T - Signal transduction mechanisms

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COG definitions	Organims	Proteins	Median Protein Length	Genes
250	2,290	426,986	351.0	231

Organism	Protein	COG	Cat	Annotation
1667	2480	COG0248	T F	Exopolyphosphatase/pppGpp-phosphohydrolase
869	1153	COG0271	K T	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation
1992	3169	COG0317	K T	(p)ppGpp synthase/hydrolase, HD superfamily
1589	3120	COG0347	T E	Nitrogen regulatory protein PII
1923	4016	COG0394	T	Protein-tyrosine-phosphatase
1254	2738	COG0464	D T M	AAA+-type ATPase, SpoVK/Ycf46/Vps4 family
535	1405	COG0467	T	RecA-superfamily ATPase, KaiC/GvpD/RAD55 family
235	242	COG0478	T	RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
491	577	COG0490	T P	K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain
1565	13905	COG0515	T	Serine/threonine protein kinase, uncludes type III secretion system effector YopO
1685	3044	COG0517	T	CBS domain
1950	5434	COG0569	T P	Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain
1832	9659	COG0589	T	Nucleotide-binding universal stress protein, UspA family
1277	1931	COG0618	A T	nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs
1375	2877	COG0631	T	Serine/threonine protein phosphatase PrpC
274	279	COG0639	T	Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family
2071	22634	COG0642	T	Signal transduction histidine kinase
1246	2833	COG0643	T	Chemotaxis protein histidine kinase CheA
1608	2608	COG0661	T H	Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family
1884	11674	COG0664	T	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases
1171	3503	COG0666	T	Ankyrin repeat
2126	31286	COG0745	K T	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain
1621	17364	COG0784	T	CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F
1767	11106	COG0834	T E	ABC-type amino acid transport/signal transduction system, periplasmic component/domain
1239	4105	COG0835	T	Chemotaxis signal transduction protein CheW
1354	16692	COG0840	T	Methyl-accepting chemotaxis protein (MCP)
696	958	COG1073	T	Fermentation-respiration switch esterase FrsA, DUF1100 family
1933	1938	COG1217	T	Predicted membrane GTPase TypA/BipA involved in stress response
104	111	COG1221	K T	Transcriptional regulators containing sigma54-interacting ATPase domain
1961	4447	COG1253	T P	Mg2+ efflux pump MpfA, contains CBS pair and CorC-HlyC domains, TlyC/UPF0053 family
1301	2870	COG1352	T	Methylase of chemotaxis methyl-accepting proteins
821	2886	COG1366	T	Anti-anti-sigma factor (antagonist of anti-sigma factor), STAS domain
1509	3424	COG1409	T	3',5'-cyclic AMP phosphodiesterase CpdA
405	454	COG1437	T R	Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)
606	615	COG1480	T	Cyclic di-AMP-specific phosphodiesterase PgpH, HD superfamily
769	783	COG1489	T G	DNA-binding protein, stimulates sugar fermentation
993	1119	COG1493	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism
1057	1720	COG1524	T	c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily
709	1034	COG1551	T	sRNA-binding carbon storage regulator CsrA
296	296	COG1623	T	c-di-AMP synthetase DisA, contains DAC, linker, and DNA-binding domains
58	60	COG1624	T	c-di-AMP synthetase, contains the diadenylate cyclase (DAC) domain
490	2085	COG1639	T	HD-like signal output (HDOD) domain, no enzymatic activity
820	833	COG1642	T	c-di-AMP synthetase CdaA, contains 3TM and DAC domains
1414	1427	COG1660	T	RNase adaptor protein RapZ for GlmZ sRNA degradation, contains a P-loop ATPase domain
925	925	COG1666	T	Cyclic di-GMP-binding protein YajQ, UPF0234 family
728	744	COG1692	T	2',3'- and 3',5'-cNMP phosphodiesterase YmdB, calcineurin family
1842	1953	COG1702	T	Phosphate starvation-inducible protein PhoH, predicted ATPase
503	530	COG1713	T R	Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase
979	4694	COG1716	T	Forkhead associated (FHA) domain, binds pSer, pThr, pTyr
411	443	COG1718	T	Serine/threonine-protein kinase RIO1
1059	2126	COG1744	T	Lipoprotein Med, regulator of KinD/Spo0A, PBP1-ABC superfamily, includes NupN
102	111	COG1751	T G	Ligand-binding PK_C domain of pyruvate kinase and diadenylate cyclases
1291	3161	COG1762	T G	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)
769	798	COG1774	T	Cell fate regulator YaaT, PSP1 superfamily (controls sporulation, competence, biofilm development)
564	960	COG1776	T	Phosphoaspartate phosphatase CheC, specific for CheY-P
905	964	COG1806	T	Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)
469	482	COG1854	T	S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis
752	931	COG1871	T	Chemotaxis receptor (MCP) glutamine deamidase CheD
1002	1065	COG1923	T	sRNA-binding regulator protein Hfq
1541	2689	COG1925	T G	HPr or related phosphotransfer protein
926	1075	COG1956	V T	GAF domain-containing protein, putative methionine-R-sulfoxide reductase
1752	2751	COG1974	K T	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)
911	1406	COG1983	K T	Phage shock protein PspC (stress-responsive transcriptional regulator)
375	422	COG1993	T	PII-like signaling protein
319	919	COG2018	T	Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family
1365	1725	COG2062	T	Phosphohistidine phosphatase SixA
115	117	COG2112	T	Predicted Ser/Thr protein kinase
1037	4156	COG2114	T	Adenylate cyclase, class 3
1033	2923	COG2172	T	Anti-sigma regulatory factor (Ser/Thr protein kinase)
367	441	COG2184	T	Fido, protein-threonine AMPylation domain
1858	17938	COG2197	K T	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains
1019	3048	COG2198	T	HPt (histidine-containing phosphotransfer) domain
1451	17086	COG2199	T	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants
1289	7124	COG2200	T	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)
1280	2819	COG2201	T	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains
1337	5294	COG2202	T	PAS domain
1525	9086	COG2203	T	GAF domain
1650	14651	COG2204	T	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains
1714	6085	COG2205	T	K+-sensing histidine kinase KdpD
988	3889	COG2206	T	HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant)
1025	3737	COG2208	K T	Phosphoserine phosphatase RsbU, regulator of sigma subunit
201	881	COG2310	T	Stress response protein SCP2
1163	1990	COG2334	T	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist
522	673	COG2339	T	Membrane proteinase PrsW, cleaves anti-sigma factor RsiW, M82 family
543	759	COG2357	T F	ppGpp synthetase catalytic domain (RelA/SpoT-type nucleotidyltranferase)
622	900	COG2365	T	Protein tyrosine/serine phosphatase Oca4
223	248	COG2404	J T	Oligoribonuclease NrnA/c-di-AMP phosphodiesterase DhhP, DHH superfamily
553	681	COG2453	T	Protein-tyrosine phosphatase
57	116	COG2469	T	Archaeal chemotaxis protein CheF
478	1162	COG2703	T	Hemerythrin
21	21	COG2724	T	c-di-AMP synthetase CdaS, contains YojJ and DAC domains
141	145	COG2725	T	c-di-AMP synthetase, DacZ/CdaZ superfamily, contains PK_C-type and DAC domains
573	679	COG2766	T	Predicted Ser/Thr protein kinase
965	2015	COG2770	T	HAMP domain
591	654	COG2808	T	Predicted FMN-binding regulatory protein PaiB
1003	1033	COG2844	T O	UTP:GlnB (protein PII) uridylyltransferase
1665	4003	COG2905	T	Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains
496	520	COG2912	T	Regulator of sirC expression, contains transglutaminase-like and TPR domains
294	294	COG2915	T X	Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation
566	567	COG2921	T	Putative lipoate-binding regulatory protein, UPF0250 family
511	1543	COG2972	T	Sensor histidine kinase YesM
611	639	COG2976	T	Ancillary subunit YfgM of SecYEG translocon, regulates RcsB-dependent stress response
390	392	COG3026	T	RseB, negative regulator of sigma E activity
362	363	COG3045	T	Periplasmic catabolite regulation protein CreA (function unknown)
179	183	COG3072	T	Adenylate cyclase, class I
381	381	COG3073	T	RseA, negative regulator of sigma E activity
208	238	COG3083	T M	Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily
461	502	COG3086	T	RseC, positive regulator of sigma E activity
325	327	COG3106	T	Ras-like GTP-binding stress-induced protein YcjX, DUF463 family
258	283	COG3109	T	sRNA-binding protein ProQ
99	113	COG3110	T W	Curli synthesis inhibitor CsgI, YccT/UPF0319 family
411	501	COG3143	T N	Phosphoaspartate phosphatase CheZ, dephosphorylates CheY~P
701	1097	COG3193	T	Formaldehyde-binding sensor protein EfgA, GlcG/HbpS family
406	527	COG3213	T	Nitric oxide response protein NnrS
300	333	COG3215	T N W	Type IV pilus assembly protein/c-di-GMP receptor domain PilZ
468	533	COG3228	T	Mlc titration factor MtfA, regulates ptsG expression
889	2985	COG3275	T	Sensor histidine kinase, LytS/YehU family
1066	3985	COG3279	K T	DNA-binding response regulator, LytR/AlgR family
457	632	COG3287	T	NO-sensing heme protein NosP, contains FIST domain
597	1258	COG3290	T	Sensor histidine kinase DipB regulating citrate/malate metabolism
456	2176	COG3292	T	Periplasmic ligand-binding sensor domain
381	532	COG3300	T	MHYT domain, NO-binding membrane sensor
271	376	COG3322	T	Iron-binding extracellular (periplasmic) sensor domain CHASE4
26	26	COG3400	T	Predicted c-di-AMP receptor, contains TrkA_N, RCK_C, and USP domains
352	372	COG3412	T	Phosphotransferase subunit DhaM of the dihydroxyacetone kinase DhaKLM complex, contains PTS-EIIA, HPr, and PEP-utilizing domains
325	328	COG3429	T G	Glucose-6-phosphate dehydrogenase activity regulator OpcA
383	698	COG3434	T	c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains
912	2438	COG3437	T	Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains
403	610	COG3447	T	Integral membrane sensor domain MASE1
1218	2159	COG3448	T	CBS-domain-containing membrane protein
293	358	COG3452	T	Extracellular (periplasmic) sensor domain CHASE (specificity unknown)
687	805	COG3476	T	Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog)
391	415	COG3480	T	Predicted secreted protein YlbL, contains PDZ domain
673	1301	COG3550	T	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module
178	182	COG3602	T	ACT domain, ACT-3 family
158	164	COG3603	T	ACT domain, ACT-7 family
797	1788	COG3604	K T	FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains
694	816	COG3605	T	Signal transduction protein containing GAF and PtsI domains
398	651	COG3614	T	Extracytoplasmic sensor domain CHASE1 (specificity unknown)
228	285	COG3641	T	Membrane regulatory protein PfoR, PTS_EIIC_2 domain (does not regulate perfringolysin expression)
302	440	COG3679	T	Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)
1234	5588	COG3706	K T	Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain
868	1390	COG3707	K T	Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains
509	2902	COG3712	T P	Periplasmic ferric-dicitrate binding protein FecR, regulates iron transport
371	502	COG3806	T	Anti-sigma factor ChrR, cupin superfamily
837	2918	COG3829	K T	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains
572	585	COG3830	T	ACT domain, binds amino acids and other small ligands
485	862	COG3835	K T	Sugar diacid utilization regulator CdaR
426	442	COG3848	T	Phosphohistidine swiveling domain of PEP-utilizing enzymes
743	1330	COG3850	T	Signal transduction histidine kinase NarQ, nitrate/nitrite-specific
92	113	COG3851	T	Signal transduction histidine kinase UhpB, glucose-6-phosphate specific
661	670	COG3852	T	Signal transduction histidine kinase NtrB, nitrogen specific
275	327	COG3870	T	Cyclic di-AMP receptor DarA/PstA
317	321	COG3887	T	Cyclic di-AMP phosphodiesterase GdpP, contains GGDEF-like and DHH domains
192	223	COG3913	T U	Type VI secretion system regulator TagF/ImpM/SciT
215	293	COG3915	T	Pterin-binding regulatory protein
312	471	COG3916	T	N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis)
831	2524	COG3920	T	Two-component sensor histidine kinase, HisKA and HATPase domains
69	69	COG3925	T G	N-terminal domain of the PTS fructose-specific IIB component
300	372	COG3937	T Q	Phasin, polyhydroxyalkanoate synthesis regulator
185	255	COG3947	K T	Two-component response regulator, SAPR family, consists of REC, wHTH and BTAD domains
28	28	COG3984	T	Stand-alone REC domain, LytT-type
412	712	COG3989	T	Transcriptional regulator, contains DNA-binding LytTR domain
828	2623	COG4191	T	Signal transduction histidine kinase regulating C4-dicarboxylate transport system
44	46	COG4192	T	Signal transduction histidine kinase regulating phosphoglycerate transport system
504	1231	COG4219	T	Signal transducer regulating beta-lactamase production, contains metallopeptidase domain
153	253	COG4250	T	DICT sensory domain found in diguanylate cyclases and two-component systems
740	2492	COG4251	T	Bacteriophytochrome (light-regulated signal transduction histidine kinase)
561	1287	COG4252	T	Extracytoplasmic sensor domain CHASE2 (specificity unknown)
697	1317	COG4319	T	SnoaL-fold ligand-binding domain
68	92	COG4371	T C	FLAP1 protein, involved in response to fluctuating light, FLAP1/DUF1517 family
226	230	COG4398	T	Small ligand-binding sensory domain FIST
447	514	COG4464	T	Tyrosine-protein phosphatase YwqE
103	169	COG4512	K T	Accessory gene regulator protein AgrB
117	120	COG4550	T	Cell fate regulator YmcA, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)
499	1150	COG4564	T	Signal transduction histidine kinase
511	800	COG4565	K T	DNA-binding response regulator DpiB of citrate/malate metabolism
553	1539	COG4566	K T	DNA-binding response regulator, FixJ family, consists of REC and HTH domains
494	559	COG4567	K T	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains
253	258	COG4579	T	Isocitrate dehydrogenase kinase/phosphatase
1302	7940	COG4585	T	Signal transduction histidine kinase ComP
638	954	COG4623	T M	Membrane-bound lytic murein transglycosylase MltF
128	133	COG4650	K T	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain
872	2493	COG4753	K T	Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains
148	170	COG4758	T	Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system
22	42	COG4831	T	Roadblock/LC7 domain
283	297	COG4832	V T	Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain
92	100	COG4846	T	Regulator of biofilm dispersion, motility, and sporulation CcdC
178	179	COG4853	T	YycI protein, regulator of the WalKR two-component signal transduction system
509	518	COG4856	T	Cyclic di-AMP synthase regulator CdaR, YbbR domain
208	273	COG4862	K T N	Negative regulator MecA of genetic competence, sporulation and motility
168	168	COG4863	T	YycH protein, regulator of the WalKR two-component signal transduction system
239	400	COG4936	T	Ligand-binding sensor domain
123	183	COG4943	T	Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains
73	100	COG4945	T G	Carbohydrate-binding DOMON domain
520	853	COG4978	T	GyrI-like small molecule binding domain
82	82	COG4999	T	Uncharacterized domain of signal transduction histidine kinase BarA
1083	1722	COG5000	T	Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation
1063	6295	COG5001	T	Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain
1792	5121	COG5002	T	Sensor histidine kinase WalK
562	568	COG5007	T	Acid stress protein IbaG/YrbA, BolA-like family
195	224	COG5018	T	3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation
157	235	COG5126	T	Ca2+-binding protein, EF-hand superfamily
83	83	COG5212	T	cAMP phosphodiesterase
653	1247	COG5278	T	Extracytoplasmic sensor domain CHASE3 (specificity unknown)
441	513	COG5343	T	Anti-sigma-K factor RskA
253	254	COG5385	T	Histidine phosphotransfer protein ChpT, HPt domain
181	369	COG5388	T	PAS/LOV-type domain, PAS_5 family
504	515	COG5394	T Q	Polyhydroxyalkanoate synthesis regulator, binds DNA and PHA
31	38	COG5440	T	Global stress regulator YbjN, DUF2299 family
249	647	COG5457	A T	RNA-binding protein CcaF1 involved in sRNA maturation, turnover, C and P metabolism, and intracellular survival, YjiS/DUF1127 family
116	172	COG5524	T C	Bacteriorhodopsin
485	595	COG5581	T N	Cyclic di-GMP-binding flagellar brake protein FlgZ/YcgR, contains PilZNR(YcgR) and PilZ domains
19	25	COG5599	T U	Type III secretion system effector, protein-tyrosine-phosphatase YopH
355	947	COG5616	T	TolB amino-terminal domain (function unknown)
323	988	COG5635	T	Predicted NTPase, NACHT family domain
133	165	COG5660	T	Anti-sigma-YlaC factor YlaD, contains Zn-finger domain
58	247	COG5750	T	Chlorophyll biosynthesis regulator GUN4/Ycf53 domain
70	72	COG5751	T	Photosynthetic regulator, contains GUN4/Ycf53 domain and N-terminal all-alpha domain
305	2035	COG5752	T	Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 porphyrin-binding domain
73	74	COG5764	T C	Cyanobacterial/chloroplast FeS cluster protein Ycf34, regulator of photosynthetic electron transport, PF10718 domain
75	76	COG5768	T C	Cyanobacterial response regulator with REC-Ycf55 domain architecture
71	71	COG5780	T C	Acclimation of photosynthesis to environment protein APE1, affects chlorophyll fluorescence, DUF2854 (PF11016) domain
74	74	COG5788	T C	Cyanobacterial/chloroplast protein SipA, regulator of sensor kinase NblS (Hik33), DUF3148 (PF11347) family
266	325	COG5792	T C	Fusion of CP12 with N-terminal CBS domain pair
71	90	COG5793	T	Heterocyst patterning and differentiation ncRNA-binding protein PatR
242	277	COG5801	D T	Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains)
99	99	COG5802	D T	Stage 0 sporulation initiation phosphotransferase Spo0B
161	211	COG5803	D T	Stage 0 sporulation initiation response regulator Spo0F
151	436	COG5804	D T	Stage 0 sporulation regulatory phosphatase Spo0E
42	58	COG5805	D T	Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ)
47	114	COG5806	D T	Sporulation sensor histidine kinase B
20	20	COG5807	D T	Sporulation sensor histidine kinase C
30	37	COG5808	D T	Sporulation sensor histidine kinase D
1006	3435	COG5809	D T	Sporulation sensor histidine kinase E
83	83	COG5810	D T	Sporulation protein KbaA, activator of histidine kinase KinB
888	1775	COG5815	D T	Stage II sporulation protein SpoIIAA (anti-anti-sigma F factor), STAS domain
165	168	COG5848	D T	SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A)
118	118	COG5849	D T	SigmaK checkpoint regulator BofC (Bypass-of-forespore protein C)
90	90	COG5867	D T	Anti-sigma-F factor Fin
30	31	COG5927	T	Spo0B-type alpha-helical domain
1256	4122	COG5975	T	KinA-related sensor histidine kinase
185	220	COG5976	T	KinB-related sensor histidine kinase
949	2048	COG5977	T	KinC-related sensor histidine kinase
233	265	COG5978	T	KinD-related sensor histidine kinase
1787	23197	COG5979	T	KinE-related sensor histidine kinase
58	202	COG6094	T	HalX domain, output domain in halobacterial response regulators
88	105	COG6095	K T	YcbB domain, DNA-binding domain in GlnL-type response regulators
15	20	COG6096	K T	BetR domain, DNA-binding domain in betaproteobacterial response regulators
27	99	COG6097	T	HalOD1 domain (halobacterial output domain 1)