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<title>Table 24, Clinical evidence profile: Treatment versus no treatment at systolic blood pressure threshold of 140–159 mmHg (without type 2 diabetes) - Evidence review for initiating treatment - NCBI Bookshelf</title>
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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch3.appf.tab4" class="table"><h3><span class="label">Table 24</span><span class="title">Clinical evidence profile: Treatment versus no treatment at systolic blood pressure threshold of 140–159 mmHg (without type 2 diabetes)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578045/table/ch3.appf.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch3.appf.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch3.appf.tab4_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch3.appf.tab4_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch3.appf.tab4_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch3.appf.tab4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch3.appf.tab4_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch3.appf.tab4_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch3.appf.tab4_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch3.appf.tab4_1_1_1_1" id="hd_h_ch3.appf.tab4_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch3.appf.tab4_1_1_1_2" id="hd_h_ch3.appf.tab4_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Treatment</th><th headers="hd_h_ch3.appf.tab4_1_1_1_2" id="hd_h_ch3.appf.tab4_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No treatment (no diabetes)</th><th headers="hd_h_ch3.appf.tab4_1_1_1_3" id="hd_h_ch3.appf.tab4_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch3.appf.tab4_1_1_1_3" id="hd_h_ch3.appf.tab4_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute<sup><a class="bk_pop" href="#ch3.appf.tab4_3">3</a></sup></th></tr></thead><tbody><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Mortality - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>860/19143</p>
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<p>(4.5%)</p>
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</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>781/19143</p>
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<p>(4.1%)</p>
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</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1.02 (0.88 to 1.18)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1 more per 1000 (from 5 fewer to 7 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch3.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>292/19143</p>
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<p>(1.5%)</p>
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</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>285/19143</p>
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<p>(1.5%)</p>
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</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 0.97 (0.78 to 1.21)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">0 fewer per 1000 (from 3 fewer to 3 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Myocardial Infarction - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>276/19143</p>
|
||
<p>(1.4%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>279/19143</p>
|
||
<p>(1.5%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1 (0.8 to 1.25)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">0 fewer per 1000 (from 3 fewer to 4 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Heart failure - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch3.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>169/19143</p>
|
||
<p>(0.88%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>131/19143</p>
|
||
<p>(0.68%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1.34 (0.96 to 1.87)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2 more per 1000 (from 0 fewer to 6 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Non-MI acute coronary syndrome - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>61/19143</p>
|
||
<p>(0.32%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>56/19143</p>
|
||
<p>(0.29%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1.19 (0.74 to 1.91)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1 more per 1000 (from 1 fewer to 3 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Hypotension - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>268/19143</p>
|
||
<p>(1.4%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>161/19143</p>
|
||
<p>(0.84%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1.69 (1.3 to 2.2)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6 more per 1000 (from 3 more to 10 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_h_ch3.appf.tab4_1_1_2_3 hd_h_ch3.appf.tab4_1_1_2_4 hd_h_ch3.appf.tab4_1_1_2_5 hd_h_ch3.appf.tab4_1_1_2_6 hd_h_ch3.appf.tab4_1_1_2_7 hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_h_ch3.appf.tab4_1_1_2_9 hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_h_ch3.appf.tab4_1_1_2_11 hd_h_ch3.appf.tab4_1_1_1_4 hd_h_ch3.appf.tab4_1_1_1_5" id="hd_b_ch3.appf.tab4_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Acute Kidney Injury - 140–159mmHg (follow-up median 5.8 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_1 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_2 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_3 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_4 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_5 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_6 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch3.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_1 hd_h_ch3.appf.tab4_1_1_2_7 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_8 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>194/19143</p>
|
||
<p>(1%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_2 hd_h_ch3.appf.tab4_1_1_2_9 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>144/19143</p>
|
||
<p>(0.75%)</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_10 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">HR 1.37 (1 to 1.88)<sup><a class="bk_pop" href="#ch3.appf.tab4_4">4</a></sup></td><td headers="hd_h_ch3.appf.tab4_1_1_1_3 hd_h_ch3.appf.tab4_1_1_2_11 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3 more per 1000 (from 0 more to 7 more)</td><td headers="hd_h_ch3.appf.tab4_1_1_1_4 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch3.appf.tab4_1_1_1_5 hd_b_ch3.appf.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch3.appf.tab4_1"><p class="no_margin">Downgraded by 1 or 2 increments because the majority of the evidence included an indirect or very indirect population respectively.</p></div></dd><dt>2</dt><dd><div id="ch3.appf.tab4_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd><dt>3</dt><dd><div id="ch3.appf.tab4_3"><p class="no_margin">Absolute effects calculated by inputting raw event data from median follow up time into GRADE.</p></div></dd><dt>4</dt><dd><div id="ch3.appf.tab4_4"><p class="no_margin">Evidence based on one study that reported HRs with raw event data.</p></div></dd></dl></div></div></div></div></div>
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<div class="post-content"><div><p>From: <a href="/books/NBK578045/" target="mainwindow">Evidence review for initiating treatment</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/niceng136er3/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng136er3-lrg.png" alt="Cover of Evidence review for initiating treatment" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Evidence review for initiating treatment: Hypertension in adults: diagnosis and management: Evidence review C.</div><div class="series-statement">NICE Guideline, No. 136.</div><div>National Guideline Centre (UK).</div><div>London: <a href="https://www.nice.org.uk" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">National Institute for Health and Care Excellence (NICE)</a>; 2019 Aug.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © NICE 2019.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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