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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Rizatriptan - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Rizatriptan">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/09/15">
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<meta name="citation_keywords" content="Risatriptan">
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<meta name="citation_keywords" content="UNII-51086HBW8G">
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<meta name="citation_keywords" content="51086HBW8G">
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<meta name="citation_keywords" content="N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501462_"><span class="title" itemprop="name">Rizatriptan</span></h1><p class="fm-aai"><a href="#_NBK501462_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 144034-80-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135110600" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135110600" alt="image 135110600 in the ncbi pubchem database" /></a><div id="LM578.Drug_Levels_and_Effects"><h2 id="_LM578_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM578.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Breastmilk levels of rizatriptan are low and the half-life in milk is relatively short. Amounts ingested by the infant are small and unlikely to affect the nursing infant. Painful, burning nipples and breast pain have been reported after doses of sumatriptan and other triptans. This has occasionally been accompanied by a decrease in milk production.</p></div><div id="LM578.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Five women who were at least 1 month postpartum and used rizatriptan to treat migraine provided one milk sample before their dose, then additional milk samples at 1, 2, 4, 8, 12 and 24 hours after their 10 mg oral dose. The average peak milk level was 58.4 mcg/L (range 14.6 to 105.6 mcg/L) and occurred 2 hours after the dose in 4 women ad 4 hours after the dose in another. The average milk level was 9 mcg/L (range 2.6 to 14.8 mcg/L) and the average half-life in milk was 2.2 hours (range 1.6 to 3.1 hours). The average daily infant dosage of rizatriptan was 1.3 mcg/kg (range 0.4 to 2.2 mcg/kg) and the weight-adjusted infant dosage averaged 0.9% (range 0.5 to 1.4%) of the maternal dose.[<a class="bibr" href="#LM578.REF.1" rid="LM578.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM578.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM578.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>A review of four European adverse reaction databases found 26 reported cases of, painful, burning nipples, painful breasts, breast engorgement and/or painful milk ejection in women who took a triptan while nursing. Pain was sometimes intense and occasionally led to decreased milk production. Pain generally subsided with time as the drug was eliminated. The authors proposed that triptans may cause vasoconstriction of the arteries in the breast, nipples, and the arteries surrounding the alveoli and milk ducts, causing a painful sensation and a painful milk ejection reflex.[<a class="bibr" href="#LM578.REF.2" rid="LM578.REF.2">2</a>]</p></div><div id="LM578.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM350/?report=reader">Eletriptan</a>, <a href="/books/n/lactmed/LM387/?report=reader">Sumatriptan</a>, <a href="/books/n/lactmed/LM579/?report=reader">Zolmitriptan</a></p></div><div id="LM578.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM578.REF.1">Amundsen
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S, Nordeng
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H, Fuskevåg
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OM, et al.
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Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding.
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Basic Clin Pharmacol Toxicol
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2021;128:795-804.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33730376" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33730376</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM578.REF.2">Conijn
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M, Maas
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V, van Tuyl
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M, et al.
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Breastfeeding-related adverse drug reactions of triptans: A descriptive analysis using four pharmacovigilance databases.
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Breastfeed Med
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2024;19:645-51.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38563407" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38563407</span></a>]</div></dd></dl></dl></div></div><div id="LM578.Substance_Identification"><h2 id="_LM578_Substance_Identification_">Substance Identification</h2><div id="LM578.Substance_Name"><h3>Substance Name</h3><p>Rizatriptan</p></div><div id="LM578.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>144034-80-0</p></div><div id="LM578.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Serotonin Receptor Agonists</p><p>Serotonin 5-HT1 Receptor Agonists</p><p>Triptans</p><p>Vasoconstrictor Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501462_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Rizatriptan. [Updated 2024 Sep 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1169/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1114/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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