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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="author" content="National Guideline Centre (UK)" /><meta name="citation_title" content="Risk factors" /><meta name="citation_publisher" content="National Institute for Health and Care Excellence (NICE)" /><meta name="citation_date" content="2018/07" /><meta name="citation_author" content="National Guideline Centre (UK)" /><meta name="citation_pmid" content="35129931" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK577109/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Risk factors" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute for Health and Care Excellence (NICE)" /><meta name="DC.Contributor" content="National Guideline Centre (UK)" /><meta name="DC.Date" content="2018/07" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK577109/" /><meta name="og:title" content="Risk factors" /><meta name="og:type" content="book" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK577109/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng100er2-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/niceng100er2/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK577109/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="https://www.nice.org.uk" title="National Institute for Health and Care Excellence (NICE)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng100er2-lrg.png" alt="Cover of Risk factors" /></a><div class="icnblk_cntnt"><h1 id="_NBK577109_"><span itemprop="name">Risk factors</span></h1><div class="subtitle">Rheumatoid arthritis in adults: diagnosis and management</div><p><b>Evidence review B</b></p><p><i>NICE Guideline, No. 100</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Centre (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2018 Jul</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3003-6</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2018.</div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div><h2>Contents</h2><ul id="toc_tllNBK577109_toc_chb1" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1"><a class="toc-item" href="/books/n/niceng100er2/chb1/">1. Prognostic factors for poor function</a><ul id="toc_lst_NBK577109_toc_chb1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s1"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s1">1.1. Review question: In adults with rheumatoid arthritis, which risk factors are associated with poorer long-term function as measured by the Health Assessment Questionnaire (HAQ)?</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s2"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s2">1.2. Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s3"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s3">1.3. PICO table</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s4"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s4">1.4. Methods and process</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s5"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s5">1.5. Clinical evidence</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s6"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s6">1.6. Economic evidence</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s7"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s7">1.7. Resource costs</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb1_s8"><a class="toc-item" href="/books/n/niceng100er2/chb1/#chb1.s8">1.8. Evidence statements</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2"><a class="toc-item" href="/books/n/niceng100er2/chb2/">2. Prognostic factors for radiographic progression</a><ul id="toc_lst_NBK577109_toc_chb2" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s1"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s1">2.1. Review question: In adults with rheumatoid arthritis, which risk factors are associated with worse radiographic progression?</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s2"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s2">2.2. Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s3"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s3">2.3. PICO table</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s4"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s4">2.4. Methods and process</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s5"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s5">2.5. Clinical evidence</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s6"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s6">2.6. Economic evidence</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s7"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s7">2.7. Resource costs</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s8"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s8">2.8. Evidence statements</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_chb2_s9"><a class="toc-item" href="/books/n/niceng100er2/chb2/#chb2.s9">2.9. The committee’s discussion of the evidence</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_rl_r1"><a class="toc-item" href="/books/n/niceng100er2/ptb.rl.r1/">References</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_appendixes_appgroupb"><a class="toc-item" href="/books/n/niceng100er2/appendixes.appgroupb/">Appendices</a><ul id="toc_lst_NBK577109_toc_appendixes_appgroupb" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appa"><a class="toc-item" href="/books/n/niceng100er2/ptb.appa/">Appendix A. Review protocols</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appb"><a class="toc-item" href="/books/n/niceng100er2/ptb.appb/">Appendix B. Literature search strategies</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appc"><a class="toc-item" href="/books/n/niceng100er2/ptb.appc/">Appendix C. Clinical evidence selection</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appd"><a class="toc-item" href="/books/n/niceng100er2/ptb.appd/">Appendix D. Clinical evidence tables</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appe"><a class="toc-item" href="/books/n/niceng100er2/ptb.appe/">Appendix E. Forest plots</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appf"><a class="toc-item" href="/books/n/niceng100er2/ptb.appf/">Appendix F. GRADE tables</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appg"><a class="toc-item" href="/books/n/niceng100er2/ptb.appg/">Appendix G. Health economic evidence selection</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_apph"><a class="toc-item" href="/books/n/niceng100er2/ptb.apph/">Appendix H. Health economic evidence tables</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appi"><a class="toc-item" href="/books/n/niceng100er2/ptb.appi/">Appendix I. Excluded studies</a></li><li class="half_rhythm" id="toc_itm_NBK577109_toc_ptb_appj"><a class="toc-item" href="/books/n/niceng100er2/ptb.appj/">Appendix J. Research recommendations</a></li></ul></li></ul></div><div><p>Final</p></div><div><p>Prognostic evidence review</p><p>Developed by the National Guideline Centre, hosted by the Royal College of
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Physicians</p></div><div><p>The recommendations in this guideline represent the view of NICE, arrived at after
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careful consideration of the evidence available. When exercising their judgement,
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professionals are expected to take this guideline fully into account, alongside the
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individual needs, preferences and values of their patients or service users. The
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recommendations in this guideline are not mandatory and the guideline does not
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override the responsibility of healthcare professionals to make decisions
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appropriate to the circumstances of the individual patient, in consultation with the
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patient and, where appropriate, their carer or guardian.</p><p>Local commissioners and providers have a responsibility to enable the guideline to be
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applied when individual health professionals and their patients or service users
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wish to use it. They should do so in the context of local and national priorities
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for funding and developing services, and in light of their duties to have due regard
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to the need to eliminate unlawful discrimination, to advance equality of opportunity
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and to reduce health inequalities. Nothing in this guideline should be interpreted
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in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in
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other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and
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<a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland
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Executive</a>. All NICE guidance is subject to regular review and may be
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updated or withdrawn.</p></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2018.</div><div class="small"><span class="label">Bookshelf ID: NBK577109</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35129931" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">35129931</a></span></div><div style="margin-top:2em" class="bk_noprnt"><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/niceng100er2/chb1/" title="Next page in this title">Next ></a></div></div></div></div>
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