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<!--
|
||
UID=87431
|
||
ConceptID=C0342208
|
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-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Multinodular goiter</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87431</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342208</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Goiter, multinodular</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Thyroid goiter multinodular (237570007); Multiple thyroid nodules (237570007); Multinodular goiter (237570007)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005987">HP:0005987</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0000334" target="_blank">MONDO:0000334</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span> Phenotypic series:</td>
|
||
<td><a href="https://omim.org/phenotypicSeries/PS138800" target="_blank">PS138800</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Enlargement of the thyroid gland related to multiple nodules in the thyroid gland. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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|
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Multinodular goiter</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="matched_ds">Multinodular goiter</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_78675"><div><strong>Alstrom syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78675</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0268425</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alström syndrome is characterized by cone-rod dystrophy, obesity, progressive bilateral sensorineural hearing impairment, acute infantile-onset cardiomyopathy and/or adolescent- or adult-onset restrictive cardiomyopathy, insulin resistance / type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and chronic progressive kidney disease. Cone-rod dystrophy presents as progressive visual impairment, photophobia, and nystagmus usually starting between birth and age 15 months. Many individuals lose all perception of light by the end of the second decade, but a minority retain the ability to read large print into the third decade. Children usually have normal birth weight but develop truncal obesity during their first year. Sensorineural hearing loss presents in the first decade in as many as 70% of individuals and may progress to the severe or moderately severe range (40-70 db) by the end of the first to second decade. Insulin resistance is typically accompanied by the skin changes of acanthosis nigricans, and proceeds to T2DM in the majority by the third decade. Nearly all demonstrate hypertriglyceridemia. Other findings can include endocrine abnormalities (hypothyroidism, hypogonadotropic hypogonadism in males, and hyperandrogenism in females), urologic dysfunction / detrusor instability, progressive decrease in renal function, and hepatic disease (ranging from elevated transaminases to steatohepatitis/NAFLD). Approximately 20% of affected individuals have delay in early developmental milestones, most commonly in gross and fine motor skills. About 30% have a learning disability. Cognitive impairment (IQ <70) is very rare. Wide clinical variability is observed among affected individuals, even within the same family.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78675">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_357232"><div><strong>Rhabdomyosarcoma, embryonal, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>357232</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867234</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. Less commonly observed tumors include ciliary body medulloepithelioma, nasal chondromesenchymal hamartoma, embryonal rhabdomyosarcoma, pituitary blastoma, pineoblastoma, central nervous system (CNS) sarcoma, other CNS tumors, and presacral malignant teratoid tumor. The majority of tumors occur in individuals younger than age 40 years. PPB typically presents in infants and children younger than age six years. Ovarian sex cord-stromal tumors are most often diagnosed before age 40 years. Cystic nephroma generally presents in young children but has also been reported in adolescents. Additional clinical features that may be seen include macrocephaly, ocular abnormalities, structural anomalies of the kidney and collecting system, and dental anomalies (bulbous crowns).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/357232">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1678330"><div><strong>Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1678330</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193062</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">CAPOK syndrome (CAPOK) is characterized by onset of symptoms in the first year of life, with the development of progressive alopecia, hypo- and hyperpigmented macular skin lesions, palmoplantar keratoderma, and nail dystrophy. Beginning in the third decade of life, patients develop recurrent squamous cell carcinomas. Some patients may have brittle teeth resulting in tooth loss, and multinodular goiter has been observed (Courcet et al., 2015).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1678330">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1824057"><div><strong>Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824057</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774284</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mosaic variegated aneuploidy syndrome-7 with inflammation and tumor predisposition (MVA7) is an autosomal recessive disorder characterized by increased susceptibility to benign and malignant neoplasms beginning in early childhood. Affected individuals show dysmorphic facies and may have early developmental delay. Patient cells show a high level of aneuploidy due to defects in cell division (Villarroya-Beltri et al., 2022). For a discussion of genetic heterogeneity of MVA, see MVA1 (257300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1824057">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78675" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alstrom syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1678330" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1824057" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_357232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rhabdomyosarcoma, embryonal, 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27521067">2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ross DS,
|
||
Burch HB,
|
||
Cooper DS,
|
||
Greenlee MC,
|
||
Laurberg P,
|
||
Maia AL,
|
||
Rivkees SA,
|
||
Samuels M,
|
||
Sosa JA,
|
||
Stan MN,
|
||
Walter MA</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2016 Oct;26(10):1343-1421.
|
||
doi: 10.1089/thy.2016.0229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27521067" target="_blank">27521067</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26926973">Hyperthyroidism: Diagnosis and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kravets I</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2016 Mar 1;93(5):363-70.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26926973" target="_blank">26926973</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21510801">Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bahn Chair RS,
|
||
Burch HB,
|
||
Cooper DS,
|
||
Garber JR,
|
||
Greenlee MC,
|
||
Klein I,
|
||
Laurberg P,
|
||
McDougall IR,
|
||
Montori VM,
|
||
Rivkees SA,
|
||
Ross DS,
|
||
Sosa JA,
|
||
Stan MN;
|
||
American Thyroid Association;
|
||
American Association of Clinical Endocrinologists</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2011 Jun;21(6):593-646.
|
||
Epub 2011 Apr 21
|
||
doi: 10.1089/thy.2010.0417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21510801" target="_blank">21510801</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22multinodular%20goiter%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (102)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36445235">The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Christofer Juhlin C,
|
||
Mete O,
|
||
Baloch ZW</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2023 Feb 1;30(2)
|
||
Epub 2022 Dec 22
|
||
doi: 10.1530/ERC-22-0293.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36445235" target="_blank">36445235</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32252086">Hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McDermott MT</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2020 Apr 7;172(7):ITC49-ITC64.
|
||
doi: 10.7326/AITC202004070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32252086" target="_blank">32252086</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31409088">DICER1 Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hořínová V,
|
||
Drábová K,
|
||
Nosková H,
|
||
Bajčiová V,
|
||
Šoukalová J,
|
||
Černá L,
|
||
Hůrková V,
|
||
Slabý O,
|
||
Štěrba J</span><br />
|
||
<span class="medgenPMjournal">Klin Onkol</span>
|
||
2019 Summer;32(Supplementum2):123-127.
|
||
doi: 10.14735/amko2019S123.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31409088" target="_blank">31409088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25707564">Procedure/Technique: endocrine tumors of the neck.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fernandes R,
|
||
Miller MA,
|
||
Morlandt A</span><br />
|
||
<span class="medgenPMjournal">Atlas Oral Maxillofac Surg Clin North Am</span>
|
||
2015 Mar;23(1):39-47.
|
||
Epub 2014 Dec 20
|
||
doi: 10.1016/j.cxom.2014.10.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25707564" target="_blank">25707564</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12803008">Multinodular goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Day TA,
|
||
Chu A,
|
||
Hoang KG</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2003 Feb;36(1):35-54.
|
||
doi: 10.1016/s0030-6665(02)00157-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12803008" target="_blank">12803008</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (684)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36445235">The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Christofer Juhlin C,
|
||
Mete O,
|
||
Baloch ZW</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2023 Feb 1;30(2)
|
||
Epub 2022 Dec 22
|
||
doi: 10.1530/ERC-22-0293.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36445235" target="_blank">36445235</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32252086">Hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McDermott MT</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2020 Apr 7;172(7):ITC49-ITC64.
|
||
doi: 10.7326/AITC202004070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32252086" target="_blank">32252086</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26926973">Hyperthyroidism: Diagnosis and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kravets I</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2016 Mar 1;93(5):363-70.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26926973" target="_blank">26926973</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15658668">Benign multinodular goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frilling A,
|
||
Liu C,
|
||
Weber F</span><br />
|
||
<span class="medgenPMjournal">Scand J Surg</span>
|
||
2004;93(4):278-81.
|
||
doi: 10.1177/145749690409300405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15658668" target="_blank">15658668</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12803008">Multinodular goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Day TA,
|
||
Chu A,
|
||
Hoang KG</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2003 Feb;36(1):35-54.
|
||
doi: 10.1016/s0030-6665(02)00157-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12803008" target="_blank">12803008</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (703)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32252086">Hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McDermott MT</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2020 Apr 7;172(7):ITC49-ITC64.
|
||
doi: 10.7326/AITC202004070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32252086" target="_blank">32252086</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27521067">2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ross DS,
|
||
Burch HB,
|
||
Cooper DS,
|
||
Greenlee MC,
|
||
Laurberg P,
|
||
Maia AL,
|
||
Rivkees SA,
|
||
Samuels M,
|
||
Sosa JA,
|
||
Stan MN,
|
||
Walter MA</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2016 Oct;26(10):1343-1421.
|
||
doi: 10.1089/thy.2016.0229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27521067" target="_blank">27521067</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26926973">Hyperthyroidism: Diagnosis and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kravets I</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2016 Mar 1;93(5):363-70.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26926973" target="_blank">26926973</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15658668">Benign multinodular goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frilling A,
|
||
Liu C,
|
||
Weber F</span><br />
|
||
<span class="medgenPMjournal">Scand J Surg</span>
|
||
2004;93(4):278-81.
|
||
doi: 10.1177/145749690409300405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15658668" target="_blank">15658668</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8814121">Treatment options for hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wartofsky L</span><br />
|
||
<span class="medgenPMjournal">Hosp Pract (1995)</span>
|
||
1996 Sep 15;31(9):69-73, 76-8, 81-4.
|
||
doi: 10.1080/21548331.1996.11443345.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8814121" target="_blank">8814121</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (413)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36681602">Incidence of incidental papillary cancer in multinodular goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gijón Román C,
|
||
Balsalobre Salmerón MD,
|
||
Cañones Martos ML</span><br />
|
||
<span class="medgenPMjournal">Med Clin (Barc)</span>
|
||
2023 May 26;160(10):456-457.
|
||
Epub 2023 Jan 19
|
||
doi: 10.1016/j.medcli.2022.12.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36681602" target="_blank">36681602</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36445235">The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Christofer Juhlin C,
|
||
Mete O,
|
||
Baloch ZW</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2023 Feb 1;30(2)
|
||
Epub 2022 Dec 22
|
||
doi: 10.1530/ERC-22-0293.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36445235" target="_blank">36445235</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35288841">Overview of the 2022 WHO Classification of Thyroid Neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baloch ZW,
|
||
Asa SL,
|
||
Barletta JA,
|
||
Ghossein RA,
|
||
Juhlin CC,
|
||
Jung CK,
|
||
LiVolsi VA,
|
||
Papotti MG,
|
||
Sobrinho-Simões M,
|
||
Tallini G,
|
||
Mete O</span><br />
|
||
<span class="medgenPMjournal">Endocr Pathol</span>
|
||
2022 Mar;33(1):27-63.
|
||
Epub 2022 Mar 14
|
||
doi: 10.1007/s12022-022-09707-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35288841" target="_blank">35288841</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34599283">DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">González IA,
|
||
Stewart DR,
|
||
Schultz KAP,
|
||
Field AP,
|
||
Hill DA,
|
||
Dehner LP</span><br />
|
||
<span class="medgenPMjournal">Mod Pathol</span>
|
||
2022 Jan;35(1):4-22.
|
||
Epub 2021 Oct 1
|
||
doi: 10.1038/s41379-021-00905-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34599283" target="_blank">34599283</a><a href="/pmc/articles/PMC8695383" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17704042">Thyroid nodules - stepwise diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polyzos SA,
|
||
Kita M,
|
||
Avramidis A</span><br />
|
||
<span class="medgenPMjournal">Hormones (Athens)</span>
|
||
2007 Apr-Jun;6(2):101-19.
|
||
doi: 10.14310/horm.2002.111107.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17704042" target="_blank">17704042</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (368)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38714868">Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Narumi S,
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Nagasaki K,
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Kiriya M,
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Uehara E,
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Akiba K,
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Tanase-Nakao K,
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Shimura K,
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Abe K,
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Sugisawa C,
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Ishii T,
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Miyako K,
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Hasegawa Y,
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Maruo Y,
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Muroya K,
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Watanabe N,
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Nishihara E,
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Ito Y,
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Kogai T,
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Kameyama K,
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Nakabayashi K,
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Hata K,
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Fukami M,
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Shima H,
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Kikuchi A,
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Takayama J,
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Tamiya G,
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Hasegawa T</span><br />
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<span class="medgenPMjournal">Nat Genet</span>
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||
2024 May;56(5):869-876.
|
||
Epub 2024 May 7
|
||
doi: 10.1038/s41588-024-01735-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38714868" target="_blank">38714868</a><a href="/pmc/articles/PMC11096107" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37931916">The Presence of Anti-TPO Antibodies Increase the Likelihood of Post-I131 Hypothyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Quataert F,
|
||
Bravenboer B,
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Keyaerts M,
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Andreescu CE</span><br />
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<span class="medgenPMjournal">Horm Metab Res</span>
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||
2024 Feb;56(2):134-141.
|
||
Epub 2023 Nov 6
|
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doi: 10.1055/a-2205-2052.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37931916" target="_blank">37931916</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31409088">DICER1 Syndrome.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Hořínová V,
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Drábová K,
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Nosková H,
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Bajčiová V,
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Šoukalová J,
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Černá L,
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Hůrková V,
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Slabý O,
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Štěrba J</span><br />
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<span class="medgenPMjournal">Klin Onkol</span>
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2019 Summer;32(Supplementum2):123-127.
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doi: 10.14735/amko2019S123.
|
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<span class="bold">PMID: </span><a href="/pubmed/31409088" target="_blank">31409088</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/29897006">An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bakhsh AD,
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Ladas I,
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Hamshere ML,
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Bullock M,
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Kirov G,
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Zhang L,
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Taylor PN,
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Gregory JW,
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Scott-Coombes D,
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Völzke H,
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Teumer A,
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Mantripragada K,
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||
Williams ED,
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||
Clifton-Bligh RJ,
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||
Williams NM,
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Ludgate ME</span><br />
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||
<span class="medgenPMjournal">Thyroid</span>
|
||
2018 Jul;28(7):891-901.
|
||
doi: 10.1089/thy.2017.0312.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29897006" target="_blank">29897006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9676561">Is it hyperthyroidism? You can't always tell from the clinical picture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haddad G</span><br />
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<span class="medgenPMjournal">Postgrad Med</span>
|
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1998 Jul;104(1):42-4, 53-5, 59.
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doi: 10.3810/pgm.1998.07.530.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9676561" target="_blank">9676561</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (381)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35777050">The clinical characteristics and outcomes of patients with pulmonary hypertension in association with hyperthyroid state: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ata F,
|
||
Khan AA,
|
||
Yousaf Z,
|
||
Choudry H,
|
||
Mohammed AM,
|
||
Ahmed B,
|
||
Umer AM,
|
||
Khan F,
|
||
Al Mohanadi DHS,
|
||
Naem E,
|
||
Zahid M</span><br />
|
||
<span class="medgenPMjournal">Medicine (Baltimore)</span>
|
||
2022 Jul 1;101(26):e29832.
|
||
doi: 10.1097/MD.0000000000029832.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35777050" target="_blank">35777050</a><a href="/pmc/articles/PMC9239623" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34028325">Meta-Analysis of Randomized Controlled Trials Comparing the Efficacy of Radioactive Iodine Monotherapy versus Radioactive Iodine Therapy and Adjunctive Lithium for the Treatment of Hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmed FW,
|
||
Kirresh OZ,
|
||
Majeed MS,
|
||
Iftikhar M,
|
||
Sajid MS</span><br />
|
||
<span class="medgenPMjournal">Endocr Res</span>
|
||
2021 Nov;46(4):160-169.
|
||
Epub 2021 May 24
|
||
doi: 10.1080/07435800.2021.1924769.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34028325" target="_blank">34028325</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23067375">Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brito JP,
|
||
Yarur AJ,
|
||
Prokop LJ,
|
||
McIver B,
|
||
Murad MH,
|
||
Montori VM</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2013 Apr;23(4):449-55.
|
||
doi: 10.1089/thy.2012.0156.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23067375" target="_blank">23067375</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19671708">Clinical outcomes after estimated versus calculated activity of radioiodine for the treatment of hyperthyroidism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de Rooij A,
|
||
Vandenbroucke JP,
|
||
Smit JW,
|
||
Stokkel MP,
|
||
Dekkers OM</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2009 Nov;161(5):771-7.
|
||
Epub 2009 Aug 11
|
||
doi: 10.1530/EJE-09-0286.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19671708" target="_blank">19671708</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18357484">Evidence-based management of toxic multinodular goiter (Plummer's Disease).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Porterfield JR Jr,
|
||
Thompson GB,
|
||
Farley DR,
|
||
Grant CS,
|
||
Richards ML</span><br />
|
||
<span class="medgenPMjournal">World J Surg</span>
|
||
2008 Jul;32(7):1278-84.
|
||
doi: 10.1007/s00268-008-9566-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18357484" target="_blank">18357484</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multinodular%20goiter%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
|
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|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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