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</div><div><span>Interstitial lung disease</span></div></div>
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</a><h1 class="with-also" itemprop="name">Interstitial lung disease</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become inflamed and then damaged.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The lungs contain tiny air sacs (alveoli), which is where oxygen is absorbed. These air sacs expand with each breath.</p><p>The tissue around these air sacs is called the interstitium. In people with interstitial lung disease, this tissue becomes inflamed, stiff, or scarred, and the air sacs are not able to expand as much. As a result, not as much oxygen can get to the body.</p><p>ILD can occur without a known cause. This is called idiopathic ILD. <a test="test" href="./000069.htm">Idiopathic pulmonary fibrosis</a> (IPF) is the most common disease of this type.</p><p>There are also dozens of known causes of ILD, including:</p><ul><li>Autoimmune diseases (in which the immune system attacks the body) such as lupus, <a test="test" href="./000431.htm">rheumatoid arthritis</a>, <a test="test" href="./000076.htm">sarcoidosis</a>, and <a test="test" href="./000429.htm">scleroderma</a>.</li><li>Lung inflammation due to breathing in a foreign substance such as certain types of dust, fungus, or mold (<a test="test" href="./000109.htm">hypersensitivity pneumonitis</a>).</li><li>Medicines (such as nitrofurantoin, sulfonamides, bleomycin, amiodarone, methotrexate, gold, infliximab, etanercept, and other chemotherapy medicines).</li><li><a test="test" href="./001918.htm">Radiation</a> treatment to the chest.</li><li>Working with or around asbestos, coal dust, cotton dust, and silica dust (called occupational lung disease). </li><li>Infection and partial recovery from diseases like COVID-19.</li></ul><p>Cigarette smoking may increase the risk of developing some forms of ILD and may cause the disease to be more severe.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p><a test="test" href="./003075.htm">Shortness of breath</a> is a main symptom of ILD. You may breathe faster or need to take deep breaths:</p><ul><li>At first, shortness of breath may not be severe and is only noticed with exercise, climbing stairs, and other activities.</li><li>Over time, it can occur with less strenuous activity such as bathing or dressing, and as the disease worsens, even with eating or talking. </li></ul><p>Most people with this condition also have a dry cough. A dry cough means you do not cough up any mucus or sputum.</p><p>Over time, weight loss, fatigue, and muscle and joint pain are also present.</p><p>People with more advanced ILD may have:</p><ul><li>Abnormal enlargement and curving of the base of the fingernails (<a test="test" href="./003282.htm">clubbing</a>).</li><li>Blue color of the lips, skin, or fingernails due to low blood oxygen levels (<a test="test" href="./003215.htm">cyanosis</a>).</li><li>Symptoms of the other diseases such as arthritis or trouble swallowing (scleroderma), associated with ILD. </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will perform a physical exam. Dry, crackling breath sounds may be heard when listening to your chest with a stethoscope. </p><p>The following tests may be done:</p><ul><li>Blood tests to check for autoimmune diseases</li><li><a test="test" href="./003857.htm">Bronchoscopy</a> with or without <a test="test" href="./003416.htm">biopsy</a></li><li><a test="test" href="./003804.htm">Chest x-ray</a></li><li>High resolution <a test="test" href="./003330.htm">CT scan</a> of the chest</li><li><a test="test" href="./003794.htm">MRI chest</a></li><li>Echocardiogram</li><li>Open <a test="test" href="./003860.htm">lung biopsy</a></li><li>Measurement of the blood oxygen level at rest or when active</li><li><a test="test" href="./003855.htm">Blood gases</a></li><li><a test="test" href="./003853.htm">Pulmonary function tests</a></li><li>Six minute walk test (checks how far you can walk in 6 minutes and how many times you need to stop to catch your breath) </li></ul><p>People who are heavily exposed to known causes of lung disease in the workplace are usually routinely screened for lung disease. These jobs include coal mining, sand blasting, and working on a ship.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Treatment depends on the cause and duration of the disease. Medicines that suppress the immune system and reduce swelling in the lungs are prescribed if an autoimmune disease is causing the problem. For some people who have IPF or certain other autoimmune diseases, pirfenidone and nintedanib are two medicines that may be used to slow worsening of the disease. If there is no specific treatment for the condition, the aim is to make you more comfortable and support lung function:</p><ul><li>If you smoke, ask your provider about how to stop smoking.</li><li>People with low blood oxygen levels will receive <a test="test" href="../patientinstructions/000048.htm">oxygen therapy in their home</a>. A respiratory therapist will help you set up the oxygen. Families need to learn <a test="test" href="../patientinstructions/000049.htm">proper oxygen storage and safety</a>. </li></ul><p>Lung rehabilitation can provide support, and help you learn:</p><ul><li>Different breathing methods</li><li>How to set up your home to save energy</li><li>How to eat enough calories and nutrients</li><li>How to stay active and strong </li></ul><p>Some people with advanced ILD may need a lung transplant.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>You can ease the stress of illness by joining a <a test="test" href="./002158.htm">support group</a>. Sharing with others who have common experiences and problems can help you not feel alone.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>The chance of recovering or ILD getting worse depends on the cause and how severe the disease was when it was first diagnosed.</p><p>Some people with ILD develop heart failure and high blood pressure in the blood vessels of their lungs (<a test="test" href="./000112.htm">pulmonary hypertension</a>).</p><p>Idiopathic pulmonary fibrosis has a poor outlook.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Contact your provider if:</p><ul><li>Your breathing is getting harder, faster, or more shallow than before</li><li>You cannot get a deep breath, or need to lean forward when sitting</li><li>You are having headaches more often</li><li>You feel sleepy or confused</li><li>You have a fever</li><li>You are coughing up dark mucus</li><li>Your fingertips or the skin around your fingernails is blue</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Diffuse parenchymal lung disease; Alveolitis; Idiopathic pulmonary pneumonitis (IPP)</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Patient Instructions</h2></div><div class="section-button"><button type="submit" aria-controls="section-carepnt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Corte TJ, Wells AU. Connective tissue diseases. In: Broaddus VC, Ernst JD, King TE, et al, eds. <em>Murray and Nadel's Textbook of Respiratory Medicine</em>. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 92.</p><p>Graney BA, Lee JS, King TE. Nonspecific interstitial pneumonitis and other idiopathic interstitial pneumonias. In: Broaddus VC, Ernst JD, King TE, et al, eds. <em>Murray and Nadel's Textbook of Respiratory Medicine</em>. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 90.</p><p>Raghu G, Martinez FJ. Interstitial lung disease. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 80.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 11/25/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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