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</div>
|
||
|
||
<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
|
||
<a href="/help/"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="user_guide">
|
||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33947203%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33947203%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 33947203 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 33947203"/>
|
||
<input type="hidden" name="email-subject-hash" value="18d8dcc2b7c75d4d6fddd710d60eb444a959dbcbd110efa7baa750cea41729c2"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="33947203">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.120.053033?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=4487&itool=Abstract-def&log$=linkouticon&uid=33947203&db=pubmed&nlmid=0147763"
|
||
title="See full text options at Atypon"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Atypon"
|
||
data-ga-label="33947203"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.ahajournals.org-pb-assets-pubmed-images-CSA-OA.gif" alt="Atypon full text link"><span class="text">
|
||
|
||
Atypon
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/33947203/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=33947203&db=pubmed&nlmid=0147763"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="33947203"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/33947203/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/33947203/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="33947203" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F33947203%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="1Gl0ApW2bpwjbFGDJm2j84mlBxsKM32Jit55dfpoL0jN56MtmFFlCcSZ9BaWFEA3"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger"
|
||
title="Open dialog with more actions to take"
|
||
ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region"><button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2021 Jul 6;144(1):7-19.</span>
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Evidence-Based Assessment of Genes in Dilated Cardiomyopathy
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data-ga-label="Cynthia A James">Cynthia A James</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.B., C.A.J., B.M.)." href="#full-view-affiliation-5" ref="linksrc=author_aff">
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5
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data-ga-label="Olga Jarinova">Olga Jarinova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada (L.B., O.J.)." href="#full-view-affiliation-3" ref="linksrc=author_aff">
|
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3
|
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Laboratory and Pathology Medicine, University of Ottawa, Ontario, Canada (L.B., O.J.)." href="#full-view-affiliation-4" ref="linksrc=author_aff">
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4
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Renee Johnson">Renee Johnson</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Victor Chang Cardiac Research Institute, Sydney, Australia (R.J.)." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
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10
|
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of New South Wales, Sydney, Australia (R.J.)." href="#full-view-affiliation-11" ref="linksrc=author_aff">
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11
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data-ga-label="Daniel P Judge">Daniel P Judge</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (D.P.J.)." href="#full-view-affiliation-12" ref="linksrc=author_aff">
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12
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Najim Lahrouchi">Najim Lahrouchi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.)." href="#full-view-affiliation-13" ref="linksrc=author_aff">
|
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13
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Ronald H Lekanne Deprez">Ronald H Lekanne Deprez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Genetics, Amsterdam University Medical Center location Academic Medical Center, the Netherlands (R.H.L.D.)." href="#full-view-affiliation-14" ref="linksrc=author_aff">
|
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14
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="R Thomas Lumbers">R Thomas Lumbers</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Health Informatics, University College London, London, UK (R.T.L.)." href="#full-view-affiliation-15" ref="linksrc=author_aff">
|
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15
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Health Data Research UK London, University College London, UK (R.T.L.)." href="#full-view-affiliation-16" ref="linksrc=author_aff">
|
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16
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="University College London British Heart Foundation Research Accelerator, London, United Kingdom (R.T.L.)." href="#full-view-affiliation-17" ref="linksrc=author_aff">
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17
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Francesco Mazzarotto">Francesco Mazzarotto</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware)." href="#full-view-affiliation-18" ref="linksrc=author_aff">
|
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18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware)." href="#full-view-affiliation-19" ref="linksrc=author_aff">
|
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19
|
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Medicine, University of Florence, Italy (F.M.)." href="#full-view-affiliation-20" ref="linksrc=author_aff">
|
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20
|
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</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M.)." href="#full-view-affiliation-21" ref="linksrc=author_aff">
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21
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Medeiros+Domingo+A&cauthor_id=33947203"
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data-ga-label="Argelia Medeiros Domingo">Argelia Medeiros Domingo</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Swiss DNAlysis Cardiogenetics, Dübendorf, Switzerland (A.M.D.)." href="#full-view-affiliation-22" ref="linksrc=author_aff">
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22
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Miller+RL&cauthor_id=33947203"
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data-ga-label="Rebecca L Miller">Rebecca L Miller</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah)." href="#full-view-affiliation-23" ref="linksrc=author_aff">
|
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23
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Morales+A&cauthor_id=33947203"
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data-ga-label="Ana Morales">Ana Morales</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Invitae Corp, San Francisco, CA (A.M.)." href="#full-view-affiliation-24" ref="linksrc=author_aff">
|
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24
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Murray+B&cauthor_id=33947203"
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ref="linksrc=author_name_link"
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data-ga-label="Brittney Murray">Brittney Murray</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.B., C.A.J., B.M.)." href="#full-view-affiliation-5" ref="linksrc=author_aff">
|
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5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Peters+S&cauthor_id=33947203"
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data-ga-label="Stacey Peters">Stacey Peters</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Cardiology and Genomic Medicine, Royal Melbourne Hospital, Australia (S.P.)." href="#full-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Pilichou+K&cauthor_id=33947203"
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data-ga-label="Kalliopi Pilichou">Kalliopi Pilichou</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Italy (R.C., K.P.)." href="#full-view-affiliation-6" ref="linksrc=author_aff">
|
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6
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Protonotarios+A&cauthor_id=33947203"
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data-ga-label="Alexandros Protonotarios">Alexandros Protonotarios</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris)." href="#full-view-affiliation-26" ref="linksrc=author_aff">
|
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26
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Semsarian+C&cauthor_id=33947203"
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data-ga-label="Christopher Semsarian">Christopher Semsarian</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Australia (C.S.)." href="#full-view-affiliation-27" ref="linksrc=author_aff">
|
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27
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Shah+P&cauthor_id=33947203"
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data-ga-label="Palak Shah">Palak Shah</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah)." href="#full-view-affiliation-23" ref="linksrc=author_aff">
|
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23
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Petros Syrris">Petros Syrris</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris)." href="#full-view-affiliation-26" ref="linksrc=author_aff">
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26
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Courtney Thaxton">Courtney Thaxton</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, University of North Carolina, Chapel Hill (C.T.)." href="#full-view-affiliation-28" ref="linksrc=author_aff">
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28
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=van+Tintelen+JP&cauthor_id=33947203"
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data-ga-label="J Peter van Tintelen">J Peter van Tintelen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.P.v.T.)." href="#full-view-affiliation-29" ref="linksrc=author_aff">
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29
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Walsh+R&cauthor_id=33947203"
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data-ga-label="Roddy Walsh">Roddy Walsh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.)." href="#full-view-affiliation-13" ref="linksrc=author_aff">
|
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13
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Wang+J&cauthor_id=33947203"
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data-ga-label="Jessica Wang">Jessica Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California, Los Angeles (J.F., J. Wang)." href="#full-view-affiliation-8" ref="linksrc=author_aff">
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8
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Ware+J&cauthor_id=33947203"
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data-ga-label="James Ware">James Ware</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware)." href="#full-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware)." href="#full-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Medical Research Council London Institute for Medical Sciences, Imperial College London, United Kingdom (J. Ware)." href="#full-view-affiliation-30" ref="linksrc=author_aff">
|
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30
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Hershberger+RE&cauthor_id=33947203"
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data-ga-label="Ray E Hershberger">Ray E Hershberger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Human Genetics (E.J., L.P., T.A., R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus." href="#full-view-affiliation-1" ref="linksrc=author_aff">
|
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1
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiovascular Medicine (R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus." href="#full-view-affiliation-31" ref="linksrc=author_aff">
|
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31
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</a></sup></span>
|
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</div>
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</div>
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<div class="short-article-details">
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Affiliations
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<div class="affiliations">
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<h3 class="title">
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Affiliations
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<li data-affiliation-id="full-view-affiliation-1"
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><sup class="key">1</sup> Division of Human Genetics (E.J., L.P., T.A., R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus.</li>
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<li data-affiliation-id="full-view-affiliation-2"
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id="full-view-affiliation-2"
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><sup class="key">2</sup> Department for Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (B.A.).</li>
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<li data-affiliation-id="full-view-affiliation-3"
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id="full-view-affiliation-3"
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><sup class="key">3</sup> Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada (L.B., O.J.).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-4"
|
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id="full-view-affiliation-4"
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><sup class="key">4</sup> Department of Laboratory and Pathology Medicine, University of Ottawa, Ontario, Canada (L.B., O.J.).</li>
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<li data-affiliation-id="full-view-affiliation-5"
|
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id="full-view-affiliation-5"
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><sup class="key">5</sup> Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.B., C.A.J., B.M.).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-6"
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id="full-view-affiliation-6"
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><sup class="key">6</sup> Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Italy (R.C., K.P.).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-7"
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id="full-view-affiliation-7"
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><sup class="key">7</sup> Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (M.E.).</li>
|
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|
||
<li data-affiliation-id="full-view-affiliation-8"
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id="full-view-affiliation-8"
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><sup class="key">8</sup> Department of Medicine, University of California, Los Angeles (J.F., J. Wang).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-9"
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id="full-view-affiliation-9"
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><sup class="key">9</sup> Cardio Genomics Program at Centenary Institute, University of Sydney, Australia (J.I.).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-10"
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id="full-view-affiliation-10"
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><sup class="key">10</sup> Victor Chang Cardiac Research Institute, Sydney, Australia (R.J.).</li>
|
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|
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<li data-affiliation-id="full-view-affiliation-11"
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id="full-view-affiliation-11"
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><sup class="key">11</sup> Department of Medicine, University of New South Wales, Sydney, Australia (R.J.).</li>
|
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|
||
<li data-affiliation-id="full-view-affiliation-12"
|
||
id="full-view-affiliation-12"
|
||
><sup class="key">12</sup> Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (D.P.J.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-13"
|
||
id="full-view-affiliation-13"
|
||
><sup class="key">13</sup> Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-14"
|
||
id="full-view-affiliation-14"
|
||
><sup class="key">14</sup> Department of Clinical Genetics, Amsterdam University Medical Center location Academic Medical Center, the Netherlands (R.H.L.D.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-15"
|
||
id="full-view-affiliation-15"
|
||
><sup class="key">15</sup> Institute of Health Informatics, University College London, London, UK (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-16"
|
||
id="full-view-affiliation-16"
|
||
><sup class="key">16</sup> Health Data Research UK London, University College London, UK (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-17"
|
||
id="full-view-affiliation-17"
|
||
><sup class="key">17</sup> University College London British Heart Foundation Research Accelerator, London, United Kingdom (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-18"
|
||
id="full-view-affiliation-18"
|
||
><sup class="key">18</sup> Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-19"
|
||
id="full-view-affiliation-19"
|
||
><sup class="key">19</sup> National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-20"
|
||
id="full-view-affiliation-20"
|
||
><sup class="key">20</sup> Department of Clinical and Experimental Medicine, University of Florence, Italy (F.M.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-21"
|
||
id="full-view-affiliation-21"
|
||
><sup class="key">21</sup> Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-22"
|
||
id="full-view-affiliation-22"
|
||
><sup class="key">22</sup> Swiss DNAlysis Cardiogenetics, Dübendorf, Switzerland (A.M.D.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-23"
|
||
id="full-view-affiliation-23"
|
||
><sup class="key">23</sup> Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-24"
|
||
id="full-view-affiliation-24"
|
||
><sup class="key">24</sup> Invitae Corp, San Francisco, CA (A.M.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-25"
|
||
id="full-view-affiliation-25"
|
||
><sup class="key">25</sup> Department of Cardiology and Genomic Medicine, Royal Melbourne Hospital, Australia (S.P.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-26"
|
||
id="full-view-affiliation-26"
|
||
><sup class="key">26</sup> Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-27"
|
||
id="full-view-affiliation-27"
|
||
><sup class="key">27</sup> Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Australia (C.S.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-28"
|
||
id="full-view-affiliation-28"
|
||
><sup class="key">28</sup> Department of Genetics, University of North Carolina, Chapel Hill (C.T.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-29"
|
||
id="full-view-affiliation-29"
|
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><sup class="key">29</sup> Department of Genetics, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.P.v.T.).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-30"
|
||
id="full-view-affiliation-30"
|
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><sup class="key">30</sup> Medical Research Council London Institute for Medical Sciences, Imperial College London, United Kingdom (J. Ware).</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-31"
|
||
id="full-view-affiliation-31"
|
||
><sup class="key">31</sup> Division of Cardiovascular Medicine (R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus.</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
||
|
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|
||
|
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</div>
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|
||
|
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|
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<h1 class="heading-title">
|
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|
||
|
||
|
||
|
||
|
||
|
||
Evidence-Based Assessment of Genes in Dilated Cardiomyopathy
|
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|
||
|
||
|
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|
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</h1>
|
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|
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|
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|
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<div class="short-citation">
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<span class="authors-list-item "><span class="full-name">Elizabeth Jordan</span><span class="citation-separator"> et al.</span></span>
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3
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8
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9
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5
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|
||
href="/?term=Jarinova+O&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Olga Jarinova">Olga Jarinova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada (L.B., O.J.)." href="#short-view-affiliation-3" ref="linksrc=author_aff">
|
||
3
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Laboratory and Pathology Medicine, University of Ottawa, Ontario, Canada (L.B., O.J.)." href="#short-view-affiliation-4" ref="linksrc=author_aff">
|
||
4
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Johnson+R&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Renee Johnson">Renee Johnson</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Victor Chang Cardiac Research Institute, Sydney, Australia (R.J.)." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of New South Wales, Sydney, Australia (R.J.)." href="#short-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Judge+DP&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Daniel P Judge">Daniel P Judge</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (D.P.J.)." href="#short-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Lahrouchi+N&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Najim Lahrouchi">Najim Lahrouchi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.)." href="#short-view-affiliation-13" ref="linksrc=author_aff">
|
||
13
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Lekanne+Deprez+RH&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Ronald H Lekanne Deprez">Ronald H Lekanne Deprez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Genetics, Amsterdam University Medical Center location Academic Medical Center, the Netherlands (R.H.L.D.)." href="#short-view-affiliation-14" ref="linksrc=author_aff">
|
||
14
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Lumbers+RT&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="R Thomas Lumbers">R Thomas Lumbers</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Health Informatics, University College London, London, UK (R.T.L.)." href="#short-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Health Data Research UK London, University College London, UK (R.T.L.)." href="#short-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="University College London British Heart Foundation Research Accelerator, London, United Kingdom (R.T.L.)." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Mazzarotto+F&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Francesco Mazzarotto">Francesco Mazzarotto</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware)." href="#short-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware)." href="#short-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Medicine, University of Florence, Italy (F.M.)." href="#short-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M.)." href="#short-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Medeiros+Domingo+A&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Argelia Medeiros Domingo">Argelia Medeiros Domingo</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Swiss DNAlysis Cardiogenetics, Dübendorf, Switzerland (A.M.D.)." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Miller+RL&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Rebecca L Miller">Rebecca L Miller</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah)." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Morales+A&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Ana Morales">Ana Morales</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Invitae Corp, San Francisco, CA (A.M.)." href="#short-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Murray+B&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Brittney Murray">Brittney Murray</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.B., C.A.J., B.M.)." href="#short-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Peters+S&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Stacey Peters">Stacey Peters</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Cardiology and Genomic Medicine, Royal Melbourne Hospital, Australia (S.P.)." href="#short-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Pilichou+K&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Kalliopi Pilichou">Kalliopi Pilichou</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Italy (R.C., K.P.)." href="#short-view-affiliation-6" ref="linksrc=author_aff">
|
||
6
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Protonotarios+A&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Alexandros Protonotarios">Alexandros Protonotarios</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris)." href="#short-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Semsarian+C&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Christopher Semsarian">Christopher Semsarian</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Australia (C.S.)." href="#short-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Shah+P&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Palak Shah">Palak Shah</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah)." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Syrris+P&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Petros Syrris">Petros Syrris</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris)." href="#short-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Thaxton+C&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Courtney Thaxton">Courtney Thaxton</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, University of North Carolina, Chapel Hill (C.T.)." href="#short-view-affiliation-28" ref="linksrc=author_aff">
|
||
28
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=van+Tintelen+JP&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="J Peter van Tintelen">J Peter van Tintelen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Genetics, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.P.v.T.)." href="#short-view-affiliation-29" ref="linksrc=author_aff">
|
||
29
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Walsh+R&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Roddy Walsh">Roddy Walsh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.)." href="#short-view-affiliation-13" ref="linksrc=author_aff">
|
||
13
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Wang+J&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Jessica Wang">Jessica Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of California, Los Angeles (J.F., J. Wang)." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ware+J&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="James Ware">James Ware</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware)." href="#short-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware)." href="#short-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Medical Research Council London Institute for Medical Sciences, Imperial College London, United Kingdom (J. Ware)." href="#short-view-affiliation-30" ref="linksrc=author_aff">
|
||
30
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Hershberger+RE&cauthor_id=33947203"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Ray E Hershberger">Ray E Hershberger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Human Genetics (E.J., L.P., T.A., R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus." href="#short-view-affiliation-1" ref="linksrc=author_aff">
|
||
1
|
||
</a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Cardiovascular Medicine (R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus." href="#short-view-affiliation-31" ref="linksrc=author_aff">
|
||
31
|
||
</a></sup></span>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="affiliations">
|
||
<h3 class="title">
|
||
Affiliations
|
||
</h3>
|
||
<ul class="item-list">
|
||
|
||
<li data-affiliation-id="short-view-affiliation-1"
|
||
id="short-view-affiliation-1"
|
||
><sup class="key">1</sup> Division of Human Genetics (E.J., L.P., T.A., R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-2"
|
||
id="short-view-affiliation-2"
|
||
><sup class="key">2</sup> Department for Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (B.A.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-3"
|
||
id="short-view-affiliation-3"
|
||
><sup class="key">3</sup> Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada (L.B., O.J.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-4"
|
||
id="short-view-affiliation-4"
|
||
><sup class="key">4</sup> Department of Laboratory and Pathology Medicine, University of Ottawa, Ontario, Canada (L.B., O.J.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-5"
|
||
id="short-view-affiliation-5"
|
||
><sup class="key">5</sup> Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.B., C.A.J., B.M.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-6"
|
||
id="short-view-affiliation-6"
|
||
><sup class="key">6</sup> Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Italy (R.C., K.P.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-7"
|
||
id="short-view-affiliation-7"
|
||
><sup class="key">7</sup> Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (M.E.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-8"
|
||
id="short-view-affiliation-8"
|
||
><sup class="key">8</sup> Department of Medicine, University of California, Los Angeles (J.F., J. Wang).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-9"
|
||
id="short-view-affiliation-9"
|
||
><sup class="key">9</sup> Cardio Genomics Program at Centenary Institute, University of Sydney, Australia (J.I.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-10"
|
||
id="short-view-affiliation-10"
|
||
><sup class="key">10</sup> Victor Chang Cardiac Research Institute, Sydney, Australia (R.J.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-11"
|
||
id="short-view-affiliation-11"
|
||
><sup class="key">11</sup> Department of Medicine, University of New South Wales, Sydney, Australia (R.J.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-12"
|
||
id="short-view-affiliation-12"
|
||
><sup class="key">12</sup> Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (D.P.J.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-13"
|
||
id="short-view-affiliation-13"
|
||
><sup class="key">13</sup> Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, the Netherlands (N.L., R.W.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-14"
|
||
id="short-view-affiliation-14"
|
||
><sup class="key">14</sup> Department of Clinical Genetics, Amsterdam University Medical Center location Academic Medical Center, the Netherlands (R.H.L.D.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-15"
|
||
id="short-view-affiliation-15"
|
||
><sup class="key">15</sup> Institute of Health Informatics, University College London, London, UK (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-16"
|
||
id="short-view-affiliation-16"
|
||
><sup class="key">16</sup> Health Data Research UK London, University College London, UK (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-17"
|
||
id="short-view-affiliation-17"
|
||
><sup class="key">17</sup> University College London British Heart Foundation Research Accelerator, London, United Kingdom (R.T.L.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-18"
|
||
id="short-view-affiliation-18"
|
||
><sup class="key">18</sup> Cardiovascular Research Center, Royal Brompton and Harefield Hospitals, National Health Service Foundation Trust, London, United Kingdom (F.M., J. Ware).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-19"
|
||
id="short-view-affiliation-19"
|
||
><sup class="key">19</sup> National Heart and Lung Institute, Imperial College London, United Kingdom (F.M., J. Ware).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-20"
|
||
id="short-view-affiliation-20"
|
||
><sup class="key">20</sup> Department of Clinical and Experimental Medicine, University of Florence, Italy (F.M.).</li>
|
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|
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<li data-affiliation-id="short-view-affiliation-21"
|
||
id="short-view-affiliation-21"
|
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><sup class="key">21</sup> Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M.).</li>
|
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|
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<li data-affiliation-id="short-view-affiliation-22"
|
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id="short-view-affiliation-22"
|
||
><sup class="key">22</sup> Swiss DNAlysis Cardiogenetics, Dübendorf, Switzerland (A.M.D.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-23"
|
||
id="short-view-affiliation-23"
|
||
><sup class="key">23</sup> Cardiovascular Genomics Center, Inova Heart and Vascular Institute, Falls Church, VA (R.L.M., P. Shah).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-24"
|
||
id="short-view-affiliation-24"
|
||
><sup class="key">24</sup> Invitae Corp, San Francisco, CA (A.M.).</li>
|
||
|
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<li data-affiliation-id="short-view-affiliation-25"
|
||
id="short-view-affiliation-25"
|
||
><sup class="key">25</sup> Department of Cardiology and Genomic Medicine, Royal Melbourne Hospital, Australia (S.P.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-26"
|
||
id="short-view-affiliation-26"
|
||
><sup class="key">26</sup> Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, United Kingdom (A.P., P. Syrris).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-27"
|
||
id="short-view-affiliation-27"
|
||
><sup class="key">27</sup> Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Australia (C.S.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-28"
|
||
id="short-view-affiliation-28"
|
||
><sup class="key">28</sup> Department of Genetics, University of North Carolina, Chapel Hill (C.T.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-29"
|
||
id="short-view-affiliation-29"
|
||
><sup class="key">29</sup> Department of Genetics, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.P.v.T.).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-30"
|
||
id="short-view-affiliation-30"
|
||
><sup class="key">30</sup> Medical Research Council London Institute for Medical Sciences, Imperial College London, United Kingdom (J. Ware).</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-31"
|
||
id="short-view-affiliation-31"
|
||
><sup class="key">31</sup> Division of Cardiovascular Medicine (R.E.H.), Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus.</li>
|
||
|
||
</ul>
|
||
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|
||
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|
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PMID:
|
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<strong class="current-id" title="PubMed ID">33947203</strong>
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|
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|
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|
||
ref="linksrc=article_id_link&article_id=PMC8247549&id_type=PMC"
|
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href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8247549/"
|
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|
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|
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|
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|
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DOI:
|
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|
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|
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|
||
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|
||
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|
||
rel="noopener"
|
||
ref="linksrc=article_id_link&article_id=10.1161/CIRCULATIONAHA.120.053033&id_type=DOI"
|
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href="https://doi.org/10.1161/circulationaha.120.053033"
|
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data-ga-category="full_text"
|
||
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|
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>
|
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10.1161/CIRCULATIONAHA.120.053033
|
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<p>
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<strong class="sub-title">
|
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Background:
|
||
</strong>
|
||
|
||
Each of the cardiomyopathies, classically categorized as hypertrophic cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy, has a signature genetic theme. Hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy are largely understood as genetic diseases of sarcomere or desmosome proteins, respectively. In contrast, >250 genes spanning >10 gene ontologies have been implicated in DCM, representing a complex and diverse genetic architecture. To clarify this, a systematic curation of evidence to establish the relationship of genes with DCM was conducted.
|
||
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|
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<p>
|
||
|
||
<strong class="sub-title">
|
||
Methods:
|
||
</strong>
|
||
|
||
An international panel with clinical and scientific expertise in DCM genetics evaluated evidence supporting monogenic relationships of genes with idiopathic DCM. The panel used the Clinical Genome Resource semiquantitative gene-disease clinical validity classification framework with modifications for DCM genetics to classify genes into categories on the basis of the strength of currently available evidence. Representation of DCM genes on clinically available genetic testing panels was evaluated.
|
||
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<p>
|
||
|
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<strong class="sub-title">
|
||
Results:
|
||
</strong>
|
||
|
||
Fifty-one genes with human genetic evidence were curated. Twelve genes (23%) from 8 gene ontologies were classified as having definitive (<i>BAG3</i>, <i>DES</i>, <i>FLNC</i>, <i>LMNA</i>, <i>MYH7</i>, <i>PLN</i>, <i>RBM20</i>, <i>SCN5A</i>, <i>TNNC1</i>, <i>TNNT2</i>, <i>TTN</i>) or strong (<i>DSP</i>) evidence. Seven genes (14%; <i>ACTC1</i>, <i>ACTN2</i>, <i>JPH2</i>, <i>NEXN</i>, <i>TNNI3</i>, <i>TPM1</i>, <i>VCL</i>) including 2 additional ontologies were classified as moderate evidence; these genes are likely to emerge as strong or definitive with additional evidence. Of these 19 genes, 6 were similarly classified for hypertrophic cardiomyopathy and 3 for arrhythmogenic right ventricular cardiomyopathy. Of the remaining 32 genes (63%), 25 (49%) had limited evidence, 4 (8%) were disputed, 2 (4%) had no disease relationship, and 1 (2%) was supported by animal model data only. Of the 16 evaluated clinical genetic testing panels, most definitive genes were included, but panels also included numerous genes with minimal human evidence.
|
||
</p>
|
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<p>
|
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|
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<strong class="sub-title">
|
||
Conclusions:
|
||
</strong>
|
||
|
||
In the curation of 51 genes, 19 had high evidence (12 definitive/strong, 7 moderate). It is notable that these 19 genes explain only a minority of cases, leaving the remainder of DCM genetic architecture incompletely addressed. Clinical genetic testing panels include most high-evidence genes; however, genes lacking robust evidence are also commonly included. We recommend that high-evidence DCM genes be used for clinical practice and that caution be exercised in the interpretation of variants in variable-evidence DCM genes.
|
||
</p>
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<p>
|
||
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<strong class="sub-title">
|
||
Keywords:
|
||
</strong>
|
||
|
||
cardiomyopathy; genetics.
|
||
</p>
|
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<p class="disclaimer" id="disclaimer">
|
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<a href="/disclaimer/" target="_blank" data-ga-category="literature_resources"
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data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a>
|
||
</p>
|
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|
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|
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<div class="figures" id="figures">
|
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Figures
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data-figure-id="F1">
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6467/8247549/96c556d387d9/cir-144-07-g002.gif"
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alt="Figure 1." />
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<strong class="figure-label">
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<p> Figure 1. </p>
|
||
</strong>
|
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|
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|
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<div class="figure-caption-contents"><b> Quantitative contributions of genetic and… </b></div>
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<strong class="figure-label">
|
||
<p> Figure 1. </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b> Quantitative contributions of genetic and experimental evidence to the clinical validity classifications of… </b></div>
|
||
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||
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||
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||
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||
</div>
|
||
|
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<figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
|
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Figure 1.
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b>Quantitative contributions of genetic and experimental evidence to the clinical validity classifications of genes curated for DCM.</b> The sums of genetic (blue) and experimental (orange) evidence scores are shown for genes classified as having definitive, strong, moderate, or limited evidence of a monogenic relationship with DCM. The 2 genes noted with an asterisk had quantitative scores within the quantitative range for a moderate classification, but a limited classification was assigned at panel review (see text). DCM indicates dilated cardiomyopathy.</div>
|
||
|
||
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||
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</figcaption>
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||
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data-image-alt="Figure 2."
|
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data-pmc-id="PMC8247549"
|
||
data-figure-id="F2">
|
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<img class="figure-thumb" itemprop="thumbnail"
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id="article-image-1"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6467/8247549/cf96b7275d35/cir-144-07-g003.gif"
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alt="Figure 2." />
|
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</a>
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<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="800">
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<strong class="figure-label">
|
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<p> Figure 2. </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b> Genetic architecture of DCM. </b> The…</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
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|
||
|
||
|
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|
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|
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|
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|
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<strong class="figure-label">
|
||
<p> Figure 2. </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b> Genetic architecture of DCM. </b> The genetic architecture of DCM spans 10 gene ontologies,…</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
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<figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
|
||
Figure 2.
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><b>Genetic architecture of DCM.</b> The genetic architecture of DCM spans 10 gene ontologies, as shown in the innermost colored text circle. The middle text circle specifies genes classified as strong or definitive (bold text) or moderate (regular text) for DCM, organized by gene ontology. Of the 19 DCM genes shown, 14 have previously been evaluated by other Clinical Genome Resource gene curations for HCM or ARVC and channelopathies, including the long-QT syndrome and Brugada S. Each of these genes has also been classified as moderate, strong, or definitive for these other phenotypes, except for <i>NEXN</i>, noted with an asterisk, which has been classified as having limited evidence in HCM. It is expected that with time, as new data emerge that are related to gene-disease relationships in cardiomyopathies and other cardiovascular phenotypes, the structure and orientation of this figure will also evolve. ARVC indicates arrhythmogenic right ventricular cardiomyopathy; Brugada S, Brugada syndrome; Co-Chap, HSP, Co-chaperone, heart shock protein; DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; and SR, sarcoplasmic reticulum.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
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|
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data-image-height="715"
|
||
data-image-alt="Figure 3."
|
||
data-pmc-id="PMC8247549"
|
||
data-figure-id="F3">
|
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|
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id="article-image-2"
|
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6467/8247549/2131848795e8/cir-144-07-g004.gif"
|
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alt="Figure 3." />
|
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|
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|
||
|
||
|
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|
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|
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<strong class="figure-label">
|
||
<p> Figure 3. </p>
|
||
</strong>
|
||
|
||
|
||
|
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<div class="figure-caption-contents"><b> Curated genes on clinically available… </b></div>
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<p> Figure 3. </p>
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</strong>
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<div class="figure-caption-contents"><b> Curated genes on clinically available DCM genetic testing panels. </b> The percentages of DCM…</div>
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Figure 3.
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</strong>
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<div class="figure-caption-contents"><b>Curated genes on clinically available DCM genetic testing panels.</b> The percentages of DCM genetic testing panels that include the genes curated for DCM herein are shown for 16 commercial laboratories identified on the National Center for Biotechnology Information genetic testing registry. Genes are grouped by clinical validity classification, ranging from definitive, strong and moderate (A) to limited, disputed, and no known disease relationship (B). DCM indicates dilated cardiomyopathy.</div>
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Falk RH, Hershberger RE. Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli G, eds. The dilated, restrictive, and infiltrative cardiomyopathies. In: Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 2018. 11th Edition. Elsevier
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Jarcho JA, McKenna W, Pare JA, Solomon SD, Holcombe RF, Dickie S, Levi T, Donis-Keller H, Seidman JG, Seidman CE. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med. 1989;321:1372–1378. doi: 10.1056/NEJM198911163212005
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Nava A, Bauce B, Basso C, Muriago M, Rampazzo A, Villanova C, Daliento L, Buja G, Corrado D, Danieli GA, et al. . Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 2000;36:2226–2233. doi: 10.1016/s0735-1097(00)00997-9
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Related information
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</h2>
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MedGen
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