| Quality assessment | No of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Treatment | No treatment (no diabetes) | Relative (95% CI) | Absolute3 | ||
| Mortality - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | no serious imprecision | none |
860/19143 (4.5%) |
781/19143 (4.1%) | HR 1.02 (0.88 to 1.18)4 | 1 more per 1000 (from 5 fewer to 7 more) |
⨁◯◯◯ VERY LOW | CRITICAL |
| Stroke - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | serious2 | none |
292/19143 (1.5%) |
285/19143 (1.5%) | HR 0.97 (0.78 to 1.21)4 | 0 fewer per 1000 (from 3 fewer to 3 more) |
⨁◯◯◯ VERY LOW | CRITICAL |
| Myocardial Infarction - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | no serious imprecision | none |
276/19143 (1.4%) |
279/19143 (1.5%) | HR 1 (0.8 to 1.25)4 | 0 fewer per 1000 (from 3 fewer to 4 more) |
⨁◯◯◯ VERY LOW | CRITICAL |
| Heart failure - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | serious2 | none |
169/19143 (0.88%) |
131/19143 (0.68%) | HR 1.34 (0.96 to 1.87)4 | 2 more per 1000 (from 0 fewer to 6 more) |
⨁◯◯◯ VERY LOW | IMPORTANT |
| Non-MI acute coronary syndrome - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | very serious2 | none |
61/19143 (0.32%) |
56/19143 (0.29%) | HR 1.19 (0.74 to 1.91)4 | 1 more per 1000 (from 1 fewer to 3 more) |
⨁◯◯◯ VERY LOW | IMPORTANT |
| Hypotension - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | no serious imprecision | none |
268/19143 (1.4%) |
161/19143 (0.84%) | HR 1.69 (1.3 to 2.2)4 | 6 more per 1000 (from 3 more to 10 more) |
⨁◯◯◯ VERY LOW | IMPORTANT |
| Acute Kidney Injury - 140–159mmHg (follow-up median 5.8 years) | ||||||||||||
| 1 | observational studies | no serious risk of bias | no serious inconsistency | very serious1 | serious2 | none |
194/19143 (1%) |
144/19143 (0.75%) | HR 1.37 (1 to 1.88)4 | 3 more per 1000 (from 0 more to 7 more) |
⨁◯◯◯ VERY LOW | IMPORTANT |
Downgraded by 1 or 2 increments because the majority of the evidence included an indirect or very indirect population respectively.
Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.
Absolute effects calculated by inputting raw event data from median follow up time into GRADE.
Evidence based on one study that reported HRs with raw event data.
From: Evidence review for initiating treatment
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