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<title>Table 23, Clinical evidence profile: Treatment versus no treatment at diastolic blood pressure thresholds (with and without type 2 diabetes) - Evidence review for initiating treatment - NCBI Bookshelf</title>
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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch3.appf.tab3" class="table"><h3><span class="label">Table 23</span><span class="title">Clinical evidence profile: Treatment versus no treatment at diastolic blood pressure thresholds (with and without type 2 diabetes)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578045/table/ch3.appf.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch3.appf.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch3.appf.tab3_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch3.appf.tab3_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch3.appf.tab3_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch3.appf.tab3_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch3.appf.tab3_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch3.appf.tab3_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch3.appf.tab3_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch3.appf.tab3_1_1_1_1" id="hd_h_ch3.appf.tab3_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch3.appf.tab3_1_1_1_2" id="hd_h_ch3.appf.tab3_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Treatment versus no treatment</th><th headers="hd_h_ch3.appf.tab3_1_1_1_2" id="hd_h_ch3.appf.tab3_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Control</th><th headers="hd_h_ch3.appf.tab3_1_1_1_3" id="hd_h_ch3.appf.tab3_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch3.appf.tab3_1_1_1_3" id="hd_h_ch3.appf.tab3_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_h_ch3.appf.tab3_1_1_2_3 hd_h_ch3.appf.tab3_1_1_2_4 hd_h_ch3.appf.tab3_1_1_2_5 hd_h_ch3.appf.tab3_1_1_2_6 hd_h_ch3.appf.tab3_1_1_2_7 hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_h_ch3.appf.tab3_1_1_2_9 hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_h_ch3.appf.tab3_1_1_2_11 hd_h_ch3.appf.tab3_1_1_1_4 hd_h_ch3.appf.tab3_1_1_1_5" id="hd_b_ch3.appf.tab3_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke (diastolic) - >80mmHg (follow-up mean 4 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_3 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_4 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_5 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_6 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch3.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_7 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>735/21807</p>
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<p>(3.4%)</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_9 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>943/20792</p>
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<p>(4.5%)</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.74 (0.68 to 0.82)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_11 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">12 fewer per 1000 (from 8 fewer to 15 fewer)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_4 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_5 hd_b_ch3.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_h_ch3.appf.tab3_1_1_2_3 hd_h_ch3.appf.tab3_1_1_2_4 hd_h_ch3.appf.tab3_1_1_2_5 hd_h_ch3.appf.tab3_1_1_2_6 hd_h_ch3.appf.tab3_1_1_2_7 hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_h_ch3.appf.tab3_1_1_2_9 hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_h_ch3.appf.tab3_1_1_2_11 hd_h_ch3.appf.tab3_1_1_1_4 hd_h_ch3.appf.tab3_1_1_1_5" id="hd_b_ch3.appf.tab3_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke (diastolic) - 80–84mmHg (follow-up mean 4 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_3 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_4 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_5 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_6 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch3.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_7 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>393/18780</p>
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<p>(2.1%)</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_9 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>516/18736</p>
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<p>(2.8%)</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.76 (0.67 to 0.87)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_11 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7 fewer per 1000 (from 4 fewer to 9 fewer)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_4 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_5 hd_b_ch3.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_h_ch3.appf.tab3_1_1_2_3 hd_h_ch3.appf.tab3_1_1_2_4 hd_h_ch3.appf.tab3_1_1_2_5 hd_h_ch3.appf.tab3_1_1_2_6 hd_h_ch3.appf.tab3_1_1_2_7 hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_h_ch3.appf.tab3_1_1_2_9 hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_h_ch3.appf.tab3_1_1_2_11 hd_h_ch3.appf.tab3_1_1_1_4 hd_h_ch3.appf.tab3_1_1_1_5" id="hd_b_ch3.appf.tab3_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke (diastolic) - 85–89mmHg (follow-up mean 4 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_3 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_4 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_5 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_6 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_7 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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<p>709/23105</p>
|
|
<p>(3.1%)</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_9 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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<p>749/16626</p>
|
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<p>(4.5%)</p>
|
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.68 (0.62 to 0.75)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_11 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">14 fewer per 1000 (from 11 fewer to 17 fewer)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_4 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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<p>⨁⨁◯◯</p>
|
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<p>LOW</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_5 hd_b_ch3.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_h_ch3.appf.tab3_1_1_2_3 hd_h_ch3.appf.tab3_1_1_2_4 hd_h_ch3.appf.tab3_1_1_2_5 hd_h_ch3.appf.tab3_1_1_2_6 hd_h_ch3.appf.tab3_1_1_2_7 hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_h_ch3.appf.tab3_1_1_2_9 hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_h_ch3.appf.tab3_1_1_2_11 hd_h_ch3.appf.tab3_1_1_1_4 hd_h_ch3.appf.tab3_1_1_1_5" id="hd_b_ch3.appf.tab3_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke (diastolic) - 90–94mmHg (follow-up mean 4 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_3 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_4 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_5 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_6 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_7 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>399/19368</p>
|
|
<p>(2.1%)</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_9 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>631/19278</p>
|
|
<p>(3.3%)</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.63 (0.56 to 0.71)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_11 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">12 fewer per 1000 (from 9 fewer to 14 fewer)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_4 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_5 hd_b_ch3.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_h_ch3.appf.tab3_1_1_2_3 hd_h_ch3.appf.tab3_1_1_2_4 hd_h_ch3.appf.tab3_1_1_2_5 hd_h_ch3.appf.tab3_1_1_2_6 hd_h_ch3.appf.tab3_1_1_2_7 hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_h_ch3.appf.tab3_1_1_2_9 hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_h_ch3.appf.tab3_1_1_2_11 hd_h_ch3.appf.tab3_1_1_1_4 hd_h_ch3.appf.tab3_1_1_1_5" id="hd_b_ch3.appf.tab3_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Stroke (diastolic) - >95mmHg (follow-up mean 4 years)</th></tr><tr><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_1 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_2 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_3 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_4 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_5 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch3.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_6 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch3.appf.tab3_1_1_1_1 hd_h_ch3.appf.tab3_1_1_2_7 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_8 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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<p>123/3331</p>
|
|
<p>(3.7%)</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_2 hd_h_ch3.appf.tab3_1_1_2_9 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>209/2864</p>
|
|
<p>(7.3%)</p>
|
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</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_10 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.51 (0.41 to 0.63)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_3 hd_h_ch3.appf.tab3_1_1_2_11 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36 fewer per 1000 (from 27 fewer to 43 fewer)</td><td headers="hd_h_ch3.appf.tab3_1_1_1_4 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch3.appf.tab3_1_1_1_5 hd_b_ch3.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch3.appf.tab3_1"><p class="no_margin">Downgraded by 1 increment due to population or outcome indirectness, or by 2 increments for both population and outcome indirectness.</p></div></dd><dt>2</dt><dd><div id="ch3.appf.tab3_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div></div>
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<div class="post-content"><div><p>From: <a href="/books/NBK578045/" target="mainwindow">Evidence review for initiating treatment</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/niceng136er3/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng136er3-lrg.png" alt="Cover of Evidence review for initiating treatment" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Evidence review for initiating treatment: Hypertension in adults: diagnosis and management: Evidence review C.</div><div class="series-statement">NICE Guideline, No. 136.</div><div>National Guideline Centre (UK).</div><div>London: <a href="https://www.nice.org.uk" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">National Institute for Health and Care Excellence (NICE)</a>; 2019 Aug.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © NICE 2019.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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