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nist-gov/www.nist.gov/mml/bbd/core-capabilities/biomaterial-measurements
Scott Williams 4063bef310 Initital commit.
2025-03-05 18:59:57 +00:00

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<h1 class="nist-page__title">Biomaterial Measurements</h1>
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<p>Strips wells containing hydrogel scaffolds seeded with human cells.&nbsp;</p>
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<div><p>A biomaterial* is a material designed to take a form that can direct, through interactions with living systems, the course of any therapeutic or diagnostic procedure.&nbsp;We develop standards, methods, tools and technology to advance the reliability of biomaterials for use in the biomedical industry, tissue engineered medical products and advanced therapies.</p></div><h2 class="nist-block__title">Current Activities &amp; Products</h2><p class="xx">&nbsp;</p><table><tbody><tr><td> <div class="align-center nist-image">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/polysaccharide%20hydrogel.jpg?itok=vDlOiqlj" width="480" height="452" alt="polysaccharide hydrogel" typeof="foaf:Image">
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</td><td><a href="https://www.nist.gov/mml/bbd/biomaterials/measuring-cell-viability-scaffolds"><span><strong>Measuring Cell Viability in Scaffolds:</strong></span></a><span><strong> </strong>We are developing a model scaffold-cell-assay system to serve as a guide for validating measurements of cell viability in a scaffold.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/SRI%206005.jpg?itok=7zzCQf4x" data-media-id="572816">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/SRI%206005.jpg?itok=d0Nx0aMm" width="480" height="285" alt="SRI 6005" title="SRI 6005" typeof="foaf:Image">
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</td><td><a href="https://www.nist.gov/sri/standard-reference-instruments/sri-6005-polymerization-stress-tensometer"><span><strong>Real-time Measurement of Multiple Polymerization Properties:</strong></span></a><span><strong> </strong>NIST Standard Reference Instrument (SRI 6005) is a tensometer for measuring polymerization kinetics of biomedical polymers.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/2910.jpg?itok=mQ746HJr" data-media-id="572791">
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</td><td><a href="https://www-s.nist.gov/srmors/view_detail.cfm?srm=2910b"><span><strong>SRM 2910b Calcium Hydroxyapatite Reference Material:</strong></span></a><span><strong> </strong>This Standard Reference Material (SRM) is intended for use in evaluating the physical and chemical properties apatites, which are often used as a biomaterial.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/collagen%20fibrils.jpg?itok=4OHuv9pO" data-media-id="572796">
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</td><td><a href="https://www.nist.gov/programs-projects/protocol-preparing-fibrillar-collagen-matrices-untreated-polystyrene-labware-petri"><span><strong>Protocol for Preparing Fibrillar Collagen Matrices with Robust and Reproducible Cell Responses:</strong></span></a><span><strong> </strong>A detailed and highly-vetted protocol for preparing fibrillar collagen substrates will well-defined properties for cell culture.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/DiameterJ%20histogram.jpg?itok=303N0pvZ" data-media-id="572806">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/DiameterJ%20histogram.jpg?itok=7po9AG0e" width="480" height="385" alt="DiameterJ histogram" title="DiameterJ histogram" typeof="foaf:Image">
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</td><td><a href="https://www.nist.gov/mml/bbd/biomaterials/diameterj"><span><strong>DiameterJ Plugin for Measuring Fiber Diameter in Tissue Engineering Scaffolds:</strong></span></a><span><strong> </strong>A validated, open-source tool for automated analysis of scanning electron micrographs for determining fiber diameter.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/3D%20cell.jpg?itok=PYIyAKwV" data-media-id="572786">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/3D%20cell.jpg?itok=IWWzB0Tv" width="480" height="373" alt="3D Cell" title="3D Cell" typeof="foaf:Image">
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</td><td><a href="https://www.nist.gov/mml/bbd/biomaterials/3d-cell-scaffold-interactions"><span><strong>3D Cell-Scaffold Interactions:</strong></span></a><span><strong> </strong>New methods for assessing how 3D scaffold structure influences 3D cell shape are being developed.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/combi-cassettes.jpg?itok=7Ep5-ug1" data-media-id="572801">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/combi-cassettes.jpg?itok=9YEp3UtZ" width="480" height="354" alt="combi-cassettes" title="combi-cassettes" typeof="foaf:Image">
</div>
</td><td><a href="https://www.nist.gov/mml/bbd/biomaterials/combinatorial-cassettes-higher-throughput-screening-osteogenesis-mice"><span><strong>Combinatorial Cassettes for Higher-Throughput Screening of Osteogenesis in Mice:</strong></span></a><span> Combi-cassettes are planar structures with many holes that can be loaded with various cell-scaffold constructs and implanted into animals for the identification of formulations that induce tissue regeneration.</span></td></tr><tr><td>
<div class="align-center nist-image--lightbox nist-image" data-lightbox="https://www.nist.gov/sites/default/files/styles/2800_x_2800_limit/public/images/2020/02/22/standards%20pyramid.jpg?itok=ESXeGpEQ" data-media-id="572821">
<img loading="lazy" src="/sites/default/files/styles/480_x_480_limit/public/images/2020/02/22/standards%20pyramid.jpg?itok=ZlTKouCy" width="480" height="283" alt="standards pyramid" title="standards pyramid" typeof="foaf:Image">
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</td><td><a href="https://www.nist.gov/programs-projects/documentary-standards/astm-f04"><span><strong>ASTM Committee F04:</strong></span></a><span>&nbsp; ASTM F04 has and is developing many standards for biomaterials that are used in tissue engineering and regenerative medicine.</span></td></tr></tbody></table><p class="xx">&nbsp;</p><p class="xx"><span>* Zhang X, Williams D (2019) Definitions of Biomaterials for the Twenty-First Century. Elsevier.</span></p>
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Created February 14, 2020, Updated September 25, 2024
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