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</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F35631587%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F35631587%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 35631587 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 35631587"/>
|
||
<input type="hidden" name="email-subject-hash" value="065ead566da69d0749c60a351c0382fa0740863a2107b4a30aba999dcc877f50"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="35631587">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://www.mdpi.com/resolver?pii=pharmaceutics14051001"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=6383&itool=Abstract-def&log$=linkouticon&uid=35631587&db=pubmed&nlmid=101534003"
|
||
title="See full text options at MDPI"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="MDPI"
|
||
data-ga-label="35631587"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--res.mdpi.com-data-pubmed-linkout.png" alt="MDPI full text link"><span class="text">
|
||
|
||
MDPI
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/35631587/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=35631587&db=pubmed&nlmid=101534003"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="35631587"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/35631587/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/35631587/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="35631587" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F35631587%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="W46TDei29ORtCIaFhGqSbpZBmtLOVCBrdRQYg4LoJpEXw9gvUZ3UFxvfUxt0Od9L"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger"
|
||
title="Open dialog with more actions to take"
|
||
ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region"><button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title">
|
||
Display options
|
||
</div><div class="content"><div class="format-container"><span class="option-label">
|
||
Format
|
||
</span><select name="format" data-initial-value="abstract" aria-label="Display format" id="sidebar-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div>
|
||
|
||
<div class="social-sharing">
|
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2022 May 6;14(5):1001.</span>
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A Comprehensive Overview of Globally Approved JAK Inhibitors
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<div class="publication-type" >Review</div>
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<h1 class="heading-title">
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A Comprehensive Overview of Globally Approved JAK Inhibitors
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Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of several genes involved in inflammatory, immune, and cancer conditions. Targeting the JAK family kinases with small-molecule inhibitors has proved to be effective in the treatment of different types of diseases. In the current review, eleven of the JAK inhibitors that received approval for clinical use have been discussed. These drugs are abrocitinib, baricitinib, delgocitinib, fedratinib, filgotinib, oclacitinib, pacritinib, peficitinib, ruxolitinib, tofacitinib, and upadacitinib. The aim of the current review was to provide an integrated overview of the chemical and pharmacological data of the globally approved JAK inhibitors. The synthetic routes of the eleven drugs were described. In addition, their inhibitory activities against different kinases and their pharmacological uses have also been explained. Moreover, their crystal structures with different kinases were summarized, with a primary focus on their binding modes and interactions. The proposed metabolic pathways and metabolites of these drugs were also illustrated. To sum up, the data in the current review could help in the design of new JAK inhibitors with potential therapeutic benefits in inflammatory and autoimmune diseases.
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Keywords:
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JAK; binding mode/interactions; kinase inhibitory activity; pharmacological uses; synthesis.
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<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">Authors declared that there is no conflict of interest and have approved the article.</p>
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</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="figures" id="figures">
|
||
<h2 class="title">
|
||
Figures
|
||
</h2>
|
||
|
||
<div class="figures-list" id="slides-container"
|
||
itemscope itemtype="http://schema.org/ImageGallery">
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="0"
|
||
data-label-slug="figure-1">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ca98d84dfea7/pharmaceutics-14-01001-g001.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-0"
|
||
role="button"
|
||
data-image-width="714"
|
||
data-image-height="219"
|
||
data-image-alt="Figure 1"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f001">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-0"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/45936693841f/pharmaceutics-14-01001-g001.gif"
|
||
alt="Figure 1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="714">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="219">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Domain structure of JAKs. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Domain structure of JAKs. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 1
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Domain structure of JAKs.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="1"
|
||
data-label-slug="figure-2">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/30fa75195807/pharmaceutics-14-01001-g002.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-1"
|
||
role="button"
|
||
data-image-width="756"
|
||
data-image-height="634"
|
||
data-image-alt="Figure 2"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f002">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-1"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8163a9b9c754/pharmaceutics-14-01001-g002.gif"
|
||
alt="Figure 2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="756">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="634">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK-STAT pathway. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK-STAT pathway. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK-STAT pathway.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="2"
|
||
data-label-slug="figure-3">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/bdbf00f37bdb/pharmaceutics-14-01001-g003.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-2"
|
||
role="button"
|
||
data-image-width="710"
|
||
data-image-height="367"
|
||
data-image-alt="Figure 3"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f003">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-2"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/c2b471f473c1/pharmaceutics-14-01001-g003.gif"
|
||
alt="Figure 3" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="710">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="367">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 3 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Classification of JAK inhibitors with… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 3 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Classification of JAK inhibitors with representative examples for each type. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 3
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Classification of JAK inhibitors with representative examples for each type.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="3"
|
||
data-label-slug="figure-4">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/62570011a763/pharmaceutics-14-01001-g004.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-3"
|
||
role="button"
|
||
data-image-width="700"
|
||
data-image-height="268"
|
||
data-image-alt="Figure 4"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f004">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-3"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/9d03cf8ddf83/pharmaceutics-14-01001-g004.gif"
|
||
alt="Figure 4" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="700">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="268">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK2 inhibitors, NVP-BBT594 and NVP-CHZ868. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK2 inhibitors, NVP-BBT594 and NVP-CHZ868. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 4
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK2 inhibitors, NVP-BBT594 and NVP-CHZ868.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="4"
|
||
data-label-slug="figure-5">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f4c9fec00a84/pharmaceutics-14-01001-g005.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-4"
|
||
role="button"
|
||
data-image-width="725"
|
||
data-image-height="177"
|
||
data-image-alt="Figure 5"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f005">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-4"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/2ee808b1f2e3/pharmaceutics-14-01001-g005.gif"
|
||
alt="Figure 5" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="725">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="177">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 5 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Allosteric JAKs inhibitors. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 5 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Allosteric JAKs inhibitors. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 5
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Allosteric JAKs inhibitors.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="5"
|
||
data-label-slug="figure-6">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a33e5e3127eb/pharmaceutics-14-01001-g006.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-5"
|
||
role="button"
|
||
data-image-width="730"
|
||
data-image-height="620"
|
||
data-image-alt="Figure 6"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f006">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-5"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/1ab60f08f91b/pharmaceutics-14-01001-g006.gif"
|
||
alt="Figure 6" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="730">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="620">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 covalent inhibitors. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 covalent inhibitors. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 6
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK3 covalent inhibitors.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="6"
|
||
data-label-slug="figure-7">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/eddf96cb3211/pharmaceutics-14-01001-g007.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-6"
|
||
role="button"
|
||
data-image-width="778"
|
||
data-image-height="451"
|
||
data-image-alt="Figure 7"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f007">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-6"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8a97bef5081c/pharmaceutics-14-01001-g007.gif"
|
||
alt="Figure 7" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="778">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="451">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 7 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 (pdb: 5TOZ) bound to… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 7 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 (pdb: 5TOZ) bound to ritlecitinib: ( <b> A </b> ) 3D representation of JAK3… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 7
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK3 (pdb: 5TOZ) bound to ritlecitinib: (<b>A</b>) 3D representation of JAK3 bound to ritlecitinib (shown as CPK); (<b>B</b>) 3D binding mode of ritlecitinib showing one covalent bond with Cys909, hydrogen bonds (shown as green-dotted lines), and multiple hydrophobic interactions, this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="7"
|
||
data-label-slug="figure-8">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/dcbe5a0683b2/pharmaceutics-14-01001-g008.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-7"
|
||
role="button"
|
||
data-image-width="789"
|
||
data-image-height="654"
|
||
data-image-alt="Figure 8"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f008">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-7"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/6c172c2f34e6/pharmaceutics-14-01001-g008.gif"
|
||
alt="Figure 8" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="789">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="654">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 8 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK1 (pdb: 6N7A) and JAK2… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 8 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK1 (pdb: 6N7A) and JAK2 (pdb: 2B7A) kinases bound to small-molecule inhibitors: (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 8
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK1 (pdb: 6N7A) and JAK2 (pdb: 2B7A) kinases bound to small-molecule inhibitors: (<b>A</b>) 3D representation of JAK1 bound to KEV (shown as CPK); (<b>B</b>) 3D binding mode of KEV into JAK1 showing the hydrogen bond interactions; (<b>C</b>) 3D representation of JAK2 bound to IZA (shown as CPK); (<b>D</b>) 3D binding mode of IZA into JAK2, hydrogen bonds are shown as green-dotted lines, this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="8"
|
||
data-label-slug="figure-9">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/e2681a80b949/pharmaceutics-14-01001-g009.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-8"
|
||
role="button"
|
||
data-image-width="718"
|
||
data-image-height="595"
|
||
data-image-alt="Figure 9"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f009">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-8"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/3fb508d9a840/pharmaceutics-14-01001-g009.gif"
|
||
alt="Figure 9" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="718">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="595">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 9 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 (pdb: 3PJC) and TYK2… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 9 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK3 (pdb: 3PJC) and TYK2 (pdb: 6VNX) kinases bound to small-molecule inhibitors: (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 9
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK3 (pdb: 3PJC) and TYK2 (pdb: 6VNX) kinases bound to small-molecule inhibitors: (<b>A</b>) 3D representation of JAK3 bound to PJC (shown as CPK); (<b>B</b>) 3D binding mode of PJC into JAK3; (<b>C</b>) 3D representation of TYK2 bound to R4V (shown as CPK); (<b>D</b>) 3D binding mode of R4V into TYK2, this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="9"
|
||
data-label-slug="figure-10">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/257e0ca80f26/pharmaceutics-14-01001-g010.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-9"
|
||
role="button"
|
||
data-image-width="770"
|
||
data-image-height="907"
|
||
data-image-alt="Figure 10"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f010">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-9"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7e3153caa12c/pharmaceutics-14-01001-g010.gif"
|
||
alt="Figure 10" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="770">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="907">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 10 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure of AG-490 and… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 10 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure of AG-490 and the globally proven JAK inhibitors with the dates… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-9" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 10
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure of AG-490 and the globally proven JAK inhibitors with the dates of their first approval.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="10"
|
||
data-label-slug="figure-11">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5bfababf82f8/pharmaceutics-14-01001-g011.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-10"
|
||
role="button"
|
||
data-image-width="703"
|
||
data-image-height="419"
|
||
data-image-alt="Figure 11"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f011">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-10"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7ebecd432518/pharmaceutics-14-01001-g011.gif"
|
||
alt="Figure 11" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="703">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="419">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 11 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of abrocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 11 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of abrocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-10" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 11
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of abrocitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="11"
|
||
data-label-slug="scheme-1">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7b8dcf5f6e94/pharmaceutics-14-01001-sch001.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-11"
|
||
role="button"
|
||
data-image-width="779"
|
||
data-image-height="327"
|
||
data-image-alt="Scheme 1"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch001">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-11"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/48ca4302aef0/pharmaceutics-14-01001-sch001.gif"
|
||
alt="Scheme 1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="779">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="327">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of abrocitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of abrocitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-11" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 1
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of abrocitinib (route 1).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="12"
|
||
data-label-slug="scheme-2">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/aaf4b5410dc9/pharmaceutics-14-01001-sch002.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-12"
|
||
role="button"
|
||
data-image-width="749"
|
||
data-image-height="542"
|
||
data-image-alt="Scheme 2"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch002">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-12"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/af8cc34ed30f/pharmaceutics-14-01001-sch002.gif"
|
||
alt="Scheme 2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="749">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="542">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of abrocitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of abrocitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-12" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of abrocitinib (route 2).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="13"
|
||
data-label-slug="figure-12">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/0276943460dd/pharmaceutics-14-01001-g012.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-13"
|
||
role="button"
|
||
data-image-width="794"
|
||
data-image-height="495"
|
||
data-image-alt="Figure 12"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f012">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-13"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/e3cc11fb5f9a/pharmaceutics-14-01001-g012.gif"
|
||
alt="Figure 12" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="794">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="495">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 12 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAKs inhibitory activities of abrocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 12 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAKs inhibitory activities of abrocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-13" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 12
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAKs inhibitory activities of abrocitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="14"
|
||
data-label-slug="figure-13">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a8e43932d4d9/pharmaceutics-14-01001-g013.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-14"
|
||
role="button"
|
||
data-image-width="775"
|
||
data-image-height="253"
|
||
data-image-alt="Figure 13"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f013">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-14"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/6367e83bbbe7/pharmaceutics-14-01001-g013.gif"
|
||
alt="Figure 13" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="775">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="253">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 13 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of abrocitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 13 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of abrocitinib (shown as sticks) into JAK1 (pdb: 6BBU): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-14" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 13
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of abrocitinib (shown as sticks) into JAK1 (pdb: 6BBU): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of binding interactions with amino acids in JAK1; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="15"
|
||
data-label-slug="figure-14">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5ccc29a173c1/pharmaceutics-14-01001-g014.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-15"
|
||
role="button"
|
||
data-image-width="745"
|
||
data-image-height="244"
|
||
data-image-alt="Figure 14"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f014">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-15"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f98233c96291/pharmaceutics-14-01001-g014.gif"
|
||
alt="Figure 14" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="745">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="244">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 14 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of abrocitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 14 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of abrocitinib (shown as sticks) into JAK2 (pdb: 6BBV): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-15" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 14
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of abrocitinib (shown as sticks) into JAK2 (pdb: 6BBV): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of binding interactions with amino acids in JAK2; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="16"
|
||
data-label-slug="figure-15">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/12611c2cd029/pharmaceutics-14-01001-g015.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-16"
|
||
role="button"
|
||
data-image-width="765"
|
||
data-image-height="591"
|
||
data-image-alt="Figure 15"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f015">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-16"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/86405b73beb9/pharmaceutics-14-01001-g015.gif"
|
||
alt="Figure 15" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="765">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="591">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 15 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 15 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites of abrocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-16" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 15
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and metabolites of abrocitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="17"
|
||
data-label-slug="figure-16">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/cab38ae532ae/pharmaceutics-14-01001-g016.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-17"
|
||
role="button"
|
||
data-image-width="706"
|
||
data-image-height="465"
|
||
data-image-alt="Figure 16"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f016">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-17"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/80fc5ac6dd02/pharmaceutics-14-01001-g016.gif"
|
||
alt="Figure 16" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="706">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="465">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 16 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of baricitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 16 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of baricitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-17" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 16
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of baricitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="18"
|
||
data-label-slug="scheme-3">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/34d406e19531/pharmaceutics-14-01001-sch003.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-18"
|
||
role="button"
|
||
data-image-width="790"
|
||
data-image-height="781"
|
||
data-image-alt="Scheme 3"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch003">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-18"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/33c51d7673d6/pharmaceutics-14-01001-sch003.gif"
|
||
alt="Scheme 3" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="790">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="781">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 3 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of baricitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 3 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of baricitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-18" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 3
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of baricitinib (route 1).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="19"
|
||
data-label-slug="scheme-4">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/2861fbb10794/pharmaceutics-14-01001-sch004.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-19"
|
||
role="button"
|
||
data-image-width="713"
|
||
data-image-height="473"
|
||
data-image-alt="Scheme 4"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch004">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-19"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ffe1487eaaf0/pharmaceutics-14-01001-sch004.gif"
|
||
alt="Scheme 4" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="713">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="473">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 4 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of baricitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 4 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of baricitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-19" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 4
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of baricitinib (route 2).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="20"
|
||
data-label-slug="figure-17">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/fe1abf7b73ef/pharmaceutics-14-01001-g017.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-20"
|
||
role="button"
|
||
data-image-width="695"
|
||
data-image-height="538"
|
||
data-image-alt="Figure 17"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f017">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-20"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/588155b6bfc3/pharmaceutics-14-01001-g017.gif"
|
||
alt="Figure 17" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="695">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="538">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 17 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAKs inhibitory activities of baricitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 17 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAKs inhibitory activities of baricitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-20" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 17
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAKs inhibitory activities of baricitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="21"
|
||
data-label-slug="figure-18">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ece54576d10f/pharmaceutics-14-01001-g018.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-21"
|
||
role="button"
|
||
data-image-width="753"
|
||
data-image-height="263"
|
||
data-image-alt="Figure 18"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f018">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-21"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/41ce2a975f1d/pharmaceutics-14-01001-g018.gif"
|
||
alt="Figure 18" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="753">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="263">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 18 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 18 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown as sticks) into BMP-2-inducible kinase (pdb: 4W9X): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-21" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 18
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of baricitinib (shown as sticks) into BMP-2-inducible kinase (pdb: 4W9X): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of binding interactions with amino acids in BMP-2-inducible kinase; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="22"
|
||
data-label-slug="figure-19">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/6e083d0ee1f5/pharmaceutics-14-01001-g019.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-22"
|
||
role="button"
|
||
data-image-width="770"
|
||
data-image-height="268"
|
||
data-image-alt="Figure 19"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f019">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-22"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/1f6581f12562/pharmaceutics-14-01001-g019.gif"
|
||
alt="Figure 19" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="770">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="268">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 19 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 19 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown as sticks) into JAK2 JH1 (pdb: 6VN8): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-22" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 19
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of baricitinib (shown as sticks) into JAK2 JH1 (pdb: 6VN8): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="23"
|
||
data-label-slug="figure-20">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/038448b0bfa3/pharmaceutics-14-01001-g020.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-23"
|
||
role="button"
|
||
data-image-width="768"
|
||
data-image-height="249"
|
||
data-image-alt="Figure 20"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f020">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-23"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ea5e71e81907/pharmaceutics-14-01001-g020.gif"
|
||
alt="Figure 20" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="768">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="249">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 20 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 20 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of baricitinib (shown as sticks) into human JAK2 JH1 (pdb: 6WTO):… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-23" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 20
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of baricitinib (shown as sticks) into human JAK2 JH1 (pdb: 6WTO): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="24"
|
||
data-label-slug="figure-21">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ac8b64851c8d/pharmaceutics-14-01001-g021.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-24"
|
||
role="button"
|
||
data-image-width="752"
|
||
data-image-height="497"
|
||
data-image-alt="Figure 21"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f021">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-24"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/dd1fff5af854/pharmaceutics-14-01001-g021.gif"
|
||
alt="Figure 21" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="752">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="497">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 21 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and major… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 21 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and major metabolites of baricitinib in human, asterisks indicate the… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-24" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 21
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and major metabolites of baricitinib in human, asterisks indicate the sites of oxidation.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="25"
|
||
data-label-slug="figure-22">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f7ecebedb6ee/pharmaceutics-14-01001-g022.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-25"
|
||
role="button"
|
||
data-image-width="696"
|
||
data-image-height="386"
|
||
data-image-alt="Figure 22"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f022">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-25"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a463a8356a66/pharmaceutics-14-01001-g022.gif"
|
||
alt="Figure 22" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="696">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="386">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 22 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of delgocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 22 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of delgocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-25" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 22
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of delgocitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="26"
|
||
data-label-slug="scheme-5">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/41678a503c73/pharmaceutics-14-01001-sch005.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-26"
|
||
role="button"
|
||
data-image-width="771"
|
||
data-image-height="683"
|
||
data-image-alt="Scheme 5"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch005">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-26"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/bdad4982ed98/pharmaceutics-14-01001-sch005.gif"
|
||
alt="Scheme 5" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="771">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="683">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 5 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of delgocitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 5 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of delgocitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-26" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 5
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of delgocitinib (route 1).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="27"
|
||
data-label-slug="scheme-6">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/06581c4eb530/pharmaceutics-14-01001-sch006.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-27"
|
||
role="button"
|
||
data-image-width="763"
|
||
data-image-height="555"
|
||
data-image-alt="Scheme 6"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch006">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-27"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f68c07b0d41a/pharmaceutics-14-01001-sch006.gif"
|
||
alt="Scheme 6" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="763">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="555">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of delgocitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of delgocitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-27" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 6
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of delgocitinib (route 2).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="28"
|
||
data-label-slug="figure-23">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/d0be3e595c7a/pharmaceutics-14-01001-g023.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-28"
|
||
role="button"
|
||
data-image-width="653"
|
||
data-image-height="460"
|
||
data-image-alt="Figure 23"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f023">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-28"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/095146c394a6/pharmaceutics-14-01001-g023.gif"
|
||
alt="Figure 23" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="653">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="460">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 23 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of delgocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 23 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of delgocitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-28" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 23
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of delgocitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="29"
|
||
data-label-slug="figure-24">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/dec1e16ea91c/pharmaceutics-14-01001-g024.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-29"
|
||
role="button"
|
||
data-image-width="746"
|
||
data-image-height="253"
|
||
data-image-alt="Figure 24"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f024">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-29"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/498c7c62cf41/pharmaceutics-14-01001-g024.gif"
|
||
alt="Figure 24" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="746">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="253">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 24 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of delgocitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 24 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of delgocitinib (shown as sticks) into JAK3 (pdb: 7C3N): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-29" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 24
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of delgocitinib (shown as sticks) into JAK3 (pdb: 7C3N): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK3; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="30"
|
||
data-label-slug="figure-25">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/bfdeb19156df/pharmaceutics-14-01001-g025.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-30"
|
||
role="button"
|
||
data-image-width="787"
|
||
data-image-height="223"
|
||
data-image-alt="Figure 25"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f025">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-30"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/fc007c1a77b6/pharmaceutics-14-01001-g025.gif"
|
||
alt="Figure 25" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="787">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="223">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 25 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and major… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 25 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and major metabolites of delgocitinib based on the data of… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-30" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 25
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and major metabolites of delgocitinib based on the data of the deliberation results [103].</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="31"
|
||
data-label-slug="figure-26">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/380b16e44518/pharmaceutics-14-01001-g026.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-31"
|
||
role="button"
|
||
data-image-width="710"
|
||
data-image-height="415"
|
||
data-image-alt="Figure 26"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f026">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-31"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/965098e8a2e9/pharmaceutics-14-01001-g026.gif"
|
||
alt="Figure 26" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="710">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="415">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 26 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of fedratinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 26 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of fedratinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-31" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 26
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of fedratinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="32"
|
||
data-label-slug="scheme-7">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/0934544ae69c/pharmaceutics-14-01001-sch007.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-32"
|
||
role="button"
|
||
data-image-width="744"
|
||
data-image-height="645"
|
||
data-image-alt="Scheme 7"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch007">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-32"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/388a33870bf0/pharmaceutics-14-01001-sch007.gif"
|
||
alt="Scheme 7" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="744">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="645">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 7 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of fedratinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 7 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of fedratinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-32" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 7
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of fedratinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="33"
|
||
data-label-slug="figure-27">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a2fabe2d88ca/pharmaceutics-14-01001-g027.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-33"
|
||
role="button"
|
||
data-image-width="752"
|
||
data-image-height="404"
|
||
data-image-alt="Figure 27"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f027">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-33"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/492845f4e7e9/pharmaceutics-14-01001-g027.gif"
|
||
alt="Figure 27" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="752">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="404">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 27 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of fedratinib… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 27 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of fedratinib (* fold selectivity compared with JAK2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-33" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 27
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of fedratinib (* fold selectivity compared with JAK2).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="34"
|
||
data-label-slug="figure-28">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/b1de32b6c26d/pharmaceutics-14-01001-g028.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-34"
|
||
role="button"
|
||
data-image-width="734"
|
||
data-image-height="261"
|
||
data-image-alt="Figure 28"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f028">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-34"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7e6fd2028779/pharmaceutics-14-01001-g028.gif"
|
||
alt="Figure 28" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="734">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="261">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 28 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 28 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown as sticks) into human bromodomain BRD4 (pdb: 4OGJ):… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-34" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 28
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of fedratinib (shown as sticks) into human bromodomain BRD4 (pdb: 4OGJ): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with BRD4; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="35"
|
||
data-label-slug="figure-29">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/c9f729141544/pharmaceutics-14-01001-g029.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-35"
|
||
role="button"
|
||
data-image-width="754"
|
||
data-image-height="282"
|
||
data-image-alt="Figure 29"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f029">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-35"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/27819ec54468/pharmaceutics-14-01001-g029.gif"
|
||
alt="Figure 29" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="754">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="282">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 29 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 29 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown as sticks) into human bromodomain BRD4 (pdb: 4PS5):… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-35" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 29
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of fedratinib (shown as sticks) into human bromodomain BRD4 (pdb: 4PS5): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with BRD4; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="36"
|
||
data-label-slug="figure-30">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/1ddc49e26410/pharmaceutics-14-01001-g030.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-36"
|
||
role="button"
|
||
data-image-width="796"
|
||
data-image-height="274"
|
||
data-image-alt="Figure 30"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f030">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-36"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/818e2bf096f3/pharmaceutics-14-01001-g030.gif"
|
||
alt="Figure 30" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="796">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="274">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 30 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 30 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of fedratinib (shown as sticks) into JAK2 JH1 (pdb: 6VNE): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-36" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 30
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of fedratinib (shown as sticks) into JAK2 JH1 (pdb: 6VNE): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; the figure was generated using Discovery Studio Visualizer.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="37"
|
||
data-label-slug="figure-31">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/33594e69df2d/pharmaceutics-14-01001-g031.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-37"
|
||
role="button"
|
||
data-image-width="741"
|
||
data-image-height="798"
|
||
data-image-alt="Figure 31"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f031">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-37"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/cd183d3a1eb9/pharmaceutics-14-01001-g031.gif"
|
||
alt="Figure 31" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="741">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="798">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 31 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathway and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 31 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathway and metabolites of fedratinib in humans. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-37" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 31
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathway and metabolites of fedratinib in humans.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="38"
|
||
data-label-slug="figure-32">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/04369a8867c4/pharmaceutics-14-01001-g032.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-38"
|
||
role="button"
|
||
data-image-width="752"
|
||
data-image-height="473"
|
||
data-image-alt="Figure 32"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f032">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-38"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7945eac8403a/pharmaceutics-14-01001-g032.gif"
|
||
alt="Figure 32" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="752">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="473">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 32 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 32 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-38" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 32
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of filgotinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="39"
|
||
data-label-slug="scheme-8">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8f3daa4e63f8/pharmaceutics-14-01001-sch008.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-39"
|
||
role="button"
|
||
data-image-width="785"
|
||
data-image-height="583"
|
||
data-image-alt="Scheme 8"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch008">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-39"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/31e2fa0f0f02/pharmaceutics-14-01001-sch008.gif"
|
||
alt="Scheme 8" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="785">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="583">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 8 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 8 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-39" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 8
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of filgotinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="40"
|
||
data-label-slug="figure-33">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/10fccc06b08f/pharmaceutics-14-01001-g033.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-40"
|
||
role="button"
|
||
data-image-width="726"
|
||
data-image-height="369"
|
||
data-image-alt="Figure 33"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f033">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-40"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5dee82d043d3/pharmaceutics-14-01001-g033.gif"
|
||
alt="Figure 33" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="726">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="369">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 33 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of filgotinib,… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 33 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of filgotinib, * indicates the IC <sub> 50 </sub> and index selectivity… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-40" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 33
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of filgotinib, * indicates the IC<sub>50</sub> and index selectivity values determined using recombinant JAKs, ** indicates the IC<sub>50</sub> values determined using a human whole blood assay [116,117].</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="41"
|
||
data-label-slug="figure-34">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/43204037cfbc/pharmaceutics-14-01001-g034.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-41"
|
||
role="button"
|
||
data-image-width="758"
|
||
data-image-height="254"
|
||
data-image-alt="Figure 34"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f034">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-41"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f791346ed3a7/pharmaceutics-14-01001-g034.gif"
|
||
alt="Figure 34" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="758">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="254">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 34 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of filgotinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 34 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of filgotinib (shown as sticks) into JAK1 (pdb: 4P7E): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-41" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 34
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of filgotinib (shown as sticks) into JAK1 (pdb: 4P7E): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK1; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="42"
|
||
data-label-slug="figure-35">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/58fd177621c7/pharmaceutics-14-01001-g035.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-42"
|
||
role="button"
|
||
data-image-width="756"
|
||
data-image-height="257"
|
||
data-image-alt="Figure 35"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f035">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-42"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f1637e485692/pharmaceutics-14-01001-g035.gif"
|
||
alt="Figure 35" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="756">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="257">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 35 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of filgotinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 35 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of filgotinib (shown as sticks) into JAK2 JH2 (pdb: 5UT5): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-42" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 35
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of filgotinib (shown as sticks) into JAK2 JH2 (pdb: 5UT5): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH2; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="43"
|
||
data-label-slug="figure-36">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f91a9ef20d64/pharmaceutics-14-01001-g036.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-43"
|
||
role="button"
|
||
data-image-width="766"
|
||
data-image-height="234"
|
||
data-image-alt="Figure 36"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f036">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-43"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/516b3503232d/pharmaceutics-14-01001-g036.gif"
|
||
alt="Figure 36" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="766">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="234">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 36 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathway of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 36 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathway of filgotinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-43" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 36
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathway of filgotinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="44"
|
||
data-label-slug="figure-37">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/60ef84d294d4/pharmaceutics-14-01001-g037.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-44"
|
||
role="button"
|
||
data-image-width="779"
|
||
data-image-height="415"
|
||
data-image-alt="Figure 37"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f037">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-44"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/65f1c90ee4bd/pharmaceutics-14-01001-g037.gif"
|
||
alt="Figure 37" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="779">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="415">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 37 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 37 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-44" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 37
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of oclacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="45"
|
||
data-label-slug="scheme-9">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/c12d579a22e5/pharmaceutics-14-01001-sch009.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-45"
|
||
role="button"
|
||
data-image-width="768"
|
||
data-image-height="551"
|
||
data-image-alt="Scheme 9"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch009">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-45"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8168df3e77dc/pharmaceutics-14-01001-sch009.gif"
|
||
alt="Scheme 9" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="768">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="551">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 9 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 9 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-45" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 9
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of oclacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="46"
|
||
data-label-slug="figure-38">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/4056d1419a34/pharmaceutics-14-01001-g038.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-46"
|
||
role="button"
|
||
data-image-width="774"
|
||
data-image-height="278"
|
||
data-image-alt="Figure 38"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f038">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-46"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a1252394bdda/pharmaceutics-14-01001-g038.gif"
|
||
alt="Figure 38" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="774">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="278">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 38 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 38 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of oclacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-46" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 38
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of oclacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="47"
|
||
data-label-slug="figure-39">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/3988cb1036bc/pharmaceutics-14-01001-g039.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-47"
|
||
role="button"
|
||
data-image-width="714"
|
||
data-image-height="305"
|
||
data-image-alt="Figure 39"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f039">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-47"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8a64a2fa673f/pharmaceutics-14-01001-g039.gif"
|
||
alt="Figure 39" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="714">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="305">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 39 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure, name, and synonyms… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 39 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure, name, and synonyms of pacritinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-47" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 39
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure, name, and synonyms of pacritinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="48"
|
||
data-label-slug="scheme-10">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/918b18b61be2/pharmaceutics-14-01001-sch010.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-48"
|
||
role="button"
|
||
data-image-width="794"
|
||
data-image-height="641"
|
||
data-image-alt="Scheme 10"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch010">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-48"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/10d5035ef9cc/pharmaceutics-14-01001-sch010.gif"
|
||
alt="Scheme 10" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="794">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="641">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 10 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of pacritinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 10 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of pacritinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-48" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 10
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of pacritinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="49"
|
||
data-label-slug="figure-40">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/8f88288cc493/pharmaceutics-14-01001-g040.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-49"
|
||
role="button"
|
||
data-image-width="751"
|
||
data-image-height="216"
|
||
data-image-alt="Figure 40"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f040">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-49"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a3525bac8ae6/pharmaceutics-14-01001-g040.gif"
|
||
alt="Figure 40" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="751">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="216">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 40 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activities of pacritinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 40 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activities of pacritinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-49" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 40
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activities of pacritinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="50"
|
||
data-label-slug="figure-41">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/1a6ca9188f0a/pharmaceutics-14-01001-g041.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-50"
|
||
role="button"
|
||
data-image-width="792"
|
||
data-image-height="313"
|
||
data-image-alt="Figure 41"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f041">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-50"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7e5622ce7098/pharmaceutics-14-01001-g041.gif"
|
||
alt="Figure 41" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="792">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="313">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 41 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of pacritinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 41 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of pacritinib (shown as sticks) into human quinone reductase 2 (NQO2)… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-50" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 41
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of pacritinib (shown as sticks) into human quinone reductase 2 (NQO2) (pdb: 5LBZ): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of binding interactions; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="51"
|
||
data-label-slug="figure-42">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/281e97c9de1f/pharmaceutics-14-01001-g042.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-51"
|
||
role="button"
|
||
data-image-width="775"
|
||
data-image-height="611"
|
||
data-image-alt="Figure 42"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f042">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-51"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/cfb9eb794bcc/pharmaceutics-14-01001-g042.gif"
|
||
alt="Figure 42" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="775">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="611">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 42 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 42 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites of pacritinib in human and mouse plasma. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-51" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 42
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and metabolites of pacritinib in human and mouse plasma.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="52"
|
||
data-label-slug="figure-43">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7c89d39bca3f/pharmaceutics-14-01001-g043.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-52"
|
||
role="button"
|
||
data-image-width="737"
|
||
data-image-height="433"
|
||
data-image-alt="Figure 43"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f043">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-52"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/795102238046/pharmaceutics-14-01001-g043.gif"
|
||
alt="Figure 43" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="737">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="433">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 43 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 43 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-52" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 43
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of peficitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="53"
|
||
data-label-slug="scheme-11">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/65893a83c0b6/pharmaceutics-14-01001-sch011.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-53"
|
||
role="button"
|
||
data-image-width="734"
|
||
data-image-height="600"
|
||
data-image-alt="Scheme 11"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch011">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-53"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ee96f33f30d4/pharmaceutics-14-01001-sch011.gif"
|
||
alt="Scheme 11" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="734">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="600">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 11 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 11 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-53" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 11
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of peficitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="54"
|
||
data-label-slug="figure-44">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a53b3cf4c7bd/pharmaceutics-14-01001-g044.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-54"
|
||
role="button"
|
||
data-image-width="702"
|
||
data-image-height="406"
|
||
data-image-alt="Figure 44"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f044">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-54"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/24354284306f/pharmaceutics-14-01001-g044.gif"
|
||
alt="Figure 44" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="702">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="406">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 44 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activities of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 44 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activities of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-54" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 44
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activities of peficitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="55"
|
||
data-label-slug="figure-45">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/d71768124cf5/pharmaceutics-14-01001-g045.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-55"
|
||
role="button"
|
||
data-image-width="721"
|
||
data-image-height="278"
|
||
data-image-alt="Figure 45"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f045">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-55"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/63c1c8201039/pharmaceutics-14-01001-g045.gif"
|
||
alt="Figure 45" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="721">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="278">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 45 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 45 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown as sticks) into JAK1 (pdb: 6AAH): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-55" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 45
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of peficitinib (shown as sticks) into JAK1 (pdb: 6AAH): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK1; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="56"
|
||
data-label-slug="figure-46">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/6048ce55ec42/pharmaceutics-14-01001-g046.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-56"
|
||
role="button"
|
||
data-image-width="780"
|
||
data-image-height="258"
|
||
data-image-alt="Figure 46"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f046">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-56"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/97ab1dbad0ed/pharmaceutics-14-01001-g046.gif"
|
||
alt="Figure 46" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="780">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="258">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 46 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 46 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown as sticks) into JAK2 (pdb: 6AAJ): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-56" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 46
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of peficitinib (shown as sticks) into JAK2 (pdb: 6AAJ): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="57"
|
||
data-label-slug="figure-47">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7814847e99e2/pharmaceutics-14-01001-g047.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-57"
|
||
role="button"
|
||
data-image-width="755"
|
||
data-image-height="252"
|
||
data-image-alt="Figure 47"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f047">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-57"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/d8ee15b96bcb/pharmaceutics-14-01001-g047.gif"
|
||
alt="Figure 47" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="755">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="252">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 47 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 47 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown as sticks) into JAK3 (pdb: 6AAK): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-57" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 47
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of peficitinib (shown as sticks) into JAK3 (pdb: 6AAK): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK3; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="58"
|
||
data-label-slug="figure-48">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/9ba9dedb33e8/pharmaceutics-14-01001-g048.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-58"
|
||
role="button"
|
||
data-image-width="769"
|
||
data-image-height="264"
|
||
data-image-alt="Figure 48"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f048">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-58"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/a6682bfba493/pharmaceutics-14-01001-g048.gif"
|
||
alt="Figure 48" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="769">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="264">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 48 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 48 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of peficitinib (shown as sticks) into TYK2 (pdb: 6AAM): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-58" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 48
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of peficitinib (shown as sticks) into TYK2 (pdb: 6AAM): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with TYK2; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="59"
|
||
data-label-slug="figure-49">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/3fc72c0d85dd/pharmaceutics-14-01001-g049.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-59"
|
||
role="button"
|
||
data-image-width="766"
|
||
data-image-height="555"
|
||
data-image-alt="Figure 49"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f049">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-59"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7623d5ee6828/pharmaceutics-14-01001-g049.gif"
|
||
alt="Figure 49" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="766">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="555">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 49 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 49 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites of peficitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-59" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 49
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and metabolites of peficitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="60"
|
||
data-label-slug="figure-50">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ead27ee2c255/pharmaceutics-14-01001-g050.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-60"
|
||
role="button"
|
||
data-image-width="779"
|
||
data-image-height="539"
|
||
data-image-alt="Figure 50"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f050">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-60"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/626b9846a621/pharmaceutics-14-01001-g050.gif"
|
||
alt="Figure 50" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="779">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="539">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 50 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of ruxolitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 50 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of ruxolitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-60" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 50
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of ruxolitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="61"
|
||
data-label-slug="scheme-12">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/58e4ffb92c2c/pharmaceutics-14-01001-sch012.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-61"
|
||
role="button"
|
||
data-image-width="799"
|
||
data-image-height="448"
|
||
data-image-alt="Scheme 12"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch012">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-61"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7f1ff883d111/pharmaceutics-14-01001-sch012.gif"
|
||
alt="Scheme 12" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="799">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="448">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 12 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of ruxolitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 12 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of ruxolitinib (route 1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-61" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 12
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of ruxolitinib (route 1).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="62"
|
||
data-label-slug="scheme-13">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/250572f6c136/pharmaceutics-14-01001-sch013.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-62"
|
||
role="button"
|
||
data-image-width="743"
|
||
data-image-height="615"
|
||
data-image-alt="Scheme 13"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch013">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-62"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/29182c065463/pharmaceutics-14-01001-sch013.gif"
|
||
alt="Scheme 13" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="743">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="615">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 13 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of ruxolitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 13 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of ruxolitinib (route 2). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-62" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 13
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of ruxolitinib (route 2).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="63"
|
||
data-label-slug="figure-51">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/faaa69e5a5a3/pharmaceutics-14-01001-g051.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-63"
|
||
role="button"
|
||
data-image-width="704"
|
||
data-image-height="532"
|
||
data-image-alt="Figure 51"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f051">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-63"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/0723f7631e2e/pharmaceutics-14-01001-g051.gif"
|
||
alt="Figure 51" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="704">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="532">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 51 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinases inhibitory activity of ruxolitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 51 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinases inhibitory activity of ruxolitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-63" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 51
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinases inhibitory activity of ruxolitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="64"
|
||
data-label-slug="figure-52">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/651881b94b45/pharmaceutics-14-01001-g052.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-64"
|
||
role="button"
|
||
data-image-width="771"
|
||
data-image-height="254"
|
||
data-image-alt="Figure 52"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f052">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-64"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ca59606dc492/pharmaceutics-14-01001-g052.gif"
|
||
alt="Figure 52" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="771">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="254">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 52 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 52 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown as sticks) into JAK2 JH1 (pdb: 6VGL): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-64" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 52
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of ruxolitinib (shown as sticks) into JAK2 JH1 (pdb: 6VGL): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="65"
|
||
data-label-slug="figure-53">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/134f9d88642f/pharmaceutics-14-01001-g053.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-65"
|
||
role="button"
|
||
data-image-width="788"
|
||
data-image-height="236"
|
||
data-image-alt="Figure 53"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f053">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-65"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/4eae4687af88/pharmaceutics-14-01001-g053.gif"
|
||
alt="Figure 53" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="788">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="236">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 53 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 53 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown as sticks) into human JAK2 JH1 (pdb: 6WTN):… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-65" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 53
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of ruxolitinib (shown as sticks) into human JAK2 JH1 (pdb: 6WTN): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="66"
|
||
data-label-slug="figure-54">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5d4f531d8564/pharmaceutics-14-01001-g054.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-66"
|
||
role="button"
|
||
data-image-width="770"
|
||
data-image-height="229"
|
||
data-image-alt="Figure 54"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f054">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-66"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/dd7b51e3f01d/pharmaceutics-14-01001-g054.gif"
|
||
alt="Figure 54" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="770">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="229">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 54 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 54 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown as sticks) into JAK2 JH1 (pdb: 6VNK): (… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-66" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 54
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of ruxolitinib (shown as sticks) into JAK2 JH1 (pdb: 6VNK): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2 JH1; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="67"
|
||
data-label-slug="figure-55">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/7812ea69bff1/pharmaceutics-14-01001-g055.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-67"
|
||
role="button"
|
||
data-image-width="767"
|
||
data-image-height="262"
|
||
data-image-alt="Figure 55"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f055">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-67"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/4c317c4ce32a/pharmaceutics-14-01001-g055.gif"
|
||
alt="Figure 55" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="767">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="262">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 55 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 55 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown as sticks) into c-Src (pdb: 4U5J): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-67" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 55
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of ruxolitinib (shown as sticks) into c-Src (pdb: 4U5J): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with c-Src; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="68"
|
||
data-label-slug="figure-56">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/e9f639694d8a/pharmaceutics-14-01001-g056.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-68"
|
||
role="button"
|
||
data-image-width="777"
|
||
data-image-height="234"
|
||
data-image-alt="Figure 56"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f056">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-68"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/d1e6f966791c/pharmaceutics-14-01001-g056.gif"
|
||
alt="Figure 56" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="777">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="234">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 56 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 56 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of ruxolitinib (shown as sticks) into the DCLK1 kinase domain (pdb:… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-68" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 56
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of ruxolitinib (shown as sticks) into the DCLK1 kinase domain (pdb: 7F3G): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with DCLK1 kinase domain; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="69"
|
||
data-label-slug="figure-57">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/9acaa97dce06/pharmaceutics-14-01001-g057.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-69"
|
||
role="button"
|
||
data-image-width="763"
|
||
data-image-height="761"
|
||
data-image-alt="Figure 57"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f057">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-69"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5c6f10a00e32/pharmaceutics-14-01001-g057.gif"
|
||
alt="Figure 57" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="763">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="761">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 57 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 57 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites of ruxolitinib in humans. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-69" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 57
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and metabolites of ruxolitinib in humans.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="70"
|
||
data-label-slug="figure-58">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/4fd0bc70bf7f/pharmaceutics-14-01001-g058.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-70"
|
||
role="button"
|
||
data-image-width="694"
|
||
data-image-height="324"
|
||
data-image-alt="Figure 58"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f058">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-70"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/56ab45159b64/pharmaceutics-14-01001-g058.gif"
|
||
alt="Figure 58" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="694">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="324">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 58 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of tofacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 58 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of tofacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-70" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 58
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of tofacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="71"
|
||
data-label-slug="scheme-14">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/86cbd7f4faae/pharmaceutics-14-01001-sch014.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-71"
|
||
role="button"
|
||
data-image-width="787"
|
||
data-image-height="575"
|
||
data-image-alt="Scheme 14"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-sch014">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-71"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/c395cc347e13/pharmaceutics-14-01001-sch014.gif"
|
||
alt="Scheme 14" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="787">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="575">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 14 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of tofacitinib citrate. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Scheme 14 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of tofacitinib citrate. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-71" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Scheme 14
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of tofacitinib citrate.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="72"
|
||
data-label-slug="figure-59">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/3216603310a1/pharmaceutics-14-01001-g059.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-72"
|
||
role="button"
|
||
data-image-width="658"
|
||
data-image-height="364"
|
||
data-image-alt="Figure 59"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f059">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-72"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/42452b7fc133/pharmaceutics-14-01001-g059.gif"
|
||
alt="Figure 59" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="658">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="364">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 59 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of tofacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 59 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of tofacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-72" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 59
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of tofacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="73"
|
||
data-label-slug="figure-60">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/b6762d60ce8f/pharmaceutics-14-01001-g060.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-73"
|
||
role="button"
|
||
data-image-width="787"
|
||
data-image-height="248"
|
||
data-image-alt="Figure 60"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f060">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-73"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/ffde0bf43042/pharmaceutics-14-01001-g060.gif"
|
||
alt="Figure 60" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="787">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="248">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 60 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 60 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown as sticks) into JAK1 (pdb: 3EYG): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-73" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 60
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of tofacitinib (shown as sticks) into JAK1 (pdb: 3EYG): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK1; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="74"
|
||
data-label-slug="figure-61">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/dc7aaa5c4d25/pharmaceutics-14-01001-g061.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-74"
|
||
role="button"
|
||
data-image-width="773"
|
||
data-image-height="241"
|
||
data-image-alt="Figure 61"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f061">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-74"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/f93351ee5431/pharmaceutics-14-01001-g061.gif"
|
||
alt="Figure 61" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="773">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="241">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 61 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 61 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown as sticks) into JAK2 (pdb: 3FUP): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-74" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 61
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of tofacitinib (shown as sticks) into JAK2 (pdb: 3FUP): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK2; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="75"
|
||
data-label-slug="figure-62">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/64b522f92907/pharmaceutics-14-01001-g062.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-75"
|
||
role="button"
|
||
data-image-width="781"
|
||
data-image-height="248"
|
||
data-image-alt="Figure 62"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f062">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-75"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/5df9cb7b1184/pharmaceutics-14-01001-g062.gif"
|
||
alt="Figure 62" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="781">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="248">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 62 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 62 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown as sticks) into JAK3 (pdb: 3LXK): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-75" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 62
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of tofacitinib (shown as sticks) into JAK3 (pdb: 3LXK): (<b>A</b>) 3D binding mode, receptor depicted as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with JAK3; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="76"
|
||
data-label-slug="figure-63">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/cb707044ac49/pharmaceutics-14-01001-g063.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-76"
|
||
role="button"
|
||
data-image-width="783"
|
||
data-image-height="242"
|
||
data-image-alt="Figure 63"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f063">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-76"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/0083c91e6ebe/pharmaceutics-14-01001-g063.gif"
|
||
alt="Figure 63" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="783">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="242">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 63 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 63 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown as sticks) into TYK2 (pdb: 3LXN): ( <b> A… </b> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-76" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 63
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of tofacitinib (shown as sticks) into TYK2 (pdb: 3LXN): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with TYK2; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="77"
|
||
data-label-slug="figure-64">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/0a12aead2f46/pharmaceutics-14-01001-g064.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-77"
|
||
role="button"
|
||
data-image-width="781"
|
||
data-image-height="252"
|
||
data-image-alt="Figure 64"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f064">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-77"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/2aa1590aa70e/pharmaceutics-14-01001-g064.gif"
|
||
alt="Figure 64" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="781">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="252">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 64 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 64 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Binding modes of tofacitinib (shown as sticks) into the PRK1 catalytic domain (pdb:… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-77" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 64
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Binding modes of tofacitinib (shown as sticks) into the PRK1 catalytic domain (pdb: 4OTI): (<b>A</b>) 3D binding mode, receptor shown as a hydrogen bond surface; (<b>B</b>) 2D binding mode showing different types of interactions with PRK1 catalytic domain; hydrogen atoms were omitted for clarity; this figure was generated using Discovery Studio Visualizer (V16.1.0.15350).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="78"
|
||
data-label-slug="figure-65">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/bbf73d32cb0a/pharmaceutics-14-01001-g065.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-78"
|
||
role="button"
|
||
data-image-width="798"
|
||
data-image-height="657"
|
||
data-image-alt="Figure 65"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f065">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-78"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/2d6e8ad74f23/pharmaceutics-14-01001-g065.gif"
|
||
alt="Figure 65" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="798">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="657">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 65 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 65 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Proposed metabolic pathways and metabolites of tofacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-78" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 65
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Proposed metabolic pathways and metabolites of tofacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item tail"
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="79"
|
||
data-label-slug="figure-66">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/e85ec3cd0642/pharmaceutics-14-01001-g066.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-79"
|
||
role="button"
|
||
data-image-width="696"
|
||
data-image-height="467"
|
||
data-image-alt="Figure 66"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f066">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-79"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/9dab1a6d2f2a/pharmaceutics-14-01001-g066.gif"
|
||
alt="Figure 66" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="696">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="467">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 66 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of upadacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
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<strong class="figure-label">
|
||
<p> Figure 66 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Chemical structure/name/synonyms of upadacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
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|
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<strong class="figure-label">
|
||
Figure 66
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Chemical structure/name/synonyms of upadacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
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alt="Scheme 15" />
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<p> Scheme 15 </p>
|
||
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||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of upadacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
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<strong class="figure-label">
|
||
<p> Scheme 15 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Synthesis of upadacitinib. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-80" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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||
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||
<strong class="figure-label">
|
||
Scheme 15
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Synthesis of upadacitinib.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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<figure class="figure-item tail"
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itemscope itemtype="http://schema.org/ImageObject"
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data-image-alt="Figure 67"
|
||
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|
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data-figure-id="pharmaceutics-14-01001-f067">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-81"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/6a32dc656120/pharmaceutics-14-01001-g067.gif"
|
||
alt="Figure 67" />
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<strong class="figure-label">
|
||
<p> Figure 67 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of upadacitinib… </p></div>
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||
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||
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||
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||
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||
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|
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</div>
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<strong class="figure-label">
|
||
<p> Figure 67 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Kinase inhibitory activity of upadacitinib (* FS, fold selectivity compared to JAK1). </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
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<figcaption id="figure-caption-81" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
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Figure 67
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Kinase inhibitory activity of upadacitinib (* FS, fold selectivity compared to JAK1).</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
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||
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||
</figure>
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<figure class="figure-item tail"
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data-label-slug="figure-68">
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<a class="figure-link"
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itemprop="contentUrl"
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aria-describedby="figure-caption-82"
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role="button"
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data-image-width="760"
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data-image-height="426"
|
||
data-image-alt="Figure 68"
|
||
data-pmc-id="PMC9146299"
|
||
data-figure-id="pharmaceutics-14-01001-f068">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
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id="article-image-82"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa4/9146299/c48a891bc399/pharmaceutics-14-01001-g068.gif"
|
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||
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||
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<strong class="figure-label">
|
||
<p> Figure 68 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK inhibitors under development. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
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|
||
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||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 68 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> JAK inhibitors under development. </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-82" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 68
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">JAK inhibitors under development.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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|
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Wilks A.F. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 1989;86:1603–1607. doi: 10.1073/pnas.86.5.1603.
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Banerjee S., Biehl A., Gadina M., Hasni S., Schwartz D.M. JAK-STAT signaling as a target for inflammatory and autoimmune diseases: Current and future prospects. Drugs. 2017;77:521–546. doi: 10.1007/s40265-017-0701-9.
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