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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch3.tab10" class="table"><h3><span class="label">Table 10</span><span class="title">Differential treatment duration results for all ages</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578045/table/ch3.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch3.tab10_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Years before meeting other criteria for treatment</th><th id="hd_h_ch3.tab10_1_1_1_2" colspan="5" rowspan="1" style="text-align:center;vertical-align:middle;">Risk threshold</th></tr><tr><th headers="hd_h_ch3.tab10_1_1_1_1" id="hd_h_ch3.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch3.tab10_1_1_1_2" id="hd_h_ch3.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Age 40</th><th headers="hd_h_ch3.tab10_1_1_1_2" id="hd_h_ch3.tab10_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Age 50</th><th headers="hd_h_ch3.tab10_1_1_1_2" id="hd_h_ch3.tab10_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Age 60</th><th headers="hd_h_ch3.tab10_1_1_1_2" id="hd_h_ch3.tab10_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Age 70</th><th headers="hd_h_ch3.tab10_1_1_1_2" id="hd_h_ch3.tab10_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Age 75</th></tr></thead><tbody><tr><th headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_h_ch3.tab10_1_1_2_3 hd_h_ch3.tab10_1_1_2_4 hd_h_ch3.tab10_1_1_2_5 hd_h_ch3.tab10_1_1_2_6" id="hd_b_ch3.tab10_1_1_1_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:middle;">MALES</th></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.2%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.1%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">6.3%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">10.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">11.8%</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.5%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">3.5%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">5.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">10.3%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">11.6%</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">2.7%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">4.8%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">20</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">1.3%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">1.9%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>
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<i>Never (base case)</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>0.7%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>1.8%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>5.0%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>9.7%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>11.4%</b>
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</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Minimum risk level</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
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<i>1.5%</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
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<i>4.0%</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
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<i>8.5%</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
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<i>16.4%</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_1_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
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<i>22.3%</i>
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</b>
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</td></tr><tr><th headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_h_ch3.tab10_1_1_2_3 hd_h_ch3.tab10_1_1_2_4 hd_h_ch3.tab10_1_1_2_5 hd_h_ch3.tab10_1_1_2_6" id="hd_b_ch3.tab10_1_1_8_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:middle;">FEMALES</th></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.8%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">4.8%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">7.5%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">8.1%</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.3%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">4.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">7.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">8.1%</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.0%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.3%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">4.5%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">20</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.6%</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>
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<i>Never (base case)</i>
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>1.7%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>2.8%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>4.9%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>7.5%</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fbd4b4;text-align:left;vertical-align:middle;">
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<b>8.5%</b>
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</td></tr><tr><td headers="hd_h_ch3.tab10_1_1_1_1 hd_h_ch3.tab10_1_1_2_1 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Minimum risk level</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_2 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
|
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<b>
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<i>0.9%</i>
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</b>
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|
</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_3 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
|
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<b>
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<i>2.3%</i>
|
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</b>
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|
</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_4 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
|
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<b>
|
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<i>5.3%</i>
|
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</b>
|
|
</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_5 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
|
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<i>11.7%</i>
|
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</b>
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</td><td headers="hd_h_ch3.tab10_1_1_1_2 hd_h_ch3.tab10_1_1_2_6 hd_b_ch3.tab10_1_1_8_1" rowspan="1" colspan="1" style="color:#e36c0a;text-align:left;vertical-align:middle;">
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<b>
|
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<i>17.0%</i>
|
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</b>
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|
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">The columns show the risk thresholds for the different age groups. The rows show the differential treatment durations tested, and also the results of the base case analysis for each age group (that is, where a lifetime of treatment was compared to a lifetime of no treatment). Additionally the minimum risk values from the QRISK2 are also presented with orange text. Cells that are orange show where it is cost effective to treat everyone at that age because the risk threshold the model predicted is lower than the minimum risk level.</p></div></dd></dl></div></div></div></div></div>
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<div class="post-content"><div><p>From: <a href="/books/NBK578045/" target="mainwindow">Evidence review for initiating treatment</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/niceng136er3/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng136er3-lrg.png" alt="Cover of Evidence review for initiating treatment" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Evidence review for initiating treatment: Hypertension in adults: diagnosis and management: Evidence review C.</div><div class="series-statement">NICE Guideline, No. 136.</div><div>National Guideline Centre (UK).</div><div>London: <a href="https://www.nice.org.uk" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">National Institute for Health and Care Excellence (NICE)</a>; 2019 Aug.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © NICE 2019.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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