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<meta name="keywords" content="C0206660, germinoma, germinoma (disease), germinomas, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A type of undifferentiated germ cell tumor that may be benign or malignant." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=64626
ConceptID=C0206660
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Germinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>64626</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0206660</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Germinoma (disease)</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Germinoma (28307001)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100620">HP:0100620</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0002598" target="_blank">MONDO:0002598</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A type of undifferentiated germ cell tumor that may be benign or malignant. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Germinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/508335" ref="tree=MeSH" title="MedGen record for Disorder of the genitourinary system">Disorder of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/22583" ref="tree=MeSH" title="MedGen record for Neoplasm of the genitourinary tract">Neoplasm of the genitourinary tract</a></span><ul><li><span class="TLline"><a href="/medgen/451067" ref="tree=MeSH" title="MedGen record for Genital neoplasm">Genital neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/866873" ref="tree=MeSH" title="MedGen record for Gonadal neoplasm">Gonadal neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/867599" ref="tree=MeSH" title="MedGen record for Germ cell neoplasia">Germ cell neoplasia</a></span><ul><li><span class="matched_ds">Germinoma</span><ul><li><span class="TLline"><a href="/medgen/41680" ref="tree=MeSH" title="MedGen record for Dysgerminoma">Dysgerminoma</a></span></li><li><span class="TLline"><a href="/medgen/11371" ref="tree=MeSH" title="MedGen record for Seminoma">Seminoma</a></span><ul><li><span class="TLline"><a href="/medgen/902353" ref="tree=MeSH" title="MedGen record for Childhood Seminoma">Childhood Seminoma</a></span></li><li><span class="TLline"><a href="/medgen/234243" ref="tree=MeSH" title="MedGen record for Extragonadal seminoma">Extragonadal seminoma</a></span><ul><li><span class="TLline"><a href="/medgen/277355" ref="tree=MeSH" title="MedGen record for Mediastinum seminoma">Mediastinum seminoma</a></span></li><li><span class="TLline"><a href="/medgen/857333" ref="tree=MeSH" title="MedGen record for Recurrent Extragonadal Seminoma">Recurrent Extragonadal Seminoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1790467" ref="tree=MeSH" title="MedGen record for Testicular seminoma">Testicular seminoma</a></span><ul><li><span class="TLline"><a href="/medgen/308258" ref="tree=MeSH" title="MedGen record for Cribriform variant testicular seminoma">Cribriform variant testicular seminoma</a></span></li><li><span class="TLline"><a href="/medgen/233471" ref="tree=MeSH" title="MedGen record for Intratubular Seminoma">Intratubular Seminoma</a></span></li><li><span class="TLline"><a href="/medgen/273633" ref="tree=MeSH" title="MedGen record for Pseudoglandular variant testicular seminoma">Pseudoglandular variant testicular seminoma</a></span></li><li><span class="TLline"><a href="/medgen/741221" ref="tree=MeSH" title="MedGen record for Stage I Testicular Seminoma AJCC v6 and v7">Stage I Testicular Seminoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/277728" ref="tree=MeSH" title="MedGen record for Stage II Testicular Seminoma AJCC v6 and v7">Stage II Testicular Seminoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/236900" ref="tree=MeSH" title="MedGen record for Stage III Testicular Seminoma AJCC v6 and v7">Stage III Testicular Seminoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/90797" ref="tree=MeSH" title="MedGen record for Testicular Seminoma with High Mitotic Index">Testicular Seminoma with High Mitotic Index</a></span></li><li><span class="TLline"><a href="/medgen/273634" ref="tree=MeSH" title="MedGen record for Testicular Seminoma with Syncytiotrophoblastic Cells">Testicular Seminoma with Syncytiotrophoblastic Cells</a></span></li><li><span class="TLline"><a href="/medgen/364806" ref="tree=MeSH" title="MedGen record for Testicular Typical Seminoma">Testicular Typical Seminoma</a></span></li><li><span class="TLline"><a href="/medgen/308259" ref="tree=MeSH" title="MedGen record for Tubular variant testicular seminoma">Tubular variant testicular seminoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=18221&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Germinoma</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34724065">EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Frappaz D,
Dhall G,
Murray MJ,
Goldman S,
Faure Conter C,
Allen J,
Kortmann RD,
Haas-Kogen D,
Morana G,
Finlay J,
Nicholson JC,
Bartels U,
Souweidane M,
Schönberger S,
Vasiljevic A,
Robertson P,
Albanese A,
Alapetite C,
Czech T,
Lau CC,
Wen P,
Schiff D,
Shaw D,
Calaminus G,
Bouffet E</span><br />
<span class="medgenPMjournal">Neuro Oncol</span>
2022 Apr 1;24(4):516-527.
doi: 10.1093/neuonc/noab252.
<span class="bold">PMID: </span><a href="/pubmed/34724065" target="_blank">34724065</a><a href="/pmc/articles/PMC8972311" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29454505">Current Management of Intracranial Germ Cell Tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bowzyk Al-Naeeb A,
Murray M,
Horan G,
Harris F,
Kortmann RD,
Nicholson J,
Ajithkumar T</span><br />
<span class="medgenPMjournal">Clin Oncol (R Coll Radiol)</span>
2018 Apr;30(4):204-214.
Epub 2018 Feb 14
doi: 10.1016/j.clon.2018.01.009.
<span class="bold">PMID: </span><a href="/pubmed/29454505" target="_blank">29454505</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22433947">Diabetes insipidus--diagnosis and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Di Iorgi N,
Napoli F,
Allegri AE,
Olivieri I,
Bertelli E,
Gallizia A,
Rossi A,
Maghnie M</span><br />
<span class="medgenPMjournal">Horm Res Paediatr</span>
2012;77(2):69-84.
Epub 2012 Mar 16
doi: 10.1159/000336333.
<span class="bold">PMID: </span><a href="/pubmed/22433947" target="_blank">22433947</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22germinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (114)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/30385005">Re-irradiation for Paediatric Tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tsang DS,
Laperriere NJ</span><br />
<span class="medgenPMjournal">Clin Oncol (R Coll Radiol)</span>
2019 Mar;31(3):191-198.
Epub 2018 Oct 29
doi: 10.1016/j.clon.2018.10.003.
<span class="bold">PMID: </span><a href="/pubmed/30385005" target="_blank">30385005</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29454505">Current Management of Intracranial Germ Cell Tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bowzyk Al-Naeeb A,
Murray M,
Horan G,
Harris F,
Kortmann RD,
Nicholson J,
Ajithkumar T</span><br />
<span class="medgenPMjournal">Clin Oncol (R Coll Radiol)</span>
2018 Apr;30(4):204-214.
Epub 2018 Feb 14
doi: 10.1016/j.clon.2018.01.009.
<span class="bold">PMID: </span><a href="/pubmed/29454505" target="_blank">29454505</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15172357">Genetic predisposition to testicular germ-cell tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lutke Holzik MF,
Rapley EA,
Hoekstra HJ,
Sleijfer DT,
Nolte IM,
Sijmons RH</span><br />
<span class="medgenPMjournal">Lancet Oncol</span>
2004 Jun;5(6):363-71.
doi: 10.1016/S1470-2045(04)01493-7.
<span class="bold">PMID: </span><a href="/pubmed/15172357" target="_blank">15172357</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12401700">Extragonadal germ cell tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schmoll HJ</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2002;13 Suppl 4:265-72.
doi: 10.1093/annonc/mdf669.
<span class="bold">PMID: </span><a href="/pubmed/12401700" target="_blank">12401700</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10614561">Pediatric germ cell tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rescorla FJ,
Breitfeld PP</span><br />
<span class="medgenPMjournal">Curr Probl Cancer</span>
1999 Nov-Dec;23(6):257-303.
doi: 10.1016/s0147-0272(99)90009-0.
<span class="bold">PMID: </span><a href="/pubmed/10614561" target="_blank">10614561</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1325)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34936742">Pupillary Light-Near Dissociation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">La Corte E,
Martinoni M</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2021 Dec 23;385(26):e94.
doi: 10.1056/NEJMicm2031597.
<span class="bold">PMID: </span><a href="/pubmed/34936742" target="_blank">34936742</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26118663">Management of CNS germinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Osorio DS,
Allen JC</span><br />
<span class="medgenPMjournal">CNS Oncol</span>
2015;4(4):273-9.
Epub 2015 Jun 29
doi: 10.2217/cns.15.13.
<span class="bold">PMID: </span><a href="/pubmed/26118663" target="_blank">26118663</a><a href="/pmc/articles/PMC6088312" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18226737">Rare sellar lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Glezer A,
Paraiba DB,
Bronstein MD</span><br />
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
2008 Mar;37(1):195-211, x.
doi: 10.1016/j.ecl.2007.10.003.
<span class="bold">PMID: </span><a href="/pubmed/18226737" target="_blank">18226737</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15001128">Neonatal liver tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">von Schweinitz D</span><br />
<span class="medgenPMjournal">Semin Neonatol</span>
2003 Oct;8(5):403-10.
doi: 10.1016/S1084-2756(03)00092-7.
<span class="bold">PMID: </span><a href="/pubmed/15001128" target="_blank">15001128</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8290818">Testicular cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brock D,
Fox S,
Gosling G,
Haney L,
Kneebone P,
Nagy C,
Qualitza B</span><br />
<span class="medgenPMjournal">Semin Oncol Nurs</span>
1993 Nov;9(4):224-36.
doi: 10.1016/s0749-2081(05)80051-8.
<span class="bold">PMID: </span><a href="/pubmed/8290818" target="_blank">8290818</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1588)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37036624">Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kremenevski N,
Buchfelder M,
Hore N</span><br />
<span class="medgenPMjournal">Curr Oncol Rep</span>
2023 Jul;25(7):765-775.
Epub 2023 Apr 10
doi: 10.1007/s11912-023-01416-2.
<span class="bold">PMID: </span><a href="/pubmed/37036624" target="_blank">37036624</a><a href="/pmc/articles/PMC10256636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10711839">Oral etoposide in germ cell tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saxman S</span><br />
<span class="medgenPMjournal">Drugs</span>
1999;58 Suppl 3:31-4.
doi: 10.2165/00003495-199958003-00005.
<span class="bold">PMID: </span><a href="/pubmed/10711839" target="_blank">10711839</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10461054">Management of non-epithelial ovarian tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bridgewater JA,
Rustin GJ</span><br />
<span class="medgenPMjournal">Oncology</span>
1999;57(2):89-98.
doi: 10.1159/000012014.
<span class="bold">PMID: </span><a href="/pubmed/10461054" target="_blank">10461054</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9649229">Integration of surgery and systemic therapy: results and principles of integration.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Donohue JP,
Leviovitch I,
Foster RS,
Baniel J,
Tognoni P</span><br />
<span class="medgenPMjournal">Semin Urol Oncol</span>
1998 May;16(2):65-71.
<span class="bold">PMID: </span><a href="/pubmed/9649229" target="_blank">9649229</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9469360">Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indian University experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saxman SB,
Finch D,
Gonin R,
Einhorn LH</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
1998 Feb;16(2):702-6.
doi: 10.1200/JCO.1998.16.2.702.
<span class="bold">PMID: </span><a href="/pubmed/9469360" target="_blank">9469360</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1016)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37036624">Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kremenevski N,
Buchfelder M,
Hore N</span><br />
<span class="medgenPMjournal">Curr Oncol Rep</span>
2023 Jul;25(7):765-775.
Epub 2023 Apr 10
doi: 10.1007/s11912-023-01416-2.
<span class="bold">PMID: </span><a href="/pubmed/37036624" target="_blank">37036624</a><a href="/pmc/articles/PMC10256636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15064970">Late relapse of testicular cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lipphardt ME,
Albers P</span><br />
<span class="medgenPMjournal">World J Urol</span>
2004 Apr;22(1):47-54.
Epub 2004 Apr 3
doi: 10.1007/s00345-004-0397-9.
<span class="bold">PMID: </span><a href="/pubmed/15064970" target="_blank">15064970</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12401700">Extragonadal germ cell tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schmoll HJ</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2002;13 Suppl 4:265-72.
doi: 10.1093/annonc/mdf669.
<span class="bold">PMID: </span><a href="/pubmed/12401700" target="_blank">12401700</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9649229">Integration of surgery and systemic therapy: results and principles of integration.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Donohue JP,
Leviovitch I,
Foster RS,
Baniel J,
Tognoni P</span><br />
<span class="medgenPMjournal">Semin Urol Oncol</span>
1998 May;16(2):65-71.
<span class="bold">PMID: </span><a href="/pubmed/9649229" target="_blank">9649229</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7992061">Salvage chemotherapy for recurrent germ cell cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nichols CR,
Roth BJ,
Loehrer PJ,
Williams SD,
Einhorn LH</span><br />
<span class="medgenPMjournal">Semin Oncol</span>
1994 Oct;21(5 Suppl 12):102-8.
<span class="bold">PMID: </span><a href="/pubmed/7992061" target="_blank">7992061</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1252)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/29415126">Central Nervous System Germinomas Express Programmed Death Ligand 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wildeman ME,
Shepard MJ,
Oldfield EH,
Lopes MBS</span><br />
<span class="medgenPMjournal">J Neuropathol Exp Neurol</span>
2018 Apr 1;77(4):312-316.
doi: 10.1093/jnen/nly008.
<span class="bold">PMID: </span><a href="/pubmed/29415126" target="_blank">29415126</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11796908">From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Woodward PJ,
Sohaey R,
O'Donoghue MJ,
Green DE</span><br />
<span class="medgenPMjournal">Radiographics</span>
2002 Jan-Feb;22(1):189-216.
doi: 10.1148/radiographics.22.1.g02ja14189.
<span class="bold">PMID: </span><a href="/pubmed/11796908" target="_blank">11796908</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9207575">Fertility after chemotherapy for testicular germ cell cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pont J,
Albrecht W</span><br />
<span class="medgenPMjournal">Fertil Steril</span>
1997 Jul;68(1):1-5.
doi: 10.1016/s0015-0282(97)81465-3.
<span class="bold">PMID: </span><a href="/pubmed/9207575" target="_blank">9207575</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7708186">MRI of intracranial germ cell tumours.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sumida M,
Uozumi T,
Kiya K,
Mukada K,
Arita K,
Kurisu K,
Sugiyama K,
Onda J,
Satoh H,
Ikawa F</span><br />
<span class="medgenPMjournal">Neuroradiology</span>
1995 Jan;37(1):32-7.
doi: 10.1007/BF00588516.
<span class="bold">PMID: </span><a href="/pubmed/7708186" target="_blank">7708186</a></div>
<div class="nl"><a target="_blank" href="/pubmed/660267">Suprasellar germinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Takeuchi J,
Handa H,
Nagata I</span><br />
<span class="medgenPMjournal">J Neurosurg</span>
1978 Jul;49(1):41-8.
doi: 10.3171/jns.1978.49.1.0041.
<span class="bold">PMID: </span><a href="/pubmed/660267" target="_blank">660267</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (647)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/39773126">Optimal treatment approach for intracranial germinoma: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Z,
Liu J,
Yue Q,
Chen L,
Zhang X,
Lin X,
Zheng L,
Wang E,
Wang Y,
Mao Y</span><br />
<span class="medgenPMjournal">BMC Cancer</span>
2025 Jan 7;25(1):26.
doi: 10.1186/s12885-024-13323-1.
<span class="bold">PMID: </span><a href="/pubmed/39773126" target="_blank">39773126</a><a href="/pmc/articles/PMC11707848" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30292900">A systematic review of shunt-related extraneural metastases of primary central nervous system tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xu K,
Khine KT,
Ooi YC,
Quinsey CS</span><br />
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
2018 Nov;174:239-243.
Epub 2018 Sep 27
doi: 10.1016/j.clineuro.2018.09.038.
<span class="bold">PMID: </span><a href="/pubmed/30292900" target="_blank">30292900</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27084646">Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leroy R,
Benahmed N,
Hulstaert F,
Van Damme N,
De Ruysscher D</span><br />
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
2016 May 1;95(1):267-278.
Epub 2015 Oct 17
doi: 10.1016/j.ijrobp.2015.10.025.
<span class="bold">PMID: </span><a href="/pubmed/27084646" target="_blank">27084646</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12435371">Treatment of testicular germ-cell cancer: a cochrane evidence-based systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shelley MD,
Burgon K,
Mason MD</span><br />
<span class="medgenPMjournal">Cancer Treat Rev</span>
2002 Oct;28(5):237-53.
doi: 10.1016/s0305-7372(02)00059-2.
<span class="bold">PMID: </span><a href="/pubmed/12435371" target="_blank">12435371</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11676973">A systematic review of lactate dehydrogenase isoenzyme 1 and germ cell tumors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">von Eyben FE</span><br />
<span class="medgenPMjournal">Clin Biochem</span>
2001 Sep;34(6):441-54.
doi: 10.1016/s0009-9120(01)00236-3.
<span class="bold">PMID: </span><a href="/pubmed/11676973" target="_blank">11676973</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Germinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Germinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22germinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Germinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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