{"id":14318,"date":"2025-01-13T10:09:27","date_gmt":"2025-01-13T15:09:27","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=14318"},"modified":"2025-01-13T11:05:49","modified_gmt":"2025-01-13T16:05:49","slug":"ncbi-resources-2025-nucleic-acids-research-database-issue","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/","title":{"rendered":"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue"},"content":{"rendered":"

The\u202f<\/span>2025<\/span>\u00a0Nucleic Acids Research<\/span><\/i>\u00a0Database Issue<\/span><\/a>\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.<\/span>\u00a0<\/span><\/span><\/p>\n

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Database resources of the National Center for Biotechnology Information in 2025<\/h6>\n

PMCID: PMC11701734<\/a><\/strong><\/p>\n

NCBI provides online information resources for biology, including the GenBank<\/span><\/span>\u00ae<\/span><\/span>\u202fnucleic acid sequence repository and the PubMed<\/span><\/span>\u00ae<\/span><\/span>\u202frepository of citations and abstracts published in life science journals.<\/span> NCBI is <\/span><\/span>currently developing the NIH Comparative Genomics Resource<\/a> (CGR) to <\/span>facilitate<\/span> reliable comparative genomics analyses with an NCBI Toolkit and community collaboration.<\/span><\/span><\/p>\n

<\/p>\n

ClinVar: updates to support classifications of both germline and somatic variants<\/h6>\n

PMCID: PMC11701624<\/a><\/strong><\/p>\n

ClinVar<\/span><\/span><\/a>\u202fis a free, public database of human genetic variants and their relationships to disease, with >3 million variants <\/span>submitted<\/span> by >2800 organizations across the world. The database was recently updated to have three types of classifications: germline, oncogenicity and clinical impact for somatic variants.\u00a0<\/span><\/span><\/p>\n

PubChem 2025 update<\/h6>\n

PMCID: PMC11701573<\/a><\/strong><\/p>\n

PubChem<\/span><\/span><\/a>\u202fis a large and <\/span>highly-integrated<\/span> public chemical database resource at NIH. In the past two years, significant updates were made to PubChem. With additions from over 130 new sources, PubChem <\/span>contains<\/span> >1000 data sources, 119 million compounds, 322 million substances and 295 million bioactivities.\u00a0<\/span><\/span><\/p>\n

GenBank 2025 update<\/h6>\n

PMCID: PMC11701615<\/a><\/strong><\/p>\n

GenBank<\/span><\/span>\u00ae<\/span><\/span><\/a>\u202fis a comprehensive, public data repository that <\/span>contains<\/span> 34 trillion base pairs from over 4.7 billion nucleotide sequences for 581 000 formally described species. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage.\u00a0<\/span><\/span><\/p>\n

The international nucleotide sequence database collaboration (INSDC): enhancing global participation<\/h6>\n

PMCID: PMC11701530<\/a><\/strong><\/p>\n

The members of the\u202f<\/span><\/span>International Nucleotide Sequence Database Collaboration<\/span><\/span><\/a>\u202f(INSDC) have built systems to collect, archive and <\/span>disseminate<\/span> sequence data for more than four decades. The three collaborating organizations, the National Library of Medicine, National Center for Biotechnology Information (NLM-NCBI) in the United States, Research Organization of Information and Systems, National Institute of Genetics (ROIS-NIG) in Japan; and the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) formalized their relationship through the adoption of an arrangement which documents their commitment to free and open access to genomic sequences.<\/span><\/span><\/p>\n

The evolution of dbSNP: 25 years of impact in genomic research<\/h6>\n

PMCID: PMC11701571<\/a><\/strong><\/p>\n

The\u202f<\/span><\/span>Single Nucleotide Polymorphism Database<\/span><\/span><\/a>\u202f(<\/span>dbSNP<\/span>), <\/span>established<\/span> in 1998 by NCBI, has been a critical resource in genomics for cataloging small genetic variations. Originally focused on single nucleotide polymorphisms (SNPs), <\/span>dbSNP<\/span> has since expanded to include a variety of genetic variants, playing a key role in genome-wide association studies (GWAS), population genetics, pharmacogenomics, and cancer research.\u00a0<\/span><\/span><\/p>\n

NCBI RefSeq: reference sequence standards through 25 years of curation and annotation<\/strong><\/h6>\n

PMCID: PMC11701664<\/a><\/strong><\/p>\n

The Reference Sequence<\/a> (<\/span>RefSeq<\/span>) resource created at NCBI leverages both automatic processes and expert curation to create a robust set of reference sequences of genomic, transcript and protein data spanning the tree of life. <\/span>RefSeq<\/span> continues to refine its annotation and quality control processes and <\/span>utilize<\/span> better quality genomes resulting from advances in sequencing technologies as well as RNA-Seq data to produce high-quality annotated genomes, ortholog predictions across more organisms and other products that are easily accessible through multiple NCBI resources.\u00a0<\/span><\/span><\/p>\n

NCBI Taxonomy: enhanced access via NCBI Datasets<\/strong><\/h6>\n

PMCID: PMC11701650<\/a><\/strong><\/p>\n

The\u202f<\/span>NCBI Taxonomy<\/span><\/a>\u202fresource\u202fhas long been a trusted, curated hub for organism names, classifications, and links to related data for all taxonomic nodes.\u202f<\/span>NCBI Datasets<\/span><\/a>\u202fis an improved way to leverage the rich data available at NCBI so users can effectively browse, search, and download information.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n

COG database update 2024<\/h6>\n

PMCID: PMC11701660<\/a><\/strong><\/p>\n

The Clusters of Orthologous Genes<\/a> (COG) database, originally created in 1997, has been updated to reflect the constantly growing collection of completely sequenced prokaryotic genomes. This update increased the genome coverage from 1309 to 2296 species, including 2103 bacteria and 193 archaea, in most cases, with a single representative genome per genus.<\/p>\n

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Stay up to date<\/h6>\n

Follow us on Twitter\u202f<\/span>@NCBI<\/span><\/a>\u202fand\u202f<\/span>join our mailing list<\/span><\/a>\u202fto keep up to date with NCBI news.<\/span><\/p>\n

Questions?<\/h6>\n

If you have questions or would like to provide feedback about NCBI products or tools, please reach out to us at\u00a0<\/span>info@ncbi.nlm.nih.gov<\/span><\/a>.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The\u202f2025\u00a0Nucleic Acids Research\u00a0Database Issue\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. The citations are available in PubMed with full-text available in PubMed Central (PMC). To read an article, click on the PMCID number listed below.\u00a0 Database resources of the National Center for Biotechnology Information in 2025 PMCID: PMC11701734 NCBI provides online … Continue reading NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":14366,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI Resources Highlighted in 2024 Nucleic Acids Research Database Issue","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[108204782,693060916,693060768,1201719,693060836,34457,6088049,27739816,10192294],"table_tags":[],"class_list":["post-14318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-clinvar","tag-clusters-of-orthologous-genes-cog","tag-comparative-genomics-resource-cgr","tag-genbank","tag-ncbi-datasets","tag-taxonomy","tag-pubchem","tag-refseq","tag-dbsnp"],"jetpack_publicize_connections":[],"yoast_head":"\nNCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2025\/01\/13\/ncbi-resources-2025-nucleic-acids-research-database-issue\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI Resources Highlighted in 2025 Nucleic Acids Research Database Issue - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"The\u202f2025\u00a0Nucleic Acids Research\u00a0Database Issue\u202ffeatures papers from NCBI staff on ClinVar, PubChem, GenBank, RefSeq, and more. 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