1369 lines
110 KiB
Text
1369 lines
110 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# ">
|
||
<head>
|
||
<meta charset="utf-8" /><script type="text/javascript">(window.NREUM||(NREUM={})).init={ajax:{deny_list:["bam.nr-data.net"]}};(window.NREUM||(NREUM={})).loader_config={licenseKey:"37b7ccb661",applicationID:"1089704227"};;/*! For license information please see nr-loader-rum-1.283.2.min.js.LICENSE.txt */
|
||
(()=>{var e,t,r={122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},217:(e,t,r)=>{"use strict";r.d(t,{D0:()=>m,gD:()=>v,xN:()=>h});r(860).K7.genericEvents;const n="experimental.marks",i="experimental.measures",o="experimental.resources",a=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var s=r(614),c=r(944),u=r(384),l=r(122);const d="[data-nr-mask]",f=()=>{const e={feature_flags:[],experimental:{marks:!1,measures:!1,resources:!1},mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},get feature_flags(){return e.feature_flags},set feature_flags(t){e.feature_flags=t},generic_events:{enabled:!0,autoStart:!0},harvest:{interval:30},jserrors:{enabled:!0,autoStart:!0},logging:{enabled:!0,autoStart:!0},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,autoStart:!0},performance:{get capture_marks(){return e.feature_flags.includes(n)||e.experimental.marks},set capture_marks(t){e.experimental.marks=t},get capture_measures(){return e.feature_flags.includes(i)||e.experimental.measures},set capture_measures(t){e.experimental.measures=t},capture_detail:!0,resources:{get enabled(){return e.feature_flags.includes(o)||e.experimental.resources},set enabled(t){e.experimental.resources=t},asset_types:[],first_party_domains:[],ignore_newrelic:!0}},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:s.wk,inactiveMs:s.BB},session_replay:{autoStart:!0,enabled:!1,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){a(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,c.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){a(t)?e.block_selector+=",".concat(t):""!==t&&(0,c.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,c.R)(7,t)}},session_trace:{enabled:!0,autoStart:!0},soft_navigations:{enabled:!0,autoStart:!0},spa:{enabled:!0,autoStart:!0},ssl:void 0,user_actions:{enabled:!0,elementAttributes:["id","className","tagName","type"]}}},g={},p="All configuration objects require an agent identifier!";function m(e){if(!e)throw new Error(p);if(!g[e])throw new Error("Configuration for ".concat(e," was never set"));return g[e]}function h(e,t){if(!e)throw new Error(p);g[e]=(0,l.a)(t,f());const r=(0,u.nY)(e);r&&(r.init=g[e])}function v(e,t){if(!e)throw new Error(p);var r=m(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>d});var n=r(122),i=r(384),o=r(154),a=r(324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0,harvester:void 0},l={};function d(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!l[e])throw new Error("Runtime for ".concat(e," was never set"));return l[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");l[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(l[e],"harvestCount")||Object.defineProperty(l[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=l[e])}},324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,xv:()=>n});const n="1.283.2",i="PROD",o="CDN"},154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>c,RI:()=>i,WN:()=>l,bv:()=>o,gm:()=>a,mw:()=>s,sb:()=>u});var n=r(863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),u=c&&"undefined"==typeof SharedWorker,l=((()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);Array.isArray(e)&&e.length>=2&&e[1]})(),Date.now()-(0,n.t)())},687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>d,x3:()=>u});var n=r(836),i=r(606),o=r(860),a=r(646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};l(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),g(e,t,!1),s[e].size&&f(e))}function l(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function d(e="",t="feature",r=!1){if(l(e),!e||!s[e].get(t)||r)return g(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),g(e,t)})))}function g(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(990),o=r(371),a=r(646),s=r(607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},l={},d=!1;try{d=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=g(n),c=m(e),l=c.length,d=0;d<l;d++)c[d].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:h,listeners:m,context:g,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:d?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:d};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function g(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=m(e).concat(t)}function m(e){return n[e]||[]}function h(t){return l[t]=l[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),l=(0,n.Zm)();l.ee||(l.ee=u)},646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(566).bz)()},566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,bz:()=>a});var n=r(154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}},614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(836),i=r(154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>l,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>d});var n=r(154),i=r(863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function l(e,t){a()[e]=t}function d(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(836),i=r(607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];l(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return l(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,l,d;try{a=this,o=[...arguments],l="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],l],e)}i(r+"start",[o,a,s],l,c);try{return d=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],l,c),e}finally{i(r+"end",[o,a,d],l,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function l(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},993:(e,t,r)=>{"use strict";r.d(t,{A$:()=>o,ET:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o={OFF:0,ERROR:1,WARN:2,INFO:3,DEBUG:4,TRACE:5},a="log";n.K7.logging},773:(e,t,r)=>{"use strict";r.d(t,{z_:()=>o,XG:()=>s,TZ:()=>n,rs:()=>i,xV:()=>a});r(154),r(566),r(384);const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},344:(e,t,r)=>{"use strict";r.d(t,{G4:()=>i});var n=r(614);r(860).K7.sessionReplay;const i={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"};n.g.ERROR,n.g.FULL,n.g.OFF},234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(836),i=r(687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},603:(e,t,r)=>{"use strict";r.d(t,{j:()=>K});var n=r(860),i=r(555),o=r(371),a=r(908),s=r(836),c=r(687),u=r(289),l=r(154),d=r(944),f=r(773),g=r(384),p=r(344);const m=["setErrorHandler","finished","addToTrace","addRelease","recordCustomEvent","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],h=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(863),b=r(614),y=r(993);var w=r(646),R=r(434);const A=new Map;function E(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,d.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,R.YM)(i),a=new w.y(s.P);a.level=n.level,a.customAttributes=n.customAttributes;const c=t[r]?.[R.Jt]||t[r];return A.set(c,a),o.inPlace(t,[r],"wrap-logger-",(()=>A.get(c))),i}function _(){const e=(0,g.pV)();m.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,d.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const x={};function N(e,t,g=!1){t||(0,c.Ak)(e,"api");const m={};var w=s.ee.get(e),R=w.get("tracer");x[e]=b.g.OFF,w.on(p.G4.REPLAY_RUNNING,(t=>{x[e]=t}));var A="api-",_=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),j(A,n,!0,o||null===r?"session":void 0)(t,r)}function k(){}m.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,w),function(e,t,r={},i=y.p_.INFO){(0,a.p)(f.xV,["API/logging/".concat(i.toLowerCase(),"/called")],void 0,n.K7.metrics,e),(0,a.p)(y.ET,[(0,v.t)(),t,r,i],void 0,n.K7.logging,e)}(w,e,t,r)},m.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,w),E(w,e,t,{customAttributes:r,level:i})},h.forEach((e=>{m[e]=j(A,e,!0,"api")})),m.addPageAction=j(A,"addPageAction",!0,n.K7.genericEvents),m.recordCustomEvent=j(A,"recordCustomEvent",!0,n.K7.genericEvents),m.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,j(A,"setPageViewName",!0)()},m.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,d.R)(40,typeof t)}else(0,d.R)(39,typeof e)},m.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,d.R)(41,typeof e)},m.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,d.R)(42,typeof e)},m.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,w),w.emit("manual-start-all")}catch(e){(0,d.R)(23,e)}},m[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,w)},m[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,w)},m.interaction=function(e){return(new k).get("object"==typeof e?e:{})};const T=k.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,w),g||(0,a.p)(_+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,w),function(){if(R.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw R.emit("fn-err",[arguments,this,t],r),t}finally{R.emit("fn-end",[(0,v.t)()],r)}}}};function j(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,w),i&&(0,a.p)(e+t,[r?(0,v.t)():performance.now(),...arguments],r?null:this,i,w),r?void 0:this}}function I(){r.e(296).then(r.bind(r,778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,d.R)(27,e),w.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{T[e]=j(_,e,void 0,g?n.K7.softNav:n.K7.spa)})),m.setCurrentRouteName=g?j(_,"routeName",void 0,n.K7.softNav):j(A,"routeName",!0,n.K7.spa),m.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,w),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!x[e]],void 0,n.K7.jserrors,w)},l.RI?(0,u.GG)((()=>I()),!0):I(),m}var k=r(217),T=r(122);const j={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},I={};var O=r(284);const S=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let P=!1;function K(e,t={},r,n){let{init:a,info:c,loader_config:u,runtime:d={},exposed:f=!0}=t;d.loaderType=r;const p=(0,g.pV)();c||(a=p.init,c=p.info,u=p.loader_config),(0,k.xN)(e.agentIdentifier,a||{}),function(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");I[e]=(0,T.a)(t,j);const r=(0,g.nY)(e);r&&(r.loader_config=I[e])}(e.agentIdentifier,u||{}),c.jsAttributes??={},l.bv&&(c.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,c);const m=(0,k.D0)(e.agentIdentifier),h=[c.beacon,c.errorBeacon];P||(m.proxy.assets&&(S(m.proxy.assets),h.push(m.proxy.assets)),m.proxy.beacon&&h.push(m.proxy.beacon),_(),(0,g.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===m.soft_navigations.enabled&&m.feature_flags.includes("soft_nav")),d.denyList=[...m.ajax.deny_list||[],...m.ajax.block_internal?h:[]],d.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,d),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=N(e.agentIdentifier,n,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=f),P=!0}},374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>u,K7:()=>s,P3:()=>c,XX:()=>i,qY:()=>n,v4:()=>a});const n="events",i="jserrors",o="browser/blobs",a="rum",s={ajax:"ajax",genericEvents:"generic_events",jserrors:i,logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},c={[s.pageViewEvent]:1,[s.pageViewTiming]:2,[s.metrics]:3,[s.jserrors]:4,[s.spa]:5,[s.ajax]:6,[s.sessionTrace]:7,[s.softNav]:8,[s.sessionReplay]:9,[s.logging]:10,[s.genericEvents]:11},u={[s.pageViewEvent]:a,[s.pageViewTiming]:n,[s.ajax]:n,[s.spa]:n,[s.softNav]:n,[s.metrics]:i,[s.jserrors]:i,[s.sessionTrace]:o,[s.sessionReplay]:o,[s.logging]:"browser/logs",[s.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>"nr-rum-1.283.2.min.js",i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.283.2.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),l=0;l<u.length;l++){var d=u[l];if(d.getAttribute("src")==r||d.getAttribute("data-webpack")==t+o){s=d;break}}if(!s){c=!0;var f={296:"sha512-2Y8GMAOGF658KnXzOZ/v+DlLch8TBFvV0tTNnOy9wrpvtDa1t5CdZMyX+LubTymBlzPp6NUjllBghMCZqXBPmg=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var g=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(g.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=g.bind(null,s.onerror),s.onload=g.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={374:0,840:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.283.2.PROD"]=self["webpackChunk:NRBA-1.283.2.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(374);var e=i(944),t=i(344),r=i(566);class n{agentIdentifier;constructor(){this.agentIdentifier=(0,r.LA)(16)}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}recordCustomEvent(e,t){return this.#e("recordCustomEvent",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(217);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var l=i(603);var d=i(687),f=i(234),g=i(289),p=i(154),m=i(384);const h=e=>p.RI&&!0===(0,s.gD)(e,"privacy.cookies_enabled");function v(e){return!!(0,m.dV)().o.MO&&h(e)&&!0===(0,s.gD)(e,"session_trace.enabled")}var b=i(389);class y extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,d.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,b.J)((()=>{(0,d.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if(h(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(296).then(i.bind(i,861));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(!this.#t(this.featureName,o))return(0,d.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(296).then(i.bind(i,103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),t.runtime.harvester.initializedAggregates.push(this.featAggregate),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,d.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,g.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return v(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var w=i(630);class R extends y{static featureName=w.T;constructor(e,t=!0){super(e,w.T,t),this.importAggregator(e)}}var A=i(908),E=i(843),_=i(878),x=i(782),N=i(863);class k extends y{static featureName=x.T;constructor(e,t=!0){super(e,x.T,t),p.RI&&((0,E.u)((()=>(0,A.p)("docHidden",[(0,N.t)()],void 0,x.T,this.ee)),!0),(0,_.sp)("pagehide",(()=>(0,A.p)("winPagehide",[(0,N.t)()],void 0,x.T,this.ee))),this.importAggregator(e))}}var T=i(773);class j extends y{static featureName=T.TZ;constructor(e,t=!0){super(e,T.TZ,t),this.importAggregator(e)}}new class extends o{constructor(t){super(),p.gm?(this.features={},(0,m.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,l.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,m.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,k,j],loaderType:"lite"})})()})();</script>
|
||
<noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style>
|
||
</noscript><script async src="https://www.googletagmanager.com/gtag/js?id=G-HEQ0YF2VYL"></script>
|
||
<script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag('set', {'cookie_flags': 'SameSite=None;Secure', 'cookie_domain': 'www.nist.gov'});gtag("config", "G-HEQ0YF2VYL", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","link_attribution":true,"allow_ad_personalization_signals":false});gtag("config", "G-CSLL4ZEK4L", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","link_attribution":true,"allow_ad_personalization_signals":false});gtag("event", "custom", {"node_title":"Genome in a Bottle: Spelling Out DNA\u2019s \u2018Dark\u2019 Sequences","node_id":"1552236","blog_author":"Justin Zook","content_type":"Blog entry"});</script>
|
||
<meta name="description" content="When the Human Genome Project began 20 years ago, its consortium of re" />
|
||
<link rel="canonical" href="https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences" />
|
||
<link rel="shortlink" href="https://www.nist.gov/node/1552236" />
|
||
<meta name="citation_title" content="Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences | NIST" />
|
||
<meta property="og:site_name" content="NIST" />
|
||
<meta property="og:type" content="Article" />
|
||
<meta property="og:url" content="https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences" />
|
||
<meta property="og:title" content="Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences" />
|
||
<meta property="og:description" content="When the Human Genome Project began 20 years ago, its consortium of re" />
|
||
<meta property="og:image" content="https://www.nist.gov/sites/default/files/styles/social/public/images/2019/03/12/justin_zook_lab.jpg?itok=EddIFNMq" />
|
||
<meta property="og:image" content="https://www.nist.gov/themes/custom/nist_www/img/homepage/nist_mark.png" />
|
||
<meta property="og:image:width" content="2400" />
|
||
<meta property="og:image:height" content="1350" />
|
||
<meta property="og:image:alt" content="Justin Zook in a lab surrounded by genetic sequencing machines" />
|
||
<meta property="article:author" content="Justin Zook" />
|
||
<meta property="article:tag" content="genome" />
|
||
<meta property="article:published_time" content="2019-03-13T08:00-04:00" />
|
||
<meta property="article:modified_time" content="2025-02-25T14:28-05:00" />
|
||
<meta name="dcterms.title" content="Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences" />
|
||
<meta name="dcterms.creator" content="Justin Zook" />
|
||
<meta name="dcterms.description" content="When the Human Genome Project began 20 years ago, its consortium of re" />
|
||
<meta name="dcterms.publisher" content="Justin Zook" />
|
||
<meta name="dcterms.contributor" content="NIST" />
|
||
<meta name="dcterms.date" content="2019-03-13T08:00-04:00" />
|
||
<meta name="dcterms.type" content="text" />
|
||
<meta name="dcterms.format" content="text/html" />
|
||
<meta name="dcterms.identifier" content="https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences" />
|
||
<meta name="dcterms.source" content="NIST" />
|
||
<meta name="dcterms.created" content="2019-03-13T08:00-04:00" />
|
||
<meta name="dcterms.modified" content="2025-02-25T14:28-05:00" />
|
||
<meta name="twitter:card" content="summary_large_image" />
|
||
<meta name="twitter:description" content="When the Human Genome Project began 20 years ago, its consortium of re" />
|
||
<meta name="twitter:site" content="NIST" />
|
||
<meta name="twitter:title" content="Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences" />
|
||
<meta name="google-site-verification" content="QMu0ODkER3rN5hLcMLqNVf7e3bkjYsNLTuhqfH48jCA" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta name="nist_search_modified" class="elastic" content="2025-02-25T14:28:00-05:00" />
|
||
<script type="application/ld+json">{
|
||
"@context": "https://schema.org",
|
||
"@graph": [
|
||
{
|
||
"@type": "Article",
|
||
"@id": "https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences",
|
||
"headline": "Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences",
|
||
"name": "Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences",
|
||
"description": "When the Human Genome Project began 20 years ago, its consortium of re",
|
||
"image": {
|
||
"@type": "ImageObject",
|
||
"url": "https://www.nist.gov/sites/default/files/styles/social/public/images/2019/03/12/justin_zook_lab.jpg?itok=EddIFNMq",
|
||
"width": "2400",
|
||
"height": "1350"
|
||
},
|
||
"datePublished": "2019-03-13T08:00-04:00",
|
||
"dateModified": "2025-02-25T14:28-05:00",
|
||
"author": {
|
||
"@type": "Person",
|
||
"@id": "https://www.nist.gov/blogs/taking-measure/authors/justin-zook",
|
||
"name": "Justin Zook",
|
||
"url": "https://www.nist.gov/blogs/taking-measure/authors/justin-zook"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nist.gov/",
|
||
"name": "National Institute of Standards and Technology",
|
||
"url": "https://www.nist.gov/"
|
||
}
|
||
}
|
||
]
|
||
}</script>
|
||
<meta name="nist_search_bundle" class="elastic" content="blog" />
|
||
<link rel="icon" href="/themes/custom/nist_www/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
|
||
<title>Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences | NIST</title>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_WFp5ij_8m_634eVp63ktbxbDLFheczhsL2eTRDraHAA.css?delta=0&language=en&theme=nist_www&include=eJxNjoFuwzAIRH_IrT_JwvalQ8UmMiRp_n5u1mmTEOIODr1M5ZlcZ60x_82Ji_bQ2Tz5Fxqmp5JppKY1VjbKgiTcn8FOc7SZNVz38SGaSX6yx3H8arz8fR_r2FaS-0eGnXFYvPp9_t4E06rQhJZR08KQGgds1W6843Ytw8LiGLHQ6vzhjI0enRcuwbQwSWqoTG-uaQmdunma4EV3jDNqR9F_kI3LUGPHNxMtawg" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_kGS0ApDpFo-_3JI4Ijxg4RCWlTqsImK3lqH7bCv5v2U.css?delta=1&language=en&theme=nist_www&include=eJxNjoFuwzAIRH_IrT_JwvalQ8UmMiRp_n5u1mmTEOIODr1M5ZlcZ60x_82Ji_bQ2Tz5Fxqmp5JppKY1VjbKgiTcn8FOc7SZNVz38SGaSX6yx3H8arz8fR_r2FaS-0eGnXFYvPp9_t4E06rQhJZR08KQGgds1W6843Ytw8LiGLHQ6vzhjI0enRcuwbQwSWqoTG-uaQmdunma4EV3jDNqR9F_kI3LUGPHNxMtawg" />
|
||
<link rel="stylesheet" media="print" href="/sites/default/files/css/css_-IXwLuTUdm8IGHxib8GX8wWKw3LjKsNWSYYskZ5fEGg.css?delta=2&language=en&theme=nist_www&include=eJxNjoFuwzAIRH_IrT_JwvalQ8UmMiRp_n5u1mmTEOIODr1M5ZlcZ60x_82Ji_bQ2Tz5Fxqmp5JppKY1VjbKgiTcn8FOc7SZNVz38SGaSX6yx3H8arz8fR_r2FaS-0eGnXFYvPp9_t4E06rQhJZR08KQGgds1W6843Ytw8LiGLHQ6vzhjI0enRcuwbQwSWqoTG-uaQmdunma4EV3jDNqR9F_kI3LUGPHNxMtawg" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_RS8YGnRq2Xi5aD-GQC3GKwBe6bOWBBmEmXrb2xB5FMM.css?delta=3&language=en&theme=nist_www&include=eJxNjoFuwzAIRH_IrT_JwvalQ8UmMiRp_n5u1mmTEOIODr1M5ZlcZ60x_82Ji_bQ2Tz5Fxqmp5JppKY1VjbKgiTcn8FOc7SZNVz38SGaSX6yx3H8arz8fR_r2FaS-0eGnXFYvPp9_t4E06rQhJZR08KQGgds1W6843Ytw8LiGLHQ6vzhjI0enRcuwbQwSWqoTG-uaQmdunma4EV3jDNqR9F_kI3LUGPHNxMtawg" />
|
||
|
||
<script src="/sites/default/files/js/js_GM8kl6wk698qKTTwusj83bCoGHHtOZ1UinjY1sE_Qbk.js?scope=header&delta=0&language=en&theme=nist_www&include=eJxdjmEOwjAIhS-0yZEIXbGitCxtZ9XT206NxoQffI_HA0fLBav1WsF9ezyXKZgFZaREeq-yFPgXpiSl4lG65q0lNfJYcw-RFCDQa1ykssQ125XhXxhXdq2eOHK_a-ooYzQPXgq5HqySLrsHgpojnd8rcGLynD-IrbUfB9_qWASft5X08MbpKp4NOTr2_W1WD0qP-zwef4VGCkmOsnQnt4LnLa4YOW2w8zx4HvwE13N6Sw"></script>
|
||
|
||
</head>
|
||
<body class="node-1552236">
|
||
<a href="#main-content" class="visually-hidden focusable" data-elastic-exclude>
|
||
Skip to main content
|
||
</a>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
<section data-elastic-exclude class="usa-banner" aria-label="Official government website">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img class="usa-banner__header-flag" src="/libraries/nist-component-library/dist/img/us_flag_small.png" alt="U.S. flag">
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto">
|
||
<p class="usa-banner__header-text">An official website of the United States government</p>
|
||
<p class="usa-banner__header-action" aria-hidden="true">Here’s how you know</p>
|
||
</div>
|
||
<button class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default">
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/libraries/nist-component-library/dist/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true">
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong>
|
||
<br/>
|
||
A <strong>.gov</strong> website belongs to an official government organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/libraries/nist-component-library/dist/img/icon-https.svg" role="img" alt="" aria-hidden="true">
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong>
|
||
<br/>
|
||
A <strong>lock</strong> ( <span class="icon-lock">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewbox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-title banner-lock-description" focusable="false">
|
||
<title id="banner-lock-title">Lock</title>
|
||
<desc id="banner-lock-description">A locked padlock</desc><path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/></svg>
|
||
</span>
|
||
) or <strong>https://</strong> means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
<div data-elastic-exclude>
|
||
<!-- nist-index-ignore-start -->
|
||
<div class="nist-print-header" style="display:none;">
|
||
<p class="nist-print-header__url">https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences</p>
|
||
<img class="nist-print-header__logo" width="289" height="38" src="/libraries/nist-component-library/dist/img/logo/nist_logo_sidestack.svg" alt="National Institute of Standards and Technology" />
|
||
</div>
|
||
|
||
|
||
<div class="usa-overlay"></div>
|
||
<header class="usa-header nist-header--www nist-header--minimal" role="banner">
|
||
<div class="usa-navbar">
|
||
<div class="usa-logo flex-fill">
|
||
<a href="/" title="National Institute of Standards and Technology" aria-label="Home">
|
||
<img src="/libraries/nist-component-library/dist/img/logo/logo.svg" alt="National Institute of Standards and Technology" width="300px" height="80px" />
|
||
</a>
|
||
</div>
|
||
<div class="usa-header__right grid-row flex-auto">
|
||
<div class="grid-col-fill nist-header__search-group">
|
||
|
||
<form class="usa-search usa-search--small"
|
||
accept-charset="UTF-8"
|
||
action="/search"
|
||
id="search_form"
|
||
method="get">
|
||
<div role="search">
|
||
<label class="usa-sr-only" for="search-form">Search NIST</label>
|
||
<input class="usa-input" id="search-form" type="search" name="s" placeholder="Search NIST" required="" maxlength="128">
|
||
<button class="usa-button" type="submit"><img src="/libraries/nist-component-library/dist/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search"></button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
<div class="grid-col-auto padding-left-1">
|
||
<button class="usa-menu-btn">Menu</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<nav aria-label="Primary navigation" class="usa-nav">
|
||
<div class="usa-nav__inner">
|
||
<button class="usa-nav__close">Close</button>
|
||
<ul class="usa-nav__primary usa-accordion">
|
||
<li class="usa-nav__primary-item">
|
||
<a class="usa-nav__link" href="/publications">Publications</a>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-2"><span>What We Do</span></button>
|
||
<div id="primary_menu-2" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/topics" class="usa-nav__link">All Topics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/advanced-communications" class="usa-nav__link">Advanced communications</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/artificial-intelligence" class="usa-nav__link">Artificial intelligence</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/bioscience" class="usa-nav__link">Bioscience</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/buildings-construction" class="usa-nav__link">Buildings and construction</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/chemistry" class="usa-nav__link">Chemistry</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/cybersecurity" class="usa-nav__link">Cybersecurity</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/electronics" class="usa-nav__link">Electronics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/energy" class="usa-nav__link">Energy</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/environment" class="usa-nav__link">Environment</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/fire" class="usa-nav__link">Fire</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/forensic-science" class="usa-nav__link">Forensic science</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/health" class="usa-nav__link">Health</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/information-technology" class="usa-nav__link">Information technology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/infrastructure" class="usa-nav__link">Infrastructure</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/manufacturing" class="usa-nav__link">Manufacturing</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/materials" class="usa-nav__link">Materials</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/mathematics-statistics" class="usa-nav__link">Mathematics and statistics</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/metrology" class="usa-nav__link">Metrology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/nanotechnology" class="usa-nav__link">Nanotechnology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/neutron-research" class="usa-nav__link">Neutron research</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/performance-excellence" class="usa-nav__link">Performance excellence</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/physics" class="usa-nav__link">Physics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/public-safety" class="usa-nav__link">Public safety</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/quantum-information-science" class="usa-nav__link">Quantum information science</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/resilience" class="usa-nav__link">Resilience</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/standards" class="usa-nav__link">Standards</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/transportation" class="usa-nav__link">Transportation</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-3"><span>Labs & Major Programs</span></button>
|
||
<div id="primary_menu-3" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/adlp" class="usa-nav__link">Assoc Director of Laboratory Programs</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories" class="usa-nav__link">Laboratories</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/ctl" class="usa-nav__link">Communications Technology Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/el" class="usa-nav__link">Engineering Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/itl" class="usa-nav__link">Information Technology Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/mml" class="usa-nav__link">Material Measurement Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml" class="usa-nav__link">Physical Measurement Laboratory</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/user-facilities" class="usa-nav__link">User Facilities</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/ncnr" class="usa-nav__link">NIST Center for Neutron Research</a>
|
||
</li>
|
||
<li>
|
||
<a href="/cnst" class="usa-nav__link">CNST NanoFab</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/labs-major-programs/research-test-beds" class="usa-nav__link">Research Test Beds</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories/projects-programs" class="usa-nav__link">Research Projects</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories/tools-instruments" class="usa-nav__link">Tools & Instruments</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/major-programs" class="usa-nav__link">Major Programs</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/baldrige" class="usa-nav__link">Baldrige Performance Excellence Program</a>
|
||
</li>
|
||
<li>
|
||
<a href="/chips" class="usa-nav__link">CHIPS for America Initiative</a>
|
||
</li>
|
||
<li>
|
||
<a href="/mep" class="usa-nav__link">Manufacturing Extension Partnership (MEP)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/oam" class="usa-nav__link">Office of Advanced Manufacturing</a>
|
||
</li>
|
||
<li>
|
||
<a href="/spo" class="usa-nav__link">Special Programs Office</a>
|
||
</li>
|
||
<li>
|
||
<a href="/tpo" class="usa-nav__link">Technology Partnerships Office</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-4"><span>Services & Resources</span></button>
|
||
<div id="primary_menu-4" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/content/standards-measurements" class="usa-nav__link">Standards and Measurements</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/calibrations" class="usa-nav__link">Calibration Services</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nvlap" class="usa-nav__link">Laboratory Accreditation (NVLAP)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-quality-system" class="usa-nav__link">Quality System</a>
|
||
</li>
|
||
<li>
|
||
<a href="/srm" class="usa-nav__link">Standard Reference Materials (SRMs)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/sri" class="usa-nav__link">Standard Reference Instruments (SRIs)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/standardsgov" class="usa-nav__link">Standards.gov</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/time-and-frequency-division/time-services" class="usa-nav__link">Time Services</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/owm" class="usa-nav__link">Office of Weights and Measures</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/services-resources/software" class="usa-nav__link">Software</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/data" class="usa-nav__link">Data</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="https://webbook.nist.gov/chemistry/" class="usa-nav__link">Chemistry WebBook</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://nvd.nist.gov/" class="usa-nav__link">National Vulnerability Database</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/productsservices/physical-reference-data" class="usa-nav__link">Physical Reference Data</a>
|
||
</li>
|
||
<li>
|
||
<a href="/srd" class="usa-nav__link">Standard Reference Data (SRD)</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="https://shop.nist.gov/" class="usa-nav__link">Storefront</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/tpo" class="usa-nav__link">License & Patents</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="https://csrc.nist.gov/" class="usa-nav__link">Computer Security Resource Center (CSRC)</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/nist-research-library" class="usa-nav__link">NIST Research Library</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-5"><span>News & Events</span></button>
|
||
<div id="primary_menu-5" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/news-events/news" class="usa-nav__link">News</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/news-events/events" class="usa-nav__link">Events</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/blogs" class="usa-nav__link">Blogs</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/feature-stories" class="usa-nav__link">Feature Stories</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/awards" class="usa-nav__link">Awards</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/video-gallery" class="usa-nav__link">Video Gallery</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/image-gallery" class="usa-nav__link">Image Gallery</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/pao/media-contacts" class="usa-nav__link">Media Contacts</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-6"><span>About NIST</span></button>
|
||
<div id="primary_menu-6" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist" class="usa-nav__link">About Us</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/director/leadership" class="usa-nav__link">Leadership</a>
|
||
</li>
|
||
<li>
|
||
<a href="/director/nist-organization-structure" class="usa-nav__link">Organization Structure</a>
|
||
</li>
|
||
<li>
|
||
<a href="/about-nist/budget-planning" class="usa-nav__link">Budget & Planning</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/contact-us" class="usa-nav__link">Contact Us</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/visit" class="usa-nav__link">Visit</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/careers" class="usa-nav__link">Careers</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/iaao/academic-affairs-office" class="usa-nav__link">Student programs</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/work-nist" class="usa-nav__link">Work with NIST</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/history" class="usa-nav__link">History</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="http://nistdigitalarchives.contentdm.oclc.org/" class="usa-nav__link">NIST Digital Archives</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-museum" class="usa-nav__link">NIST Museum</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-and-nobel" class="usa-nav__link">NIST and the Nobel</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/education" class="usa-nav__link">Educational Resources</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
|
||
|
||
</header>
|
||
<!-- nist-index-ignore-end -->
|
||
</div>
|
||
|
||
<div class="grid-container">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div
|
||
id="block-nist-www-content" class="nist-block"
|
||
>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<section
|
||
class="nist-page__content usa-section clearfix"
|
||
>
|
||
|
||
<a id="main-content" tabindex="-1"></a>
|
||
|
||
<div
|
||
class="nist-page__region nist-page__region--content-top-full"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div class="entity-reference">
|
||
|
||
<div class="nist-blog-header nist-blog-header--purple nist-blog-header--inner">
|
||
<div class="nist-blog-header__bkgrd">
|
||
<div class="nist-blog-header__main grid-container">
|
||
<div class="grid-row">
|
||
<h2 class="nist-blog-header__title">
|
||
<a href="/blogs/taking-measure"> Taking Measure
|
||
</a>
|
||
</h2>
|
||
<div class="nist-blog-header__tagline">
|
||
<p class="text">Just a Standard Blog</p>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="grid-container margin-top-4">
|
||
<div
|
||
class="nist-page__region nist-page__region--content-top"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<h1 class="nist-page__title">Genome in a Bottle: Spelling Out DNA’s ‘Dark’ Sequences</h1>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="font-body-md"
|
||
>
|
||
|
||
|
||
|
||
<div class="daterange"><time datetime="2019-03-13T12:00:00Z">March 13, 2019</time>
|
||
</div>
|
||
|
||
</div>
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
|
||
<span>By: </span>
|
||
<a href="/blogs/taking-measure/authors/justin-zook" hreflang="en">Justin Zook</a>
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
<div data-elastic-exclude class="nist-block nist-social__wrapper">
|
||
<h2 class="nist-social__title">Share</h2>
|
||
<div class="social-media-sharing">
|
||
<div class="nist-social__wrapper--share">
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://www.facebook.com/share.php?u=https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences"
|
||
title="Facebook" class="nist-social nist-social--facebook-gray">
|
||
<span>Facebook</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences&source=https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences"
|
||
title="Linkedin" class="nist-social nist-social--linkedin-gray">
|
||
<span>Linkedin</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://x.com/intent/tweet?url=https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences&status=https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences"
|
||
title="X.com" class="nist-social nist-social--x-gray">
|
||
<span>X.com</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a href="mailto:?subject=NIST.gov&body=Check out this site https://www.nist.gov/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences"
|
||
title="Email" class="nist-social nist-social--envelope-gray">
|
||
<span>Email</span>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="grid-container margin-top-4">
|
||
<div class="grid-row grid-gap-6">
|
||
|
||
|
||
|
||
<div
|
||
class="nist-page__region nist-page__region--content tablet-lg:grid-col-8"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div class="text-with-summary">
|
||
|
||
<figure class="nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2019/03/12/justin_zook_lab.jpg?itok=rXQlRG51" data-media-id="487371">
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/960_x_960_limit/public/images/2019/03/12/justin_zook_lab.jpg?itok=9xCLSIE0" width="960" height="540" alt="Justin Zook in a lab surrounded by genetic sequencing machines" typeof="foaf:Image" />
|
||
|
||
|
||
|
||
|
||
<figcaption class="nist-image__caption">
|
||
<div data-caption-editable="true" class="nist-image__caption-content">
|
||
|
||
<p>These genetic sequencing machines produce a tremendous amount of data; my job is to analyze it and develop reference materials to help other researchers look for genetic variants, like those responsible for disease, with confidence that their tests are working properly. </p>
|
||
|
||
</div>
|
||
<div class="nist-image__credit">
|
||
<span class="nist-image__credit-label">Credit:</span>
|
||
|
||
M. Esser/NIST
|
||
|
||
</div>
|
||
</figcaption>
|
||
</figure>
|
||
|
||
|
||
|
||
|
||
<p>When the <a href="https://www.genome.gov/12011238/an-overview-of-the-human-genome-project/">Human Genome Project</a> began 20 years ago, its consortium of researchers at 20 research institutes spent more than $1 billion to sequence that first genome’s billion plus bases. Recently, researchers from the Harvard <a href="https://www.genome.gov/12011238/an-overview-of-the-human-genome-project/">Personal Genome Project</a> (PGP) sent me my whole genome sequence, costing perhaps a few thousand dollars. They compared my genome to the reference genome generated by the Human Genome Project and found over 3 million small differences, or variants. I was excited to explore my genome and perhaps find some clues related to the source of my type 1 diabetes and lymphedema, which are sometimes genetic but don’t run in my family. Yet, based on our collaborative work in the NIST-hosted <a href="/programs-projects/genome-bottle" data-entity-type="node" data-entity-uuid="b3670f8f-5e6e-453e-875b-9788e01fb478" data-entity-substitution="canonical" title="Genome in a Bottle">“Genome in a Bottle” (GIAB) Consortium</a>, I know there are still many challenges both in characterizing the sequence of all of the billions of bases in the human genome and in understanding what the sequence means.</p><p>Out of the more than three million variants found in my genome, fewer than 100 currently have a clear meaning. Some were unsurprising, like a variant that gives me seven times higher risk of male baldness, as evidenced by the many bald men in my family, including me. A few also tell me that I carry variants related to rare diseases in my DNA, so if my wife happened to be a carrier our children might be affected. Some variants also tell me I should be careful when taking certain kinds of medicines. Finally, a few variants suggest I may have a slightly higher risk for certain diseases, including one variant that gives me about five times higher risk of developing type 1 diabetes; still, half of the population has the variant and most of them do not get the disorder. None of my variants are currently known to be linked to lymphedema. This type of uncertainty is common even when sequencing someone with a severe disease thought to be genetic, but why?</p><p>Many explanations exist for why we often can’t find a clear genetic cause for a disease. For example, many diseases have both environmental and genetic causes. Also, the genetic causes of many diseases are complex, often weakly related to many different variants across the genome, so researchers will need to analyze millions of individuals from different ancestries. In addition, our current methods are not powerful enough to characterize the many types of variants and regions of the genome, which motivates my current work. Even though my NIST research for the past seven years has revolved around analyzing genome sequencing data, the amount of data and its complexity is still overwhelming.</p><p> </p> <figure class=" align-center nist-image" role="group">
|
||
<div>
|
||
|
||
<img alt="a bookcase of containing over 100 volumes" height="699" loading="lazy" src="/sites/default/files/images/2019/03/06/wellcome_genome_bookcase.png" typeof="foaf:Image" width="800">
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<figcaption class="nist-image__caption">The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. The 3.4 billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.<div class="nist-image__credit">
|
||
<span class="nist-image__credit-label">Credit:</span>
|
||
|
||
Russ London/Creative Commons Attribution-Share Alike 3.0 Unported
|
||
|
||
</div></figcaption>
|
||
</figure>
|
||
|
||
<p>DNA sequencing technologies have greatly improved during and since the Human Genome Project, so that today sequencing a typical genome only costs $1,000 to $10,000, depending on the technology. However, the new methods come with trade-offs and require complex computer analysis to piece together millions of sequence fragments from the human genome. This analysis is highly accurate today for about 80-90 percent of the genome’s small variants, but larger changes in the genome and changes in the repetitive, poorly understood “dark matter” of the genome are much more challenging. Fortunately, sequencing technologies and analysis methods are continually improving to characterize increasingly challenging regions of the genome at lower cost.</p><p>To gain trust in the results of new sequencing methods and improve them, experts from industry, academic labs and government formed the Genome in a Bottle Consortium (GIAB). This NIST-led collaboration includes companies and researchers developing new sequencing technologies and analysis methods working together to help clinical and research labs answer the question “So you’ve sequenced a genome, how well did you do?” We focus on characterizing a small number of genomes and literally put them in “bottles” that anyone can purchase from NIST as <a href="https://www.nist.gov/news-events/news/2016/09/nist-releases-new-family-standardized-genomes">reference materials</a>. Reference materials are essentially materials for which we have extensively characterized at least one thing about them. For example, we have reference materials with a known amount of cholesterol that clinical laboratories can use when testing your blood to ensure they get the correct answer whether you get tested in the U.S., Asia, or anywhere else in the world.</p><p>For our DNA reference materials, our genomes in a bottle, we chose two mother-father-son trios from the Personal Genome Project and characterized their DNA sequences exceptionally well with many sequencing methods. While different sequencing methods compete in the marketplace, everyone works together openly in GIAB to take advantage of the strengths of each method and approximate, given some uncertainty, the true sequence of these genomes. Much of our NIST work for Genome in a Bottle has been developing methods to integrate results from all sequencing methods and develop our best estimate of the true sequence. Then, similar to how clinical laboratories test cholesterol reference materials periodically to make sure they get a similar value to NIST’s, they sequence our publicly available DNA reference materials and compare their DNA sequence results to our approximation of the true sequence. Methods developers use these genomes to optimize their methods, and some have even used it to train artificial intelligence models to characterize genomes more accurately. Standards like our reference materials are part of delivering the promise of “precision medicine,” which will enable doctors to tailor treatments and give the right drug to the right person at the right time. Just like how the NIST-developed atomic clocks have enabled unexpected technologies like GPS, our precisely characterized genomes have enabled new technologies we hadn’t imagined at the start.</p><p>To help others use our precisely characterized genomes, we led the Global Alliance for Genomics and Health Benchmarking Team. This team developed standardized methods for any lab to compare the variants they find in the DNA of NIST’s reference materials to NIST’s answer. Comparing variants is complex because they can be represented in many different ways, so the biggest part of the team’s work was a “meta-comparison” of the tools used to compare variants. After a few years of regular conference calls with scientists from New Zealand to the UK to the USA, we just <a href="https://doi.org/10.1038/s41587-019-0054-x">published</a> best practices for benchmarking so that performance of any sequencing method can be compared to any other method.</p><p> </p><div class="nist-video" data-media-id="319836">
|
||
<div class="video-embed-field"><div class="video-embed-field-lazy" data-video-embed-field-lazy="<div class="video-embed-field-provider-nist-kaltura video-embed-field-responsive-video"><iframe width="854" height="480" frameborder="0" allow="autoplay *; fullscreen *; encrypted-media *" allowfullscreen="allowfullscreen" src="https://www.kaltura.com/p/684682/embedPlaykitJs/uiconf_id/55674542?iframeembed=true&amp;entry_id=0_ufeabe9o"></iframe>
|
||
</div>
|
||
"><img alt="Genome in a Bottle and the Genome Sequencing Process" loading="lazy" src="https://cdnsecakmi.kaltura.com/p/684682/sp/68468200/thumbnail/entry_id/0_ufeabe9o/width/1280" typeof="foaf:Image">
|
||
<button class="video-embed-field-lazy-play"></button>
|
||
<div class="video-embed-field-lazy-title">Genome in a Bottle and the Genome Sequencing Process</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<p>While the variants found by most prominent DNA tests are likely accurate in the easier regions of the genome, interpretation can be challenging. DNA frequently has a certain mystique, such that it’s easy to believe anything “genetic” determines our destiny. In fact, most of our characteristics are a complex interplay between the sequence in many different parts of our genome and our environment. In addition, clinical genome sequencing tests often give “variants of uncertain significance”, for which the evidence is not yet clear whether they might cause any disease. It is even more challenging to interpret popular DNA-based ancestry tests ordered by millions of people around the world. These tests can give a view into the paternal or maternal line, The NY Times <a href="https://nyti.ms/2AeE3Xg">published</a> a series of articles about the misuse of ancestry tests in support of white supremacist ideology, and genetics experts in the American Society of Human Genetics strongly <a href="https://www.cell.com/ajhg/fulltext/S0002-9297(18)30363-X">condemned</a> this misinterpretation. NPR’s Code Switch hosted a <a href="https://www.npr.org/templates/transcript/transcript.php?storyId=679287399">podcast</a> with an interesting discussion of the important differences between race and ancestry. That said, it can be fun to see, for example, how one ancestry test clearly predicted that many of my ancestors migrated from Switzerland to eastern and central Pennsylvania, as I’d expect based on my Mennonite heritage.</p><p>Working with genomes from the PGP has been important for the Genome in a Bottle project. As a participant in the PGP (though I’m not one of the GIAB genomes), I went through their rigorous consent process to understand the potential risks for making my genome data and samples publicly available. These risks range from learning about diseases I could do nothing about to life insurance companies raising my premiums due to disease predicted by my genome to someone synthesizing my DNA and planting it at a crime scene. We are very grateful to the PGP and its participants because they have consented to allow anyone to make secondary reference samples. For example, several companies have already made about 100 different secondary reference samples from the GIAB/PGP genomes to meet specific needs for clinical laboratory testing such as samples that try to mimic small DNA fragments from tumors found in blood. One current challenge is the lack of families of non-Caucasian ancestry, so PGP wrote <a href="https://personalgenomes.wordpress.com/2012/11/29/seeking-diversity/">a blog describing the need for diverse volunteers</a> for the project. We are working on finding reference samples from individuals of ancestries other than the Caucasian and Asian families we’ve characterized so far because this will help ensure the accuracy of sequencing tests across all ancestries.</p><p>Perhaps the cause of my diseases will be found in the “dark matter” of the genome. More importantly, a deeper understanding of the genome may help us treat conditions like cancer, muscular dystrophy, Huntington’s disease and schizophrenia. I am honored to be among the wide variety of experts in the Genome in a Bottle Consortium working to enable the new technologies that will measure these challenging parts of the genome and shed light on a path to cures for previously untreatable diseases.</p><p><em>*Edited June 17, 2021</em></p>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
|
||
<div class="nist-tags">
|
||
|
||
<a href="/blogs/taking-measure/categories/248321">Bioscience</a>,
|
||
<a href="/blogs/taking-measure/categories/248341">Engineering / synthetic biology</a>,
|
||
<a href="/blogs/taking-measure/categories/2816286">Genome engineering</a>,
|
||
<a href="/blogs/taking-measure/categories/2813426">Genome editing</a>,
|
||
<a href="/blogs/taking-measure/categories/248346">Genomics</a>,
|
||
<a href="/blogs/taking-measure/categories/248651">Health</a>,
|
||
<a href="/blogs/taking-measure/categories/2813441">Cell and gene therapy</a>,
|
||
<a href="/blogs/taking-measure/categories/249341">Standards</a> and
|
||
<a href="/blogs/taking-measure/categories/249386">Reference materials</a></div>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>About the author</h2>
|
||
|
||
<div class="nist-field nist-field--label-hidden entity-reference">
|
||
<div class="nist-field__items">
|
||
<div class="nist-field__item">
|
||
|
||
<article
|
||
about="/blogs/taking-measure/authors/justin-zook" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
||
<div class="entity-reference"> <a href="/blogs/taking-measure/authors/justin-zook" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2019/03/06/Zook%20headshot.jpg?itok=TP9wTyNe" width="100" height="100" alt="portrait of Justin Zook" typeof="foaf:Image" />
|
||
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="nist-teaser__content-wrapper">
|
||
<header>
|
||
<h3 class="nist-teaser__title"><a href="/blogs/taking-measure/authors/justin-zook"><span>Justin Zook</span>
|
||
</a></h3>
|
||
|
||
</header>
|
||
<div class="nist-teaser__content">
|
||
<div class="text-with-summary"><p><span><span>Justin Zook co-leads the Biomarker and Genomic Sciences Group in NIST’s Material Measurement Laboratory. Since 2013, he has co-led Genome in a Bottle, an open science consortium with industry, academia, and government to authoritatively sequence the DNA of NIST’s human genome Reference Materials. For this work, in 2017, he received the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the United States Government on science and engineering professionals in the early stages of their independent research careers.</span></span></p></div>
|
||
|
||
</div>
|
||
</div>
|
||
</article>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<div
|
||
class="views-element-container nist-block no-print"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Related posts</h2>
|
||
|
||
<div><div class="js-view-dom-id-885c8263c9d552e6434bc58411786a4f99fcf851dc57e1a33f27b1c91123a196">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
|
||
<article
|
||
about="/blogs/taking-measure/robots-and-ai-are-working-together-bring-you-better-medicines-shampoo-and-more" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
||
<div class="entity-reference"> <a href="/blogs/taking-measure/robots-and-ai-are-working-together-bring-you-better-medicines-shampoo-and-more" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2024/12/18/peter_beaucage_afl_equipment_121024.jpg?itok=CdxapNjs" width="100" height="67" alt="Peter Beaucage wears safety glasses as he stands in the lab, holding a piece of equipment on display. " typeof="foaf:Image" />
|
||
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="nist-teaser__content-wrapper">
|
||
<header>
|
||
<h3 class="nist-teaser__title"><a href="/blogs/taking-measure/robots-and-ai-are-working-together-bring-you-better-medicines-shampoo-and-more"><span>Robots and AI Are Working Together to Bring You Better Medicines, Shampoo and More</span>
|
||
</a></h3>
|
||
<div class="nist-teaser__date">
|
||
<div class="daterange"><time datetime="2025-01-15T12:00:00Z">January 15, 2025</time>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</header>
|
||
<div class="nist-teaser__content">
|
||
<div class="text-with-summary"> Products you use every day are carefully formulated in a lab. Experts at NIST are now working to revolutionize how those products are made.
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</article>
|
||
</div>
|
||
<div>
|
||
|
||
<article
|
||
about="/blogs/taking-measure/safer-skies-fewer-fires-10-ways-nist-impacts-your-daily-life" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
||
<div class="entity-reference"> <a href="/blogs/taking-measure/safer-skies-fewer-fires-10-ways-nist-impacts-your-daily-life" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2024/12/12/2024_EndofYearBlogPost_960x600_v1.png?itok=qqCEC65E" width="100" height="63" alt="Photos of everyday objects like an iron, a gas can and a laptop along with high-tech items like an atomic clock and a mass balance. Label reads: 10 Ways NIST Impacts Your Daily Life. " typeof="foaf:Image" />
|
||
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="nist-teaser__content-wrapper">
|
||
<header>
|
||
<h3 class="nist-teaser__title"><a href="/blogs/taking-measure/safer-skies-fewer-fires-10-ways-nist-impacts-your-daily-life"><span>From Safer Skies to Fewer Fires: 10 Ways NIST Impacts Your Daily Life</span>
|
||
</a></h3>
|
||
<div class="nist-teaser__date">
|
||
<div class="daterange"><time datetime="2024-12-19T12:00:00Z">December 19, 2024</time>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</header>
|
||
<div class="nist-teaser__content">
|
||
<div class="text-with-summary"> If you’ve ever had a medical test, flown on an airplane, or needed to check the time, NIST’s work affects your life every day.
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</article>
|
||
</div>
|
||
<div>
|
||
|
||
<article
|
||
about="/blogs/taking-measure/how-atomic-clocks-have-changed-our-world" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
||
<div class="entity-reference"> <a href="/blogs/taking-measure/how-atomic-clocks-have-changed-our-world" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2024/08/22/Harold%20Lyons%20photo%20-%20AP%20license.jpg?itok=NTzFO3PA" width="80" height="100" alt="Historical photo shows three men standing next to a refrigerator-sized piece of machinery with an analog clock attached to the top. " typeof="foaf:Image" />
|
||
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="nist-teaser__content-wrapper">
|
||
<header>
|
||
<h3 class="nist-teaser__title"><a href="/blogs/taking-measure/how-atomic-clocks-have-changed-our-world"><span>How Atomic Clocks Have Changed Our World</span>
|
||
</a></h3>
|
||
<div class="nist-teaser__date">
|
||
<div class="daterange"><time datetime="2024-11-04T12:00:00Z">November 4, 2024</time>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</header>
|
||
<div class="nist-teaser__content">
|
||
<div class="text-with-summary"> We spend our days immersed in time. But where does time come from? How do we track it? This has evolved along with technology in recent years.
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</article>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div
|
||
class="nist-block no-print"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Comments</h2>
|
||
|
||
<section>
|
||
|
||
|
||
|
||
<h2>Add new comment</h2>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_Lx5yvw0vUi4TN7C0L-5Rdrp4Q049mXEKn-dXREWOtBs.css?delta=0&language=en&theme=nist_www&include=eJxLzCvJTMov0U-E0Hpp-UW5OsmJBSXJGYn6SYnFqTppmTklqUX6KUWlBYk5ehAeAD47FNs&exclude=eJx1UAuuwyAMuxAdR0IBsi5bIBWfdb39QrunVZOeRFDsWI7BQ3i4JnoW67-9u1fj_xlRkGxmkZnRQQbeGoVqfwmTqTZ3JeWirJkFomtFbSjPdoZjXKkhpaXIE-0vMSLsXLthQt0s7KG4JNFGquDVmCk_TN1qw6QJK-56O7N44HM_fazsDSFi-YNuXdez-oSHBF9tLLCx9AX48oHmSbhWu98XDdMZTV0gaWUr_tprgKaUBAJ2CSPByEbBMGzSm9PwQZ9XNisZg_Bh6O49LSrP_bCeBp4G_kZLFIqMH3oD_KWsjg" />
|
||
<form class="comment-comment-node-blog-form comment-form usa-form antibot" novalidate="novalidate" data-drupal-selector="comment-form" data-action="/comment/reply/node/1552236/comment_node_blog" action="/antibot" method="post" id="comment-form" accept-charset="UTF-8">
|
||
<noscript>
|
||
<div class="antibot-no-js antibot-message antibot-message-warning">You must have JavaScript enabled to use this form.</div>
|
||
</noscript>
|
||
<div class="form-item js-form-item form-type-textfield js-form-type-textfield form-item-name js-form-item-name">
|
||
<label for="edit-name" class="usa-label">
|
||
Your name
|
||
</label>
|
||
|
||
|
||
<input data-drupal-default-value="Anonymous" data-drupal-selector="edit-name" type="text" id="edit-name" name="name" value="" size="30" maxlength="60" class="form-text usa-input" />
|
||
|
||
|
||
|
||
</div>
|
||
<input data-drupal-selector="form-d4ijcopzoab9b-nfbfmsitaiv5s-lsurehy1zrc3k0s" type="hidden" name="form_build_id" value="form-D4IjCOpzoAb9B_nFbfMSItaiV5s_lsureHY1ZRc3k0s" class="usa-input" /><input data-drupal-selector="edit-comment-comment-node-blog-form" type="hidden" name="form_id" value="comment_comment_node_blog_form" class="usa-input" /><input data-drupal-selector="edit-antibot-key" type="hidden" name="antibot_key" value="" class="usa-input" /><div class="field--type-text-long field--name-comment-body field--widget-text-textarea js-form-wrapper form-wrapper" data-drupal-selector="edit-comment-body-wrapper" id="edit-comment-body-wrapper"> <div class="js-text-format-wrapper js-form-item form-item">
|
||
<div class="form-item js-form-item form-type-textarea js-form-type-textarea form-item-comment-body-0-value js-form-item-comment-body-0-value">
|
||
<label for="edit-comment-body-0-value" class="usa-label form-required">
|
||
Comment
|
||
<span class="usa-label--required"> <span class="usa-sr-only">Required</span>*</span></label>
|
||
|
||
|
||
<div class="form-textarea-wrapper">
|
||
<textarea class="js-text-full text-full form-textarea required usa-textarea resize-vertical" data-entity_embed-host-entity-langcode="en" data-media-embed-host-entity-langcode="en" data-drupal-selector="edit-comment-body-0-value" id="edit-comment-body-0-value" name="comment_body[0][value]" rows="5" cols="60" placeholder="" required="required" aria-required="true"></textarea>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="js-filter-wrapper filter-wrapper hidden js-form-wrapper form-wrapper" data-drupal-selector="edit-comment-body-0-format" id="edit-comment-body-0-format"><div class="js-filter-guidelines filter-guidelines js-form-wrapper form-wrapper" data-drupal-selector="edit-comment-body-0-format-guidelines" id="edit-comment-body-0-format-guidelines"><div data-drupal-format-id="plain_text">
|
||
<h4>Plain text</h4>
|
||
|
||
|
||
|
||
<ul>
|
||
<li>No HTML tags allowed.</li>
|
||
<li>Web page addresses and email addresses turn into links automatically.</li>
|
||
<li>Lines and paragraphs break automatically.</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<fieldset data-drupal-selector="edit-captcha" class="captcha captcha-type-challenge--image">
|
||
<legend class="captcha__title js-form-required form-required">
|
||
CAPTCHA
|
||
</legend>
|
||
<div class="captcha__element">
|
||
<input data-drupal-selector="edit-captcha-sid" type="hidden" name="captcha_sid" value="652061356" class="usa-input" /><input data-drupal-selector="edit-captcha-token" type="hidden" name="captcha_token" value="QawJsREN3eKwV9Mqo6irdRZ2bNVDWo6jadKxT0Lkqo0" class="usa-input" /><div class="captcha__image-wrapper js-form-wrapper form-wrapper" data-drupal-selector="edit-captcha-image-wrapper" id="edit-captcha-image-wrapper"><img data-drupal-selector="edit-captcha-image" src="/image-captcha-generate/652061356/1741067501" width="180" height="60" alt="Image CAPTCHA" title="Image CAPTCHA" loading="lazy" typeof="foaf:Image" />
|
||
</div>
|
||
<div class="form-item js-form-item form-type-textfield js-form-type-textfield form-item-captcha-response js-form-item-captcha-response">
|
||
<label for="edit-captcha-response" class="usa-label form-required">
|
||
What code is in the image?
|
||
<span class="usa-label--required"> <span class="usa-sr-only">Required</span>*</span></label>
|
||
|
||
|
||
<input autocomplete="off" data-drupal-selector="edit-captcha-response" aria-describedby="edit-captcha-response--description" type="text" id="edit-captcha-response" name="captcha_response" value="" size="15" maxlength="128" class="form-text required usa-input" required="required" aria-required="true" />
|
||
|
||
|
||
|
||
<div id="edit-captcha-response--description" class="description help-block">
|
||
Enter the characters shown in the image.
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<div class="captcha__description description">This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.</div>
|
||
</fieldset>
|
||
<div data-drupal-selector="edit-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-actions--2"><input data-drupal-selector="edit-submit" type="submit" id="edit-submit" name="op" value="Save" class="button button--primary js-form-submit form-submit usa-button" /></div>
|
||
|
||
<div class="comments__disclaimer padding-top-2">
|
||
<em>Please be respectful when posting comments. We will post all comments without editing as long as they are appropriate for a public, family friendly website, are on topic and do not contain profanity, personal attacks, misleading or false information/accusations or promote specific commercial products, services or organizations. Comments that violate our comment policy or include links to non-government organizations/web pages will not be posted.</em>
|
||
</div>
|
||
</form>
|
||
|
||
|
||
</section>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<aside class="nist-page__region nist-page__region--sidebar-second tablet-lg:grid-col-4">
|
||
|
||
<div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
|
||
<div>
|
||
<div about="/blogs/taking-measure">
|
||
|
||
|
||
<div
|
||
class="nist-block no-print"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Our Science in Your Inbox</h2>
|
||
|
||
<div class="text-long"><p>Subscribe to our weekly emails.</p>
|
||
<form action="https://public.govdelivery.com/accounts/USNIST/subscribers/qualify" accept-charset="UTF-8" method="post">
|
||
<input name="utf8" type="hidden" value="✓">
|
||
<input type="hidden" name="authenticity_token" value="GleKn0r3EFkuIRsIWsyLN6Mrqim4qc3U7eIUCWGqBFz2ziQ/qv0gnQTJUhVbKHMSlmrsC7UHIm6S8IfK6qk9EQ==">
|
||
<input type="hidden" name="topic_id" id="topic_id" value="USNIST_309">
|
||
<div class="grid-row grid-gap-1">
|
||
<div class="tablet:grid-col-8">
|
||
<label class="usa-sr-only" for="email">Enter Email Address</label>
|
||
<input class="usa-input" type="text" name="email" id="email" title="email" placeholder="Your Email Address">
|
||
</div>
|
||
<div class="tablet:grid-col-4">
|
||
<input type="submit" name="commit" value="Sign Up" class="usa-button margin-top-1">
|
||
</div>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="views-exposed-form usa-form filters nist-block" novalidate="novalidate" data-drupal-selector="views-exposed-form-search-blog-taking-measure-search-page"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Search</h2>
|
||
|
||
<form action="/blogs/taking-measure/search" method="get" id="views-exposed-form-search-blog-taking-measure-search-page" accept-charset="UTF-8" class="usa-form">
|
||
<div class="form-item js-form-item form-type-textfield js-form-type-textfield form-item-k js-form-item-k form-no-label">
|
||
|
||
|
||
<input placeholder="Search this blog" data-drupal-selector="edit-k" type="text" id="edit-k" name="k" value="" size="30" maxlength="128" class="form-text usa-input" />
|
||
|
||
|
||
|
||
<div id="edit-k--description" class="description help-block">
|
||
Put exact phrase in quotes (e.g., "artificial intelligence")
|
||
</div>
|
||
</div>
|
||
<div class="grid-col-12 form-actions js-form-wrapper form-wrapper" data-drupal-selector="edit-actions" id="edit-actions"><input data-drupal-selector="edit-submit-search-blog" type="submit" id="edit-submit-search-blog" value="Search" class="button js-form-submit form-submit usa-button" /></div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
</div>
|
||
<div
|
||
class="nist-block no-print"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Stay connected</h2>
|
||
|
||
|
||
|
||
<div><a href="https://www.facebook.com/nist" class="nist-social nist-social--facebook" title="Facebook" ><span>Facebook</span></a><a href="https://www.linkedin.com/company/nist" class="nist-social nist-social--linkedin" title="LinkedIn" ><span>LinkedIn</span></a><a href="https://www.x.com/nist" class="nist-social nist-social--x" title="X (Twitter)" ><span>X (Twitter)</span></a><a href="https://www.youtube.com/nist" class="nist-social nist-social--youtube" title="Youtube" ><span>Youtube</span></a><a href="https://www.instagram.com/nist/" class="nist-social nist-social--instagram" title="Instagram" ><span>Instagram</span></a><a href="https://public.govdelivery.com/accounts/USNIST/subscriber/new?topic_id=USNIST_309" class="nist-social nist-social--envelope" title="GovDelivery" ><span>GovDelivery</span></a></div>
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="views-element-container nist-block"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Categories</h2>
|
||
|
||
<div><div class="js-view-dom-id-7799eab950eea495fbec7abb4fbe9d96ca090ca4be170b5b9b727e3cea5dabda">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<select class="usa-select ViewsJumpMenu js-viewsJumpMenu" title="-- Choose --" id="blog-categories-takingm-jump-menu">
|
||
<option>-- Choose --</option>
|
||
<option data-url="/blogs/taking-measure/categories/249466">Advanced communications</option>
|
||
<option data-url="/blogs/taking-measure/categories/248321">Bioscience</option>
|
||
<option data-url="/blogs/taking-measure/categories/248371">Buildings and Construction</option>
|
||
<option data-url="/blogs/taking-measure/categories/248416">Chemistry</option>
|
||
<option data-url="/blogs/taking-measure/categories/248486">Electronics</option>
|
||
<option data-url="/blogs/taking-measure/categories/248531">Energy</option>
|
||
<option data-url="/blogs/taking-measure/categories/248561">Environment</option>
|
||
<option data-url="/blogs/taking-measure/categories/248586">Fire</option>
|
||
<option data-url="/blogs/taking-measure/categories/248616">Forensic Science</option>
|
||
<option data-url="/blogs/taking-measure/categories/248651">Health</option>
|
||
<option data-url="/blogs/taking-measure/categories/249421">Information technology</option>
|
||
<option data-url="/blogs/taking-measure/categories/2748236">Infrastructure</option>
|
||
<option data-url="/blogs/taking-measure/categories/248866">Manufacturing</option>
|
||
<option data-url="/blogs/taking-measure/categories/248946">Materials</option>
|
||
<option data-url="/blogs/taking-measure/categories/249011">Mathematics and statistics</option>
|
||
<option data-url="/blogs/taking-measure/categories/249051">Metrology</option>
|
||
<option data-url="/blogs/taking-measure/categories/249126">Nanotechnology</option>
|
||
<option data-url="/blogs/taking-measure/categories/249451">Neutron research</option>
|
||
<option data-url="/blogs/taking-measure/categories/249426">Performance excellence</option>
|
||
<option data-url="/blogs/taking-measure/categories/249241">Physics</option>
|
||
<option data-url="/blogs/taking-measure/categories/249461">Public safety</option>
|
||
<option data-url="/blogs/taking-measure/categories/249456">Resilience</option>
|
||
<option data-url="/blogs/taking-measure/categories/249341">Standards</option>
|
||
<option data-url="/blogs/taking-measure/categories/2813456">Technology transfer</option>
|
||
<option data-url="/blogs/taking-measure/categories/249396">Transportation</option>
|
||
</select>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</aside>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="grid-container">
|
||
|
||
|
||
</div>
|
||
|
||
</section>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div data-elastic-exclude>
|
||
<!-- nist-index-ignore-start -->
|
||
|
||
<footer class="nist-footer padding-bottom-4">
|
||
|
||
|
||
<div class="grid-container nist-footer__info">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-6">
|
||
<div class="nist-footer__logo">
|
||
<a href="/" title="National Institute of Standards and Technology" rel="home">
|
||
<img class="nist-footer__logo-img" src="/libraries/nist-component-library/dist/img/logo/NIST-Logo-Brand-White.svg" alt="National Institute of Standards and Technology logo" width="300px" height="42px" />
|
||
</a>
|
||
</div>
|
||
<div class="nist-footer__contact">
|
||
<h3 class="nist-footer__contact-heading">HEADQUARTERS</h3>
|
||
<address>
|
||
100 Bureau Drive<br>
|
||
Gaithersburg, MD 20899<br>
|
||
<a href="tel:301-975-2000">301-975-2000</a>
|
||
</address>
|
||
<p>
|
||
<a href="mailto:do-webmaster@nist.gov">Webmaster</a> | <a href="https://www.nist.gov/about-nist/contact-us">Contact Us</a> | <a href="https://www.nist.gov/visit">Our Other Offices</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="tablet:grid-col-6">
|
||
<div class="nist-footer__social-links">
|
||
|
||
<a class="nist-social nist-social--x-white" href=" https://x.com/NIST">
|
||
<span>X.com</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--facebook-white" href=" https://www.facebook.com/NIST">
|
||
<span>Facebook</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--linkedin-white" href=" https://www.linkedin.com/company/nist">
|
||
<span>LinkedIn</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--instagram-white" href=" https://www.instagram.com/nist/">
|
||
<span>Instagram</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--youtube-white" href=" https://www.youtube.com/NIST">
|
||
<span>YouTube</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--giphy-white" href=" https://giphy.com/nist">
|
||
<span>Giphy</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--rss-white" href=" https://www.nist.gov/news-events/nist-rss-feeds">
|
||
<span>RSS Feed</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--envelope-white" href=" https://public.govdelivery.com/accounts/USNIST/subscriber/new">
|
||
<span>Mailing List</span>
|
||
</a>
|
||
</div>
|
||
<div class="nist-footer__feedback">
|
||
How are we doing? <a class="usa-button" rel="nofollow" href="/form/nist-gov-feedback?destination=/blogs/taking-measure/genome-bottle-spelling-out-dnas-dark-sequences" title="Provide feedback">Feedback</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="grid-container">
|
||
<div class="nist-footer__nav" role="navigation">
|
||
<ul>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/privacy-policy">Site Privacy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/oism/accessibility">Accessibility</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/privacy">Privacy Program</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/oism/copyrights">Copyrights</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.commerce.gov/vulnerability-disclosure-policy">Vulnerability Disclosure</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/no-fear-act-policy">No Fear Act Policy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/office-director/freedom-information-act">FOIA</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/environmental-policy-statement">Environmental Policy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/summary-report-scientific-integrity">Scientific Integrity</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/nist-information-quality-standards">Information Quality Standards</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.commerce.gov/">Commerce.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="http://www.science.gov/">Science.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="http://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://vote.gov/">Vote.gov</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</footer>
|
||
<!-- nist-index-ignore-end -->
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/1552236","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"back_to_top":{"back_to_top_button_trigger":100,"back_to_top_speed":1200,"back_to_top_prevent_on_mobile":false,"back_to_top_prevent_in_admin":true,"back_to_top_button_type":"image","back_to_top_button_text":"Back to top"},"google_analytics":{"account":"G-HEQ0YF2VYL","trackOutbound":true,"trackMailto":true,"trackTel":true,"trackDownload":true,"trackDownloadExtensions":"7z|aac|arc|arj|asf|asx|avi|bin|bsh|c|csv|doc(x|m)?|dot(x|m)?|dw(fx|g|gd)|dxf|eps|epub|exe|f(90)|flv|gif|gz|gzip|hqx|jar|jpe?g|js|m1v|mp(2|3|4|e?g)|mobi|mov(ie)?|msi|msp|pdf|phps|pl|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|rfa|rtf|rvt|sch|sea|sit|swf|tar|tgz|tif|txt|txz|wav|wma|wmv|wpd|wrl|xls(x|m|b)?|xlt(x|m)|xlam|xml|xsd|z|zip"},"nist_search":{"clickTracking":"search-report-click","isDebug":false,"clickTrackEnabled":true,"message":"NIST Search in debug mode. Check the browsers network inspector for Click Track reporting results..."},"data":{"extlink":{"extTarget":false,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"\\.gov\\\/|\\.mil\\\/|\\manufacturingusa\\.com\\\/","extInclude":"","extCssExclude":".ck-editor, .nist-video-thumbnail__lightbox-trigger, a.nist-icon--mail-blue","extCssExplicit":"","extAlert":true,"extAlertText":"Thank you for visiting NIST. We hope your visit was informative. We have provided a link to this site because it has information that may be of interest to our users. NIST does not necessarily endorse the views expressed or the facts presented on this site. Further, NIST does not endorse any commercial products that may be advertised or available on this site. Click OK to be directed to your link.","mailtoClass":"0","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"after","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"viewsJumpMenu":{"blog-categories-takingm-jump-menu":{"new_window":false}},"ajaxTrustedUrl":{"\/blogs\/taking-measure\/search":true,"\/comment\/reply\/node\/1552236\/comment_node_blog":true},"user":{"uid":0,"permissionsHash":"bd6a443844dbe99b4e6942f3b1397526e760137efd2b1ee6b2d588fc414dff20"},"antibot":{"forms":{"comment-form":{"id":"comment-form","key":"8s3HerPNUiBWAup-NU0eICdfN5XSJ1VRGAW7gyEytXD"}}}}</script>
|
||
<script src="/sites/default/files/js/js_jDaFaXhHm6gPUKstNYX9eIyoQXghVs3g7rbR0QoqpYY.js?scope=footer&delta=0&language=en&theme=nist_www&include=eJxdkIGuwiAMRX-I2U8iZXRYLXQBJvq-_sE2ozEhKedy29vgcL7bqv2s4D53eysmqAYhiwnlVXku8CuYxKXahbvmtSVR9LbmPoRTgIDHc-FKHNesD4JfYaTsWr1SpJ6r4jDbqB48F3R9sHC67x4Iog5lOlvgSugpv9G21r4c9KyjEXzeVpTLiebBntRSdOT72iQeBP9e01j8GBoxJF547k5qxd62uNpIaYOdp8HTYIOpstMKZ70smqPpP1Epv0MP-gdBq4qH"></script>
|
||
<script src="https://siteimproveanalytics.com/js/siteanalyze_6017546.js" async></script>
|
||
<script src="/sites/default/files/js/js_ZoFeIo8scpoq94kP7QAN_ozR-baIqyktDACCoUJcoMg.js?scope=footer&delta=2&language=en&theme=nist_www&include=eJxdkIGuwiAMRX-I2U8iZXRYLXQBJvq-_sE2ozEhKedy29vgcL7bqv2s4D53eysmqAYhiwnlVXku8CuYxKXahbvmtSVR9LbmPoRTgIDHc-FKHNesD4JfYaTsWr1SpJ6r4jDbqB48F3R9sHC67x4Iog5lOlvgSugpv9G21r4c9KyjEXzeVpTLiebBntRSdOT72iQeBP9e01j8GBoxJF547k5qxd62uNpIaYOdp8HTYIOpstMKZ70smqPpP1Epv0MP-gdBq4qH"></script>
|
||
<script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"37b7ccb661","applicationID":"1089704227","transactionName":"YFxUN0sADEdYVkBaClkWdwBNCA1aFnFGRhVWVWoNVgUHaHpaWkcXWFVaBks9LFtdUGJaAEB6WQ1NEw1YVVBGHltBUFMU","queueTime":4,"applicationTime":1350,"atts":"TBtXQQMaH0k=","errorBeacon":"bam.nr-data.net","agent":""}</script></body>
|
||
</html>
|