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{"id":14318,"date":"2025-01-13T10:09:27","date_gmt":"2025-01-13T15:09:27","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=14318"},"modified":"2025-01-13T11:05:49","modified_gmt":"2025-01-13T16:05:49","slug":"ncbi-resources-2025-nucleic-acids-research-database-issue","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/","title":{"rendered":"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue"},"content":{"rendered":"<p><span data-contrast=\"none\">The\u202f<\/span><a href=\"https:\/\/academic.oup.com\/nar\/issue\/53\/D1\"><span data-contrast=\"none\">2025<\/span>\u00a0<i><span data-contrast=\"none\">Nucleic Acids Research<\/span><\/i><span data-contrast=\"none\">\u00a0Database Issue<\/span><\/a><span data-contrast=\"none\">\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.<\/span><span data-ccp-props=\"{"201341983":0,"335559739":0,"335559740":240}\">\u00a0<\/span><span id=\"more-10966\"><\/span><\/p>\n<div id=\"ch_outer\" class=\"ch_outerExpanded\">\n<div id=\"ch_inner\">\n<h6>Database resources of the National Center for Biotechnology Information in 2025<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701734\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701734<\/a><\/strong><\/p>\n<p><span class=\"TextRun SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266111855 BCX8\">NCBI provides online information resources for biology, including the GenBank<\/span><\/span><span class=\"TextRun SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun Superscript SCXW266111855 BCX8\" data-fontsize=\"12\">\u00ae<\/span><\/span><span class=\"TextRun SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266111855 BCX8\">\u202fnucleic acid sequence repository and the PubMed<\/span><\/span><span class=\"TextRun SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun Superscript SCXW266111855 BCX8\" data-fontsize=\"12\">\u00ae<\/span><\/span><span class=\"TextRun SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266111855 BCX8\">\u202frepository of citations and abstracts published in life science journals.<\/span> <span class=\"NormalTextRun SCXW266111855 BCX8\">NCBI is <\/span><\/span><span class=\"TextRun Highlight SCXW266111855 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266111855 BCX8\">currently developing the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/comparative-genomics-resource\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">NIH Comparative Genomics Resource<\/a> (CGR) to <\/span><span class=\"NormalTextRun SCXW266111855 BCX8\">facilitate<\/span><span class=\"NormalTextRun SCXW266111855 BCX8\"> reliable comparative genomics analyses with an NCBI Toolkit and community collaboration.<\/span><\/span><\/p>\n<p><!--more--><\/p>\n<h6>ClinVar: updates to support classifications of both germline and somatic variants<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701624\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701624<\/a><\/strong><\/p>\n<p><a class=\"Hyperlink SCXW129170801 BCX8\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/clinvar\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun SCXW129170801 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW129170801 BCX8\">ClinVar<\/span><\/span><\/a><span class=\"TextRun SCXW129170801 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW129170801 BCX8\">\u202fis a free, public database of human genetic variants and their relationships to disease, with >3 million variants <\/span><span class=\"NormalTextRun SCXW129170801 BCX8\">submitted<\/span><span class=\"NormalTextRun SCXW129170801 BCX8\"> by >2800 organizations across the world. The database was recently updated to have three types of classifications: germline, oncogenicity and clinical impact for somatic variants.\u00a0<\/span><\/span><\/p>\n<h6>PubChem 2025 update<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701573\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701573<\/a><\/strong><\/p>\n<p><a class=\"Hyperlink SCXW242637681 BCX8\" href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun SCXW242637681 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW242637681 BCX8\">PubChem<\/span><\/span><\/a><span class=\"TextRun SCXW242637681 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW242637681 BCX8\">\u202fis a large and <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW242637681 BCX8\">highly-integrated<\/span><span class=\"NormalTextRun SCXW242637681 BCX8\"> public chemical database resource at NIH. In the past two years, significant updates were made to PubChem. With additions from over 130 new sources, PubChem <\/span><span class=\"NormalTextRun SCXW242637681 BCX8\">contains<\/span><span class=\"NormalTextRun SCXW242637681 BCX8\"> >1000 data sources, 119 million compounds, 322 million substances and 295 million bioactivities.\u00a0<\/span><\/span><\/p>\n<h6>GenBank 2025 update<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701615\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701615<\/a><\/strong><\/p>\n<p><a class=\"Hyperlink SCXW113507665 BCX8\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/genbank\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun SCXW113507665 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW113507665 BCX8\">GenBank<\/span><\/span><span class=\"TextRun SCXW113507665 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun Superscript SCXW113507665 BCX8\" data-fontsize=\"12\">\u00ae<\/span><\/span><\/a><span class=\"TextRun SCXW113507665 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW113507665 BCX8\">\u202fis a comprehensive, public data repository that <\/span><span class=\"NormalTextRun SCXW113507665 BCX8\">contains<\/span><span class=\"NormalTextRun SCXW113507665 BCX8\"> 34 trillion base pairs from over 4.7 billion nucleotide sequences for 581 000 formally described species. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage.\u00a0<\/span><\/span><\/p>\n<h6>The international nucleotide sequence database collaboration (INSDC): enhancing global participation<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701530\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701530<\/a><\/strong><\/p>\n<p><span class=\"TextRun SCXW95786745 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW95786745 BCX8\">The members of the\u202f<\/span><\/span><a class=\"Hyperlink SCXW95786745 BCX8\" href=\"https:\/\/insdc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun SCXW95786745 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW95786745 BCX8\">International Nucleotide Sequence Database Collaboration<\/span><\/span><\/a><span class=\"TextRun SCXW95786745 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW95786745 BCX8\">\u202f(INSDC) have built systems to collect, archive and <\/span><span class=\"NormalTextRun SCXW95786745 BCX8\">disseminate<\/span><span class=\"NormalTextRun SCXW95786745 BCX8\"> sequence data for more than four decades. The three collaborating organizations, the National Library of Medicine, National Center for Biotechnology Information (NLM-NCBI) in the United States, Research Organization of Information and Systems, National Institute of Genetics (ROIS-NIG) in Japan; and the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) formalized their relationship through the adoption of an arrangement which documents their commitment to free and open access to genomic sequences.<\/span><\/span><\/p>\n<h6>The evolution of dbSNP: 25 years of impact in genomic research<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701571\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701571<\/a><\/strong><\/p>\n<p><span class=\"TextRun SCXW139708750 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW139708750 BCX8\">The\u202f<\/span><\/span><a class=\"Hyperlink SCXW139708750 BCX8\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/snp\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun SCXW139708750 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW139708750 BCX8\">Single Nucleotide Polymorphism Database<\/span><\/span><\/a><span class=\"TextRun SCXW139708750 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW139708750 BCX8\">\u202f(<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW139708750 BCX8\">dbSNP<\/span><span class=\"NormalTextRun SCXW139708750 BCX8\">), <\/span><span class=\"NormalTextRun SCXW139708750 BCX8\">established<\/span><span class=\"NormalTextRun SCXW139708750 BCX8\"> in 1998 by NCBI, has been a critical resource in genomics for cataloging small genetic variations. Originally focused on single nucleotide polymorphisms (SNPs), <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW139708750 BCX8\">dbSNP<\/span><span class=\"NormalTextRun SCXW139708750 BCX8\"> has since expanded to include a variety of genetic variants, playing a key role in genome-wide association studies (GWAS), population genetics, pharmacogenomics, and cancer research.\u00a0<\/span><\/span><\/p>\n<h6><strong>NCBI RefSeq: reference sequence standards through 25 years of curation and annotation<\/strong><\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701664\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701664<\/a><\/strong><\/p>\n<p><span class=\"TextRun SCXW263028290 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW263028290 BCX8\">The <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">Reference Sequence<\/a> (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW263028290 BCX8\">RefSeq<\/span><span class=\"NormalTextRun SCXW263028290 BCX8\">) resource created at NCBI leverages both automatic processes and expert curation to create a robust set of reference sequences of genomic, transcript and protein data spanning the tree of life. <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW263028290 BCX8\">RefSeq<\/span><span class=\"NormalTextRun SCXW263028290 BCX8\"> continues to refine its annotation and quality control processes and <\/span><span class=\"NormalTextRun SCXW263028290 BCX8\">utilize<\/span><span class=\"NormalTextRun SCXW263028290 BCX8\"> better quality genomes resulting from advances in sequencing technologies as well as RNA-Seq data to produce high-quality annotated genomes, ortholog predictions across more organisms and other products that are easily accessible through multiple NCBI resources.\u00a0<\/span><\/span><\/p>\n<h6><strong>NCBI Taxonomy: enhanced access via NCBI Datasets<\/strong><\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701650\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701650<\/a><\/strong><\/p>\n<p><span data-contrast=\"none\">The\u202f<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/taxonomy?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\"><span data-contrast=\"none\">NCBI Taxonomy<\/span><\/a><span data-contrast=\"none\">\u202fresource\u202fhas long been a trusted, curated hub for organism names, classifications, and links to related data for all taxonomic nodes.\u202f<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\"><span data-contrast=\"none\">NCBI Datasets<\/span><\/a><span data-contrast=\"none\">\u202fis an improved way to leverage the rich data available at NCBI so users can effectively browse, search, and download information.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n<h6>COG database update 2024<\/h6>\n<p><strong>PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11701660\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">PMC11701660<\/a><\/strong><\/p>\n<p>The <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/research\/cog?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=nar-2025-issue-20250113\">Clusters of Orthologous Genes<\/a> (COG) database, originally created in 1997, has been updated to reflect the constantly growing collection of completely sequenced prokaryotic genomes. This update increased the genome coverage from 1309 to 2296 species, including 2103 bacteria and 193 archaea, in most cases, with a single representative genome per genus.<\/p>\n<div id=\"ch_outer\" class=\"ch_outerExpanded\">\n<div id=\"ch_inner\">\n<h6>Stay up to date<\/h6>\n<p><span data-contrast=\"none\">Follow us on Twitter\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"none\">@NCBI<\/span><\/a><span data-contrast=\"none\">\u202fand\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"none\">join our mailing list<\/span><\/a><span data-contrast=\"none\">\u202fto keep up to date with NCBI news.<\/span><\/p>\n<h6>Questions?<\/h6>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback about NCBI products or tools, please reach out to us at\u00a0<\/span><a href=\"mailto:info@ncbi.nlm.nih.gov\"><span data-contrast=\"none\">info@ncbi.nlm.nih.gov<\/span><\/a><span data-contrast=\"auto\">.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The\u202f2025\u00a0Nucleic Acids Research\u00a0Database Issue\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.\u00a0 Database resources of the National Center for Biotechnology Information in 2025 PMCID: PMC11701734 NCBI provides online … <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue<\/span> <span class=\"meta-nav\">→<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":14366,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI Resources Highlighted in 2024 Nucleic Acids Research Database Issue","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[108204782,693060916,693060768,1201719,693060836,34457,6088049,27739816,10192294],"table_tags":[],"class_list":["post-14318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-clinvar","tag-clusters-of-orthologous-genes-cog","tag-comparative-genomics-resource-cgr","tag-genbank","tag-ncbi-datasets","tag-taxonomy","tag-pubchem","tag-refseq","tag-dbsnp"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"The\u202f2025\u00a0Nucleic Acids Research\u00a0Database Issue\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.\u00a0 Database resources of the National Center for Biotechnology Information in 2025 PMCID: PMC11701734 NCBI provides online … Continue reading NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue →\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-13T15:09:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-13T16:05:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2025\/01\/Nucleic_Acids_Research_2025-1-e1736778975506.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1100\" \/>\n\t<meta property=\"og:image:height\" content=\"575\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue\",\"datePublished\":\"2025-01-13T15:09:27+00:00\",\"dateModified\":\"2025-01-13T16:05:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\"},\"wordCount\":676,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2025\/01\/Nucleic_Acids_Research_2025-1-e1736778975506.png?fit=1100%2C575&ssl=1\",\"keywords\":[\"ClinVar\",\"Clusters of Orthologous Genes (COG)\",\"Comparative Genomics Resource (CGR)\",\"GenBank\",\"NCBI Datasets\",\"NCBI Taxonomy\",\"PubChem\",\"RefSeq\",\"Single Nucleotide Polymorphism Database (dbSNP)\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\",\"name\":\"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue - 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