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<span class="headername">Database of Clusters of Orthologous Genes (COGs)</span>
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J - Translation, ribosomal structure and biogenesis</a>
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L - Replication, recombination and repair</a>
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B - Chromatin structure and dynamics</a>
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D - Cell cycle control, cell division, chromosome partitioning</a>
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Y - Nuclear structure</a>
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V - Defense mechanisms</a>
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T - Signal transduction mechanisms</a>
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M - Cell wall/membrane/envelope biogenesis</a>
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N - Cell motility</a>
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W - Extracellular structures</a>
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O - Posttranslational modification, protein turnover, chaperones</a>
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C - Energy production and conversion</a>
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E - Amino acid transport and metabolism</a>
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F - Nucleotide transport and metabolism</a>
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H - Coenzyme transport and metabolism</a>
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I - Lipid transport and metabolism</a>
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<h1>T<span style='font-weight: 100'> - Signal transduction mechanisms</span></h1>
<div style="float: right; clear: both;margin-top: -53px;">
<a class="usa-button" href="#" onclick="download_table_as_tsv('cog_result_table');">Download</a>
</div>
<h2>Stats</h2>
<div style="width: 60%">
<div class="ui-ncbigrid-outer-div organism_cog_table">
<div class="ui-ncbigrid-inner-div">
<table data-jig="ncbigrid">
<thead>
<tr>
<th>COG<br>definitions</th>
<th>Organims</th>
<th>Proteins</th>
<th>Median Protein<br>Length</th>
<th>Genes</th>
</tr>
</thead>
<tbody>
<tr>
<td>250</td>
<td>2,290</td>
<td>426,986</td>
<td>351.0</td>
<td>231</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="ui-ncbigrid-outer-div" style="font-size: 80%;">
<div class="ui-ncbigrid-inner-div">
<table id="cog_result_table" data-jig="ncbigrid">
<thead>
<tr>
<th>Organism</th>
<th>Protein</th>
<th>COG</th>
<th>Cat</th>
<th>Annotation</th>
</tr>
</thead>
<tbody>
<tr>
<td>1667</td>
<td>2480</td>
<td><a href="/research/cog/cog/COG0248/">COG0248</a></td>
<td>
T
F
</td>
<td>Exopolyphosphatase/pppGpp-phosphohydrolase</td>
</tr>
<tr>
<td>869</td>
<td>1153</td>
<td><a href="/research/cog/cog/COG0271/">COG0271</a></td>
<td>
K
T
</td>
<td>DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation</td>
</tr>
<tr>
<td>1992</td>
<td>3169</td>
<td><a href="/research/cog/cog/COG0317/">COG0317</a></td>
<td>
K
T
</td>
<td>(p)ppGpp synthase/hydrolase, HD superfamily</td>
</tr>
<tr>
<td>1589</td>
<td>3120</td>
<td><a href="/research/cog/cog/COG0347/">COG0347</a></td>
<td>
T
E
</td>
<td>Nitrogen regulatory protein PII</td>
</tr>
<tr>
<td>1923</td>
<td>4016</td>
<td><a href="/research/cog/cog/COG0394/">COG0394</a></td>
<td>
T
</td>
<td>Protein-tyrosine-phosphatase</td>
</tr>
<tr>
<td>1254</td>
<td>2738</td>
<td><a href="/research/cog/cog/COG0464/">COG0464</a></td>
<td>
D
T
M
</td>
<td>AAA+-type ATPase, SpoVK/Ycf46/Vps4 family</td>
</tr>
<tr>
<td>535</td>
<td>1405</td>
<td><a href="/research/cog/cog/COG0467/">COG0467</a></td>
<td>
T
</td>
<td>RecA-superfamily ATPase, KaiC/GvpD/RAD55 family</td>
</tr>
<tr>
<td>235</td>
<td>242</td>
<td><a href="/research/cog/cog/COG0478/">COG0478</a></td>
<td>
T
</td>
<td>RIO-like serine/threonine protein kinase fused to N-terminal HTH domain</td>
</tr>
<tr>
<td>491</td>
<td>577</td>
<td><a href="/research/cog/cog/COG0490/">COG0490</a></td>
<td>
T
P
</td>
<td>K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain</td>
</tr>
<tr>
<td>1565</td>
<td>13905</td>
<td><a href="/research/cog/cog/COG0515/">COG0515</a></td>
<td>
T
</td>
<td>Serine/threonine protein kinase, uncludes type III secretion system effector YopO</td>
</tr>
<tr>
<td>1685</td>
<td>3044</td>
<td><a href="/research/cog/cog/COG0517/">COG0517</a></td>
<td>
T
</td>
<td>CBS domain</td>
</tr>
<tr>
<td>1950</td>
<td>5434</td>
<td><a href="/research/cog/cog/COG0569/">COG0569</a></td>
<td>
T
P
</td>
<td>Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain</td>
</tr>
<tr>
<td>1832</td>
<td>9659</td>
<td><a href="/research/cog/cog/COG0589/">COG0589</a></td>
<td>
T
</td>
<td>Nucleotide-binding universal stress protein, UspA family</td>
</tr>
<tr>
<td>1277</td>
<td>1931</td>
<td><a href="/research/cog/cog/COG0618/">COG0618</a></td>
<td>
A
T
</td>
<td>nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs</td>
</tr>
<tr>
<td>1375</td>
<td>2877</td>
<td><a href="/research/cog/cog/COG0631/">COG0631</a></td>
<td>
T
</td>
<td>Serine/threonine protein phosphatase PrpC</td>
</tr>
<tr>
<td>274</td>
<td>279</td>
<td><a href="/research/cog/cog/COG0639/">COG0639</a></td>
<td>
T
</td>
<td>Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family</td>
</tr>
<tr>
<td>2071</td>
<td>22634</td>
<td><a href="/research/cog/cog/COG0642/">COG0642</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase</td>
</tr>
<tr>
<td>1246</td>
<td>2833</td>
<td><a href="/research/cog/cog/COG0643/">COG0643</a></td>
<td>
T
</td>
<td>Chemotaxis protein histidine kinase CheA</td>
</tr>
<tr>
<td>1608</td>
<td>2608</td>
<td><a href="/research/cog/cog/COG0661/">COG0661</a></td>
<td>
T
H
</td>
<td>Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family</td>
</tr>
<tr>
<td>1884</td>
<td>11674</td>
<td><a href="/research/cog/cog/COG0664/">COG0664</a></td>
<td>
T
</td>
<td>cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</td>
</tr>
<tr>
<td>1171</td>
<td>3503</td>
<td><a href="/research/cog/cog/COG0666/">COG0666</a></td>
<td>
T
</td>
<td>Ankyrin repeat</td>
</tr>
<tr>
<td>2126</td>
<td>31286</td>
<td><a href="/research/cog/cog/COG0745/">COG0745</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain</td>
</tr>
<tr>
<td>1621</td>
<td>17364</td>
<td><a href="/research/cog/cog/COG0784/">COG0784</a></td>
<td>
T
</td>
<td>CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F</td>
</tr>
<tr>
<td>1767</td>
<td>11106</td>
<td><a href="/research/cog/cog/COG0834/">COG0834</a></td>
<td>
T
E
</td>
<td>ABC-type amino acid transport/signal transduction system, periplasmic component/domain</td>
</tr>
<tr>
<td>1239</td>
<td>4105</td>
<td><a href="/research/cog/cog/COG0835/">COG0835</a></td>
<td>
T
</td>
<td>Chemotaxis signal transduction protein CheW</td>
</tr>
<tr>
<td>1354</td>
<td>16692</td>
<td><a href="/research/cog/cog/COG0840/">COG0840</a></td>
<td>
T
</td>
<td>Methyl-accepting chemotaxis protein (MCP)</td>
</tr>
<tr>
<td>696</td>
<td>958</td>
<td><a href="/research/cog/cog/COG1073/">COG1073</a></td>
<td>
T
</td>
<td>Fermentation-respiration switch esterase FrsA, DUF1100 family</td>
</tr>
<tr>
<td>1933</td>
<td>1938</td>
<td><a href="/research/cog/cog/COG1217/">COG1217</a></td>
<td>
T
</td>
<td>Predicted membrane GTPase TypA/BipA involved in stress response</td>
</tr>
<tr>
<td>104</td>
<td>111</td>
<td><a href="/research/cog/cog/COG1221/">COG1221</a></td>
<td>
K
T
</td>
<td>Transcriptional regulators containing sigma54-interacting ATPase domain</td>
</tr>
<tr>
<td>1961</td>
<td>4447</td>
<td><a href="/research/cog/cog/COG1253/">COG1253</a></td>
<td>
T
P
</td>
<td>Mg2+ efflux pump MpfA, contains CBS pair and CorC-HlyC domains, TlyC/UPF0053 family</td>
</tr>
<tr>
<td>1301</td>
<td>2870</td>
<td><a href="/research/cog/cog/COG1352/">COG1352</a></td>
<td>
T
</td>
<td>Methylase of chemotaxis methyl-accepting proteins</td>
</tr>
<tr>
<td>821</td>
<td>2886</td>
<td><a href="/research/cog/cog/COG1366/">COG1366</a></td>
<td>
T
</td>
<td>Anti-anti-sigma factor (antagonist of anti-sigma factor), STAS domain</td>
</tr>
<tr>
<td>1509</td>
<td>3424</td>
<td><a href="/research/cog/cog/COG1409/">COG1409</a></td>
<td>
T
</td>
<td>3&#x27;,5&#x27;-cyclic AMP phosphodiesterase CpdA</td>
</tr>
<tr>
<td>405</td>
<td>454</td>
<td><a href="/research/cog/cog/COG1437/">COG1437</a></td>
<td>
T
R
</td>
<td>Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)</td>
</tr>
<tr>
<td>606</td>
<td>615</td>
<td><a href="/research/cog/cog/COG1480/">COG1480</a></td>
<td>
T
</td>
<td>Cyclic di-AMP-specific phosphodiesterase PgpH, HD superfamily</td>
</tr>
<tr>
<td>769</td>
<td>783</td>
<td><a href="/research/cog/cog/COG1489/">COG1489</a></td>
<td>
T
G
</td>
<td>DNA-binding protein, stimulates sugar fermentation</td>
</tr>
<tr>
<td>993</td>
<td>1119</td>
<td><a href="/research/cog/cog/COG1493/">COG1493</a></td>
<td>
T
</td>
<td>Serine kinase of the HPr protein, regulates carbohydrate metabolism</td>
</tr>
<tr>
<td>1057</td>
<td>1720</td>
<td><a href="/research/cog/cog/COG1524/">COG1524</a></td>
<td>
T
</td>
<td>c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily</td>
</tr>
<tr>
<td>709</td>
<td>1034</td>
<td><a href="/research/cog/cog/COG1551/">COG1551</a></td>
<td>
T
</td>
<td>sRNA-binding carbon storage regulator CsrA</td>
</tr>
<tr>
<td>296</td>
<td>296</td>
<td><a href="/research/cog/cog/COG1623/">COG1623</a></td>
<td>
T
</td>
<td>c-di-AMP synthetase DisA, contains DAC, linker, and DNA-binding domains</td>
</tr>
<tr>
<td>58</td>
<td>60</td>
<td><a href="/research/cog/cog/COG1624/">COG1624</a></td>
<td>
T
</td>
<td>c-di-AMP synthetase, contains the diadenylate cyclase (DAC) domain</td>
</tr>
<tr>
<td>490</td>
<td>2085</td>
<td><a href="/research/cog/cog/COG1639/">COG1639</a></td>
<td>
T
</td>
<td>HD-like signal output (HDOD) domain, no enzymatic activity</td>
</tr>
<tr>
<td>820</td>
<td>833</td>
<td><a href="/research/cog/cog/COG1642/">COG1642</a></td>
<td>
T
</td>
<td>c-di-AMP synthetase CdaA, contains 3TM and DAC domains</td>
</tr>
<tr>
<td>1414</td>
<td>1427</td>
<td><a href="/research/cog/cog/COG1660/">COG1660</a></td>
<td>
T
</td>
<td>RNase adaptor protein RapZ for GlmZ sRNA degradation, contains a P-loop ATPase domain</td>
</tr>
<tr>
<td>925</td>
<td>925</td>
<td><a href="/research/cog/cog/COG1666/">COG1666</a></td>
<td>
T
</td>
<td>Cyclic di-GMP-binding protein YajQ, UPF0234 family</td>
</tr>
<tr>
<td>728</td>
<td>744</td>
<td><a href="/research/cog/cog/COG1692/">COG1692</a></td>
<td>
T
</td>
<td>2&#x27;,3&#x27;- and 3&#x27;,5&#x27;-cNMP phosphodiesterase YmdB, calcineurin family</td>
</tr>
<tr>
<td>1842</td>
<td>1953</td>
<td><a href="/research/cog/cog/COG1702/">COG1702</a></td>
<td>
T
</td>
<td>Phosphate starvation-inducible protein PhoH, predicted ATPase</td>
</tr>
<tr>
<td>503</td>
<td>530</td>
<td><a href="/research/cog/cog/COG1713/">COG1713</a></td>
<td>
T
R
</td>
<td>Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase</td>
</tr>
<tr>
<td>979</td>
<td>4694</td>
<td><a href="/research/cog/cog/COG1716/">COG1716</a></td>
<td>
T
</td>
<td>Forkhead associated (FHA) domain, binds pSer, pThr, pTyr</td>
</tr>
<tr>
<td>411</td>
<td>443</td>
<td><a href="/research/cog/cog/COG1718/">COG1718</a></td>
<td>
T
</td>
<td>Serine/threonine-protein kinase RIO1</td>
</tr>
<tr>
<td>1059</td>
<td>2126</td>
<td><a href="/research/cog/cog/COG1744/">COG1744</a></td>
<td>
T
</td>
<td>Lipoprotein Med, regulator of KinD/Spo0A, PBP1-ABC superfamily, includes NupN</td>
</tr>
<tr>
<td>102</td>
<td>111</td>
<td><a href="/research/cog/cog/COG1751/">COG1751</a></td>
<td>
T
G
</td>
<td>Ligand-binding PK_C domain of pyruvate kinase and diadenylate cyclases</td>
</tr>
<tr>
<td>1291</td>
<td>3161</td>
<td><a href="/research/cog/cog/COG1762/">COG1762</a></td>
<td>
T
G
</td>
<td>Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)</td>
</tr>
<tr>
<td>769</td>
<td>798</td>
<td><a href="/research/cog/cog/COG1774/">COG1774</a></td>
<td>
T
</td>
<td>Cell fate regulator YaaT, PSP1 superfamily (controls sporulation, competence, biofilm development)</td>
</tr>
<tr>
<td>564</td>
<td>960</td>
<td><a href="/research/cog/cog/COG1776/">COG1776</a></td>
<td>
T
</td>
<td>Phosphoaspartate phosphatase CheC, specific for CheY-P</td>
</tr>
<tr>
<td>905</td>
<td>964</td>
<td><a href="/research/cog/cog/COG1806/">COG1806</a></td>
<td>
T
</td>
<td>Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)</td>
</tr>
<tr>
<td>469</td>
<td>482</td>
<td><a href="/research/cog/cog/COG1854/">COG1854</a></td>
<td>
T
</td>
<td>S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis</td>
</tr>
<tr>
<td>752</td>
<td>931</td>
<td><a href="/research/cog/cog/COG1871/">COG1871</a></td>
<td>
T
</td>
<td>Chemotaxis receptor (MCP) glutamine deamidase CheD</td>
</tr>
<tr>
<td>1002</td>
<td>1065</td>
<td><a href="/research/cog/cog/COG1923/">COG1923</a></td>
<td>
T
</td>
<td>sRNA-binding regulator protein Hfq</td>
</tr>
<tr>
<td>1541</td>
<td>2689</td>
<td><a href="/research/cog/cog/COG1925/">COG1925</a></td>
<td>
T
G
</td>
<td>HPr or related phosphotransfer protein</td>
</tr>
<tr>
<td>926</td>
<td>1075</td>
<td><a href="/research/cog/cog/COG1956/">COG1956</a></td>
<td>
V
T
</td>
<td>GAF domain-containing protein, putative methionine-R-sulfoxide reductase</td>
</tr>
<tr>
<td>1752</td>
<td>2751</td>
<td><a href="/research/cog/cog/COG1974/">COG1974</a></td>
<td>
K
T
</td>
<td>SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)</td>
</tr>
<tr>
<td>911</td>
<td>1406</td>
<td><a href="/research/cog/cog/COG1983/">COG1983</a></td>
<td>
K
T
</td>
<td>Phage shock protein PspC (stress-responsive transcriptional regulator)</td>
</tr>
<tr>
<td>375</td>
<td>422</td>
<td><a href="/research/cog/cog/COG1993/">COG1993</a></td>
<td>
T
</td>
<td>PII-like signaling protein</td>
</tr>
<tr>
<td>319</td>
<td>919</td>
<td><a href="/research/cog/cog/COG2018/">COG2018</a></td>
<td>
T
</td>
<td>Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family</td>
</tr>
<tr>
<td>1365</td>
<td>1725</td>
<td><a href="/research/cog/cog/COG2062/">COG2062</a></td>
<td>
T
</td>
<td>Phosphohistidine phosphatase SixA</td>
</tr>
<tr>
<td>115</td>
<td>117</td>
<td><a href="/research/cog/cog/COG2112/">COG2112</a></td>
<td>
T
</td>
<td>Predicted Ser/Thr protein kinase</td>
</tr>
<tr>
<td>1037</td>
<td>4156</td>
<td><a href="/research/cog/cog/COG2114/">COG2114</a></td>
<td>
T
</td>
<td>Adenylate cyclase, class 3</td>
</tr>
<tr>
<td>1033</td>
<td>2923</td>
<td><a href="/research/cog/cog/COG2172/">COG2172</a></td>
<td>
T
</td>
<td>Anti-sigma regulatory factor (Ser/Thr protein kinase)</td>
</tr>
<tr>
<td>367</td>
<td>441</td>
<td><a href="/research/cog/cog/COG2184/">COG2184</a></td>
<td>
T
</td>
<td>Fido, protein-threonine AMPylation domain</td>
</tr>
<tr>
<td>1858</td>
<td>17938</td>
<td><a href="/research/cog/cog/COG2197/">COG2197</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains</td>
</tr>
<tr>
<td>1019</td>
<td>3048</td>
<td><a href="/research/cog/cog/COG2198/">COG2198</a></td>
<td>
T
</td>
<td>HPt (histidine-containing phosphotransfer) domain</td>
</tr>
<tr>
<td>1451</td>
<td>17086</td>
<td><a href="/research/cog/cog/COG2199/">COG2199</a></td>
<td>
T
</td>
<td>GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants</td>
</tr>
<tr>
<td>1289</td>
<td>7124</td>
<td><a href="/research/cog/cog/COG2200/">COG2200</a></td>
<td>
T
</td>
<td>EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)</td>
</tr>
<tr>
<td>1280</td>
<td>2819</td>
<td><a href="/research/cog/cog/COG2201/">COG2201</a></td>
<td>
T
</td>
<td>Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains</td>
</tr>
<tr>
<td>1337</td>
<td>5294</td>
<td><a href="/research/cog/cog/COG2202/">COG2202</a></td>
<td>
T
</td>
<td>PAS domain</td>
</tr>
<tr>
<td>1525</td>
<td>9086</td>
<td><a href="/research/cog/cog/COG2203/">COG2203</a></td>
<td>
T
</td>
<td>GAF domain</td>
</tr>
<tr>
<td>1650</td>
<td>14651</td>
<td><a href="/research/cog/cog/COG2204/">COG2204</a></td>
<td>
T
</td>
<td>DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains</td>
</tr>
<tr>
<td>1714</td>
<td>6085</td>
<td><a href="/research/cog/cog/COG2205/">COG2205</a></td>
<td>
T
</td>
<td>K+-sensing histidine kinase KdpD</td>
</tr>
<tr>
<td>988</td>
<td>3889</td>
<td><a href="/research/cog/cog/COG2206/">COG2206</a></td>
<td>
T
</td>
<td>HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant)</td>
</tr>
<tr>
<td>1025</td>
<td>3737</td>
<td><a href="/research/cog/cog/COG2208/">COG2208</a></td>
<td>
K
T
</td>
<td>Phosphoserine phosphatase RsbU, regulator of sigma subunit</td>
</tr>
<tr>
<td>201</td>
<td>881</td>
<td><a href="/research/cog/cog/COG2310/">COG2310</a></td>
<td>
T
</td>
<td>Stress response protein SCP2</td>
</tr>
<tr>
<td>1163</td>
<td>1990</td>
<td><a href="/research/cog/cog/COG2334/">COG2334</a></td>
<td>
T
</td>
<td>Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist</td>
</tr>
<tr>
<td>522</td>
<td>673</td>
<td><a href="/research/cog/cog/COG2339/">COG2339</a></td>
<td>
T
</td>
<td>Membrane proteinase PrsW, cleaves anti-sigma factor RsiW, M82 family</td>
</tr>
<tr>
<td>543</td>
<td>759</td>
<td><a href="/research/cog/cog/COG2357/">COG2357</a></td>
<td>
T
F
</td>
<td>ppGpp synthetase catalytic domain (RelA/SpoT-type nucleotidyltranferase)</td>
</tr>
<tr>
<td>622</td>
<td>900</td>
<td><a href="/research/cog/cog/COG2365/">COG2365</a></td>
<td>
T
</td>
<td>Protein tyrosine/serine phosphatase Oca4</td>
</tr>
<tr>
<td>223</td>
<td>248</td>
<td><a href="/research/cog/cog/COG2404/">COG2404</a></td>
<td>
J
T
</td>
<td>Oligoribonuclease NrnA/c-di-AMP phosphodiesterase DhhP, DHH superfamily</td>
</tr>
<tr>
<td>553</td>
<td>681</td>
<td><a href="/research/cog/cog/COG2453/">COG2453</a></td>
<td>
T
</td>
<td>Protein-tyrosine phosphatase</td>
</tr>
<tr>
<td>57</td>
<td>116</td>
<td><a href="/research/cog/cog/COG2469/">COG2469</a></td>
<td>
T
</td>
<td>Archaeal chemotaxis protein CheF</td>
</tr>
<tr>
<td>478</td>
<td>1162</td>
<td><a href="/research/cog/cog/COG2703/">COG2703</a></td>
<td>
T
</td>
<td>Hemerythrin</td>
</tr>
<tr>
<td>21</td>
<td>21</td>
<td><a href="/research/cog/cog/COG2724/">COG2724</a></td>
<td>
T
</td>
<td>c-di-AMP synthetase CdaS, contains YojJ and DAC domains</td>
</tr>
<tr>
<td>141</td>
<td>145</td>
<td><a href="/research/cog/cog/COG2725/">COG2725</a></td>
<td>
T
</td>
<td>c-di-AMP synthetase, DacZ/CdaZ superfamily, contains PK_C-type and DAC domains</td>
</tr>
<tr>
<td>573</td>
<td>679</td>
<td><a href="/research/cog/cog/COG2766/">COG2766</a></td>
<td>
T
</td>
<td>Predicted Ser/Thr protein kinase</td>
</tr>
<tr>
<td>965</td>
<td>2015</td>
<td><a href="/research/cog/cog/COG2770/">COG2770</a></td>
<td>
T
</td>
<td>HAMP domain</td>
</tr>
<tr>
<td>591</td>
<td>654</td>
<td><a href="/research/cog/cog/COG2808/">COG2808</a></td>
<td>
T
</td>
<td>Predicted FMN-binding regulatory protein PaiB</td>
</tr>
<tr>
<td>1003</td>
<td>1033</td>
<td><a href="/research/cog/cog/COG2844/">COG2844</a></td>
<td>
T
O
</td>
<td>UTP:GlnB (protein PII) uridylyltransferase</td>
</tr>
<tr>
<td>1665</td>
<td>4003</td>
<td><a href="/research/cog/cog/COG2905/">COG2905</a></td>
<td>
T
</td>
<td>Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains</td>
</tr>
<tr>
<td>496</td>
<td>520</td>
<td><a href="/research/cog/cog/COG2912/">COG2912</a></td>
<td>
T
</td>
<td>Regulator of sirC expression, contains transglutaminase-like and TPR domains</td>
</tr>
<tr>
<td>294</td>
<td>294</td>
<td><a href="/research/cog/cog/COG2915/">COG2915</a></td>
<td>
T
X
</td>
<td>Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation</td>
</tr>
<tr>
<td>566</td>
<td>567</td>
<td><a href="/research/cog/cog/COG2921/">COG2921</a></td>
<td>
T
</td>
<td>Putative lipoate-binding regulatory protein, UPF0250 family</td>
</tr>
<tr>
<td>511</td>
<td>1543</td>
<td><a href="/research/cog/cog/COG2972/">COG2972</a></td>
<td>
T
</td>
<td>Sensor histidine kinase YesM</td>
</tr>
<tr>
<td>611</td>
<td>639</td>
<td><a href="/research/cog/cog/COG2976/">COG2976</a></td>
<td>
T
</td>
<td>Ancillary subunit YfgM of SecYEG translocon, regulates RcsB-dependent stress response</td>
</tr>
<tr>
<td>390</td>
<td>392</td>
<td><a href="/research/cog/cog/COG3026/">COG3026</a></td>
<td>
T
</td>
<td>RseB, negative regulator of sigma E activity</td>
</tr>
<tr>
<td>362</td>
<td>363</td>
<td><a href="/research/cog/cog/COG3045/">COG3045</a></td>
<td>
T
</td>
<td>Periplasmic catabolite regulation protein CreA (function unknown)</td>
</tr>
<tr>
<td>179</td>
<td>183</td>
<td><a href="/research/cog/cog/COG3072/">COG3072</a></td>
<td>
T
</td>
<td>Adenylate cyclase, class I</td>
</tr>
<tr>
<td>381</td>
<td>381</td>
<td><a href="/research/cog/cog/COG3073/">COG3073</a></td>
<td>
T
</td>
<td>RseA, negative regulator of sigma E activity</td>
</tr>
<tr>
<td>208</td>
<td>238</td>
<td><a href="/research/cog/cog/COG3083/">COG3083</a></td>
<td>
T
M
</td>
<td>Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily</td>
</tr>
<tr>
<td>461</td>
<td>502</td>
<td><a href="/research/cog/cog/COG3086/">COG3086</a></td>
<td>
T
</td>
<td>RseC, positive regulator of sigma E activity</td>
</tr>
<tr>
<td>325</td>
<td>327</td>
<td><a href="/research/cog/cog/COG3106/">COG3106</a></td>
<td>
T
</td>
<td>Ras-like GTP-binding stress-induced protein YcjX, DUF463 family</td>
</tr>
<tr>
<td>258</td>
<td>283</td>
<td><a href="/research/cog/cog/COG3109/">COG3109</a></td>
<td>
T
</td>
<td>sRNA-binding protein ProQ</td>
</tr>
<tr>
<td>99</td>
<td>113</td>
<td><a href="/research/cog/cog/COG3110/">COG3110</a></td>
<td>
T
W
</td>
<td>Curli synthesis inhibitor CsgI, YccT/UPF0319 family</td>
</tr>
<tr>
<td>411</td>
<td>501</td>
<td><a href="/research/cog/cog/COG3143/">COG3143</a></td>
<td>
T
N
</td>
<td>Phosphoaspartate phosphatase CheZ, dephosphorylates CheY~P</td>
</tr>
<tr>
<td>701</td>
<td>1097</td>
<td><a href="/research/cog/cog/COG3193/">COG3193</a></td>
<td>
T
</td>
<td>Formaldehyde-binding sensor protein EfgA, GlcG/HbpS family</td>
</tr>
<tr>
<td>406</td>
<td>527</td>
<td><a href="/research/cog/cog/COG3213/">COG3213</a></td>
<td>
T
</td>
<td>Nitric oxide response protein NnrS</td>
</tr>
<tr>
<td>300</td>
<td>333</td>
<td><a href="/research/cog/cog/COG3215/">COG3215</a></td>
<td>
T
N
W
</td>
<td>Type IV pilus assembly protein/c-di-GMP receptor domain PilZ</td>
</tr>
<tr>
<td>468</td>
<td>533</td>
<td><a href="/research/cog/cog/COG3228/">COG3228</a></td>
<td>
T
</td>
<td>Mlc titration factor MtfA, regulates ptsG expression</td>
</tr>
<tr>
<td>889</td>
<td>2985</td>
<td><a href="/research/cog/cog/COG3275/">COG3275</a></td>
<td>
T
</td>
<td>Sensor histidine kinase, LytS/YehU family</td>
</tr>
<tr>
<td>1066</td>
<td>3985</td>
<td><a href="/research/cog/cog/COG3279/">COG3279</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator, LytR/AlgR family</td>
</tr>
<tr>
<td>457</td>
<td>632</td>
<td><a href="/research/cog/cog/COG3287/">COG3287</a></td>
<td>
T
</td>
<td>NO-sensing heme protein NosP, contains FIST domain</td>
</tr>
<tr>
<td>597</td>
<td>1258</td>
<td><a href="/research/cog/cog/COG3290/">COG3290</a></td>
<td>
T
</td>
<td>Sensor histidine kinase DipB regulating citrate/malate metabolism</td>
</tr>
<tr>
<td>456</td>
<td>2176</td>
<td><a href="/research/cog/cog/COG3292/">COG3292</a></td>
<td>
T
</td>
<td>Periplasmic ligand-binding sensor domain</td>
</tr>
<tr>
<td>381</td>
<td>532</td>
<td><a href="/research/cog/cog/COG3300/">COG3300</a></td>
<td>
T
</td>
<td>MHYT domain, NO-binding membrane sensor</td>
</tr>
<tr>
<td>271</td>
<td>376</td>
<td><a href="/research/cog/cog/COG3322/">COG3322</a></td>
<td>
T
</td>
<td>Iron-binding extracellular (periplasmic) sensor domain CHASE4</td>
</tr>
<tr>
<td>26</td>
<td>26</td>
<td><a href="/research/cog/cog/COG3400/">COG3400</a></td>
<td>
T
</td>
<td>Predicted c-di-AMP receptor, contains TrkA_N, RCK_C, and USP domains</td>
</tr>
<tr>
<td>352</td>
<td>372</td>
<td><a href="/research/cog/cog/COG3412/">COG3412</a></td>
<td>
T
</td>
<td>Phosphotransferase subunit DhaM of the dihydroxyacetone kinase DhaKLM complex, contains PTS-EIIA, HPr, and PEP-utilizing domains</td>
</tr>
<tr>
<td>325</td>
<td>328</td>
<td><a href="/research/cog/cog/COG3429/">COG3429</a></td>
<td>
T
G
</td>
<td>Glucose-6-phosphate dehydrogenase activity regulator OpcA</td>
</tr>
<tr>
<td>383</td>
<td>698</td>
<td><a href="/research/cog/cog/COG3434/">COG3434</a></td>
<td>
T
</td>
<td>c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains</td>
</tr>
<tr>
<td>912</td>
<td>2438</td>
<td><a href="/research/cog/cog/COG3437/">COG3437</a></td>
<td>
T
</td>
<td>Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains</td>
</tr>
<tr>
<td>403</td>
<td>610</td>
<td><a href="/research/cog/cog/COG3447/">COG3447</a></td>
<td>
T
</td>
<td>Integral membrane sensor domain MASE1</td>
</tr>
<tr>
<td>1218</td>
<td>2159</td>
<td><a href="/research/cog/cog/COG3448/">COG3448</a></td>
<td>
T
</td>
<td>CBS-domain-containing membrane protein</td>
</tr>
<tr>
<td>293</td>
<td>358</td>
<td><a href="/research/cog/cog/COG3452/">COG3452</a></td>
<td>
T
</td>
<td>Extracellular (periplasmic) sensor domain CHASE (specificity unknown)</td>
</tr>
<tr>
<td>687</td>
<td>805</td>
<td><a href="/research/cog/cog/COG3476/">COG3476</a></td>
<td>
T
</td>
<td>Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog)</td>
</tr>
<tr>
<td>391</td>
<td>415</td>
<td><a href="/research/cog/cog/COG3480/">COG3480</a></td>
<td>
T
</td>
<td>Predicted secreted protein YlbL, contains PDZ domain</td>
</tr>
<tr>
<td>673</td>
<td>1301</td>
<td><a href="/research/cog/cog/COG3550/">COG3550</a></td>
<td>
T
</td>
<td>Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module</td>
</tr>
<tr>
<td>178</td>
<td>182</td>
<td><a href="/research/cog/cog/COG3602/">COG3602</a></td>
<td>
T
</td>
<td>ACT domain, ACT-3 family</td>
</tr>
<tr>
<td>158</td>
<td>164</td>
<td><a href="/research/cog/cog/COG3603/">COG3603</a></td>
<td>
T
</td>
<td>ACT domain, ACT-7 family</td>
</tr>
<tr>
<td>797</td>
<td>1788</td>
<td><a href="/research/cog/cog/COG3604/">COG3604</a></td>
<td>
K
T
</td>
<td>FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains</td>
</tr>
<tr>
<td>694</td>
<td>816</td>
<td><a href="/research/cog/cog/COG3605/">COG3605</a></td>
<td>
T
</td>
<td>Signal transduction protein containing GAF and PtsI domains</td>
</tr>
<tr>
<td>398</td>
<td>651</td>
<td><a href="/research/cog/cog/COG3614/">COG3614</a></td>
<td>
T
</td>
<td>Extracytoplasmic sensor domain CHASE1 (specificity unknown)</td>
</tr>
<tr>
<td>228</td>
<td>285</td>
<td><a href="/research/cog/cog/COG3641/">COG3641</a></td>
<td>
T
</td>
<td>Membrane regulatory protein PfoR, PTS_EIIC_2 domain (does not regulate perfringolysin expression)</td>
</tr>
<tr>
<td>302</td>
<td>440</td>
<td><a href="/research/cog/cog/COG3679/">COG3679</a></td>
<td>
T
</td>
<td>Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)</td>
</tr>
<tr>
<td>1234</td>
<td>5588</td>
<td><a href="/research/cog/cog/COG3706/">COG3706</a></td>
<td>
K
T
</td>
<td>Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain</td>
</tr>
<tr>
<td>868</td>
<td>1390</td>
<td><a href="/research/cog/cog/COG3707/">COG3707</a></td>
<td>
K
T
</td>
<td>Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains</td>
</tr>
<tr>
<td>509</td>
<td>2902</td>
<td><a href="/research/cog/cog/COG3712/">COG3712</a></td>
<td>
T
P
</td>
<td>Periplasmic ferric-dicitrate binding protein FecR, regulates iron transport</td>
</tr>
<tr>
<td>371</td>
<td>502</td>
<td><a href="/research/cog/cog/COG3806/">COG3806</a></td>
<td>
T
</td>
<td>Anti-sigma factor ChrR, cupin superfamily</td>
</tr>
<tr>
<td>837</td>
<td>2918</td>
<td><a href="/research/cog/cog/COG3829/">COG3829</a></td>
<td>
K
T
</td>
<td>RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains</td>
</tr>
<tr>
<td>572</td>
<td>585</td>
<td><a href="/research/cog/cog/COG3830/">COG3830</a></td>
<td>
T
</td>
<td>ACT domain, binds amino acids and other small ligands</td>
</tr>
<tr>
<td>485</td>
<td>862</td>
<td><a href="/research/cog/cog/COG3835/">COG3835</a></td>
<td>
K
T
</td>
<td>Sugar diacid utilization regulator CdaR</td>
</tr>
<tr>
<td>426</td>
<td>442</td>
<td><a href="/research/cog/cog/COG3848/">COG3848</a></td>
<td>
T
</td>
<td>Phosphohistidine swiveling domain of PEP-utilizing enzymes</td>
</tr>
<tr>
<td>743</td>
<td>1330</td>
<td><a href="/research/cog/cog/COG3850/">COG3850</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase NarQ, nitrate/nitrite-specific</td>
</tr>
<tr>
<td>92</td>
<td>113</td>
<td><a href="/research/cog/cog/COG3851/">COG3851</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase UhpB, glucose-6-phosphate specific</td>
</tr>
<tr>
<td>661</td>
<td>670</td>
<td><a href="/research/cog/cog/COG3852/">COG3852</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase NtrB, nitrogen specific</td>
</tr>
<tr>
<td>275</td>
<td>327</td>
<td><a href="/research/cog/cog/COG3870/">COG3870</a></td>
<td>
T
</td>
<td>Cyclic di-AMP receptor DarA/PstA</td>
</tr>
<tr>
<td>317</td>
<td>321</td>
<td><a href="/research/cog/cog/COG3887/">COG3887</a></td>
<td>
T
</td>
<td>Cyclic di-AMP phosphodiesterase GdpP, contains GGDEF-like and DHH domains</td>
</tr>
<tr>
<td>192</td>
<td>223</td>
<td><a href="/research/cog/cog/COG3913/">COG3913</a></td>
<td>
T
U
</td>
<td>Type VI secretion system regulator TagF/ImpM/SciT</td>
</tr>
<tr>
<td>215</td>
<td>293</td>
<td><a href="/research/cog/cog/COG3915/">COG3915</a></td>
<td>
T
</td>
<td>Pterin-binding regulatory protein</td>
</tr>
<tr>
<td>312</td>
<td>471</td>
<td><a href="/research/cog/cog/COG3916/">COG3916</a></td>
<td>
T
</td>
<td>N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis)</td>
</tr>
<tr>
<td>831</td>
<td>2524</td>
<td><a href="/research/cog/cog/COG3920/">COG3920</a></td>
<td>
T
</td>
<td>Two-component sensor histidine kinase, HisKA and HATPase domains</td>
</tr>
<tr>
<td>69</td>
<td>69</td>
<td><a href="/research/cog/cog/COG3925/">COG3925</a></td>
<td>
T
G
</td>
<td>N-terminal domain of the PTS fructose-specific IIB component</td>
</tr>
<tr>
<td>300</td>
<td>372</td>
<td><a href="/research/cog/cog/COG3937/">COG3937</a></td>
<td>
T
Q
</td>
<td>Phasin, polyhydroxyalkanoate synthesis regulator</td>
</tr>
<tr>
<td>185</td>
<td>255</td>
<td><a href="/research/cog/cog/COG3947/">COG3947</a></td>
<td>
K
T
</td>
<td>Two-component response regulator, SAPR family, consists of REC, wHTH and BTAD domains</td>
</tr>
<tr>
<td>28</td>
<td>28</td>
<td><a href="/research/cog/cog/COG3984/">COG3984</a></td>
<td>
T
</td>
<td>Stand-alone REC domain, LytT-type</td>
</tr>
<tr>
<td>412</td>
<td>712</td>
<td><a href="/research/cog/cog/COG3989/">COG3989</a></td>
<td>
T
</td>
<td>Transcriptional regulator, contains DNA-binding LytTR domain</td>
</tr>
<tr>
<td>828</td>
<td>2623</td>
<td><a href="/research/cog/cog/COG4191/">COG4191</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase regulating C4-dicarboxylate transport system</td>
</tr>
<tr>
<td>44</td>
<td>46</td>
<td><a href="/research/cog/cog/COG4192/">COG4192</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase regulating phosphoglycerate transport system</td>
</tr>
<tr>
<td>504</td>
<td>1231</td>
<td><a href="/research/cog/cog/COG4219/">COG4219</a></td>
<td>
T
</td>
<td>Signal transducer regulating beta-lactamase production, contains metallopeptidase domain</td>
</tr>
<tr>
<td>153</td>
<td>253</td>
<td><a href="/research/cog/cog/COG4250/">COG4250</a></td>
<td>
T
</td>
<td>DICT sensory domain found in diguanylate cyclases and two-component systems</td>
</tr>
<tr>
<td>740</td>
<td>2492</td>
<td><a href="/research/cog/cog/COG4251/">COG4251</a></td>
<td>
T
</td>
<td>Bacteriophytochrome (light-regulated signal transduction histidine kinase)</td>
</tr>
<tr>
<td>561</td>
<td>1287</td>
<td><a href="/research/cog/cog/COG4252/">COG4252</a></td>
<td>
T
</td>
<td>Extracytoplasmic sensor domain CHASE2 (specificity unknown)</td>
</tr>
<tr>
<td>697</td>
<td>1317</td>
<td><a href="/research/cog/cog/COG4319/">COG4319</a></td>
<td>
T
</td>
<td>SnoaL-fold ligand-binding domain</td>
</tr>
<tr>
<td>68</td>
<td>92</td>
<td><a href="/research/cog/cog/COG4371/">COG4371</a></td>
<td>
T
C
</td>
<td>FLAP1 protein, involved in response to fluctuating light, FLAP1/DUF1517 family</td>
</tr>
<tr>
<td>226</td>
<td>230</td>
<td><a href="/research/cog/cog/COG4398/">COG4398</a></td>
<td>
T
</td>
<td>Small ligand-binding sensory domain FIST</td>
</tr>
<tr>
<td>447</td>
<td>514</td>
<td><a href="/research/cog/cog/COG4464/">COG4464</a></td>
<td>
T
</td>
<td>Tyrosine-protein phosphatase YwqE</td>
</tr>
<tr>
<td>103</td>
<td>169</td>
<td><a href="/research/cog/cog/COG4512/">COG4512</a></td>
<td>
K
T
</td>
<td>Accessory gene regulator protein AgrB</td>
</tr>
<tr>
<td>117</td>
<td>120</td>
<td><a href="/research/cog/cog/COG4550/">COG4550</a></td>
<td>
T
</td>
<td>Cell fate regulator YmcA, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)</td>
</tr>
<tr>
<td>499</td>
<td>1150</td>
<td><a href="/research/cog/cog/COG4564/">COG4564</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase</td>
</tr>
<tr>
<td>511</td>
<td>800</td>
<td><a href="/research/cog/cog/COG4565/">COG4565</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator DpiB of citrate/malate metabolism</td>
</tr>
<tr>
<td>553</td>
<td>1539</td>
<td><a href="/research/cog/cog/COG4566/">COG4566</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator, FixJ family, consists of REC and HTH domains</td>
</tr>
<tr>
<td>494</td>
<td>559</td>
<td><a href="/research/cog/cog/COG4567/">COG4567</a></td>
<td>
K
T
</td>
<td>DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains</td>
</tr>
<tr>
<td>253</td>
<td>258</td>
<td><a href="/research/cog/cog/COG4579/">COG4579</a></td>
<td>
T
</td>
<td>Isocitrate dehydrogenase kinase/phosphatase</td>
</tr>
<tr>
<td>1302</td>
<td>7940</td>
<td><a href="/research/cog/cog/COG4585/">COG4585</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase ComP</td>
</tr>
<tr>
<td>638</td>
<td>954</td>
<td><a href="/research/cog/cog/COG4623/">COG4623</a></td>
<td>
T
M
</td>
<td>Membrane-bound lytic murein transglycosylase MltF</td>
</tr>
<tr>
<td>128</td>
<td>133</td>
<td><a href="/research/cog/cog/COG4650/">COG4650</a></td>
<td>
K
T
</td>
<td>Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain</td>
</tr>
<tr>
<td>872</td>
<td>2493</td>
<td><a href="/research/cog/cog/COG4753/">COG4753</a></td>
<td>
K
T
</td>
<td>Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains</td>
</tr>
<tr>
<td>148</td>
<td>170</td>
<td><a href="/research/cog/cog/COG4758/">COG4758</a></td>
<td>
T
</td>
<td>Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system</td>
</tr>
<tr>
<td>22</td>
<td>42</td>
<td><a href="/research/cog/cog/COG4831/">COG4831</a></td>
<td>
T
</td>
<td>Roadblock/LC7 domain</td>
</tr>
<tr>
<td>283</td>
<td>297</td>
<td><a href="/research/cog/cog/COG4832/">COG4832</a></td>
<td>
V
T
</td>
<td>Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain</td>
</tr>
<tr>
<td>92</td>
<td>100</td>
<td><a href="/research/cog/cog/COG4846/">COG4846</a></td>
<td>
T
</td>
<td>Regulator of biofilm dispersion, motility, and sporulation CcdC</td>
</tr>
<tr>
<td>178</td>
<td>179</td>
<td><a href="/research/cog/cog/COG4853/">COG4853</a></td>
<td>
T
</td>
<td>YycI protein, regulator of the WalKR two-component signal transduction system</td>
</tr>
<tr>
<td>509</td>
<td>518</td>
<td><a href="/research/cog/cog/COG4856/">COG4856</a></td>
<td>
T
</td>
<td>Cyclic di-AMP synthase regulator CdaR, YbbR domain</td>
</tr>
<tr>
<td>208</td>
<td>273</td>
<td><a href="/research/cog/cog/COG4862/">COG4862</a></td>
<td>
K
T
N
</td>
<td>Negative regulator MecA of genetic competence, sporulation and motility</td>
</tr>
<tr>
<td>168</td>
<td>168</td>
<td><a href="/research/cog/cog/COG4863/">COG4863</a></td>
<td>
T
</td>
<td>YycH protein, regulator of the WalKR two-component signal transduction system</td>
</tr>
<tr>
<td>239</td>
<td>400</td>
<td><a href="/research/cog/cog/COG4936/">COG4936</a></td>
<td>
T
</td>
<td>Ligand-binding sensor domain</td>
</tr>
<tr>
<td>123</td>
<td>183</td>
<td><a href="/research/cog/cog/COG4943/">COG4943</a></td>
<td>
T
</td>
<td>Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains</td>
</tr>
<tr>
<td>73</td>
<td>100</td>
<td><a href="/research/cog/cog/COG4945/">COG4945</a></td>
<td>
T
G
</td>
<td>Carbohydrate-binding DOMON domain</td>
</tr>
<tr>
<td>520</td>
<td>853</td>
<td><a href="/research/cog/cog/COG4978/">COG4978</a></td>
<td>
T
</td>
<td>GyrI-like small molecule binding domain</td>
</tr>
<tr>
<td>82</td>
<td>82</td>
<td><a href="/research/cog/cog/COG4999/">COG4999</a></td>
<td>
T
</td>
<td>Uncharacterized domain of signal transduction histidine kinase BarA</td>
</tr>
<tr>
<td>1083</td>
<td>1722</td>
<td><a href="/research/cog/cog/COG5000/">COG5000</a></td>
<td>
T
</td>
<td>Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation</td>
</tr>
<tr>
<td>1063</td>
<td>6295</td>
<td><a href="/research/cog/cog/COG5001/">COG5001</a></td>
<td>
T
</td>
<td>Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain</td>
</tr>
<tr>
<td>1792</td>
<td>5121</td>
<td><a href="/research/cog/cog/COG5002/">COG5002</a></td>
<td>
T
</td>
<td>Sensor histidine kinase WalK</td>
</tr>
<tr>
<td>562</td>
<td>568</td>
<td><a href="/research/cog/cog/COG5007/">COG5007</a></td>
<td>
T
</td>
<td>Acid stress protein IbaG/YrbA, BolA-like family</td>
</tr>
<tr>
<td>195</td>
<td>224</td>
<td><a href="/research/cog/cog/COG5018/">COG5018</a></td>
<td>
T
</td>
<td>3&#x27;-5&#x27; exonuclease KapD, inhibitor of KinA-controlled sporulation</td>
</tr>
<tr>
<td>157</td>
<td>235</td>
<td><a href="/research/cog/cog/COG5126/">COG5126</a></td>
<td>
T
</td>
<td>Ca2+-binding protein, EF-hand superfamily</td>
</tr>
<tr>
<td>83</td>
<td>83</td>
<td><a href="/research/cog/cog/COG5212/">COG5212</a></td>
<td>
T
</td>
<td>cAMP phosphodiesterase</td>
</tr>
<tr>
<td>653</td>
<td>1247</td>
<td><a href="/research/cog/cog/COG5278/">COG5278</a></td>
<td>
T
</td>
<td>Extracytoplasmic sensor domain CHASE3 (specificity unknown)</td>
</tr>
<tr>
<td>441</td>
<td>513</td>
<td><a href="/research/cog/cog/COG5343/">COG5343</a></td>
<td>
T
</td>
<td>Anti-sigma-K factor RskA</td>
</tr>
<tr>
<td>253</td>
<td>254</td>
<td><a href="/research/cog/cog/COG5385/">COG5385</a></td>
<td>
T
</td>
<td>Histidine phosphotransfer protein ChpT, HPt domain</td>
</tr>
<tr>
<td>181</td>
<td>369</td>
<td><a href="/research/cog/cog/COG5388/">COG5388</a></td>
<td>
T
</td>
<td>PAS/LOV-type domain, PAS_5 family</td>
</tr>
<tr>
<td>504</td>
<td>515</td>
<td><a href="/research/cog/cog/COG5394/">COG5394</a></td>
<td>
T
Q
</td>
<td>Polyhydroxyalkanoate synthesis regulator, binds DNA and PHA</td>
</tr>
<tr>
<td>31</td>
<td>38</td>
<td><a href="/research/cog/cog/COG5440/">COG5440</a></td>
<td>
T
</td>
<td>Global stress regulator YbjN, DUF2299 family</td>
</tr>
<tr>
<td>249</td>
<td>647</td>
<td><a href="/research/cog/cog/COG5457/">COG5457</a></td>
<td>
A
T
</td>
<td>RNA-binding protein CcaF1 involved in sRNA maturation, turnover, C and P metabolism, and intracellular survival, YjiS/DUF1127 family</td>
</tr>
<tr>
<td>116</td>
<td>172</td>
<td><a href="/research/cog/cog/COG5524/">COG5524</a></td>
<td>
T
C
</td>
<td>Bacteriorhodopsin</td>
</tr>
<tr>
<td>485</td>
<td>595</td>
<td><a href="/research/cog/cog/COG5581/">COG5581</a></td>
<td>
T
N
</td>
<td>Cyclic di-GMP-binding flagellar brake protein FlgZ/YcgR, contains PilZNR(YcgR) and PilZ domains</td>
</tr>
<tr>
<td>19</td>
<td>25</td>
<td><a href="/research/cog/cog/COG5599/">COG5599</a></td>
<td>
T
U
</td>
<td>Type III secretion system effector, protein-tyrosine-phosphatase YopH</td>
</tr>
<tr>
<td>355</td>
<td>947</td>
<td><a href="/research/cog/cog/COG5616/">COG5616</a></td>
<td>
T
</td>
<td>TolB amino-terminal domain (function unknown)</td>
</tr>
<tr>
<td>323</td>
<td>988</td>
<td><a href="/research/cog/cog/COG5635/">COG5635</a></td>
<td>
T
</td>
<td>Predicted NTPase, NACHT family domain</td>
</tr>
<tr>
<td>133</td>
<td>165</td>
<td><a href="/research/cog/cog/COG5660/">COG5660</a></td>
<td>
T
</td>
<td>Anti-sigma-YlaC factor YlaD, contains Zn-finger domain</td>
</tr>
<tr>
<td>58</td>
<td>247</td>
<td><a href="/research/cog/cog/COG5750/">COG5750</a></td>
<td>
T
</td>
<td>Chlorophyll biosynthesis regulator GUN4/Ycf53 domain</td>
</tr>
<tr>
<td>70</td>
<td>72</td>
<td><a href="/research/cog/cog/COG5751/">COG5751</a></td>
<td>
T
</td>
<td>Photosynthetic regulator, contains GUN4/Ycf53 domain and N-terminal all-alpha domain</td>
</tr>
<tr>
<td>305</td>
<td>2035</td>
<td><a href="/research/cog/cog/COG5752/">COG5752</a></td>
<td>
T
</td>
<td>Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 porphyrin-binding domain</td>
</tr>
<tr>
<td>73</td>
<td>74</td>
<td><a href="/research/cog/cog/COG5764/">COG5764</a></td>
<td>
T
C
</td>
<td>Cyanobacterial/chloroplast FeS cluster protein Ycf34, regulator of photosynthetic electron transport, PF10718 domain</td>
</tr>
<tr>
<td>75</td>
<td>76</td>
<td><a href="/research/cog/cog/COG5768/">COG5768</a></td>
<td>
T
C
</td>
<td>Cyanobacterial response regulator with REC-Ycf55 domain architecture</td>
</tr>
<tr>
<td>71</td>
<td>71</td>
<td><a href="/research/cog/cog/COG5780/">COG5780</a></td>
<td>
T
C
</td>
<td>Acclimation of photosynthesis to environment protein APE1, affects chlorophyll fluorescence, DUF2854 (PF11016) domain</td>
</tr>
<tr>
<td>74</td>
<td>74</td>
<td><a href="/research/cog/cog/COG5788/">COG5788</a></td>
<td>
T
C
</td>
<td>Cyanobacterial/chloroplast protein SipA, regulator of sensor kinase NblS (Hik33), DUF3148 (PF11347) family</td>
</tr>
<tr>
<td>266</td>
<td>325</td>
<td><a href="/research/cog/cog/COG5792/">COG5792</a></td>
<td>
T
C
</td>
<td>Fusion of CP12 with N-terminal CBS domain pair</td>
</tr>
<tr>
<td>71</td>
<td>90</td>
<td><a href="/research/cog/cog/COG5793/">COG5793</a></td>
<td>
T
</td>
<td>Heterocyst patterning and differentiation ncRNA-binding protein PatR</td>
</tr>
<tr>
<td>242</td>
<td>277</td>
<td><a href="/research/cog/cog/COG5801/">COG5801</a></td>
<td>
D
T
</td>
<td>Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains)</td>
</tr>
<tr>
<td>99</td>
<td>99</td>
<td><a href="/research/cog/cog/COG5802/">COG5802</a></td>
<td>
D
T
</td>
<td>Stage 0 sporulation initiation phosphotransferase Spo0B</td>
</tr>
<tr>
<td>161</td>
<td>211</td>
<td><a href="/research/cog/cog/COG5803/">COG5803</a></td>
<td>
D
T
</td>
<td>Stage 0 sporulation initiation response regulator Spo0F</td>
</tr>
<tr>
<td>151</td>
<td>436</td>
<td><a href="/research/cog/cog/COG5804/">COG5804</a></td>
<td>
D
T
</td>
<td>Stage 0 sporulation regulatory phosphatase Spo0E</td>
</tr>
<tr>
<td>42</td>
<td>58</td>
<td><a href="/research/cog/cog/COG5805/">COG5805</a></td>
<td>
D
T
</td>
<td>Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ)</td>
</tr>
<tr>
<td>47</td>
<td>114</td>
<td><a href="/research/cog/cog/COG5806/">COG5806</a></td>
<td>
D
T
</td>
<td>Sporulation sensor histidine kinase B</td>
</tr>
<tr>
<td>20</td>
<td>20</td>
<td><a href="/research/cog/cog/COG5807/">COG5807</a></td>
<td>
D
T
</td>
<td>Sporulation sensor histidine kinase C</td>
</tr>
<tr>
<td>30</td>
<td>37</td>
<td><a href="/research/cog/cog/COG5808/">COG5808</a></td>
<td>
D
T
</td>
<td>Sporulation sensor histidine kinase D</td>
</tr>
<tr>
<td>1006</td>
<td>3435</td>
<td><a href="/research/cog/cog/COG5809/">COG5809</a></td>
<td>
D
T
</td>
<td>Sporulation sensor histidine kinase E</td>
</tr>
<tr>
<td>83</td>
<td>83</td>
<td><a href="/research/cog/cog/COG5810/">COG5810</a></td>
<td>
D
T
</td>
<td>Sporulation protein KbaA, activator of histidine kinase KinB</td>
</tr>
<tr>
<td>888</td>
<td>1775</td>
<td><a href="/research/cog/cog/COG5815/">COG5815</a></td>
<td>
D
T
</td>
<td>Stage II sporulation protein SpoIIAA (anti-anti-sigma F factor), STAS domain</td>
</tr>
<tr>
<td>165</td>
<td>168</td>
<td><a href="/research/cog/cog/COG5848/">COG5848</a></td>
<td>
D
T
</td>
<td>SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A)</td>
</tr>
<tr>
<td>118</td>
<td>118</td>
<td><a href="/research/cog/cog/COG5849/">COG5849</a></td>
<td>
D
T
</td>
<td>SigmaK checkpoint regulator BofC (Bypass-of-forespore protein C)</td>
</tr>
<tr>
<td>90</td>
<td>90</td>
<td><a href="/research/cog/cog/COG5867/">COG5867</a></td>
<td>
D
T
</td>
<td>Anti-sigma-F factor Fin</td>
</tr>
<tr>
<td>30</td>
<td>31</td>
<td><a href="/research/cog/cog/COG5927/">COG5927</a></td>
<td>
T
</td>
<td>Spo0B-type alpha-helical domain</td>
</tr>
<tr>
<td>1256</td>
<td>4122</td>
<td><a href="/research/cog/cog/COG5975/">COG5975</a></td>
<td>
T
</td>
<td>KinA-related sensor histidine kinase</td>
</tr>
<tr>
<td>185</td>
<td>220</td>
<td><a href="/research/cog/cog/COG5976/">COG5976</a></td>
<td>
T
</td>
<td>KinB-related sensor histidine kinase</td>
</tr>
<tr>
<td>949</td>
<td>2048</td>
<td><a href="/research/cog/cog/COG5977/">COG5977</a></td>
<td>
T
</td>
<td>KinC-related sensor histidine kinase</td>
</tr>
<tr>
<td>233</td>
<td>265</td>
<td><a href="/research/cog/cog/COG5978/">COG5978</a></td>
<td>
T
</td>
<td>KinD-related sensor histidine kinase</td>
</tr>
<tr>
<td>1787</td>
<td>23197</td>
<td><a href="/research/cog/cog/COG5979/">COG5979</a></td>
<td>
T
</td>
<td>KinE-related sensor histidine kinase</td>
</tr>
<tr>
<td>58</td>
<td>202</td>
<td><a href="/research/cog/cog/COG6094/">COG6094</a></td>
<td>
T
</td>
<td>HalX domain, output domain in halobacterial response regulators</td>
</tr>
<tr>
<td>88</td>
<td>105</td>
<td><a href="/research/cog/cog/COG6095/">COG6095</a></td>
<td>
K
T
</td>
<td>YcbB domain, DNA-binding domain in GlnL-type response regulators</td>
</tr>
<tr>
<td>15</td>
<td>20</td>
<td><a href="/research/cog/cog/COG6096/">COG6096</a></td>
<td>
K
T
</td>
<td>BetR domain, DNA-binding domain in betaproteobacterial response regulators</td>
</tr>
<tr>
<td>27</td>
<td>99</td>
<td><a href="/research/cog/cog/COG6097/">COG6097</a></td>
<td>
T
</td>
<td>HalOD1 domain (halobacterial output domain 1)</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</section>
</main>
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