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<meta name="keywords" content="C0280324, cancer of the larynx, squamous cell, epidermoid carcinoma of larynx, epidermoid carcinoma of the larynx, laryngeal conventional squamous cell carcinoma, laryngeal epidermoid carcinoma, laryngeal squamous cell carcinoma, laryngeal throat squamous cell cancer, larynx epidermoid carcinoma, larynx squamous cell carcinoma, lxsc, neoplastic process, primary squamous cell carcinoma of larynx, squamous cell carcinoma of larynx, squamous cell carcinoma of the larynx, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A rare head and neck tumor characterized by a malignant epithelial neoplasm with evidence of squamous differentiation, most commonly located in the supraglottis or glottis. The tumor can spread directly to adjacent structures or metastasize via lymphatic and blood vessels to regional lymph nodes, or lung, liver, and bones, respectively. Primary risk factors are tobacco smoking and (to a lesser extent) alcohol consumption. Patients may present with hoarseness, dyspnea, stridor, dysphagia, hemoptysis, or odynophagia." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=83630
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ConceptID=C0280324
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Laryngeal squamous cell carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83630</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0280324</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Laryngeal Squamous Cell Carcinoma; Squamous Cell Carcinoma of Larynx; Squamous Cell Carcinoma of the Larynx</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Squamous cell carcinoma of larynx (405822008); Primary squamous cell carcinoma of larynx (707358000); Cancer of the larynx, squamous cell (405822008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005595" target="_blank">MONDO:0005595</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=494550">ORPHA494550</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">A rare head and neck tumor characterized by a malignant epithelial neoplasm with evidence of squamous differentiation, most commonly located in the supraglottis or glottis. The tumor can spread directly to adjacent structures or metastasize via lymphatic and blood vessels to regional lymph nodes, or lung, liver, and bones, respectively. Primary risk factors are tobacco smoking and (to a lesser extent) alcohol consumption. Patients may present with hoarseness, dyspnea, stridor, dysphagia, hemoptysis, or odynophagia. [from <a title="Orphanet Rare Disease Ontology (ORDO)" href="http://www.orphadata.org/cgi-bin/inc/ordo_orphanet.inc.php" class="defSource" target="_blank">ORDO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Laryngeal squamous cell carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232269" ref="tree=MeSH" title="MedGen record for Head and Neck Disorder">Head and Neck Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/6728" ref="tree=MeSH" title="MedGen record for Head and neck neoplasm">Head and neck neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/78920" ref="tree=MeSH" title="MedGen record for Head and neck cancer">Head and neck cancer</a></span><ul><li><span class="TLline"><a href="/medgen/155434" ref="tree=MeSH" title="MedGen record for Malignant tumor of neck">Malignant tumor of neck</a></span><ul><li><span class="TLline"><a href="/medgen/2868" ref="tree=MeSH" title="MedGen record for Larynx cancer">Larynx cancer</a></span><ul><li><span class="TLline"><a href="/medgen/108889" ref="tree=MeSH" title="MedGen record for Laryngeal carcinoma">Laryngeal carcinoma</a></span><ul><li><span class="matched_ds">Laryngeal squamous cell carcinoma</span><ul><li><span class="TLline"><a href="/medgen/76096" ref="tree=MeSH" title="MedGen record for Glottis squamous cell carcinoma">Glottis squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/83631" ref="tree=MeSH" title="MedGen record for Glottis verrucous carcinoma">Glottis verrucous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/313337" ref="tree=MeSH" title="MedGen record for Laryngeal Acantholytic Squamous Cell Carcinoma">Laryngeal Acantholytic Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/353839" ref="tree=MeSH" title="MedGen record for Laryngeal Basaloid Squamous Cell Carcinoma">Laryngeal Basaloid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/473519" ref="tree=MeSH" title="MedGen record for Laryngeal Papillary Squamous Cell Carcinoma">Laryngeal Papillary Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/310918" ref="tree=MeSH" title="MedGen record for Laryngeal Spindle Cell Squamous Carcinoma">Laryngeal Spindle Cell Squamous Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76097" ref="tree=MeSH" title="MedGen record for Larynx verrucous carcinoma">Larynx verrucous carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/124738" ref="tree=MeSH" title="MedGen record for Recurrent Laryngeal Verrucous Carcinoma">Recurrent Laryngeal Verrucous Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/236848" ref="tree=MeSH" title="MedGen record for Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8">Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8</a></span></li><li><span class="TLline"><a href="/medgen/1615091" ref="tree=MeSH" title="MedGen record for Stage I Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage I Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1617416" ref="tree=MeSH" title="MedGen record for Stage II Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage II Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1626613" ref="tree=MeSH" title="MedGen record for Stage III Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage III Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/124737" ref="tree=MeSH" title="MedGen record for Stage IV Laryngeal Verrucous Carcinoma AJCC v7">Stage IV Laryngeal Verrucous Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/277733" ref="tree=MeSH" title="MedGen record for Stage IVA Laryngeal Verrucous Carcinoma AJCC v7">Stage IVA Laryngeal Verrucous Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/234873" ref="tree=MeSH" title="MedGen record for Stage IVB Laryngeal Verrucous Carcinoma AJCC v7">Stage IVB Laryngeal Verrucous Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233528" ref="tree=MeSH" title="MedGen record for Stage IVC Laryngeal Verrucous Carcinoma AJCC v7">Stage IVC Laryngeal Verrucous Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124721" ref="tree=MeSH" title="MedGen record for Subglottis verrucous carcinoma">Subglottis verrucous carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76098" ref="tree=MeSH" title="MedGen record for Supraglottis verrucous carcinoma">Supraglottis verrucous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83649" ref="tree=MeSH" title="MedGen record for Metastatic Laryngeal Squamous Cell Carcinoma">Metastatic Laryngeal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1665175" ref="tree=MeSH" title="MedGen record for Advanced Laryngeal Squamous Cell Carcinoma">Advanced Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712205" ref="tree=MeSH" title="MedGen record for Locally Advanced Laryngeal Squamous Cell Carcinoma">Locally Advanced Laryngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79114" ref="tree=MeSH" title="MedGen record for Recurrent Laryngeal Squamous Cell Carcinoma">Recurrent Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1654726" ref="tree=MeSH" title="MedGen record for Refractory Laryngeal Squamous Cell Carcinoma">Refractory Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1619618" ref="tree=MeSH" title="MedGen record for Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8">Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8</a></span><ul><li><span class="TLline"><a href="/medgen/1624733" ref="tree=MeSH" title="MedGen record for Stage 0 Epiglottic Carcinoma AJCC v6, v7, and v8">Stage 0 Epiglottic Carcinoma AJCC v6, v7, and v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1620522" ref="tree=MeSH" title="MedGen record for Stage I Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage I Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1624646" ref="tree=MeSH" title="MedGen record for Stage II Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1620020" ref="tree=MeSH" title="MedGen record for Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1656464" ref="tree=MeSH" title="MedGen record for Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/234866" ref="tree=MeSH" title="MedGen record for Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/234872" ref="tree=MeSH" title="MedGen record for Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233527" ref="tree=MeSH" title="MedGen record for Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124720" ref="tree=MeSH" title="MedGen record for Subglottis squamous cell carcinoma">Subglottis squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/152890" ref="tree=MeSH" title="MedGen record for Supraglottis squamous cell carcinoma">Supraglottis squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793656" ref="tree=MeSH" title="MedGen record for Epiglottic Squamous Cell Carcinoma">Epiglottic Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1732482" ref="tree=MeSH" title="MedGen record for Unresectable Laryngeal Squamous Cell Carcinoma">Unresectable Laryngeal Squamous Cell Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34424405">Management of Laryngeal Dysplasia and Early Invasive Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hrelec C</span><br />
|
||
<span class="medgenPMjournal">Curr Treat Options Oncol</span>
|
||
2021 Aug 23;22(10):90.
|
||
doi: 10.1007/s11864-021-00881-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34424405" target="_blank">34424405</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30527228">Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grégoire V,
|
||
Grau C,
|
||
Lapeyre M,
|
||
Maingon P</span><br />
|
||
<span class="medgenPMjournal">Oral Oncol</span>
|
||
2018 Dec;87:131-137.
|
||
Epub 2018 Nov 3
|
||
doi: 10.1016/j.oraloncology.2018.10.034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30527228" target="_blank">30527228</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15241816">Controversies in the management of advanced laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weber RS,
|
||
Forastiere A,
|
||
Rosenthal DI,
|
||
Laccourreye O</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2004 Jul 15;101(2):211-9.
|
||
doi: 10.1002/cncr.20231.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15241816" target="_blank">15241816</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22laryngeal%20squamous%20cell%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (77)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38610001">RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu Q,
|
||
Zhang X,
|
||
Lu F,
|
||
Miao S,
|
||
Zhang C,
|
||
Liu Z,
|
||
Gao Z,
|
||
Qi M,
|
||
An X,
|
||
Geng P,
|
||
Wang S,
|
||
Ren H,
|
||
Han F,
|
||
Zhang R,
|
||
Zha D</span><br />
|
||
<span class="medgenPMjournal">Cell Commun Signal</span>
|
||
2024 Apr 12;22(1):227.
|
||
doi: 10.1186/s12964-024-01605-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38610001" target="_blank">38610001</a><a href="/pmc/articles/PMC11010429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37629093">Updates on Larynx Cancer: Risk Factors and Oncogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liberale C,
|
||
Soloperto D,
|
||
Marchioni A,
|
||
Monzani D,
|
||
Sacchetto L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2023 Aug 18;24(16)
|
||
doi: 10.3390/ijms241612913.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37629093" target="_blank">37629093</a><a href="/pmc/articles/PMC10454133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36881167">Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de Ridder M,
|
||
Rijken JA,
|
||
Smits HJG,
|
||
Smid EJ,
|
||
Doornaert PAH,
|
||
de Bree R</span><br />
|
||
<span class="medgenPMjournal">Eur Arch Otorhinolaryngol</span>
|
||
2023 Jul;280(7):3345-3352.
|
||
Epub 2023 Mar 7
|
||
doi: 10.1007/s00405-023-07904-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36881167" target="_blank">36881167</a><a href="/pmc/articles/PMC10220095" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32638385">Cellular heterogeneity landscape in laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Song L,
|
||
Zhang S,
|
||
Yu S,
|
||
Ma F,
|
||
Wang B,
|
||
Zhang C,
|
||
Sun J,
|
||
Mao X,
|
||
Wei L</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2020 Nov 15;147(10):2879-2890.
|
||
Epub 2020 Jul 31
|
||
doi: 10.1002/ijc.33192.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32638385" target="_blank">32638385</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26443436">Spontaneous regression of laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sipaul F,
|
||
Ling B,
|
||
Mason C,
|
||
Keast A</span><br />
|
||
<span class="medgenPMjournal">J Laryngol Otol</span>
|
||
2015 Dec;129(12):1248-50.
|
||
Epub 2015 Oct 7
|
||
doi: 10.1017/S0022215115002595.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26443436" target="_blank">26443436</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laryngeal%20squamous%20cell%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (895)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38610001">RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu Q,
|
||
Zhang X,
|
||
Lu F,
|
||
Miao S,
|
||
Zhang C,
|
||
Liu Z,
|
||
Gao Z,
|
||
Qi M,
|
||
An X,
|
||
Geng P,
|
||
Wang S,
|
||
Ren H,
|
||
Han F,
|
||
Zhang R,
|
||
Zha D</span><br />
|
||
<span class="medgenPMjournal">Cell Commun Signal</span>
|
||
2024 Apr 12;22(1):227.
|
||
doi: 10.1186/s12964-024-01605-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38610001" target="_blank">38610001</a><a href="/pmc/articles/PMC11010429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38191598">Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun Y,
|
||
Chen S,
|
||
Lu Y,
|
||
Xu Z,
|
||
Fu W,
|
||
Yan W</span><br />
|
||
<span class="medgenPMjournal">Commun Biol</span>
|
||
2024 Jan 8;7(1):63.
|
||
doi: 10.1038/s42003-024-05765-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38191598" target="_blank">38191598</a><a href="/pmc/articles/PMC10774275" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37820109">Laryngeal verrucous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lechien JR,
|
||
Vaira LA,
|
||
Chiesa-Estomba CM</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
|
||
2024 Apr 1;32(2):118-124.
|
||
Epub 2023 Oct 10
|
||
doi: 10.1097/MOO.0000000000000910.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37820109" target="_blank">37820109</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34558723">Dysfunction of miR-802 in tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao T,
|
||
Zou M,
|
||
Shen T,
|
||
Duan S</span><br />
|
||
<span class="medgenPMjournal">J Clin Lab Anal</span>
|
||
2021 Nov;35(11):e23989.
|
||
Epub 2021 Sep 24
|
||
doi: 10.1002/jcla.23989.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34558723" target="_blank">34558723</a><a href="/pmc/articles/PMC8605121" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34242969">Biomarkers of laryngeal squamous cell carcinoma: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cavaliere M,
|
||
Bisogno A,
|
||
Scarpa A,
|
||
D'Urso A,
|
||
Marra P,
|
||
Colacurcio V,
|
||
De Luca P,
|
||
Ralli M,
|
||
Cassandro E,
|
||
Cassandro C</span><br />
|
||
<span class="medgenPMjournal">Ann Diagn Pathol</span>
|
||
2021 Oct;54:151787.
|
||
Epub 2021 Jul 2
|
||
doi: 10.1016/j.anndiagpath.2021.151787.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34242969" target="_blank">34242969</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laryngeal%20squamous%20cell%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (597)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39357981">Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong Y,
|
||
Zhang Z,
|
||
Luan S,
|
||
Zheng M,
|
||
Wang Z,
|
||
Chen Y,
|
||
Chen X,
|
||
Tong A,
|
||
Yang H</span><br />
|
||
<span class="medgenPMjournal">J Immunother Cancer</span>
|
||
2024 Oct 2;12(10)
|
||
doi: 10.1136/jitc-2024-009710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39357981" target="_blank">39357981</a><a href="/pmc/articles/PMC11448212" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37629093">Updates on Larynx Cancer: Risk Factors and Oncogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liberale C,
|
||
Soloperto D,
|
||
Marchioni A,
|
||
Monzani D,
|
||
Sacchetto L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2023 Aug 18;24(16)
|
||
doi: 10.3390/ijms241612913.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37629093" target="_blank">37629093</a><a href="/pmc/articles/PMC10454133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26542064">Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gama RR,
|
||
Carvalho AL,
|
||
Longatto Filho A,
|
||
Scorsato AP,
|
||
López RV,
|
||
Rautava J,
|
||
Syrjänen S,
|
||
Syrjänen K</span><br />
|
||
<span class="medgenPMjournal">Laryngoscope</span>
|
||
2016 Apr;126(4):885-93.
|
||
Epub 2015 Nov 6
|
||
doi: 10.1002/lary.25738.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26542064" target="_blank">26542064</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23219843">Chemoradiotherapy vs. total laryngectomy for primary treatment of advanced laryngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Strojan P,
|
||
Haigentz M Jr,
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Qi H</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/35178302">BIRC5 promotes cancer progression and predicts prognosis in laryngeal squamous cell carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wang N,
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<div class="nl"><a target="_blank" href="/pubmed/33234130">circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gao W,
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<div class="nl"><a target="_blank" href="/pubmed/32638385">Cellular heterogeneity landscape in laryngeal squamous cell carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Song L,
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Zhang S,
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Yu S,
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Ma F,
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Wang B,
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Zhang C,
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Sun J,
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Mao X,
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<span class="bold">PMID: </span><a href="/pubmed/32638385" target="_blank">32638385</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laryngeal%20squamous%20cell%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1028)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38610001">RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhu Q,
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Zhang X,
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Lu F,
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Miao S,
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Zhang C,
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Gao Z,
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2024 Apr 12;22(1):227.
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doi: 10.1186/s12964-024-01605-x.
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<span class="bold">PMID: </span><a href="/pubmed/38610001" target="_blank">38610001</a><a href="/pmc/articles/PMC11010429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32521839">mdm2 oncogene in laryngeal squamous cell carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mastronikolis N,
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Ragos V,
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Fotiades P,
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Papanikolaou V,
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2020 Mar-Apr;25(2):594-596.
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<div class="nl"><a target="_blank" href="/pubmed/31028202">Combined EGFR/ALK Expression Analysis in Laryngeal Squamous Cell Carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Politi A,
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Peschos D,
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Kyrodimos E,
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Armata IE,
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Chrysovergis A,
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<div class="nl"><a target="_blank" href="/pubmed/30536660">Sclerosis of the arytenoid cartilage and glottic carcinoma: A clinical-pathological study.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laryngeal%20squamous%20cell%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (764)</a></div></div>
|
||
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|
||
|
||
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/39488177">Perineural invasion and laryngeal squamous cell carcinoma: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Quintana DMVO,
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Dedivitis RA,
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Kowalski LP</span><br />
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<span class="medgenPMjournal">Braz J Otorhinolaryngol</span>
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2025 Jan-Feb;91(1):101519.
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Epub 2024 Nov 1
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||
doi: 10.1016/j.bjorl.2024.101519.
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||
<span class="bold">PMID: </span><a href="/pubmed/39488177" target="_blank">39488177</a><a href="/pmc/articles/PMC11565387" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38093339">Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Lechien JR,
|
||
Hans S</span><br />
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<span class="medgenPMjournal">J Otolaryngol Head Neck Surg</span>
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2023 Dec 13;52(1):81.
|
||
doi: 10.1186/s40463-023-00666-1.
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||
<span class="bold">PMID: </span><a href="/pubmed/38093339" target="_blank">38093339</a><a href="/pmc/articles/PMC10716941" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33475248">Paediatric laryngeal squamous cell carcinoma: Systematic review and pooled analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mur T,
|
||
Jaleel Z,
|
||
Agarwal P,
|
||
Edwards H,
|
||
Levi JR</span><br />
|
||
<span class="medgenPMjournal">Clin Otolaryngol</span>
|
||
2021 May;46(3):494-500.
|
||
Epub 2021 Feb 2
|
||
doi: 10.1111/coa.13719.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33475248" target="_blank">33475248</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32608245">Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sharbel DD,
|
||
Abkemeier M,
|
||
Groves MW,
|
||
Albergotti WG,
|
||
Byrd JK,
|
||
Reyes-Gelves C</span><br />
|
||
<span class="medgenPMjournal">Ann Otol Rhinol Laryngol</span>
|
||
2021 Jan;130(1):67-77.
|
||
Epub 2020 Jul 1
|
||
doi: 10.1177/0003489420937744.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32608245" target="_blank">32608245</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26542064">Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gama RR,
|
||
Carvalho AL,
|
||
Longatto Filho A,
|
||
Scorsato AP,
|
||
López RV,
|
||
Rautava J,
|
||
Syrjänen S,
|
||
Syrjänen K</span><br />
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<span class="medgenPMjournal">Laryngoscope</span>
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2016 Apr;126(4):885-93.
|
||
Epub 2015 Nov 6
|
||
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|
||
<span class="bold">PMID: </span><a href="/pubmed/26542064" target="_blank">26542064</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laryngeal%20squamous%20cell%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div></div>
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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