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<a href="/topics" class="usa-nav__link">All Topics</a>
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<a href="/advanced-communications" class="usa-nav__link">Advanced communications</a>
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<a href="/energy" class="usa-nav__link">Energy</a>
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
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<a href="/environment" class="usa-nav__link">Environment</a>
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<a href="/fire" class="usa-nav__link">Fire</a>
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<a href="/forensic-science" class="usa-nav__link">Forensic science</a>
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<a href="/health" class="usa-nav__link">Health</a>
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<a href="/nanotechnology" class="usa-nav__link">Nanotechnology</a>
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<a href="/neutron-research" class="usa-nav__link">Neutron research</a>
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<a href="/performance-excellence" class="usa-nav__link">Performance excellence</a>
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<a href="/physics" class="usa-nav__link">Physics</a>
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<a href="/public-safety" class="usa-nav__link">Public safety</a>
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<a href="/quantum-information-science" class="usa-nav__link">Quantum information science</a>
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<a href="/resilience" class="usa-nav__link">Resilience</a>
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<li class="usa-nav__submenu-item">
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<a href="/standards" class="usa-nav__link">Standards</a>
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<li class="usa-nav__submenu-item">
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<a href="/transportation" class="usa-nav__link">Transportation</a>
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</ul>
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</div>
|
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</div>
|
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</div>
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</li>
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<li class="usa-nav__primary-item">
|
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<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-3"><span>Labs & Major Programs</span></button>
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<div class="grid-row">
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<div class="tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
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<li class="usa-nav__submenu-item">
|
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<a href="/adlp" class="usa-nav__link">Assoc Director of Laboratory Programs</a>
|
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|
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</li>
|
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|
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<li class="usa-nav__submenu-item">
|
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|
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<a href="/laboratories" class="usa-nav__link">Laboratories</a>
|
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<ul class="usa-nav__submenu-list">
|
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|
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<li>
|
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|
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<a href="/ctl" class="usa-nav__link">Communications Technology Laboratory</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/el" class="usa-nav__link">Engineering Laboratory</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/itl" class="usa-nav__link">Information Technology Laboratory</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/mml" class="usa-nav__link">Material Measurement Laboratory</a>
|
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|
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</li>
|
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|
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<li>
|
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<a href="/pml" class="usa-nav__link">Physical Measurement Laboratory</a>
|
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|
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</li>
|
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</ul>
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
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<li class="usa-nav__submenu-item">
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<a href="/user-facilities" class="usa-nav__link">User Facilities</a>
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<ul class="usa-nav__submenu-list">
|
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|
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<li>
|
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|
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<a href="/ncnr" class="usa-nav__link">NIST Center for Neutron Research</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/cnst" class="usa-nav__link">CNST NanoFab</a>
|
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|
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|
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|
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</ul>
|
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<li class="usa-nav__submenu-item">
|
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<a href="/labs-major-programs/research-test-beds" class="usa-nav__link">Research Test Beds</a>
|
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<li class="usa-nav__submenu-item">
|
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<a href="/laboratories/projects-programs" class="usa-nav__link">Research Projects</a>
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|
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<a href="/laboratories/tools-instruments" class="usa-nav__link">Tools & Instruments</a>
|
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
|
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|
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<a href="/major-programs" class="usa-nav__link">Major Programs</a>
|
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<ul class="usa-nav__submenu-list">
|
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|
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<li>
|
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|
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<a href="/baldrige" class="usa-nav__link">Baldrige Performance Excellence Program</a>
|
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|
|
</li>
|
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|
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<li>
|
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|
|
<a href="/chips" class="usa-nav__link">CHIPS for America Initiative</a>
|
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|
|
</li>
|
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|
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<li>
|
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|
|
<a href="/mep" class="usa-nav__link">Manufacturing Extension Partnership (MEP)</a>
|
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|
|
</li>
|
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|
|
<li>
|
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|
|
<a href="/oam" class="usa-nav__link">Office of Advanced Manufacturing</a>
|
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|
|
</li>
|
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|
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<li>
|
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|
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<a href="/spo" class="usa-nav__link">Special Programs Office</a>
|
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|
|
</li>
|
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|
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<li>
|
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|
|
<a href="/tpo" class="usa-nav__link">Technology Partnerships Office</a>
|
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|
|
</li>
|
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|
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</ul>
|
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|
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</li>
|
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|
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</ul>
|
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|
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</div>
|
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</div>
|
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</div>
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</li>
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<li class="usa-nav__primary-item">
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<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-4"><span>Services & Resources</span></button>
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<div id="primary_menu-4" class="usa-nav__submenu usa-megamenu">
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<div class="grid-row">
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|
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<li class="usa-nav__submenu-item">
|
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<a href="/content/standards-measurements" class="usa-nav__link">Standards and Measurements</a>
|
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<ul class="usa-nav__submenu-list">
|
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|
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<li>
|
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<a href="/calibrations" class="usa-nav__link">Calibration Services</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/nvlap" class="usa-nav__link">Laboratory Accreditation (NVLAP)</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/nist-quality-system" class="usa-nav__link">Quality System</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/srm" class="usa-nav__link">Standard Reference Materials (SRMs)</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/sri" class="usa-nav__link">Standard Reference Instruments (SRIs)</a>
|
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|
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</li>
|
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|
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<li>
|
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|
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<a href="/standardsgov" class="usa-nav__link">Standards.gov</a>
|
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|
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</li>
|
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<li>
|
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<a href="/pml/time-and-frequency-division/time-services" class="usa-nav__link">Time Services</a>
|
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</li>
|
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<li>
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<a href="/pml/owm" class="usa-nav__link">Office of Weights and Measures</a>
|
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|
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</li>
|
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</ul>
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</li>
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
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<li class="usa-nav__submenu-item">
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<a href="/services-resources/software" class="usa-nav__link">Software</a>
|
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<li class="usa-nav__submenu-item">
|
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<a href="/data" class="usa-nav__link">Data</a>
|
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<ul class="usa-nav__submenu-list">
|
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<li>
|
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<a href="https://webbook.nist.gov/chemistry/" class="usa-nav__link">Chemistry WebBook</a>
|
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|
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</li>
|
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|
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<li>
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|
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<a href="https://nvd.nist.gov/" class="usa-nav__link">National Vulnerability Database</a>
|
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|
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</li>
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<li>
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<a href="/pml/productsservices/physical-reference-data" class="usa-nav__link">Physical Reference Data</a>
|
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<li>
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<a href="/srd" class="usa-nav__link">Standard Reference Data (SRD)</a>
|
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</ul>
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<li class="usa-nav__submenu-item">
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<a href="https://shop.nist.gov/" class="usa-nav__link">Storefront</a>
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<a href="/tpo" class="usa-nav__link">License & Patents</a>
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
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<li class="usa-nav__submenu-item">
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<a href="https://csrc.nist.gov/" class="usa-nav__link">Computer Security Resource Center (CSRC)</a>
|
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|
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</li>
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<li class="usa-nav__submenu-item">
|
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<a href="/nist-research-library" class="usa-nav__link">NIST Research Library</a>
|
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</li>
|
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|
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</ul>
|
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</div>
|
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</div>
|
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</div>
|
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</li>
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<li class="usa-nav__primary-item">
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<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-5"><span>News & Events</span></button>
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<div id="primary_menu-5" class="usa-nav__submenu usa-megamenu">
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<div class="grid-row">
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<li class="usa-nav__submenu-item">
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<a href="/news-events/news" class="usa-nav__link">News</a>
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</li>
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<li class="usa-nav__submenu-item">
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<a href="/news-events/events" class="usa-nav__link">Events</a>
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<li class="usa-nav__submenu-item">
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<a href="/blogs" class="usa-nav__link">Blogs</a>
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<li class="usa-nav__submenu-item">
|
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<a href="/feature-stories" class="usa-nav__link">Feature Stories</a>
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<a href="/awards" class="usa-nav__link">Awards</a>
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</ul></div><div class="column-break tablet:grid-col-fill"><ul class="usa-nav__submenu-list">
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<li class="usa-nav__submenu-item">
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<a href="/video-gallery" class="usa-nav__link">Video Gallery</a>
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<li class="usa-nav__submenu-item">
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<a href="/image-gallery" class="usa-nav__link">Image Gallery</a>
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<li class="usa-nav__submenu-item">
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<a href="/pao/media-contacts" class="usa-nav__link">Media Contacts</a>
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</ul>
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</div>
|
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</div>
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</li>
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<li class="usa-nav__primary-item">
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<button class="usa-accordion__button usa-nav__link" aria-expanded="false" aria-controls="primary_menu-6"><span>About NIST</span></button>
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<a href="/about-nist" class="usa-nav__link">About Us</a>
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<a href="/director/leadership" class="usa-nav__link">Leadership</a>
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<h1 class="nist-page__title">Nano-Measurement Protocols</h1>
|
|||
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|
|||
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|
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|
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|
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<div data-elastic-exclude class="nist-block nist-social__wrapper">
|
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<h2 class="nist-social__title">Share</h2>
|
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<a target="_blank" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.nist.gov/mml/nano-measurement-protocols&source=https://www.nist.gov/mml/nano-measurement-protocols"
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|
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|
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<a href="mailto:?subject=NIST.gov&body=Check out this site https://www.nist.gov/mml/nano-measurement-protocols"
|
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|
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|
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<h3><strong>Background</strong></h3><p>Advances in R&D and commercialization of nanotechnology have been significant, yet numerous challenges remain to realize the tremendous benefits of this interdisciplinary and growing field. These challenges include reproducibility and scale up in manufacturing of engineered nanomaterials (ENMs) and nanotechnology–enabled products (NEPs), and assessing the potential risks of ENMs and NEPs to humans and to the environment across the full material and product life cycles. Addressing these and other challenges requires accurate and reproducible measurements of physico-chemical and biological properties in relevant media, including complex environmental and biological matrices.</p><h3><strong>Protocols</strong></h3><p>The development of protocols, defined here as step-by-step, reproducible, and validated procedures, is an essential first step in the harmonization of ENM/NEP property measurements to enable direct comparisons between laboratories and greater consistency in reporting. Protocols may address, either separately or conjointly, sample preparation, conduct of measurements, and data analysis. The need for protocols is highlighted by agencies that regulate ENMs and NEPs, by industry, and by researchers from diverse organizations. Protocols can form the basis for the development of documentary standards published by ISO, ASTM, and other standards development organizations. Information on existing documentary standards may be found in the <a href="http://nanostandards.ansi.org/tiki-index.php">American National Standards Institute Nanotechnology Standards Database</a>.</p><h3><strong>NIST Protocols</strong></h3><p>NIST has actively developed protocols of relevance to nanomaterial measurements since 2007; some of these protocols have been published in a series of NIST Special Publications (SPs), each with a citable digital object identifier (DOI) to provide persistent identification. Some of these NIST protocols were developed in collaboration with external partners. The original versions of these protocols were posted on external collaborator web sites; all previous versions are superseded by the corresponding NIST SP versions. Updates to the SP protocols may be released in the future. Check this page to see when revisions of these protocols are made available or when new protocols are posted.</p><p>NIST encourages users to cite the protocols in their publications. NIST greatly values user comments and suggestions to improve or further validate the protocols, as well as input on high-priority needs for protocols. Please submit feedback or comments to <span class="spamspan"><span class="u">nanoprotocols</span> [at] <span class="d">nist.gov</span><span class="t"> (nanoprotocols[at]nist[dot]gov)</span></span>, noting the protocol to which you are referring.</p><p>Currently available protocols are assigned to three categories:</p><ul><li><a href="/mml/sample-preparation-protocols" data-entity-type="node" data-entity-uuid="3b169eca-e853-4e30-b58b-475c017b0bc9" data-entity-substitution="canonical" title="Sample Preparation Protocols">Sample preparation</a></li><li><a href="/mml/physico-chemical-measurement-protocols" data-entity-type="node" data-entity-uuid="ba6ae3e2-0344-43c4-9fca-72a276f696fa" data-entity-substitution="canonical" title="Physico-Chemical Measurement Protocols">Physico-chemical measurements</a></li><li><a href="/mml/biological-measurement-protocols" data-entity-type="node" data-entity-uuid="a0dc7b7e-3e04-4c5f-8b29-a8e6ccfc8141" data-entity-substitution="canonical" title="Biological Measurement Protocols">Biological measurements</a></li></ul><p>Additional protocols in the review or development stage will be added as they become available.</p><p><a href="/mml/nano-measurements-complete-list-protocols" data-entity-type="node" data-entity-uuid="d08ebedc-469b-4a59-a376-de1888b311d0" data-entity-substitution="canonical" title="Nano-Measurements: Complete List of Protocols">Click here to browse the full list of protocols</a>.</p>
|
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<a href="/topic-terms/metrology" hreflang="en">Metrology</a>, <a href="/topic-terms/nanotechnology" hreflang="en">Nanotechnology</a>, <a href="/topic-terms/nanomaterials" hreflang="en">Nanomaterials</a> and <a href="/topic-terms/nanometrology" hreflang="en">Nanometrology</a></div>
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|
|||
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Created February 19, 2015, Updated February 7, 2025
|
|||
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