer are derived from + epidemiological + studies performed in. Populations receiving high doses where, + according to Ron et al, the threshold in 100 mSv. Extrapolation + of + this risk to exposures at much lower doses is compromised by the + lack of an accurate model of the dose response curve for thyroid + cancer at low doses. Moreover, such population based estimates + fail + to take into account the contribution of individual genetic + variability to the risk estimate. Individuals with an increased + genetic predisposition to develop thyroid cancer are not + identified, + and it is precisely these individuals who will be at greatest + risk + at low doses. The GENRISK-T consortium is composed of thyroid + cancer + experts with experience in the fields of radiation biology, + animal + models of radiation-induced cancer, tumor banking, cancer + biology, + molecular genetics, histopathology, cyto genetics and risk + modelling. We will use this interdisciplinary knowledge to + define + the genetic component influencing the risk of radiation-induced + thyroid cancer. This will be achieved through a combination of + studies using animal models and in human radiation-induced + thyroid + tumors. This new understanding of the genetic risk modifiers + will be + used to develop an animal model of thyroid cancer that is + responsive + to low dose radiation in the cGy range, thereby providing an + experimental solution to resolving the uncertainties of the low + dose-response curve. This EC collaborative project (PI Professor + M + Atkinson, Helmholtz Zentrum, Munich) combines the use of animal + models and human studies. This particular application is to + support + the investigation of human germline SNPs that may predispose to + radioiodine induced thyroid cancer in those exposed as children + and + adolescents. +

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  • +
  • [002/2008] Expression profiling of childhood follicular tumors: a comparison + of + those exposed and not exposed to radiation. Defining the genetic component + of + thyroid cancer risk at low doses. +
    + B Jarzab, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, Poland + Email +
    +

    + +

    +
    +
    +

    + The aim of the study is to investigate transcriptomic profiles + of + follicular thyroid tumors (malignant and benign) that arose + after + expose to radioiodine fallout from Chernobyl power station and + to + low level radiocesium exposure present in the contaminated + environment. Affimetrix microarray technology will be employed + to + define transcriptomic profiles in two cohorts of children + matched on + age, oblast and pathological type of tumor. This project is the + continuation of a series of projects that are carry on to + investigate the transcriptomic and genetic profile of radiation + induced thyroid cancer. +

    +
    +
    +
  • +
  • [003/2008] Array CGH analysis of follicular post-Chernobyl thyroid tumors. +
    + H Zitzelsberger, Helmholtz Zentrum Muenchen, Neuherberg Germany + Email +
    +

    + +

    +
    +
    +

    + Follicular thyroid cancers are less frequent than papillary + thyroid + carcinomas (PTC), however, they are associated with a poorer + survival outcome than PTC. Although several genetic changes have + been identified so far, the molecular genetic mechanisms of + tumor + development in follicular thyroid neoplasms are still unclear. +

    + To investigate novel gene alterations and potential radiation + signatures in follicular thyroid adenomas (FA) and follicular + thyroid carcinomas (FTC) it is proposed to investigate + genome-wide + copy number changes of 100 thyroid tissue samples by array CGH + using + 1 Mb BAC arrays. For this purpose we want to compare genomic + profiles of tumors (FA and FTC) developed pre- and post-fallout + of + the Chernobyl accident. The proposed study aims to identify gene + alterations in follicular thyroid neoplasms from altered genomic + regions and to determine aberrations patterns that correlate + with + the radiation history of patients as well as with any of the + clinical phenotypes of the tumors. +

    +
    +
    +
  • +
  • [001/2009] Defining the genetic component of thyroid cancer risk at low + doses + request for RNA aliquots for QPCR validation and for the exon arrays. + (This project is an expansion of project 002/2008) +
    + B Jarzab, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, Poland + Email +
    +

    + +

    +
    +
    +

    + The aim of the study is to seek for differences in + transcriptomic + profiles of childhood papillary thyroid cancers that arose after + radiation exposure from Chernobyl power station fallout and + sporadic + cancers. As the first step Affimetrix microarray technology was + employed to define transcriptomic profiles in two cohorts of + children matched on age, oblast and pathological type of tumor. + The + second step of the study is to validate microarray results with + Q-PCR analysis. We also plan to extent the analysis to exon + microarray study which allow to detect transcript isoforms, + chromosomal deletions and amplifications. +

    +
    +
    +
  • +
  • [002/2009] Identification of somatically acquired rearrangements in + post-Chernobyl paediatric thyroid cancers using genome-wide massively + parallel + paired-end sequencing +
    + JA Fagin, Memorial Sloan-Kettering Cancer Center, New York, USA + Email +
    +

    + +

    +
    +
    +

    + Post-Chernobyl pediatric thyroid cancers are associated with a + high + frequency of recombination events leading to the generation of + fusion oncogenes, resulting in aberrant expression and + activation of + RET, and less frequently of NTRK and BRAF. Altogether, ~60% of + PTC + arising in this patient population harbor one of these + abnormalities. The discovery of novel somatic rearrangements + using + conventional methods has low sensitivity and/or resolution. We + propose to use genome-wide parallel paired-end sequencing to + identify somatic rearrangements in childhood thyroid cancers + induced + by radiation, as compared to age-matched thyroid cancers without + radiation exposure. Altogether we will select 6 samples of each + population: 2 with a known rearrangement in RET, NTRK or BRAF + (as + positive controls), and 4 without. We will construct 3kb insert + Illumina libraries from each tumor DNA sample, and ~35bp of + sequence + from both ends of each fragment will be obtained. Each end will + be + mapped back to the reference genome. Fragments for which the + ends do + not map back within 3kb of each other and/or are in + inappropriate + orientation will be further studied as they may represent + rearrangements present in the thyroid cancer genome. We will + acquire + ~1 fold genome coverage (~3Gb) from each sample. This will + approximate to 30-fold physical coverage, allowing detection of + essentially all rearrangements present in the dominant clone of + the + cancer. Rearrangements will be processed using a suite of + informatics tools to predict which may generate an in-frame + fusion + gene. RNA from each of the samples will then be tested by + exon-exon + PCR to determine whether the fusion is expressed, and based on + its + predicted function, whether it may correspond to a driver + mutation. + The number of rearrangements in each cancer and their + architecture + will then be compared between the two classes. Sequences at the + rearrangement junctions will also be compared particularly to + examine the complexity of the rearrangement, sequence contexts + of + breaks, presence of repeats and overlapping microhomology of the + rearrangement. Each of these indices may provide clues to the + way + large radiation doses induce DNA double strand breaks and how + they + are repaired. +

    +
    +
    +
  • +
  • [003/2009] miRNA profiles in childhood thyroid cancer +
    + GA Thomas, Imperial College London, Hammersmith Hospital, London + Email +
    +

    + +

    +
    +
    +

    + MicroRNAs (miRNAs) are 21-23 nucleotide long non-coding RNA + molecules that have been shown to regulate the stability or + translational efficiency of target messenger RNAs. Dysregulation + of + miRNAs has been implicated in a variety of cancers, and in the + thyroid germline SNPs in miRNA binding sites and in the coding + sequence for miRNAs themselves, have been implicated in + Papillary + Thyroid carcinogenesis. The Human Cancer Studies Group is part + of an + EC sponsored consortium (Genrisk-T) that has intensively studied + papillary carcinomas from a series of 100 patients, and is + currently + extending this approach to follicular tumors. Half of this group + were exposed to radiation and half were born after 1/1/87 and + not + exposed to radioiodine in fallout. The cohort is carefully age + and + sex matched. The Genrisk-T project has provided data on RNA + expression using Affymetrix technology, bac array CGH data on + copy + number variation in the tumors and SNP array data from normal + tissue + from these patients. We now seek to add miRNA data from this + cohort + and to correlate data on SNPs and copy number variation in the + tumor, with changes in miRNA level, and miRNA expression levels + with + changes in RNA expression levels. The combination of this data + will + give us a thorough understanding of the regulation of a number + of + different growth control pathways involved in carcinogenesis of + the + thyroid follicular cell and their relationship to radiation + exposure. +

    +
    +
    +
  • +
  • [002/2007-1] Validation of statistical and bioinformatics technologies to + allow + integration of Next generation RNA Sequencing and microarray data. +
    + L van Zyl, ArrayXpress, Inc. Raleigh, North Carolina, USA + Email +
    +

    + +

    +
    +
    +

    + We are a small biotech company developing statistical and + bioinformatics methodology that would allow for the direct + integration and co-analyses of RNA-seq and microarray data. As + quantitative RNA-seq data is becoming the method of choice for + gene + expression analyses, we are developing the statistical and + bioinformatics technology which that allow all previous + published + microarray data to be incorporated with new gene expression + platform + data, to ultimately provide more comprehensive data-sets for + downstream applications/analyses. +

    + We have been working with Dr C Maenhauts group to develop the + methodology to integrate her published Affymetrix gene + expression + data with our own Illumina RNA-seq data from papillary thyroid + cancers. We propose now to subject surplus material from the + samples + that Dr Maenhaut received from the CTB (project 002/2007) to + RNA-seq + in order to not only obtain additional expression data over and + above that obtained by microarray but also to further validate + our + methodologies. +

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+ +

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+
    +
  • [001/2011] EpiRadiBio +
    K Unger, Helmholtz Centre, Munich, Germany + Email +
    +

    + +

    +
    +
    +

    The EU funded project EpiRadBio project seeks to model the cancer + of the lung, breast and the thyroid after exposure to radiation + in the low-dose range (cumulative dose < 100 mGy). The + formalin-fixed paraffin-embedded (FFPE) papillary thyroid cancer + tissue sections we apply for will be used in a work package of + EpiRadBio that focuses on the cancer risk of papillary thyroid + cancer. In another, recently finished EU funded project on young + onset childhood thyroid carcinomas that also used CTB material + we found that a gain of the chromosome band 7q11 was associated + with exposure to low-dose ionising radiation (He et al., PNAS, + in press). The FFPE tumor sections from patients, which are part + of the UkrAm cohort and which come with estimates on radiation + dose the patients have received will be used for validation and + further characterisation of this marker. The FFPE sections will + be used for in situ hybridisation (FISH) using 7q11 specific + probes. DNA and total RNA will also be extracted from the FFPE + sections. The DNA will be used for high-resolution array CGH and + the total RNA for qRT-PCR mRNA expression analysis of candidate + genes from the gained region. The copy number data and qRT-PCR + data will be integrated with the dose estimates in order to + identify a potential relationship between the + radiation-associated biomarker and radiation dose. The resulting + data will be provided to the modellers of the project who will + use this information to build and refine their models on + radiation risk of papillary thyroid cancer after exposure to + low-dose ionising radiation.

    +
    +
    +
  • +
  • [002/2011] Molecular specificities of radiation-induced thyroid tumors. +
    + C Ory, Commissariat Energie Atomique, Departement Sciences du vivant, Institut de radiobiologie cellulaire et moleculaire, Laboratoire de Cancerologie Experimentale (CEA), France + UK. Email +
    +

    + +

    +
    +
    + The constituted network to realise this program involved two teams + well known in diagnosis and treatment of thyroid tumors and one team + which were already implicated in the search of radiation-induced + signatures in the thyroid and in the identification of the molecular + mechanisms of radiation-induced tumorigenesis. To date, we focused + our approach at the transcriptomic level. We wish now to analyse + miRNA and mRNA deregulations in a series of post-Chernobyl thyroid + tumors by microarray analysis: 1) to identify a radiation-induced + miRNA and mRNA signatures. We will assess the robustness of these + signatures for a potential use as a diagnostic tool alone or in + combination. 2) to obtain an integrated miRNA/mRNA overview of + radiation-induced tumorigenesis by taking advantage of the + deregulated pathway identified by the transcriptomic approach. To + date, no such integrated analysis has been performed as most of the + studies focused on either transcriptome analysis or miRNA analysis + separately. Ultimately, we will cross the obtained data with others + results from analysis of post-radiotherapy tumors (Ory et al. 2011; + Ugolin et al. PLosONE under revision). +
    +
    +
  • +
  • [003/2011] EpiRadBio - Validation of radiation-associated gain of chromosome + band 7q11. +
    + K Unger, Helmholtz Centre, Munich, Germany + Email +
    +

    + +

    +
    +
    + The project using the applied biomaterial is an extension of the + EU-funded GENRISK-T project and aims to validate a gain on + chromosome band 7q11 that was found to be associated with papillary + thyroid carcinomas from young patients (< 19 years) that were + exposed to radiation from the Chernobyl fallout at very young age + (median: 2 years). The validation set containing exposed and + unexposed cases will be matched for age, morphology and residence - + these criteria were already used for case selection of the GENRISK-T + set. A high-definition array CGH platform will be used to validate + the gain and to type for additional radiation-markers that are + smaller in size and were therefore not detectable by 1Mb BAC array + CGH that was used in GENRISK-T. Further, we will use RNA samples and + paraffin sections for characterisation of expression candidate genes + and proteins by qRT-PCR and immunohistochemistry. Fresh-frozen + tissue from selected samples expressing the candidate gene CLIP2 + from the gained region on 7q11 and those that do not express the + gene will be analysed using a whole proteomics approach (liquid + chromatography-tandem mass spectrometry, LC-MS/MS). The results will + be used to identify the dysregulation networks in which CLIP2 is + specifically involved. The projects aims to validate the radiation + marker on chromosome band 7q11, to identify the networks that are + dysregulated in tumors harbouring the marker and to find new markers + that are associated with exposure to radiation. +
    +
    +
  • +
  • [004/2011] A Sequence-based Approach to Identify Genetic Determinants of + Tumorigenesis in Radiation-Induced Pediatric Papillary Thyroid Carcinomas. +
    + L Hawthorn, Georgia Health Sciences University, USA + Email +
    +

    + +

    +
    +
    +

    + Cancer is a genetic disease, a concept which has been + consistently + observed for all tumors. Our approach is to survey the entire + genome + of these tumors to look for mutations and other perturbations + that + are involved in radiation-induced papillary thyroid carcinoma + (RI-PTC) and create a genomic profile of this tumor. A new + technology, termed Next-generation sequencing allows sequencing + of + the entire human genome in 8 days. We will begin by sequencing + the + DNA of 50 individual RI-PTC tumors from Chernobyl pediatric + patients + to look for mutations in genes. We will correlate this data with + RNA + sequencing from the same patient samples. This data will provide + information about events that are taking place at the level of + gene + expression, providing information about over and under expressed + genes and the expression of aberrant genes, and gene fusion + products. This data will be compared to RIP-PTC in age matched + patients who were not exposed to radiation to develop a + radiation-specific profile. We have bioinformatic specialists in + the + group who will integrate these various kinds of data. This study + will provide a comprehensive profile of RIP-PTC.

    +
    +
    +
  • +
  • [001/2012] EpiRadBio integrative analysis of molecular data. + +
    + W van Wieringen, VU University Medical Centre, Amsterdam, The Netherlands + Email +
    +

    + +

    +
    +
    +

    Within the scope of the EpiRadBio-project, Mark van de Wiel, + Carel Peeters and Wessel van Wieringen from the department of + Epidemiology & Biostatistics of the VU University Medical Center + are responsible for integrative analysis of the molecular data + from (radiation) exposed and non-exposed thyroid cancer samples. + Integrative analysis combines heterogeneous biological data, be + it experimental (e.g., copy number, gene expression, microRNA + expression) or from the biological literature (e.g., gene + annotation, pathway information). Integration of data from + multiple sources is imperative for a mechanistic understanding + of cancer. By putting together partial views of a complex + process like tumorgenesis, we may obtain a more accurate and + complete picture of the molecular mechanisms underlying it. No + off-the-shelf methodology for the statistical analysis of the + data is available. We therefore aim to develop statistical + models from the experimental data of these biological processes. + Such models will enhance our ability to identify biomarkers and + therapeutic targets more unambiguously and to interpret genotype + information. This should enhance the understanding of what + distinguishes the exposed from the non-exposed thyroid cancers. + In addition, the biological insight these models provide is + likely to result in more targeted follow-up experiments and + efficient use of available resources.

    +
    +
    +
  • +
  • [002/2012] Validation of the gene signature differentiating exposed from + non-exposed PTCs, obtained in the Genrisk-T project (no.: 036495) with an + independent QPCR method. +
    + B Jarzab, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, Poland + Email +
    +

    + +

    +
    +
    +

    The aim of the study is to investigate transcriptomic profiles of + papillary thyroid carcinomas that arose after expose to + radioiodine fallout from Chernobyl power station and to low + level radiocesium exposure present in the contaminated + environment. This project is the continuation of a series of + projects that are carry on to investigate the transcriptomic and + genetic profile of radiation induced thyroid cancer. + As a first step of the study Affimetrix microarray technology + was employed to define transcriptomic profiles in two cohorts of + children matched on age, oblast and pathological type of tumor. + At present we want to validate the results with qPCR.

    +
    +
    +
  • +
  • [001/2013] A detailed study of the somatic genomics of radiation induced + thyroid cancer. +
    + GA Thomas, Imperial College, London + Email +
    +

    + +

    +
    +
    +

    + It has long been accepted that cancers arise by the sequential + accumulation of errors in the DNA of a clone of cells within a + given tissue. This in part explains their long latency. However, + recent studies using whole genome sequencing have suggested a + different mechanism for some cancers, particularly those that + arise in children. This mechanism is called chromothripsis and + involves shattering of chromosomes and then restitching them + together. This results in multiple small changes in the DNA that + occur simultaneously rather than sequentially. The aim of this + study is to use whole genome sequencing to identify novel + mutations in radiation induced thyroid cancer, to identify + changes in the mitochondrial genome and to investigate the + frequency of chromothripsis in childhood thyroid cancer, + especially with respect to radiation exposure.

    +
    +
    +
  • +
  • [001/2014] Assessing the impact of radiation exposure on the development of + medullary thyroid carcinoma. +
    + Elizabeth Grubbs, Department Surgical Oncology, MD Anderson Cancer Center, Houston, USA + Email +
    +

    + +

    +
    +
    +

    Convincing epidemiologic data has established a strong causative + association between ionizing radiation and the development of + papillary thyroid cancer (PTC). This finding was due, in large + part, to studying those affected by the Chernobyl accident. More + recently other solid tumors, such as lung and breast, have been + associated with radiation. Medullary thyroid cancer (MTC), a + rarer but more lethal thyroid cancer than PTC, has not been + associated with radiation exposure to date. However, there + appears to be a higher number of MTC cases than would be + expected in the Chernobyl population. We would like to determine + if there is a link between radiation and MTC by studying this + population to look for mutations that are associated with + radiation exposure. Additionally, because MTC is a hereditary + condition in 25% of cases, we would also like to assess whether + there could be a hereditary cause to MTC in this small + geographic region. Such data will give us an insight into the + mechanisms in which tumors are formed in MTC and potentially + help us target ways to stop these tumors.

    +
    +
    +
  • +
  • [002/2014] Anaplastic lymphoma kinase (ALK) rearrangements in + radiation-induced papillary thyroid carcinomas: a study on post Chernobyl + tissue samples +
    + S Eder, Bundeswehr Institute of Radiobiology, Munich Germany + Email +
    +

    + +

    +
    +
    +

    Previous analysis of data derived from the Chernobyl accident has + shown strong correlation between absorbed doses of IR and the + induction of papillary thyroid cancer (PTC). Specific genetic + alterations, such as rearrangements of the RET oncogene, are + linked to previous exposure to radioiodine. Recently, + rearrangements of the anaplastic lymphoma kinase (ALK) gene have + been found to be selectively expressed in papillary thyroid + cancer (PTC) amongst atomic bomb survivors (ABS), but not in PTC + patients lacking radiation exposure. In PTC, ALK rearrangements + have been shown to be associated with tumor aggressiveness and, + importantly, represent a possible pharmacologicaltarget for the + compound Crizotinib. Interestingly, radiation-induced PTCs that + show ALK rearrangements lack additional genetic alterations that + are frequently found in sporadic thyroid cancer, such as RET, + NTRK1, BRAF, or RAS; these findings underline the oncogenic + potential of ALK rearrangements in radiation-induced PTC. We + plan to investigate a possible correlation between radiation + exposure and ALK rearrangements in PTC biospecimens from + patients exposed to radioiodine in the context of the Chernobyl + accident as well as in a control cohort of sporadic PTCs, + performing fluorescence in situ hybridization (FISH) analyses. + Furthermore, we intend to assess the mutation status of commonly + altered oncogenes in PTC, such as BRAF or RAS, using + pyrosequencing.

    +
    +
    +
  • +
  • [003/2014] Comprehensive Genomic Characterization of Radiation-Related + Thyroid Cancer in Ukraine +
    + S Channock, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA + Email +
    +

    + +

    +
    +
    +

    New advances in genomic characterization technologies afford new + opportunities to comprehensively investigate the genetic basis + of the established association between childhood exposure to + iodine-131 (I-131) from the Chernobyl Nuclear Power Plant + accident and risk of thyroid cancer. The opportunity to analyze + a large set of thyroid cancers and normal tissue/blood from the + Chernobyl Tissue Bank (CTB) could further our understanding of + the molecular mechanisms of radiation carcinogenesis in humans + based on careful evaluation of epidemiological risk factors and + genomic alterations. Previously, we had reported a preliminary + study of dose-related alterations in gene expression and + chromosomal translocations in approximately 70 cases drawn from + the Ukrainian-American (UkrAm) cohort component of the CTB + biorepository. Recently, we have completed a pilot study in + which we have conducted a comprehensive genomic characterization + of 12 UkrAm cases, including paired fresh frozen and + formalin-fixed paraffin-embedded tissue samples using the + infrastructure and analytical pipeline of the Cancer Genome + Atlas (TCGA) of the U.S.A. National Cancer Institute (NCI). This + includes whole genome sequence analysis of RNA, DNA and + micro-RNAs as well SNP and methylation microarrays of the tumor + tissue. SNP microarray and DNA analysis was performed on + peripheral blood for comparison of germline to somatic + alterations. The success of the feasibility study establishes a + strong scientific basis for extending this approach to a + substantially larger study of thyroid cancer cases drawn from + the CTB. Here, we propose conducting a comprehensive genomic + characterization study of 500 papillary thyroid cancers (PTC) + from the Ukraine using biological samples, information on + radiation exposure, and demographic characteristics. The main + objective of the study is to provide comprehensive, integrated + characterization of the genomic, transcriptomic, and epigenomic + landscapes of radiation-related PTC for comparison across a + spectrum of I-131 exposure as well as a comparison with + approximately 500 sporadic PTCs available from The Cancer Genome + Atlas recently published in Cell. The proposed study has the + potential to provide unique insights into the mechanisms of + radiation carcinogenesis and to generate a rich data resource + accessible to other investigators.

    +
    +
    +
  • +
  • [001/2018] Liquid biopsy in assessment of radio-induced thyroid cancer in + children and young adults +
    + Kirk Jensen, Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA + Email +
    +

    + +

    +
    +
    +

    In this study we plan to analyze samples from patients with + papillary thyroid cancer. We will examine primary tumors and + serum samples in 40 pediatric patients (aged ≤ 18 years in + 1986), and in 40 young adults (18-25 years in 1986). To + determine a possible correlation between the presence of + mutations/fusion in liquid biopsy and the extent of metastatic + spread we plan to examine samples from patients presenting with + lymph node metastases only and from patients with distant + metastases.

    +

    + We will first identify driver mutations in the primary tumor by + performing Ion Torrent Oncomine Pan-Cancer assay analysis using + DNA/RNA extracted from tumor. Next, we will employ the same + approach for analysis of DNA/RNA extracted from the serum sample + of the same patient. We expect to show that in patients with + metastatic thyroid cancers, results of NGS analysis in serum + will recapitulate results of NGS analysis in primary tumors. We + also plan to perform quantitative assessment of genomic + abnormalities using the digital PCR technique. To do so, we will + examine the presence of specific driver mutation(s) in primary + tumor by dPCR, and determine the mutant/wild copy numbers in + DNA/RNA samples extracted from the whole tumor. We also plan to + complete the assessment of primary tumors through the detection + of oncogenic proteins by immunohistochemistry, and by evaluation + of mutant/wild copy numbers after performing laser captured + microdissection. Serum from the same patient will be then + examined by dPCR.

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Contact CBIIT

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General Questions

If you have questions about CBIIT, email ncicbiit@mail.nih.gov.

IT Support for NCI Employees

If you’re an NCI staff member and need help or want to learn more about available IT services, visit NCI at Your Service. Services included but are not limited to:

  • Account Administration and Access (e.g., password resets, creating/modifying existing accounts including mailboxes, calendars, and share/group drives)
  • Collaboration Tools (e.g., Wiki/Collaborate, Microsoft productivity and collaboration tools such as Forms, SharePoint Online, and Teams)
  • Emails and Telecommunications (e.g., MobileIron, Webex, NCI Conference Bridge)
  • IT Security (e.g., approval requests for use of SaaS products, on-demand scans for testing/detecting network, operating system, and application vulnerabilities)
  • Network (e.g., wired and wireless connectivity)
  • Software (e.g., Adobe, Microsoft Office Suite, Microsoft Office 365, operating systems)
  • Workstation Hardware & Accessories (e.g., monitors, keyboards, mice, encrypted USBs, network printers)

CBIIT Application Support

CBIIT Application Support is available at NCIAppSupport@mail.nih.gov and by telephone, 9:00 a.m. to 5:00 p.m. ET, Monday to Friday except federal holidays: (240) 781-5115 or (888) 478-4423 (toll-free).

Learn more about Application Support.

CBIIT Staff Directory

Check out the CBIIT staff directory for contact information, roles, and responsibilities of CBIIT federal employees.

Social Media

Follow us on X and LinkedIn.

Media Requests

For Media requests please contact the NCI Media Relations Branch at ncipressofficers@mail.nih.gov or (240) 760-6600.

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ALSO IN THIS SECTION

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Jeff Shilling

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NCI CIO, Associate Director for Infrastructure and IT Operations

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Organization

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The Center for Biomedical Informatics and Information Technology (CBIIT) mission is supported by the:

Office of Business Operations (OBO)

Director: Marcos Munozramos, M.S.

The OBO provides essential services and support to CBIIT by managing its business portfolio, financial and contract management, and staffing to improve the efficiency of CBIIT’s service to NCI. The OBO also:

  • coordinates timely and accurate information for NCI IT data calls from the U.S. Department of Health and Human Services (HHS), NIH, and the Office of Management and Budget.
  • administers the strategic and capital planning process, conforming to federal requirements.

Meet the OBO Team

 

Informatics and Data Science Program (IDS)

Acting CBIIT Director and Associate Director: Jill Barnholtz-Sloan, Ph.D.

The IDS Program delivers:

  • standardized vocabularies and data standards.
  • informatics infrastructure for NCI-sponsored precision medicine trials and clinical trials reporting.
  • centralized management and coordination of scientific software and training across NCI.
  • computational biology services for intramural research labs.
  • data science infrastructure for data storage, access and use, which leverages cloud computing, high-performance computing, and scientific collaboration tools.

These activities further the use of informatics and data science within the cancer research community.

Learn More About IDS
 

Office of the Chief Information Officer (OCIO)

NCI Chief Information Officer and OCIO Associate Director: Jeff Shilling

The OCIO oversees the implementation of IT at NCI, considering risks; costs; efficiencies, benefits, and other opportunities; according to governing federal mandates.

Meet the OCIO Team

 

Digital Services and Solutions Branch (DSSB)

Branch Chief: Sue Pan

DSSB:

  • provides professional services, business intelligence, and data analytics that support NCI’s adoption of emerging digital technologies and modernization of both business process and IT service management.
  • provides technical advisory and consultation for IT architecture and engineering design.
  • provides governance and management of cloud computing platforms, as well as enterprise Software‐as‐a‐Service (SaaS) platforms and tools, to develop security‐accredited digital systems and software solutions.
  • provides governance and management of processes for IT engineering and IT service management with a focus on human‐centered design.

NCI Cybersecurity Branch (NCB)

Branch Chief: Craig Hayn

NCB:

  • secures NCI’s systems, networks, and user endpoints against viruses, malware, misconfiguration, insider threats, and cyber attackers.
  • ensures all NCI’s IT systems are assessed, authorized, and monitored using the National Institute of Standards and Technology Risk Management Framework.
  • provides cybersecurity incident management, response, and coordination with NIH’s Threat Management and Incident Response team.
  • ensures NCI‐specific security policies, standards, and guidance are developed, maintained, and communicated to NCI staff and stakeholders.

IT Services and Support Branch (ITSSB)

Branch Chief: Jim Racheff

ITSSB:

  • provides IT support for all NCI staff, which includes computing needs (e.g., laptops, desktops, network, software, and data storage).
  • manages NCI’s IT infrastructure, including network resources, operational security architecture, scientific and business data repositories, telecommunications, and collaboration tools.
  • provides data protection, disaster recovery, IT training, and problem tracking services.
  • recommends state‐of‐the‐art scientific computing solutions and technologies and manages scientific computing support models based on NCI staff needs.

Office of Data Sharing (ODS)

Director: Jaime M. Guidry Auvil, Ph.D.

The mission of ODS is to create a comprehensive vision and strategy to enhance broad and equitable data sharing for NCI and the cancer research community at large. Data sharing is critical to foster collaboration, facilitate innovation, accelerate scientific discovery, and enhance rigor and reproducibility. ODS engages with many stakeholders within and across the cancer research community to guide interpretation and implementation of complex processes, programmatic initiatives, and policies needed to ensure impactful data sharing.

Learn More About ODS

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Informatics and Data Science Program (IDS)

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Informatics and Data Science Program (IDS)

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Our work at IDS lays the foundation for many of NCI’s biomedical informatics and data science initiatives, giving cancer researchers (like you) the resources you need to use data more efficiently and effectively.

Our program consists of three branches: the Clinical & Translational Research Informatics Branch, the Data Ecosystems Branch, and the Computational Genomics & Bioinformatics Branch.

NCI’s Cancer Research Data Commons (CRDC) just reached a significant milestone! Read about the CRDC in a four-part series commemorating the first 10 years of this important initiative.

Find Out What We Do

Clinical & Translational Research Informatics Branch (CTRIB)

Branch Chief: Umit Topaloglu, Ph.D.

At CTRIB, we’re working on new ways to use informatics across NCI, NIH, and the cancer research community. Our goal is to speed the translation of data-driven research into clinical practice. In particular, we’re focusing on:

Promoting Precision Medicine. We’re developing tools and pipelines that someday will help clinicians diagnose cancer early in the course of disease (when it’s highly treatable). We’re also helping develop new ways of predicting the best treatment for the best outcome for each person with cancer.

Capturing and Managing Data. We’re working on streamlining how researchers capture and report data from NCI-sponsored precision medicine trials and clinical trials. We’re also helping to advance the use of Real-World Data (RWD) from Electronic Health Records (EHRs). We’re identifying and addressing gaps in EHR data pipelines, establishing criteria for informatic tools to support quality RWD, and advancing reliable research methods.

Making Data Useful. We’re working to make certain the data you generate are useful to others in the cancer research field. We do this by developing and maintaining semantic resources and vocabularies.

Data Ecosystems Branch (DEB)

Branch Chief: Tanja Davidsen, Ph.D.

Our work at DEB centers on building, strengthening, and maintaining the infrastructure and tools that make up a sophisticated data ecosystem. We’re especially working on:

Fostering Collaboration. We work closely with other government agencies, industry, and academia to stay abreast of the latest in technology. This ensures we’re tapping the latest resources and most novel ideas for cancer research, especially in the areas of informatics, high-performance computing, and artificial intelligence (AI).

Setting Standards. We also work closely with international coordinating bodies to make certain that we keep pace with the latest data standards. We promote FAIR (i.e., Findable, Accessible, Interoperable, and Reusable) data principles, and ensure that data adhere to NIH’s Data Management and Sharing policy.

Sharing Resources. We’re centralizing resources, such as software and training, to help others (at NCI and the broader cancer research field) access and use data. This includes looking at new ways of working with data—both in the cloud and locally, using technologies such as federated learning and edge computing.

Computational Genomics & Bioinformatics Branch (CGBB)

Branch Chief: Daoud Meerzaman, Ph.D.

At CGBB, we help solve research problems. Our staff offer skills and expertise to others (at NCI, NIH, and in the broader research community) to develop new bioinformatic and computational-genomics tools. We’re focused on:

Advancing Research. We’re using the latest tools and technologies—such as proteogenomic approaches for sequencing and interpreting genomic, transcriptomics, and proteomic data—to advance cancer research.

Developing Tomorrow’s Technology. Our team also is working to develop and implement new approaches, such as AI, machine learning, and algorithms, to find better ways of using data (e.g., genomic, proteomic, and imaging) to predict, diagnose, and treat cancer.

Education and Training. We’re fostering the next generation of researchers and fellows through a robust training program. We also coordinate webinars and seminars, featuring renowned experts in the biomedical and technology fields, who share their insight and skills in bioinformatics and computational-genomics tools.

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Meet the Rest of the Team

 

Read the Latest From Us

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The NCI Cancer Research Data Commons (CRDC) is a great resource for accessing cancer research data. So, how have your colleagues been using it recently? Read this article to find out!
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If you’re working with adverse event cancer and immune-related data, USCDI+ program staff need to hear from you! See how you can give your feedback on the new USCDI+Cancer draft data set.
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She speaks to how these areas are interconnected, shares her personal career journey, and uses her experience to advise you on how to be a successful cancer researcher.
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Read More News

 

Collaborate/Work With Us

Want to collaborate? Email us for more information.

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