1123 lines
89 KiB
Text
1123 lines
89 KiB
Text
<!DOCTYPE html>
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<html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# ">
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<div class="OutlineElement Ltr SCXW113598435 BCX0"><p class="Paragraph SCXW113598435 BCX0"><span lang="EN-US">Bioinformatics plays a crucial role in advancing NIST's mission by computationally analyzing large amounts of complex biological data generated by NIST and its collaborators. NIST provides benchmarks for the computational tools and methodologies necessary for conducting such work. Omics (genomic, proteomic, metabolomic, metagenomic, and transcriptomic) data, generated both inside and outside of NIST, NIST’s reference materials, benchmark datasets, and metadata standards underpin biological research and innovation. These standards help ensure the accuracy and reliability of large-scale biological measurements, which is essential for fields such as engineering biology, precision medicine, biotechnology, and public health. </span><span> </span></p><p class="Paragraph SCXW113598435 BCX0"><span lang="EN-US">The NIST-hosted</span><a href="/programs-projects/cancer-genome-bottle" data-entity-type="node" data-entity-uuid="36ddd0cd-f5d3-41c2-9e6b-09f4eeb3396f" data-entity-substitution="canonical" title="Cancer Genome in a Bottle"><span lang="EN-US"> Genome in a Bottle Consortium</span></a><span lang="EN-US"> has developed authoritatively characterized human genome reference materials. As the first RMs to be characterized for billions of properties, these have been used to train and test AI-based models and other bioinformatics tools. Similarly, the </span><a href="/programs-projects/nist-genome-editing-program" data-entity-type="node" data-entity-uuid="5736e356-ccdf-42db-b08d-e72f2615e045" data-entity-substitution="canonical" title="NIST Genome Editing Program"><span lang="EN-US">NIST Genome Editing Program</span></a><span lang="EN-US">, including the public-private partnership </span><a href="/programs-projects/nist-genome-editing-consortium" data-entity-type="node" data-entity-uuid="d7f7208d-1c42-4357-955e-fd8661f23771" data-entity-substitution="canonical" title="NIST Genome Editing Consortium "><span lang="EN-US">NIST Genome Editing Consortium</span></a><span lang="EN-US">, is developing benchmark samples, control datasets, and metadata norms, and conducting interlaboratory studies to qualify bioinformatics tools and approaches used to detect intended and unintended genome edits which is essential information for clinical applications. </span><span> </span></p><p class="Paragraph SCXW113598435 BCX0"><span lang="EN-US">Further work in this area includes onboarding and deploying systematic approaches to add confidence to computational pipelines and their outputs for measurements used to identify where genome editing technologies may have made unintended (off-target) changes in a genome. NIST’s Microbial Metrology Program develops advanced measurements, reference materials, and standards for microbial systems to promote human health, precision medicine, advanced manufacturing, and other industrial applications. The </span><a href="/mml/bbd/cellular-engineering-group" data-entity-type="node" data-entity-uuid="235d95f0-137b-4d5f-b1b6-5da08bef4dd6" data-entity-substitution="canonical" title="Cellular Engineering Group"><span lang="EN-US">Cellular Engineering Group</span></a><span lang="EN-US"> is developing predictable and versatile RNA circuits, based on nucleic acid strand displacement reactions to meet emerging molecular computation and measurement needs in biological systems. The </span><a href="/mml/biomolecular-measurement/mass-spectrometry-data-center" data-entity-type="node" data-entity-uuid="bcb4d47b-8900-484a-bd9e-1ec4de3b9ffd" data-entity-substitution="canonical" title="Mass Spectrometry Data Center"><span lang="EN-US">NIST Mass Spectrometry Data Center</span></a><span lang="EN-US"> develops evaluated mass spectral libraries and provides related software tools.</span><span> </span></p></div>
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<a href="/blogs/taking-measure/how-secure-your-dna"> <div class="entity-reference"> <img loading="lazy" src="/sites/default/files/styles/600w_x_360h/public/images/2022/05/25/GenomicData_Cybersecurity_960x600_Option_A.png.webp?itok=NInR_DaT" width="600" height="360" alt="Illustration shows a pattern of repeating DNA strands with a shadowy figure in a trenchcoat and hat lurking behind. " typeof="foaf:Image" />
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<h3><span>How Secure Is Your DNA?</span>
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<div class="text-with-summary"> Is genomic data distinct from other data types? How should cybersecurity protection be tailored to genomic data? NIST is working to find the answers.
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<h3><span property="schema:name">Spotlight: For Bioinformaticist Sierra Miller, the Scientific Breakthrough Is Hidden in the Data</span>
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<div>
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<article
|
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about="/programs-projects/h5-influenza-positive-controls" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
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<div class="entity-reference"> <a href="/programs-projects/h5-influenza-positive-controls" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2024/11/01/RGTM10263_2.JPG?itok=Q7TAUNqL" width="100" height="58" alt="Unit of RGTM 10263 -- H5N1 Avian flu synthetic RNA fragments" typeof="foaf:Image" />
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</a>
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</div>
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</div>
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<div class="nist-teaser__content-wrapper">
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<header>
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||
<h3 class="nist-teaser__title"><a href="/programs-projects/h5-influenza-positive-controls"><span>H5 Influenza Positive Controls</span>
|
||
</a></h3>
|
||
<div class="nist-teaser__type">
|
||
<div class="nist-badge display-inline-block margin-y-1 nist-badge--blue boolean">Ongoing</div>
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</div>
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||
</header>
|
||
<div class="nist-teaser__content">
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||
<div class="text-with-summary"> In response to the current H5N1 avian influenza outbreak, NIST has developed a research grade test material (RGTM) for PCR-based assays. This material contains 3 vials with RNA fragments for HA (Part A), NA (Part B), and MP (Part C). A NIST Reference Material is also under development. The guidance
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</div>
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</div>
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</div>
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</article>
|
||
</div>
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||
<div>
|
||
<article
|
||
about="/programs-projects/mpox-mpxv-synthetic-dna-pcr-standards" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
||
<div class="entity-reference"> <a href="/programs-projects/mpox-mpxv-synthetic-dna-pcr-standards" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2022/07/11/wrapped-linear-insert.png?itok=91o6-yTa" width="100" height="25" alt="MPXV RGTM wrapped linear insert" typeof="foaf:Image" />
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|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
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<div class="nist-teaser__content-wrapper">
|
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<header>
|
||
<h3 class="nist-teaser__title"><a href="/programs-projects/mpox-mpxv-synthetic-dna-pcr-standards"><span>Mpox (MPXV) Synthetic DNA PCR Standards</span>
|
||
</a></h3>
|
||
<div class="nist-teaser__type">
|
||
<div class="nist-badge display-inline-block margin-y-1 nist-badge--blue boolean">Ongoing</div>
|
||
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</div>
|
||
|
||
</header>
|
||
<div class="nist-teaser__content">
|
||
<div class="text-with-summary"> A new material from NIST can aid in the evaluation and development of selected qPCR assays for the mpox virus. We are offering a unit free of charge in exchange for your feedback, which will help us improve and further develop the material. Questions? Contact <span class="spamspan"><span class="u">MPXV-RGTM</span> [at] <span class="d">nist.gov</span><span class="t"> (MPXV-RGTM[at]nist[dot]gov)</span></span> . NIST supports the
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</article>
|
||
</div>
|
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|
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<article
|
||
about="/programs-projects/cancer-genome-bottle" class="nist-teaser"
|
||
>
|
||
<div class="nist-teaser__image">
|
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<div class="entity-reference"> <a href="/programs-projects/cancer-genome-bottle" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/thumbnail/public/images/2019/05/15/giab_logo_color.png?itok=KdsryiNW" width="72" height="100" alt="GIAB Logo" typeof="foaf:Image" />
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|
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<h3 class="nist-teaser__title"><a href="/programs-projects/cancer-genome-bottle"><span>Cancer Genome in a Bottle</span>
|
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</a></h3>
|
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<div class="nist-teaser__type">
|
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<div class="nist-badge display-inline-block margin-y-1 nist-badge--blue boolean">Ongoing</div>
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|
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|
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<div class="nist-teaser__content">
|
||
<div class="text-with-summary"> Goals: This project is an extension of the Genome in a Bottle Consortium to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of cancer genome sequencing to clinical practice and innovations in technologies. The priority of GIAB
|
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|
||
</div>
|
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|
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</div>
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</article>
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<article
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about="/programs-projects/measuring-antimicrobial-resistance" class="nist-teaser"
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|
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<h3 class="nist-teaser__title"><a href="/programs-projects/measuring-antimicrobial-resistance"><span>Measuring Antimicrobial Resistance</span>
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<div class="nist-teaser__content">
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<div class="text-with-summary"> Antibiotic resistance has been identified in the Nation’s Action Plan to improve the health and wellbeing of the American people. NIST scientists are leveraging a wide range of measurement capabilities to study microbial community dynamics with regard to antimicrobial resistance. Using a range of
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