241 lines
32 KiB
Text
241 lines
32 KiB
Text
<!DOCTYPE html>
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" class="no-js no-jr">
|
|
<head>
|
|
<!-- For pinger, set start time and add meta elements. -->
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books">
|
|
<meta name="ncbi_pdid" content="book-part">
|
|
<meta name="ncbi_acc" content="NBK501286">
|
|
<meta name="ncbi_domain" content="lactmed">
|
|
<meta name="ncbi_report" content="reader">
|
|
<meta name="ncbi_type" content="fulltext">
|
|
<meta name="ncbi_objectid" content="">
|
|
<meta name="ncbi_pcid" content="/NBK501286/?report=reader">
|
|
<meta name="ncbi_pagename" content="Trimethoprim - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf">
|
|
<meta name="ncbi_bookparttype" content="chapter">
|
|
<meta name="ncbi_app" content="bookshelf">
|
|
<!-- Logger end -->
|
|
|
|
<!--component id="Page" label="meta"/-->
|
|
<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Trimethoprim - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
|
|
<meta charset="utf-8">
|
|
<meta name="apple-mobile-web-app-capable" content="no">
|
|
<meta name="viewport" content="initial-scale=1,minimum-scale=1,maximum-scale=1,user-scalable=no">
|
|
<meta name="jr-col-layout" content="auto">
|
|
<meta name="jr-prev-unit" content="/books/n/lactmed/LM1403/?report=reader">
|
|
<meta name="jr-next-unit" content="/books/n/lactmed/LM417/?report=reader">
|
|
<meta name="bk-toc-url" content="/books/n/lactmed/?report=toc">
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE">
|
|
<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
|
|
<meta name="citation_title" content="Trimethoprim">
|
|
<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
|
|
<meta name="citation_date" content="2024/11/15">
|
|
<meta name="citation_pmid" content="30000345">
|
|
<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501286/">
|
|
<meta name="citation_keywords" content="trimethoprim">
|
|
<meta name="citation_keywords" content="Proloprim">
|
|
<meta name="citation_keywords" content="Trimpex">
|
|
<meta name="citation_keywords" content="Trimetoprim">
|
|
<meta name="citation_keywords" content="Monotrimin">
|
|
<meta name="citation_keywords" content="Bactramin">
|
|
<meta name="citation_keywords" content="Monotrim">
|
|
<meta name="citation_keywords" content="Trimopan">
|
|
<meta name="citation_keywords" content="Wellcoprim">
|
|
<meta name="citation_keywords" content="Monoprim">
|
|
<meta name="citation_keywords" content="Syraprim">
|
|
<meta name="citation_keywords" content="Trimanyl">
|
|
<meta name="citation_keywords" content="Triprim">
|
|
<meta name="citation_keywords" content="Uretrim">
|
|
<meta name="citation_keywords" content="Sulfamethoprim">
|
|
<meta name="citation_keywords" content="Trimethoprime">
|
|
<meta name="citation_keywords" content="Trimethoprimum">
|
|
<meta name="citation_keywords" content="Trimetoprima">
|
|
<meta name="citation_keywords" content="Sulmeprim">
|
|
<meta name="citation_keywords" content="Abaprim">
|
|
<meta name="citation_keywords" content="Veltrim">
|
|
<meta name="citation_keywords" content="Trimeth/Sulfa">
|
|
<meta name="citation_keywords" content="Briscotrim">
|
|
<meta name="citation_keywords" content="Novotrimel">
|
|
<meta name="citation_keywords" content="Streptoplus">
|
|
<meta name="citation_keywords" content="Sulfoxaprim">
|
|
<meta name="citation_keywords" content="Urobactrim">
|
|
<meta name="citation_keywords" content="Wellcoprin">
|
|
<meta name="citation_keywords" content="Bactoprim">
|
|
<meta name="citation_keywords" content="Bethaprim">
|
|
<meta name="citation_keywords" content="Biosulten">
|
|
<meta name="citation_keywords" content="Chemotrin">
|
|
<meta name="citation_keywords" content="Espectrin">
|
|
<meta name="citation_keywords" content="Salvatrim">
|
|
<meta name="citation_keywords" content="Trisulcom">
|
|
<meta name="citation_keywords" content="Trisulfam">
|
|
<meta name="citation_keywords" content="Zamboprim">
|
|
<meta name="citation_keywords" content="Antrimox">
|
|
<meta name="citation_keywords" content="Bacticel">
|
|
<meta name="citation_keywords" content="Colizole">
|
|
<meta name="citation_keywords" content="Cotrimel">
|
|
<meta name="citation_keywords" content="Fermagex">
|
|
<meta name="citation_keywords" content="Kombinax">
|
|
<meta name="citation_keywords" content="Lagatrim">
|
|
<meta name="citation_keywords" content="Metoprim">
|
|
<meta name="citation_keywords" content="Pancidim">
|
|
<meta name="citation_keywords" content="Sinotrim">
|
|
<meta name="citation_keywords" content="Sugaprim">
|
|
<meta name="citation_keywords" content="Sulfamar">
|
|
<meta name="citation_keywords" content="Sulthrim">
|
|
<meta name="citation_keywords" content="Trimexol">
|
|
<meta name="citation_keywords" content="Trimezol">
|
|
<meta name="citation_keywords" content="Trisural">
|
|
<meta name="citation_keywords" content="Xeroprim">
|
|
<meta name="citation_keywords" content="Anitrim">
|
|
<meta name="citation_keywords" content="Antrima">
|
|
<meta name="citation_keywords" content="Bacidal">
|
|
<meta name="citation_keywords" content="Bencole">
|
|
<meta name="citation_keywords" content="Conprim">
|
|
<meta name="citation_keywords" content="Duocide">
|
|
<meta name="citation_keywords" content="Esbesul">
|
|
<meta name="citation_keywords" content="Euctrim">
|
|
<meta name="citation_keywords" content="Exbesul">
|
|
<meta name="citation_keywords" content="Fortrim">
|
|
<meta name="citation_keywords" content="Ikaprim">
|
|
<meta name="citation_keywords" content="Lastrim">
|
|
<meta name="citation_keywords" content="Protrin">
|
|
<meta name="citation_keywords" content="Resprim">
|
|
<meta name="citation_keywords" content="Setprin">
|
|
<meta name="citation_keywords" content="Sultrex">
|
|
<meta name="citation_keywords" content="Trimono">
|
|
<meta name="citation_keywords" content="Utetrin">
|
|
<meta name="citation_keywords" content="Velaten">
|
|
<meta name="citation_keywords" content="Bacdan">
|
|
<meta name="citation_keywords" content="Bacide">
|
|
<meta name="citation_keywords" content="Deprim">
|
|
<meta name="citation_keywords" content="Omstat">
|
|
<meta name="citation_keywords" content="Purbal">
|
|
<meta name="citation_keywords" content="Roubac">
|
|
<meta name="citation_keywords" content="Roubal">
|
|
<meta name="citation_keywords" content="Stopan">
|
|
<meta name="citation_keywords" content="Toprim">
|
|
<meta name="citation_keywords" content="Trisul">
|
|
<meta name="citation_keywords" content="Bacin">
|
|
<meta name="citation_keywords" content="Bacta">
|
|
<meta name="citation_keywords" content="Cidal">
|
|
<meta name="citation_keywords" content="Futin">
|
|
<meta name="citation_keywords" content="Co-Trimoxizole">
|
|
<meta name="citation_keywords" content="Lagatrim Forte">
|
|
<meta name="citation_keywords" content="Septrin Forte">
|
|
<meta name="citation_keywords" content="Sulfatrim">
|
|
<meta name="citation_keywords" content="Bactifor">
|
|
<meta name="citation_keywords" content="Diseptyl">
|
|
<meta name="citation_keywords" content="Dosulfin">
|
|
<meta name="citation_keywords" content="Bactrim">
|
|
<meta name="citation_keywords" content="Centrim">
|
|
<meta name="citation_keywords" content="Cotrim">
|
|
<meta name="citation_keywords" content="Lescot">
|
|
<meta name="citation_keywords" content="Septra">
|
|
<meta name="citation_keywords" content="Acuco">
|
|
<meta name="citation_keywords" content="Alcorim-F">
|
|
<meta name="citation_keywords" content="Colizole DS">
|
|
<meta name="citation_keywords" content="Septrin S">
|
|
<meta name="citation_keywords" content="Septrin DS">
|
|
<meta name="citation_keywords" content="Resprim Forte">
|
|
<meta name="citation_keywords" content="Smz-Tmp">
|
|
<meta name="citation_keywords" content="Trimez-IFSA">
|
|
<meta name="citation_keywords" content="component of Bactrim">
|
|
<meta name="citation_keywords" content="U-Prin">
|
|
<meta name="citation_keywords" content="Trimpex 200">
|
|
<meta name="citation_keywords" content="component of Septra">
|
|
<meta name="citation_keywords" content="Tmp Smx">
|
|
<meta name="citation_keywords" content="Trimetoprim [DCIT]">
|
|
<meta name="citation_keywords" content="Trimetoprim [Polish]">
|
|
<meta name="citation_keywords" content="Uro-D S">
|
|
<meta name="citation_keywords" content="Bacterial [Antibiotic]">
|
|
<meta name="citation_keywords" content="NIH 204">
|
|
<meta name="citation_keywords" content="SMZ/TMP">
|
|
<meta name="citation_keywords" content="UNII-AN164J8Y0X">
|
|
<meta name="citation_keywords" content="NIH 204 (VAN)">
|
|
<meta name="citation_keywords" content="NSC-106568">
|
|
<meta name="citation_keywords" content="CCRIS 2410">
|
|
<meta name="citation_keywords" content="BW 56-72">
|
|
<meta name="citation_keywords" content="HSDB 6781">
|
|
<meta name="citation_keywords" content="AN164J8Y0X">
|
|
<meta name="citation_keywords" content="NSC 106568">
|
|
<meta name="citation_keywords" content="EINECS 212-006-2">
|
|
<meta name="citation_keywords" content="WR 5949">
|
|
<meta name="citation_keywords" content="BRN 0625127">
|
|
<meta name="citation_keywords" content="AI3-52594">
|
|
<meta name="citation_keywords" content="5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine">
|
|
<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
|
|
<meta name="DC.Title" content="Trimethoprim">
|
|
<meta name="DC.Type" content="Text">
|
|
<meta name="DC.Publisher" content="National Institute of Child Health and Human Development">
|
|
<meta name="DC.Date" content="2024/11/15">
|
|
<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501286/">
|
|
<meta name="description" content="Because of the low levels of trimethoprim in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.">
|
|
<meta name="og:title" content="Trimethoprim">
|
|
<meta name="og:type" content="book">
|
|
<meta name="og:description" content="Because of the low levels of trimethoprim in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.">
|
|
<meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501286/">
|
|
<meta name="og:site_name" content="NCBI Bookshelf">
|
|
<meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png">
|
|
<meta name="twitter:card" content="summary">
|
|
<meta name="twitter:site" content="@ncbibooks">
|
|
<meta name="bk-non-canon-loc" content="/books/n/lactmed/LM414/?report=reader">
|
|
<link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501286/">
|
|
<link href="https://fonts.googleapis.com/css?family=Archivo+Narrow:400,700,400italic,700italic&subset=latin" rel="stylesheet" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/libs.min.css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/jr.min.css">
|
|
<meta name="format-detection" content="telephone=no">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css//books_print.min.css" type="text/css" media="print">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_reader.min.css" type="text/css">
|
|
<style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style>
|
|
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico">
|
|
<meta name="ncbi_phid" content="CE8D5DB47D83BD810000000000A6008E.m_5">
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3849091.css"></head>
|
|
<body>
|
|
<!-- Book content! -->
|
|
|
|
|
|
<div id="jr" data-jr-path="/corehtml/pmc/jatsreader/ptpmc_3.22/"><div class="jr-unsupported"><table class="modal"><tr><td><span class="attn inline-block"></span><br />Your browser does not support the NLM PubReader view.<br />Go to <a href="/pmc/about/pr-browsers/">this page</a> to see a list of supported browsers<br />or return to the <br /><a href="/books/NBK501286/?report=classic">regular view</a>.</td></tr></table></div><div id="jr-ui" class="hidden"><nav id="jr-head"><div class="flexh tb"><div id="jr-tb1"><a id="jr-links-sw" class="hidden" title="Links"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" x="0px" y="0px" viewBox="0 0 70.6 85.3" style="enable-background:new 0 0 70.6 85.3;vertical-align:middle" xml:space="preserve" width="24" height="24">
|
|
<style type="text/css">.st0{fill:#939598;}</style>
|
|
<g>
|
|
<path class="st0" d="M36,0C12.8,2.2-22.4,14.6,19.6,32.5C40.7,41.4-30.6,14,35.9,9.8"></path>
|
|
<path class="st0" d="M34.5,85.3c23.2-2.2,58.4-14.6,16.4-32.5c-21.1-8.9,50.2,18.5-16.3,22.7"></path>
|
|
<path class="st0" d="M34.7,37.1c66.5-4.2-4.8-31.6,16.3-22.7c42.1,17.9,6.9,30.3-16.4,32.5h1.7c-66.2,4.4,4.8,31.6-16.3,22.7 c-42.1-17.9-6.9-30.3,16.4-32.5"></path>
|
|
</g>
|
|
</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"><a href="/books/n/lactmed/LM1403/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="body"><div class="t">Trimethoprim</div><div class="j">Drugs and Lactation Database (LactMed®) [Internet]</div></div><div class="tail"><a href="/books/n/lactmed/LM417/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 c-11.235,4.66-23.919,4.333-34.905-0.889l-28.723-13.653l-39.234,39.234l13.653,28.721c5.219,10.979,5.545,23.681,0.889,34.91 c-0.002,0.004-0.004,0.009-0.006,0.013c-4.649,11.214-13.834,19.931-25.271,23.998L50,228.257v55.485l29.98,10.661 c11.431,4.065,20.627,12.794,25.274,24c0.002,0.005,0.003,0.01,0.005,0.014c4.66,11.236,4.334,23.921-0.888,34.906l-13.654,28.723 l39.234,39.234l28.721-13.652c10.979-5.219,23.681-5.546,34.909-0.889c0.005,0.002,0.01,0.004,0.014,0.006 c11.214,4.649,19.93,13.833,23.998,25.271L228.257,462h55.484l10.595-29.79c4.103-11.538,12.908-20.824,24.216-25.525 c0.005-0.002,0.009-0.004,0.014-0.006c11.127-4.628,23.694-4.311,34.578,0.863l28.902,13.738l39.234-39.234l-13.66-28.737 c-5.214-10.969-5.539-23.659-0.886-34.877c0.002-0.005,0.004-0.009,0.006-0.014c4.654-11.225,13.848-19.949,25.297-24.021 L462,283.742z M256,331.546c-41.724,0-75.548-33.823-75.548-75.546s33.824-75.547,75.548-75.547 c41.723,0,75.546,33.824,75.546,75.547S297.723,331.546,256,331.546z"></path></svg></a><a id="jr-fip-sw" class="btn wsprkl hidden" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-rtoc-sw" class="btn wsprkl hidden" title="Table of Contents"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,20h10v8H20V20zM36,20h44v8H36V20zM20,37.33h10v8H20V37.33zM36,37.33h44v8H36V37.33zM20,54.66h10v8H20V54.66zM36,54.66h44v8H36V54.66zM20,72h10v8 H20V72zM36,72h44v8H36V72z"></path></svg></a></div></div></nav><nav id="jr-dash" class="noselect"><nav id="jr-dash" class="noselect"><div id="jr-pi" class="hidden"><a id="jr-pi-prev" class="hidden" title="Previous page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a><div class="pginfo">Page <i class="jr-pg-pn">0</i> of <i class="jr-pg-lp">0</i></div><a id="jr-pi-next" class="hidden" title="Next page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div><div id="jr-is-tb"><a id="jr-is-sw" class="btn wsprkl hidden" title="Switch between Figures/Tables strip and Progress bar"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><rect x="10" y="40" width="20" height="20"></rect><rect x="40" y="40" width="20" height="20"></rect><rect x="70" y="40" width="20" height="20"></rect></svg></a></div><nav id="jr-istrip" class="istrip hidden"><a id="jr-is-prev" href="#" class="hidden" title="Previous"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M80,40 60,65 80,90 70,90 50,65 70,40z M50,40 30,65 50,90 40,90 20,65 40,40z"></path><text x="35" y="25" textLength="60" style="font-size:25px">Prev</text></svg></a><a id="jr-is-next" href="#" class="hidden" title="Next"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,40 40,65 20,90 30,90 50,65 30,40z M50,40 70,65 50,90 60,90 80,65 60,40z"></path><text x="15" y="25" textLength="60" style="font-size:25px">Next</text></svg></a></nav><nav id="jr-progress"></nav></nav></nav><aside id="jr-links-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">NCBI Bookshelf</div></div><div class="cnt lol f1"><a href="/books/">Home</a><a href="/books/browse/">Browse All Titles</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/sharer/sharer.php?u=https://www.ncbi.nlm.nih.gov/books/NBK501286/"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24" preserveAspectRatio="none"><g><path d="M 17.996,32L 12,32 L 12,16 l-4,0 l0-5.514 l 4-0.002l-0.006-3.248C 11.993,2.737, 13.213,0, 18.512,0l 4.412,0 l0,5.515 l-2.757,0 c-2.063,0-2.163,0.77-2.163,2.209l-0.008,2.76l 4.959,0 l-0.585,5.514L 18,16L 17.996,32z"></path></g></svg> Share on Facebook</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://twitter.com/intent/tweet?url=https://www.ncbi.nlm.nih.gov/books/NBK501286/&text=Trimethoprim"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24"><g><path d="M 32,6.076c-1.177,0.522-2.443,0.875-3.771,1.034c 1.355-0.813, 2.396-2.099, 2.887-3.632 c-1.269,0.752-2.674,1.299-4.169,1.593c-1.198-1.276-2.904-2.073-4.792-2.073c-3.626,0-6.565,2.939-6.565,6.565 c0,0.515, 0.058,1.016, 0.17,1.496c-5.456-0.274-10.294-2.888-13.532-6.86c-0.565,0.97-0.889,2.097-0.889,3.301 c0,2.278, 1.159,4.287, 2.921,5.465c-1.076-0.034-2.088-0.329-2.974-0.821c-0.001,0.027-0.001,0.055-0.001,0.083 c0,3.181, 2.263,5.834, 5.266,6.438c-0.551,0.15-1.131,0.23-1.73,0.23c-0.423,0-0.834-0.041-1.235-0.118 c 0.836,2.608, 3.26,4.506, 6.133,4.559c-2.247,1.761-5.078,2.81-8.154,2.81c-0.53,0-1.052-0.031-1.566-0.092 c 2.905,1.863, 6.356,2.95, 10.064,2.95c 12.076,0, 18.679-10.004, 18.679-18.68c0-0.285-0.006-0.568-0.019-0.849 C 30.007,8.548, 31.12,7.392, 32,6.076z"></path></g></svg> Share on Twitter</a></div></aside><aside id="jr-rtoc-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Table of Content</div></div><div class="cnt lol f1"><a href="/books/n/lactmed/?report=reader">Title Information</a><a href="/books/n/lactmed/toc/?report=reader">Table of Contents Page</a></div></aside><aside id="jr-help-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Settings</div></div><div class="cnt f1"><div id="jr-typo-p" class="typo"><div><a class="sf btn wsprkl">A-</a><a class="lf btn wsprkl">A+</a></div><div><a class="bcol-auto btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 200 100" preserveAspectRatio="none"><text x="10" y="70" style="font-size:60px;font-family: Trebuchet MS, ArialMT, Arial, sans-serif" textLength="180">AUTO</text></svg></a><a class="bcol-1 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M15,25 85,25zM15,40 85,40zM15,55 85,55zM15,70 85,70z"></path></svg></a><a class="bcol-2 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M5,25 45,25z M55,25 95,25zM5,40 45,40z M55,40 95,40zM5,55 45,55z M55,55 95,55zM5,70 45,70z M55,70 95,70z"></path></svg></a></div></div><div class="lol"><a class="" href="/books/NBK501286/?report=classic">Switch to classic view</a><a href="/books/NBK501286/pdf/Bookshelf_NBK501286.pdf">PDF (108K)</a><a href="/books/NBK501286/?report=printable">Print View</a></div></div></aside><aside id="jr-bkhelp-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Help</div></div><div class="cnt f1 lol"><a id="jr-helpobj-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/help.xml" href="">Help</a><a href="mailto:info@ncbi.nlm.nih.gov?subject=PubReader%20feedback%20%2F%20NBK501286%20%2F%20sid%3ACE8B5AF87C7FFCB1_0191SID%20%2F%20phid%3ACE8D5DB47D83BD810000000000A6008E.4">Send us feedback</a><a id="jr-about-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/about.xml" href="">About PubReader</a></div></aside><aside id="jr-objectbox" class="thidden hidden"><div class="jr-objectbox-close wsprkl">✘</div><div class="jr-objectbox-inner cnt"><div class="jr-objectbox-drawer"></div></div></aside><nav id="jr-pm-left" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Previous Page</text></svg></nav><nav id="jr-pm-right" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Next Page</text></svg></nav><nav id="jr-fip" class="hidden"><nav id="jr-fip-term-p"><input type="search" placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501286_"><span class="title" itemprop="name">Trimethoprim</span></h1><p class="fm-aai"><a href="#_NBK501286_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 738-70-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135269979" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135269979" alt="image 135269979 in the ncbi pubchem database" /></a><div id="LM414.Drug_Levels_and_Effects"><h2 id="_LM414_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM414.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low levels of trimethoprim in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.</p></div><div id="LM414.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> In 20 mothers in the immediate postpartum period given oral trimethoprim, peak milk levels occurred 3 hours after the dose. In 14 of these women who received a daily dosage of 320 mg, the peak milk level averaged 2.4 mg/L and the trough averaged 1 mg/L. In 6 other women who received a daily dosage of 480 mg, the peak milk level averaged 4 mg/L and the trough averaged 1.5 mg/L. The authors calculated that a breastfed infant would receive a daily dosage of 0.75 mg with a maternal dosage of 320 mg daily and 1.7 mg with a maternal dosage of 480 mg.[<a class="bibr" href="#LM414.REF.1" rid="LM414.REF.1">1</a>,<a class="bibr" href="#LM414.REF.2" rid="LM414.REF.2">2</a>]</p><p>Forty women in the early postpartum period received oral co-trimoxazole and had milk levels measured several times daily for 5 days. After trimethoprim doses of 320 mg daily, average milk levels were about 2 mg/L. Milk levels increased to about 3 mg/L by day 5 of therapy. In 10 other women who received trimethoprim 480 mg daily, average milk levels were only slightly higher.[<a class="bibr" href="#LM414.REF.3" rid="LM414.REF.3">3</a>] With the usual dose of trimethoprim 320 mg daily, an exclusively breastfed infant would be expected to receive 0.45 mg/kg daily of trimethoprim. This is very low in comparison to the established treatment dosages of 8 mg/kg daily for infants over 2 months of age.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM414.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In one study, no adverse effects were noted in infants during 4 days of maternal therapy with co-trimoxazole.[<a class="bibr" href="#LM414.REF.1" rid="LM414.REF.1">1</a>]</p><p>In a telephone follow-up study, 12 nursing mothers reported taking co-trimoxazole (dosage unspecified). Two mothers reported poor feeding in their infants. Diarrhea was not reported among the exposed infants.[<a class="bibr" href="#LM414.REF.4" rid="LM414.REF.4">4</a>]</p></div><div id="LM414.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM414.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM69/?report=reader">Ciprofloxacin</a>, <a href="/books/n/lactmed/LM157/?report=reader">Levofloxacin</a>, <a href="/books/n/lactmed/LM202/?report=reader">Nitrofurantoin</a></p></div><div id="LM414.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM414.REF.1">Arnauld
|
|
R, Soutoul
|
|
JH, Gallier
|
|
J, et al.
|
|
Study on the passage of trimethoprim into mother's milk.
|
|
Ouest Med
|
|
1972;25:959-64.</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM414.REF.2">Borderon
|
|
E, Soutoul
|
|
JH, Borderon
|
|
JC, et al.
|
|
Excretion of antibiotics in human milk.
|
|
Med Mal Infect
|
|
1975;5:373-6.</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM414.REF.3">Miller RD, Salter AJ. The passage of trimethoprim/sulfamethoxazole into breast milk and its significance. In, Daikos CK, ed. Progress in Chemotherapy. Antibacterial chemotherapy 1974;1:687-91.</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM414.REF.4">Ito
|
|
S, Blajchman
|
|
A, Stephenson
|
|
M, et al.
|
|
Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication.
|
|
Am J Obstet Gynecol
|
|
1993;168:1393-9.
|
|
[<a href="https://pubmed.ncbi.nlm.nih.gov/8498418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8498418</span></a>]</div></dd></dl></dl></div></div><div id="LM414.Substance_Identification"><h2 id="_LM414_Substance_Identification_">Substance Identification</h2><div id="LM414.Substance_Name"><h3>Substance Name</h3><p>Trimethoprim</p></div><div id="LM414.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>738-70-5</p></div><div id="LM414.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents, Urinary</p><p>Antibacterial Agents</p><p>Folic Acid Antagonists</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501286_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Trimethoprim. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1403/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM417/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
|
|
|
|
|
|
|
|
|
|
<!-- Book content -->
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal106 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3968615.js" snapshot="books"></script></body>
|
|
</html>
|