970 lines
82 KiB
Text
970 lines
82 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# ">
|
||
<head>
|
||
<meta charset="utf-8" /><script type="text/javascript">(window.NREUM||(NREUM={})).init={ajax:{deny_list:["bam.nr-data.net"]}};(window.NREUM||(NREUM={})).loader_config={licenseKey:"37b7ccb661",applicationID:"1089704227"};;/*! For license information please see nr-loader-rum-1.283.2.min.js.LICENSE.txt */
|
||
(()=>{var e,t,r={122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},217:(e,t,r)=>{"use strict";r.d(t,{D0:()=>m,gD:()=>v,xN:()=>h});r(860).K7.genericEvents;const n="experimental.marks",i="experimental.measures",o="experimental.resources",a=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var s=r(614),c=r(944),u=r(384),l=r(122);const d="[data-nr-mask]",f=()=>{const e={feature_flags:[],experimental:{marks:!1,measures:!1,resources:!1},mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},get feature_flags(){return e.feature_flags},set feature_flags(t){e.feature_flags=t},generic_events:{enabled:!0,autoStart:!0},harvest:{interval:30},jserrors:{enabled:!0,autoStart:!0},logging:{enabled:!0,autoStart:!0},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,autoStart:!0},performance:{get capture_marks(){return e.feature_flags.includes(n)||e.experimental.marks},set capture_marks(t){e.experimental.marks=t},get capture_measures(){return e.feature_flags.includes(i)||e.experimental.measures},set capture_measures(t){e.experimental.measures=t},capture_detail:!0,resources:{get enabled(){return e.feature_flags.includes(o)||e.experimental.resources},set enabled(t){e.experimental.resources=t},asset_types:[],first_party_domains:[],ignore_newrelic:!0}},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:s.wk,inactiveMs:s.BB},session_replay:{autoStart:!0,enabled:!1,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){a(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,c.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){a(t)?e.block_selector+=",".concat(t):""!==t&&(0,c.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,c.R)(7,t)}},session_trace:{enabled:!0,autoStart:!0},soft_navigations:{enabled:!0,autoStart:!0},spa:{enabled:!0,autoStart:!0},ssl:void 0,user_actions:{enabled:!0,elementAttributes:["id","className","tagName","type"]}}},g={},p="All configuration objects require an agent identifier!";function m(e){if(!e)throw new Error(p);if(!g[e])throw new Error("Configuration for ".concat(e," was never set"));return g[e]}function h(e,t){if(!e)throw new Error(p);g[e]=(0,l.a)(t,f());const r=(0,u.nY)(e);r&&(r.init=g[e])}function v(e,t){if(!e)throw new Error(p);var r=m(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>d});var n=r(122),i=r(384),o=r(154),a=r(324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0,harvester:void 0},l={};function d(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!l[e])throw new Error("Runtime for ".concat(e," was never set"));return l[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");l[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(l[e],"harvestCount")||Object.defineProperty(l[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=l[e])}},324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,xv:()=>n});const n="1.283.2",i="PROD",o="CDN"},154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>c,RI:()=>i,WN:()=>l,bv:()=>o,gm:()=>a,mw:()=>s,sb:()=>u});var n=r(863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),u=c&&"undefined"==typeof SharedWorker,l=((()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);Array.isArray(e)&&e.length>=2&&e[1]})(),Date.now()-(0,n.t)())},687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>d,x3:()=>u});var n=r(836),i=r(606),o=r(860),a=r(646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};l(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),g(e,t,!1),s[e].size&&f(e))}function l(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function d(e="",t="feature",r=!1){if(l(e),!e||!s[e].get(t)||r)return g(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),g(e,t)})))}function g(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(990),o=r(371),a=r(646),s=r(607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},l={},d=!1;try{d=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=g(n),c=m(e),l=c.length,d=0;d<l;d++)c[d].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:h,listeners:m,context:g,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:d?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:d};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function g(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=m(e).concat(t)}function m(e){return n[e]||[]}function h(t){return l[t]=l[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),l=(0,n.Zm)();l.ee||(l.ee=u)},646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(566).bz)()},566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,bz:()=>a});var n=r(154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}},614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(836),i=r(154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>l,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>d});var n=r(154),i=r(863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function l(e,t){a()[e]=t}function d(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(836),i=r(607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];l(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return l(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,l,d;try{a=this,o=[...arguments],l="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],l],e)}i(r+"start",[o,a,s],l,c);try{return d=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],l,c),e}finally{i(r+"end",[o,a,d],l,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function l(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},993:(e,t,r)=>{"use strict";r.d(t,{A$:()=>o,ET:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o={OFF:0,ERROR:1,WARN:2,INFO:3,DEBUG:4,TRACE:5},a="log";n.K7.logging},773:(e,t,r)=>{"use strict";r.d(t,{z_:()=>o,XG:()=>s,TZ:()=>n,rs:()=>i,xV:()=>a});r(154),r(566),r(384);const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},344:(e,t,r)=>{"use strict";r.d(t,{G4:()=>i});var n=r(614);r(860).K7.sessionReplay;const i={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"};n.g.ERROR,n.g.FULL,n.g.OFF},234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(836),i=r(687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},603:(e,t,r)=>{"use strict";r.d(t,{j:()=>K});var n=r(860),i=r(555),o=r(371),a=r(908),s=r(836),c=r(687),u=r(289),l=r(154),d=r(944),f=r(773),g=r(384),p=r(344);const m=["setErrorHandler","finished","addToTrace","addRelease","recordCustomEvent","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],h=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(863),b=r(614),y=r(993);var w=r(646),R=r(434);const A=new Map;function E(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,d.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,R.YM)(i),a=new w.y(s.P);a.level=n.level,a.customAttributes=n.customAttributes;const c=t[r]?.[R.Jt]||t[r];return A.set(c,a),o.inPlace(t,[r],"wrap-logger-",(()=>A.get(c))),i}function _(){const e=(0,g.pV)();m.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,d.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const x={};function N(e,t,g=!1){t||(0,c.Ak)(e,"api");const m={};var w=s.ee.get(e),R=w.get("tracer");x[e]=b.g.OFF,w.on(p.G4.REPLAY_RUNNING,(t=>{x[e]=t}));var A="api-",_=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),j(A,n,!0,o||null===r?"session":void 0)(t,r)}function k(){}m.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,w),function(e,t,r={},i=y.p_.INFO){(0,a.p)(f.xV,["API/logging/".concat(i.toLowerCase(),"/called")],void 0,n.K7.metrics,e),(0,a.p)(y.ET,[(0,v.t)(),t,r,i],void 0,n.K7.logging,e)}(w,e,t,r)},m.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,w),E(w,e,t,{customAttributes:r,level:i})},h.forEach((e=>{m[e]=j(A,e,!0,"api")})),m.addPageAction=j(A,"addPageAction",!0,n.K7.genericEvents),m.recordCustomEvent=j(A,"recordCustomEvent",!0,n.K7.genericEvents),m.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,j(A,"setPageViewName",!0)()},m.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,d.R)(40,typeof t)}else(0,d.R)(39,typeof e)},m.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,d.R)(41,typeof e)},m.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,d.R)(42,typeof e)},m.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,w),w.emit("manual-start-all")}catch(e){(0,d.R)(23,e)}},m[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,w)},m[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,w),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,w)},m.interaction=function(e){return(new k).get("object"==typeof e?e:{})};const T=k.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,w),g||(0,a.p)(_+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,w),function(){if(R.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw R.emit("fn-err",[arguments,this,t],r),t}finally{R.emit("fn-end",[(0,v.t)()],r)}}}};function j(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,w),i&&(0,a.p)(e+t,[r?(0,v.t)():performance.now(),...arguments],r?null:this,i,w),r?void 0:this}}function I(){r.e(296).then(r.bind(r,778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,d.R)(27,e),w.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{T[e]=j(_,e,void 0,g?n.K7.softNav:n.K7.spa)})),m.setCurrentRouteName=g?j(_,"routeName",void 0,n.K7.softNav):j(A,"routeName",!0,n.K7.spa),m.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,w),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!x[e]],void 0,n.K7.jserrors,w)},l.RI?(0,u.GG)((()=>I()),!0):I(),m}var k=r(217),T=r(122);const j={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},I={};var O=r(284);const S=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let P=!1;function K(e,t={},r,n){let{init:a,info:c,loader_config:u,runtime:d={},exposed:f=!0}=t;d.loaderType=r;const p=(0,g.pV)();c||(a=p.init,c=p.info,u=p.loader_config),(0,k.xN)(e.agentIdentifier,a||{}),function(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");I[e]=(0,T.a)(t,j);const r=(0,g.nY)(e);r&&(r.loader_config=I[e])}(e.agentIdentifier,u||{}),c.jsAttributes??={},l.bv&&(c.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,c);const m=(0,k.D0)(e.agentIdentifier),h=[c.beacon,c.errorBeacon];P||(m.proxy.assets&&(S(m.proxy.assets),h.push(m.proxy.assets)),m.proxy.beacon&&h.push(m.proxy.beacon),_(),(0,g.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===m.soft_navigations.enabled&&m.feature_flags.includes("soft_nav")),d.denyList=[...m.ajax.deny_list||[],...m.ajax.block_internal?h:[]],d.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,d),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=N(e.agentIdentifier,n,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=f),P=!0}},374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>u,K7:()=>s,P3:()=>c,XX:()=>i,qY:()=>n,v4:()=>a});const n="events",i="jserrors",o="browser/blobs",a="rum",s={ajax:"ajax",genericEvents:"generic_events",jserrors:i,logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},c={[s.pageViewEvent]:1,[s.pageViewTiming]:2,[s.metrics]:3,[s.jserrors]:4,[s.spa]:5,[s.ajax]:6,[s.sessionTrace]:7,[s.softNav]:8,[s.sessionReplay]:9,[s.logging]:10,[s.genericEvents]:11},u={[s.pageViewEvent]:a,[s.pageViewTiming]:n,[s.ajax]:n,[s.spa]:n,[s.softNav]:n,[s.metrics]:i,[s.jserrors]:i,[s.sessionTrace]:o,[s.sessionReplay]:o,[s.logging]:"browser/logs",[s.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>"nr-rum-1.283.2.min.js",i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.283.2.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),l=0;l<u.length;l++){var d=u[l];if(d.getAttribute("src")==r||d.getAttribute("data-webpack")==t+o){s=d;break}}if(!s){c=!0;var f={296:"sha512-2Y8GMAOGF658KnXzOZ/v+DlLch8TBFvV0tTNnOy9wrpvtDa1t5CdZMyX+LubTymBlzPp6NUjllBghMCZqXBPmg=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var g=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(g.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=g.bind(null,s.onerror),s.onload=g.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={374:0,840:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.283.2.PROD"]=self["webpackChunk:NRBA-1.283.2.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(374);var e=i(944),t=i(344),r=i(566);class n{agentIdentifier;constructor(){this.agentIdentifier=(0,r.LA)(16)}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}recordCustomEvent(e,t){return this.#e("recordCustomEvent",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(217);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var l=i(603);var d=i(687),f=i(234),g=i(289),p=i(154),m=i(384);const h=e=>p.RI&&!0===(0,s.gD)(e,"privacy.cookies_enabled");function v(e){return!!(0,m.dV)().o.MO&&h(e)&&!0===(0,s.gD)(e,"session_trace.enabled")}var b=i(389);class y extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,d.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,b.J)((()=>{(0,d.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if(h(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(296).then(i.bind(i,861));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(!this.#t(this.featureName,o))return(0,d.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(296).then(i.bind(i,103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),t.runtime.harvester.initializedAggregates.push(this.featAggregate),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,d.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,g.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return v(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var w=i(630);class R extends y{static featureName=w.T;constructor(e,t=!0){super(e,w.T,t),this.importAggregator(e)}}var A=i(908),E=i(843),_=i(878),x=i(782),N=i(863);class k extends y{static featureName=x.T;constructor(e,t=!0){super(e,x.T,t),p.RI&&((0,E.u)((()=>(0,A.p)("docHidden",[(0,N.t)()],void 0,x.T,this.ee)),!0),(0,_.sp)("pagehide",(()=>(0,A.p)("winPagehide",[(0,N.t)()],void 0,x.T,this.ee))),this.importAggregator(e))}}var T=i(773);class j extends y{static featureName=T.TZ;constructor(e,t=!0){super(e,T.TZ,t),this.importAggregator(e)}}new class extends o{constructor(t){super(),p.gm?(this.features={},(0,m.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,l.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,m.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,k,j],loaderType:"lite"})})()})();</script>
|
||
<noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style>
|
||
</noscript><script async src="https://www.googletagmanager.com/gtag/js?id=G-HEQ0YF2VYL"></script>
|
||
<script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag('set', {'cookie_flags': 'SameSite=None;Secure', 'cookie_domain': 'www.nist.gov'});gtag("config", "G-HEQ0YF2VYL", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","link_attribution":true,"allow_ad_personalization_signals":false});gtag("config", "G-CSLL4ZEK4L", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","link_attribution":true,"allow_ad_personalization_signals":false});gtag("event", "custom", {"node_title":"NISTmAb: Portrait of an \u0026quot;Anchor Molecule\u0026quot;","node_id":"1084186","content_type":"News"});</script>
|
||
<meta name="description" content="Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the" />
|
||
<link rel="canonical" href="https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule" />
|
||
<link rel="shortlink" href="https://www.nist.gov/node/1084186" />
|
||
<meta name="citation_title" content="NISTmAb: Portrait of an "Anchor Molecule" | NIST" />
|
||
<meta property="og:site_name" content="NIST" />
|
||
<meta property="og:type" content="Article" />
|
||
<meta property="og:url" content="https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule" />
|
||
<meta property="og:title" content="NISTmAb: Portrait of an "Anchor Molecule"" />
|
||
<meta property="og:description" content="Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the" />
|
||
<meta property="og:image" content="https://www.nist.gov/themes/custom/nist_www/img/homepage/nist_mark.png" />
|
||
<meta property="article:published_time" content="2016-07-28T08:00-04:00" />
|
||
<meta property="article:modified_time" content="2025-02-03T17:13-05:00" />
|
||
<meta name="dcterms.title" content="NISTmAb: Portrait of an "Anchor Molecule"" />
|
||
<meta name="dcterms.description" content="Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the" />
|
||
<meta name="dcterms.date" content="2016-07-28T08:00-04:00" />
|
||
<meta name="dcterms.type" content="text" />
|
||
<meta name="dcterms.format" content="text/html" />
|
||
<meta name="dcterms.identifier" content="https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule" />
|
||
<meta name="dcterms.source" content="NIST" />
|
||
<meta name="dcterms.created" content="2016-07-28T08:00-04:00" />
|
||
<meta name="dcterms.modified" content="2025-02-03T17:13-05:00" />
|
||
<meta name="twitter:card" content="summary_large_image" />
|
||
<meta name="twitter:description" content="Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the" />
|
||
<meta name="twitter:site" content="NIST" />
|
||
<meta name="twitter:title" content="NISTmAb: Portrait of an "Anchor Molecule"" />
|
||
<meta name="google-site-verification" content="QMu0ODkER3rN5hLcMLqNVf7e3bkjYsNLTuhqfH48jCA" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta name="nist_search_modified" class="elastic" content="2025-02-03T17:13:00-05:00" />
|
||
<script type="application/ld+json">{
|
||
"@context": "https://schema.org",
|
||
"@graph": [
|
||
{
|
||
"@type": "Article",
|
||
"@id": "https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule",
|
||
"headline": "NISTmAb: Portrait of an \u0022Anchor Molecule\u0022",
|
||
"name": "NISTmAb: Portrait of an \u0022Anchor Molecule\u0022",
|
||
"description": "Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the",
|
||
"datePublished": "2016-07-28T08:00-04:00",
|
||
"dateModified": "2025-02-03T17:13-05:00",
|
||
"publisher": {
|
||
"@type": "Organization",
|
||
"@id": "https://www.nist.gov/",
|
||
"name": "National Institute of Standards and Technology",
|
||
"url": "https://www.nist.gov/"
|
||
}
|
||
}
|
||
]
|
||
}</script>
|
||
<meta name="nist_search_bundle" class="elastic" content="article" />
|
||
<link rel="icon" href="/themes/custom/nist_www/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
|
||
<title>NISTmAb: Portrait of an "Anchor Molecule" | NIST</title>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_c-bRt_EZNE8XLc3DvKT29M9IkmPwfqYpjxmv9Akau9M.css?delta=0&language=en&theme=nist_www&include=eJxtTkkKwzAM_JCJnyS8TFsR2QqWU7e_r9OFXApCaIZZFENaqeuczcfzJk5aXWXr1G8omJxKDI2KZp_ZQhSQcF2dPa2jTK_hrfdX0Rjk4x1j_DAe_dD73PYtyPKFzjRxECrIHI4QTu7OGObfe5l1u8B1tEINFzTUNJ9pgP_DUTI7iwunpsYdLzMsWhw" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_kGS0ApDpFo-_3JI4Ijxg4RCWlTqsImK3lqH7bCv5v2U.css?delta=1&language=en&theme=nist_www&include=eJxtTkkKwzAM_JCJnyS8TFsR2QqWU7e_r9OFXApCaIZZFENaqeuczcfzJk5aXWXr1G8omJxKDI2KZp_ZQhSQcF2dPa2jTK_hrfdX0Rjk4x1j_DAe_dD73PYtyPKFzjRxECrIHI4QTu7OGObfe5l1u8B1tEINFzTUNJ9pgP_DUTI7iwunpsYdLzMsWhw" />
|
||
<link rel="stylesheet" media="print" href="/sites/default/files/css/css_-IXwLuTUdm8IGHxib8GX8wWKw3LjKsNWSYYskZ5fEGg.css?delta=2&language=en&theme=nist_www&include=eJxtTkkKwzAM_JCJnyS8TFsR2QqWU7e_r9OFXApCaIZZFENaqeuczcfzJk5aXWXr1G8omJxKDI2KZp_ZQhSQcF2dPa2jTK_hrfdX0Rjk4x1j_DAe_dD73PYtyPKFzjRxECrIHI4QTu7OGObfe5l1u8B1tEINFzTUNJ9pgP_DUTI7iwunpsYdLzMsWhw" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_jmXeSZNqhh6ayjrVIlS8rDw3mcnQaE5dzE2ZwwPSzNA.css?delta=3&language=en&theme=nist_www&include=eJxtTkkKwzAM_JCJnyS8TFsR2QqWU7e_r9OFXApCaIZZFENaqeuczcfzJk5aXWXr1G8omJxKDI2KZp_ZQhSQcF2dPa2jTK_hrfdX0Rjk4x1j_DAe_dD73PYtyPKFzjRxECrIHI4QTu7OGObfe5l1u8B1tEINFzTUNJ9pgP_DUTI7iwunpsYdLzMsWhw" />
|
||
|
||
<script src="/sites/default/files/js/js_GM8kl6wk698qKTTwusj83bCoGHHtOZ1UinjY1sE_Qbk.js?scope=header&delta=0&language=en&theme=nist_www&include=eJxdjW0OwjAIhi805UiErtjhWFlatHp7O53RLOEHPLwfgcYZ3fqsEH47XuuQzJIyUiZ9uowVjmDIUh0v0lm0ltUoopceIjlBos-7irMsa7E7wxFsLW_mEy_ce00DFVwsQpRKoQer5PmtgaQWSE-7BSamyOV7YmvtT8EP34wQy20lPe_nC6DrXYU"></script>
|
||
|
||
</head>
|
||
<body class="node-1084186">
|
||
<a href="#main-content" class="visually-hidden focusable" data-elastic-exclude>
|
||
Skip to main content
|
||
</a>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
<section data-elastic-exclude class="usa-banner" aria-label="Official government website">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img class="usa-banner__header-flag" src="/libraries/nist-component-library/dist/img/us_flag_small.png" alt="U.S. flag">
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto">
|
||
<p class="usa-banner__header-text">An official website of the United States government</p>
|
||
<p class="usa-banner__header-action" aria-hidden="true">Here’s how you know</p>
|
||
</div>
|
||
<button class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default">
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/libraries/nist-component-library/dist/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true">
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong>
|
||
<br/>
|
||
A <strong>.gov</strong> website belongs to an official government organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/libraries/nist-component-library/dist/img/icon-https.svg" role="img" alt="" aria-hidden="true">
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong>
|
||
<br/>
|
||
A <strong>lock</strong> ( <span class="icon-lock">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewbox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-title banner-lock-description" focusable="false">
|
||
<title id="banner-lock-title">Lock</title>
|
||
<desc id="banner-lock-description">A locked padlock</desc><path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/></svg>
|
||
</span>
|
||
) or <strong>https://</strong> means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
<div data-elastic-exclude>
|
||
<!-- nist-index-ignore-start -->
|
||
<div class="nist-print-header" style="display:none;">
|
||
<p class="nist-print-header__url">https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule</p>
|
||
<img class="nist-print-header__logo" width="289" height="38" src="/libraries/nist-component-library/dist/img/logo/nist_logo_sidestack.svg" alt="National Institute of Standards and Technology" />
|
||
</div>
|
||
|
||
|
||
<div class="usa-overlay"></div>
|
||
<header class="usa-header nist-header--www nist-header--minimal" role="banner">
|
||
<div class="usa-navbar">
|
||
<div class="usa-logo flex-fill">
|
||
<a href="/" title="National Institute of Standards and Technology" aria-label="Home">
|
||
<img src="/libraries/nist-component-library/dist/img/logo/logo.svg" alt="National Institute of Standards and Technology" width="300px" height="80px" />
|
||
</a>
|
||
</div>
|
||
<div class="usa-header__right grid-row flex-auto">
|
||
<div class="grid-col-fill nist-header__search-group">
|
||
|
||
<form class="usa-search usa-search--small"
|
||
accept-charset="UTF-8"
|
||
action="/search"
|
||
id="search_form"
|
||
method="get">
|
||
<div role="search">
|
||
<label class="usa-sr-only" for="search-form">Search NIST</label>
|
||
<input class="usa-input" id="search-form" type="search" name="s" placeholder="Search NIST" required="" maxlength="128">
|
||
<button class="usa-button" type="submit"><img src="/libraries/nist-component-library/dist/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search"></button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
<div class="grid-col-auto padding-left-1">
|
||
<button class="usa-menu-btn">Menu</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<nav aria-label="Primary navigation" class="usa-nav">
|
||
<div class="usa-nav__inner">
|
||
<button class="usa-nav__close">Close</button>
|
||
<ul class="usa-nav__primary usa-accordion">
|
||
<li class="usa-nav__primary-item">
|
||
<a class="usa-nav__link" href="/publications">Publications</a>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-2"><span>What We Do</span></button>
|
||
<div id="primary_menu-2" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/topics" class="usa-nav__link">All Topics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/advanced-communications" class="usa-nav__link">Advanced communications</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/artificial-intelligence" class="usa-nav__link">Artificial intelligence</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/bioscience" class="usa-nav__link">Bioscience</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/buildings-construction" class="usa-nav__link">Buildings and construction</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/chemistry" class="usa-nav__link">Chemistry</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/cybersecurity" class="usa-nav__link">Cybersecurity</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/electronics" class="usa-nav__link">Electronics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/energy" class="usa-nav__link">Energy</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/environment" class="usa-nav__link">Environment</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/fire" class="usa-nav__link">Fire</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/forensic-science" class="usa-nav__link">Forensic science</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/health" class="usa-nav__link">Health</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/information-technology" class="usa-nav__link">Information technology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/infrastructure" class="usa-nav__link">Infrastructure</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/manufacturing" class="usa-nav__link">Manufacturing</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/materials" class="usa-nav__link">Materials</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/mathematics-statistics" class="usa-nav__link">Mathematics and statistics</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/metrology" class="usa-nav__link">Metrology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/nanotechnology" class="usa-nav__link">Nanotechnology</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/neutron-research" class="usa-nav__link">Neutron research</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/performance-excellence" class="usa-nav__link">Performance excellence</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/physics" class="usa-nav__link">Physics</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/public-safety" class="usa-nav__link">Public safety</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/quantum-information-science" class="usa-nav__link">Quantum information science</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/resilience" class="usa-nav__link">Resilience</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/standards" class="usa-nav__link">Standards</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/transportation" class="usa-nav__link">Transportation</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-3"><span>Labs & Major Programs</span></button>
|
||
<div id="primary_menu-3" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/adlp" class="usa-nav__link">Assoc Director of Laboratory Programs</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories" class="usa-nav__link">Laboratories</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/ctl" class="usa-nav__link">Communications Technology Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/el" class="usa-nav__link">Engineering Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/itl" class="usa-nav__link">Information Technology Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/mml" class="usa-nav__link">Material Measurement Laboratory</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml" class="usa-nav__link">Physical Measurement Laboratory</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/user-facilities" class="usa-nav__link">User Facilities</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/ncnr" class="usa-nav__link">NIST Center for Neutron Research</a>
|
||
</li>
|
||
<li>
|
||
<a href="/cnst" class="usa-nav__link">CNST NanoFab</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/labs-major-programs/research-test-beds" class="usa-nav__link">Research Test Beds</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories/projects-programs" class="usa-nav__link">Research Projects</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/laboratories/tools-instruments" class="usa-nav__link">Tools & Instruments</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/major-programs" class="usa-nav__link">Major Programs</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/baldrige" class="usa-nav__link">Baldrige Performance Excellence Program</a>
|
||
</li>
|
||
<li>
|
||
<a href="/chips" class="usa-nav__link">CHIPS for America Initiative</a>
|
||
</li>
|
||
<li>
|
||
<a href="/mep" class="usa-nav__link">Manufacturing Extension Partnership (MEP)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/oam" class="usa-nav__link">Office of Advanced Manufacturing</a>
|
||
</li>
|
||
<li>
|
||
<a href="/spo" class="usa-nav__link">Special Programs Office</a>
|
||
</li>
|
||
<li>
|
||
<a href="/tpo" class="usa-nav__link">Technology Partnerships Office</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-4"><span>Services & Resources</span></button>
|
||
<div id="primary_menu-4" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/content/standards-measurements" class="usa-nav__link">Standards and Measurements</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/calibrations" class="usa-nav__link">Calibration Services</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nvlap" class="usa-nav__link">Laboratory Accreditation (NVLAP)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-quality-system" class="usa-nav__link">Quality System</a>
|
||
</li>
|
||
<li>
|
||
<a href="/srm" class="usa-nav__link">Standard Reference Materials (SRMs)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/sri" class="usa-nav__link">Standard Reference Instruments (SRIs)</a>
|
||
</li>
|
||
<li>
|
||
<a href="/standardsgov" class="usa-nav__link">Standards.gov</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/time-and-frequency-division/time-services" class="usa-nav__link">Time Services</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/owm" class="usa-nav__link">Office of Weights and Measures</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/services-resources/software" class="usa-nav__link">Software</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/data" class="usa-nav__link">Data</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="https://webbook.nist.gov/chemistry/" class="usa-nav__link">Chemistry WebBook</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://nvd.nist.gov/" class="usa-nav__link">National Vulnerability Database</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pml/productsservices/physical-reference-data" class="usa-nav__link">Physical Reference Data</a>
|
||
</li>
|
||
<li>
|
||
<a href="/srd" class="usa-nav__link">Standard Reference Data (SRD)</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="https://shop.nist.gov/" class="usa-nav__link">Storefront</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/tpo" class="usa-nav__link">License & Patents</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="https://csrc.nist.gov/" class="usa-nav__link">Computer Security Resource Center (CSRC)</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/nist-research-library" class="usa-nav__link">NIST Research Library</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-5"><span>News & Events</span></button>
|
||
<div id="primary_menu-5" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/news-events/news" class="usa-nav__link">News</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/news-events/events" class="usa-nav__link">Events</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/blogs" class="usa-nav__link">Blogs</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/feature-stories" class="usa-nav__link">Feature Stories</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/awards" class="usa-nav__link">Awards</a>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/video-gallery" class="usa-nav__link">Video Gallery</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/image-gallery" class="usa-nav__link">Image Gallery</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/pao/media-contacts" class="usa-nav__link">Media Contacts</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<li class="usa-nav__primary-item">
|
||
<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-6"><span>About NIST</span></button>
|
||
<div id="primary_menu-6" class="usa-nav__submenu usa-megamenu">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist" class="usa-nav__link">About Us</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/director/leadership" class="usa-nav__link">Leadership</a>
|
||
</li>
|
||
<li>
|
||
<a href="/director/nist-organization-structure" class="usa-nav__link">Organization Structure</a>
|
||
</li>
|
||
<li>
|
||
<a href="/about-nist/budget-planning" class="usa-nav__link">Budget & Planning</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/contact-us" class="usa-nav__link">Contact Us</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/visit" class="usa-nav__link">Visit</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/careers" class="usa-nav__link">Careers</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="/iaao/academic-affairs-office" class="usa-nav__link">Student programs</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/about-nist/work-nist" class="usa-nav__link">Work with NIST</a>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/history" class="usa-nav__link">History</a>
|
||
<ul class="usa-nav__submenu-list">
|
||
<li>
|
||
<a href="http://nistdigitalarchives.contentdm.oclc.org/" class="usa-nav__link">NIST Digital Archives</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-museum" class="usa-nav__link">NIST Museum</a>
|
||
</li>
|
||
<li>
|
||
<a href="/nist-and-nobel" class="usa-nav__link">NIST and the Nobel</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="usa-nav__submenu-item">
|
||
<a href="/education" class="usa-nav__link">Educational Resources</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
|
||
|
||
</header>
|
||
<!-- nist-index-ignore-end -->
|
||
</div>
|
||
|
||
<div class="grid-container">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div
|
||
id="block-nist-www-content" class="nist-block"
|
||
>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<section
|
||
class="nist-page__content usa-section clearfix"
|
||
>
|
||
|
||
<a id="main-content" tabindex="-1"></a>
|
||
|
||
|
||
<div class="grid-container margin-top-4">
|
||
<div
|
||
class="nist-page__region nist-page__region--content-top"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div>
|
||
<a class="usa-button usa-button--accent-cool" href="/news-events/news">NEWS</a>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<h1 class="nist-page__title">NISTmAb: Portrait of an "Anchor Molecule"</h1>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div class="font-heading-md"><time datetime="2016-07-28T12:00:00Z">July 28, 2016</time>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
<div data-elastic-exclude class="nist-block nist-social__wrapper">
|
||
<h2 class="nist-social__title">Share</h2>
|
||
<div class="social-media-sharing">
|
||
<div class="nist-social__wrapper--share">
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://www.facebook.com/share.php?u=https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule"
|
||
title="Facebook" class="nist-social nist-social--facebook-gray">
|
||
<span>Facebook</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule&source=https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule"
|
||
title="Linkedin" class="nist-social nist-social--linkedin-gray">
|
||
<span>Linkedin</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a target="_blank" rel="noopener" href="https://x.com/intent/tweet?url=https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule&status=https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule"
|
||
title="X.com" class="nist-social nist-social--x-gray">
|
||
<span>X.com</span>
|
||
</a>
|
||
</div>
|
||
<div>
|
||
<a href="mailto:?subject=NIST.gov&body=Check out this site https://www.nist.gov/news-events/news/2016/07/nistmab-portrait-anchor-molecule"
|
||
title="Email" class="nist-social nist-social--envelope-gray">
|
||
<span>Email</span>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="grid-container margin-top-4">
|
||
<div class="grid-row grid-gap-6">
|
||
|
||
|
||
|
||
<div
|
||
class="nist-page__region nist-page__region--content tablet-lg:grid-col-8"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div class="text-with-summary">
|
||
|
||
|
||
|
||
<p>Companies will continue to generate and maintain their own in-house standards for each specific monoclonal antibody therapeutic drugs, but the <a href="https://www-s.nist.gov/srmors/view_detail.cfm?srm=8671">new NIST reference material provides a benchmark</a> that all can share, especially useful for qualifying and validating methods for characterizing biopharmaceuticals up to the latter stages of product and process development.</p>
|
||
|
||
<p>Like other classes of drugs, mAb therapeutics go through an extensive clinical testing and regulatory approval process. However, mAbs are far more complex than small molecule drugs such as aspirin or statins, or simple biological drugs such as insulin. (<a data-entity-substitution="canonical" data-entity-type="media" data-entity-uuid="d19aa6c0-6d5f-46ea-b4b7-ecb14b1038f8" href="/image/16mml017mabinfographic700pxwidepng" title="NIST's Monoclonal Antibody Reference Material--infographic">See infographic</a>.)</p>
|
||
|
||
<p>The entire production process spans weeks to months. And unlike small-molecule drugs synthesized in controlled chemical reactions that yield identical copies, mAbs are made by cells and may not be exactly alike, atom for atom. Yet, they must be so consistently similar that levels of safety and effectiveness are equivalent.</p>
|
||
|
||
<p>Throughout their lifecycle—from the start of production to injection into patients—mAb therapeutics undergo repeated rounds of testing and analysis, ultimately aiming to ensure that these products are of the appropriate identity, potency and purity, and that they can be reliably manufactured.</p>
|
||
|
||
<p>"The NISTmAb should help in answering a simple, yet critical, question that can consume a disproportionate amount of time when deviations arise with testing; is it the sample or the method that is varying?" said NIST's Michael Tarlov.</p>
|
||
|
||
<p>And for patients, said Kurt Brorson of the Food and Drug Administration (FDA), the "more robust and universally consistent" analytical methods fostered by NISTmAb should give a boost to their "confidence in the quality and consistency in the biopharmaceuticals and biosimilars that they need."</p>
|
||
|
||
<p>NIST RM 8671 should prove useful during regulatory evaluation of biosimilar mAb therapeutic drugs, follow-on versions of drugs at the end of their patent life. A biosimilar, according to the FDA, is a biological product shown to be "highly similar to an FDA-approved biological product, and has no clinically meaningful differences in terms of safety and effectiveness." Only minor differences in clinically inactive components are allowable in biosimilar products.</p>
|
||
|
||
<p>In early April 2016, the FDA approved the first and only biosimilar mAb therapeutic in the United States, a follow-on version of infliximab, which is approved for treatment of rheumatoid arthritis, Crohn's disease and several other disorders. With patents expiring on six other mAb-based therapeutics by 2020, a batch of biosimilar applications for FDA approval is anticipated.</p>
|
||
|
||
<p>For both regulators and biosimilar developers, NIST's John Schiel explained, the NISTmAb can serve as an "anchor molecule." It can be used, he said, to evaluate whether analytical methods are useful for reliably determining whether a follow-on compound, likely made with substantially different manufacturing technology, is sufficiently similar to the originator molecule. If, for example, comparisons of molecular structure differ, measurements on the NISTmAb could be used to establish whether the difference is real—caused by, say, a true structural divergence—or due to an artifact, or peculiarity, of the instrument or method used.</p>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
<div data-elastic-exclude="" class="nist-tags">
|
||
<a href="/topic-terms/bioscience" hreflang="en">Bioscience</a>, <a href="/topic-terms/biomanufacturing" hreflang="en">Biomanufacturing</a>, <a href="/topic-terms/biopharmaceuticals" hreflang="en">Biopharmaceuticals</a>, <a href="/topic-terms/metrology" hreflang="en">Metrology</a> and <a href="/topic-terms/reference-materials" hreflang="en">Reference materials</a></div>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<aside class="nist-page__region nist-page__region--sidebar-second tablet-lg:grid-col-4">
|
||
|
||
<div>
|
||
<div
|
||
class="nist-block nist-block--no-margin"
|
||
>
|
||
|
||
|
||
<!-- nist-index-ignore-start -->
|
||
|
||
|
||
|
||
|
||
<div
|
||
about="/news-events/news/2016/07/nistmab-portrait-anchor-molecule" typeof="schema:Article" data-elastic-exclude="" class="nist-block nist-block--contact"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Media Contact</h2>
|
||
<span property="schema:name" content="NISTmAb: Portrait of an "Anchor Molecule"" class="hidden"></span>
|
||
|
||
301-975-2762
|
||
|
||
</div>
|
||
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
|
||
</div>
|
||
<!-- nist-index-ignore-start -->
|
||
<div
|
||
class="views-element-container nist-block nist-block--org" data-elastic-exclude=""
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Organizations</h2>
|
||
|
||
<div><div class="js-view-dom-id-b3d3a479da2b15f16237007c38b4598f35a0d77cb9eba4b36ff1301e2c1dee47">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="nist-related-orgs"><div class="term-tree-list">
|
||
<ul class="term"><li><a href="/nist-organizations/nist-headquarters" class="selected" hreflang="en">NIST Headquarters</a></li><li><ul class="term"><li><a href="/nist-organizations/nist-headquarters/laboratory-programs" class="selected" hreflang="en">Laboratory Programs</a></li><li><ul class="term"><li><a href="/nist-organizations/nist-headquarters/laboratory-programs/material-measurement-laboratory" class="selected" hreflang="en">Material Measurement Laboratory</a></li><li><ul class="term"><li><a href="/nist-organizations/nist-headquarters/laboratory-programs/material-measurement-laboratory-0" class="selected" hreflang="en">Biomolecular Measurement Division</a></li></ul></li></ul></li></ul></li></ul>
|
||
</div>
|
||
</div>
|
||
<div class="nist-related-orgs"></div>
|
||
<div class="nist-related-orgs"></div>
|
||
<div class="nist-related-orgs"></div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<!-- nist-index-ignore-end -->
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Related News</h2>
|
||
|
||
<div class="nist-field nist-field--label-hidden nist-field--link-list entity-reference">
|
||
<div class="nist-field__items">
|
||
<div class="nist-field__item"><a href="/news-events/news/2016/07/extraordinary-standard-new-nist-protein-could-spur-biopharmaceutical" hreflang="en">An Extraordinary Standard: New NIST Protein Could Spur Biopharmaceutical Innovation</a></div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<!-- nist-index-ignore-start -->
|
||
<div
|
||
data-elastic-exclude="" class="nist-block no-print"
|
||
>
|
||
|
||
<h2
|
||
class="nist-block__title"
|
||
>Sign up for updates from NIST</h2>
|
||
|
||
<div class='nist-subscribe-form'>
|
||
<form class='usa-form' action='https://public.govdelivery.com/accounts/USNIST/subscribers/qualify' method='post'>
|
||
<input type='hidden' name='topic_id' id='topic_id' value='USNIST' />
|
||
<label class='usa-label' for='email'>Enter Email Address</label>
|
||
<input class='usa-input' id='email' name='email' onfocus='this.value='' title='email' type='text' />
|
||
<input class='usa-button' id='signupbutton' name='signupbutton' type='submit' value='Sign up' />
|
||
</form>
|
||
</div>
|
||
|
||
</div>
|
||
<!-- nist-index-ignore-end -->
|
||
|
||
</div>
|
||
</aside>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="grid-container">
|
||
|
||
<div
|
||
class="nist-page__region nist-page__region--content-bottom"
|
||
>
|
||
|
||
<div
|
||
class="nist-block"
|
||
>
|
||
|
||
|
||
<div class="text-italic font-sans-2xs">
|
||
Released July 28, 2016, Updated February 3, 2025
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</section>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div data-elastic-exclude>
|
||
<!-- nist-index-ignore-start -->
|
||
|
||
<footer class="nist-footer padding-bottom-4">
|
||
|
||
|
||
<div class="grid-container nist-footer__info">
|
||
<div class="grid-row">
|
||
<div class="tablet:grid-col-6">
|
||
<div class="nist-footer__logo">
|
||
<a href="/" title="National Institute of Standards and Technology" rel="home">
|
||
<img class="nist-footer__logo-img" src="/libraries/nist-component-library/dist/img/logo/NIST-Logo-Brand-White.svg" alt="National Institute of Standards and Technology logo" width="300px" height="42px" />
|
||
</a>
|
||
</div>
|
||
<div class="nist-footer__contact">
|
||
<h3 class="nist-footer__contact-heading">HEADQUARTERS</h3>
|
||
<address>
|
||
100 Bureau Drive<br>
|
||
Gaithersburg, MD 20899<br>
|
||
<a href="tel:301-975-2000">301-975-2000</a>
|
||
</address>
|
||
<p>
|
||
<a href="mailto:do-webmaster@nist.gov">Webmaster</a> | <a href="https://www.nist.gov/about-nist/contact-us">Contact Us</a> | <a href="https://www.nist.gov/visit">Our Other Offices</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="tablet:grid-col-6">
|
||
<div class="nist-footer__social-links">
|
||
|
||
<a class="nist-social nist-social--x-white" href=" https://x.com/NIST">
|
||
<span>X.com</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--facebook-white" href=" https://www.facebook.com/NIST">
|
||
<span>Facebook</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--linkedin-white" href=" https://www.linkedin.com/company/nist">
|
||
<span>LinkedIn</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--instagram-white" href=" https://www.instagram.com/nist/">
|
||
<span>Instagram</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--youtube-white" href=" https://www.youtube.com/NIST">
|
||
<span>YouTube</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--giphy-white" href=" https://giphy.com/nist">
|
||
<span>Giphy</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--rss-white" href=" https://www.nist.gov/news-events/nist-rss-feeds">
|
||
<span>RSS Feed</span>
|
||
</a>
|
||
|
||
<a class="nist-social nist-social--envelope-white" href=" https://public.govdelivery.com/accounts/USNIST/subscriber/new">
|
||
<span>Mailing List</span>
|
||
</a>
|
||
</div>
|
||
<div class="nist-footer__feedback">
|
||
How are we doing? <a class="usa-button" rel="nofollow" href="/form/nist-gov-feedback?destination=/news-events/news/2016/07/nistmab-portrait-anchor-molecule" title="Provide feedback">Feedback</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="grid-container">
|
||
<div class="nist-footer__nav" role="navigation">
|
||
<ul>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/privacy-policy">Site Privacy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/oism/accessibility">Accessibility</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/privacy">Privacy Program</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/oism/copyrights">Copyrights</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.commerce.gov/vulnerability-disclosure-policy">Vulnerability Disclosure</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/no-fear-act-policy">No Fear Act Policy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/office-director/freedom-information-act">FOIA</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/environmental-policy-statement">Environmental Policy</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/summary-report-scientific-integrity">Scientific Integrity</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.nist.gov/nist-information-quality-standards">Information Quality Standards</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://www.commerce.gov/">Commerce.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="http://www.science.gov/">Science.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="http://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
<li class="nist-footer__menu-item">
|
||
<a href="https://vote.gov/">Vote.gov</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</footer>
|
||
<!-- nist-index-ignore-end -->
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/1084186","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"back_to_top":{"back_to_top_button_trigger":100,"back_to_top_speed":1200,"back_to_top_prevent_on_mobile":false,"back_to_top_prevent_in_admin":true,"back_to_top_button_type":"image","back_to_top_button_text":"Back to top"},"google_analytics":{"account":"G-HEQ0YF2VYL","trackOutbound":true,"trackMailto":true,"trackTel":true,"trackDownload":true,"trackDownloadExtensions":"7z|aac|arc|arj|asf|asx|avi|bin|bsh|c|csv|doc(x|m)?|dot(x|m)?|dw(fx|g|gd)|dxf|eps|epub|exe|f(90)|flv|gif|gz|gzip|hqx|jar|jpe?g|js|m1v|mp(2|3|4|e?g)|mobi|mov(ie)?|msi|msp|pdf|phps|pl|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|rfa|rtf|rvt|sch|sea|sit|swf|tar|tgz|tif|txt|txz|wav|wma|wmv|wpd|wrl|xls(x|m|b)?|xlt(x|m)|xlam|xml|xsd|z|zip"},"nist_search":{"clickTracking":"search-report-click","isDebug":false,"clickTrackEnabled":true,"message":"NIST Search in debug mode. Check the browsers network inspector for Click Track reporting results..."},"data":{"extlink":{"extTarget":false,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"\\.gov\\\/|\\.mil\\\/|\\manufacturingusa\\.com\\\/","extInclude":"","extCssExclude":".ck-editor, .nist-video-thumbnail__lightbox-trigger, a.nist-icon--mail-blue","extCssExplicit":"","extAlert":true,"extAlertText":"Thank you for visiting NIST. We hope your visit was informative. We have provided a link to this site because it has information that may be of interest to our users. NIST does not necessarily endorse the views expressed or the facts presented on this site. Further, NIST does not endorse any commercial products that may be advertised or available on this site. Click OK to be directed to your link.","mailtoClass":"0","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"after","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"user":{"uid":0,"permissionsHash":"bd6a443844dbe99b4e6942f3b1397526e760137efd2b1ee6b2d588fc414dff20"}}</script>
|
||
<script src="/sites/default/files/js/js_jDaFaXhHm6gPUKstNYX9eIyoQXghVs3g7rbR0QoqpYY.js?scope=footer&delta=0&language=en&theme=nist_www&include=eJxdjW0OwjAIhi805UiErtjhWFlatHp7O53RLOEHPLwfgcYZ3fqsEH47XuuQzJIyUiZ9uowVjmDIUh0v0lm0ltUoopceIjlBos-7irMsa7E7wxFsLW_mEy_ce00DFVwsQpRKoQer5PmtgaQWSE-7BSamyOV7YmvtT8EP34wQy20lPe_nC6DrXYU"></script>
|
||
<script src="https://siteimproveanalytics.com/js/siteanalyze_6017546.js" async></script>
|
||
<script src="/sites/default/files/js/js_709kuJyJYTt2lWrlwglvgNyqkgqlZSSNCLusQNdUubs.js?scope=footer&delta=2&language=en&theme=nist_www&include=eJxdjW0OwjAIhi805UiErtjhWFlatHp7O53RLOEHPLwfgcYZ3fqsEH47XuuQzJIyUiZ9uowVjmDIUh0v0lm0ltUoopceIjlBos-7irMsa7E7wxFsLW_mEy_ce00DFVwsQpRKoQer5PmtgaQWSE-7BSamyOV7YmvtT8EP34wQy20lPe_nC6DrXYU"></script>
|
||
<script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"37b7ccb661","applicationID":"1089704227","transactionName":"YFxUN0sADEdYVkBaClkWdwBNCA1aFnFGRhVWVWoNVgUHaHpaWkcXWFVaBks9LFtdUGJaAEB6WQ1NEw1YVVBGHltBUFMU","queueTime":5,"applicationTime":548,"atts":"TBtXQQMaH0k=","errorBeacon":"bam.nr-data.net","agent":""}</script></body>
|
||
</html>
|