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5.4 KiB
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74 lines
5.4 KiB
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<title>COGs - Clusters of Orthologous Groups</title>
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<meta name="author" content="Yuri Wolf">
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<meta name="keywords" content="national center for biotechnology information, ncbi, national library of medicine, nlm, national institutes of health, nih, COG, genome, cluster, bioinformatics, phylogeny">
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<meta name="description" content="Each COG (Cluster of Orthologous Groups of proteins) assembles the descendants from the same gene in the ancestral genome.">
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<td><img border=0 width=52 height=52 src=gog2.gif></td>
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<font color=#ff99cc size=+2>COGs</font><br>
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<font color=#ffff00>Phylogenetic classification of proteins encoded in complete genomes</font>
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<td><img border=0 width=52 height=52 src=koglogo.gif></td>
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<td align=right><a href=https://www.ncbi.nlm.nih.gov/><img border=0 height=52 src=left.GIF></a></td>
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<b>COG links</b><br>
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<ul>
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<li><a href=https://www.ncbi.nlm.nih.gov/research/cog>2024 COGs update [Web interface]</a><img border=0 src="new.gif">
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/COG/COG2024/data>2024 COGs update [FTP]</a><img border=0 src="new.gif">
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/COG/COG2020/data>2020 COGs update [FTP]</a>
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<li>2003 COGs, 2014 update [Web interface] (superceded by 2020 update)
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/COG/COG2014/data>2003 COGs, 2014 update [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/COG/COG>2003 COGs, original format [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/COG/KOG>2003 KOGs, original format [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/wolf/COGs/COG0303>2003 COGs [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/wolf/COGs/arCOG>arCOGs [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/wolf/COGs/NCVOG>NCVOGs [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/wolf/COGs/mimiCOG>mimiCOOGs [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/kristensen/thousandgenomespogs>2013 POGs [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/kristensen/annotatedPOGs-07>2011 POGs, annotated [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/kristensen/extendedPOGs-10>2011 POGs, extended [FTP]</a>
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<li><a href=https://ftp.ncbi.nlm.nih.gov/pub/wolf/COGs/COGsoft>COG software [FTP]</a>
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</ul>
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<b>Publications</b><br>
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<ul>
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<li>COG database update 2024. <a href=https://pubmed.ncbi.nlm.nih.gov/39494517/><i>Nucleic Acids Res.</i> 2025 Jan 6; D356-D363</a>.<img border=0 src="new.gif">
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<li>COG database update: focus on microbial diversity, model organisms, and widespread pathogens. <a href=https://pubmed.ncbi.nlm.nih.gov/33167031><i>Nucleic Acids Res.</i> 2020 Nov 9; gkaa1018</a>.
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<li>2019 The COG approach. <a href=https://pubmed.ncbi.nlm.nih.gov/28968633><i>Brief Bioinform.</i> 2019 Jul 19;20(4):1063-1070</a>.
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<li>2017 ATGC-COGs. <a href=https://pubmed.ncbi.nlm.nih.gov/28053163><i>Nucleic Acids Res.</i> 2017 Jan 4;45(D1):D210-D218</a>.
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<li>2014 archaeal COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/25764277><i>Life</i> 2015 Mar 10;5(1):818-840</a>.
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<li>2014 update of 2003 COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/25428365><i>Nucleic Acids Res.</i> 2015 Jan;43:D261-D269</a>.
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<li>mimiCOGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/23557328><i>Virol J.</i> 2013 Apr 4;10:106</a>.
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<li>2013 phage COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/23222723><i>J Bacteriol.</i> 2013 Mar;195(5):941-950</a>.
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<li>2012 archaeal COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/23241446><i>Biol Direct</i> 2012 Dec 14;7:46</a>.
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<li>Orthologs and BBH. <a href=https://www.ncbi.nlm.nih.gov/pubmed/23160176><i>Genome Biol Evol.</i> 2012 Jan;4(12):1286-1294</a>.
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<li>2011 phage COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/21317336><i>J Bacteriol.</i> 2011 Apr;193(8):1806-1814</a>.
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<li>Improved COG algorithm. <a href=https://www.ncbi.nlm.nih.gov/pubmed/20439257><i>Bioinformatics</i> 2010 Jun 15;26(12):1481-1487</a>.
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<li>NCLDV COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/20017929><i>Virol J.</i> 2009 Dec 17;6:223</a>.
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<li>2007 archaeal COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/18042280><i>Biol Direct</i> 2007 Nov 27;2:33</a>.
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<li>Lactic acid bacteria COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/17030793><i>Proc Natl Acad Sci U.S.A.</i> 2006 Oct 17;103(42):15611-15616</a>.
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<li>Cyanobacterial COGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/16924101><i>Proc Natl Acad Sci U.S.A.</i> 2006 Aug 29;103(35):13126-13131</a>.
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<li>2003 eukaryotic KOGs. <a href=https://www.ncbi.nlm.nih.gov/pubmed/14759257><i>Genome Biol.</i> 2004 Jan 15;5(2):R7</a>.
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<li>2003 database update. <a href=https://www.ncbi.nlm.nih.gov/pubmed/12969510><i>BMC Bioinformatics</i> 2003 Sep 11;4(1):41</a>
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<li>Original COG paper. <a href=https://www.ncbi.nlm.nih.gov/pubmed/9381173><i>Science</i> 1997 Oct 24;278(5338):631-7</a>
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</ul>
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<br><hr>
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Comments and questions to <A HREF="mailto:cogs@ncbi.nlm.nih.gov">cogs@ncbi.nlm.nih.gov</A> or to the project <A HREF="mailto:koonin@ncbi.nlm.nih.gov">supervisor</a>.
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<br><br>
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Updated: <i>February 2025</i>
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