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<div class="h1">USP Source Information</div>
</div>
</div>
<div id="source-doc-wrapper">
<div id="source-doc-intro">
<p> </p>
<p>Click on a topic below the Source Synopsis section to display details.</p>
</div>
<h2>Source Synopsis</h2>
<p><strong>Web site:</strong><br />
<a href="http://www.usp.org/health-quality-safety/compendial-nomenclature" target="_blank">http://www.usp.org/health-quality-safety/compendial-nomenclature</a></p>
<p><strong>Authority</strong><br />
The United States Pharmacopeia (USP) Compendial Nomenclature is a product supported by the United States Pharmacopeial Convention. </p>
<p><strong>Purpose</strong><br />
The USP Compendial Nomenclature provides official substance and official preparation (product) naming for Food and Drug Administration (FDA)-approved drugs and their ingredients. </p>
<p><strong>Description</strong><br />
The USP Compendial Nomenclature contains names and identifiers of an official substance or official preparation (product). The presence of an identifier code signifies potential or current work on the nomenclature of a drug.</p>
<p><strong>Update Frequency</strong><br/>
The USP Compendial Nomenclature is updated monthly.</p>
<p><strong>RxNorm Update Frequency</strong><br />
Updated in each RxNorm monthly release.</p>
<p><strong>Sites Consulted</strong></p>
<p>Compendial Nomenclature [Internet]. [place unknown: publisher unknown]; [cited 2018 August 14]. Available from <a href="http://www.usp.org/health-quality-safety/compendial-nomenclature" target="_blank">http://www.usp.org/health-quality-safety/compendial-nomenclature</a></p>
<p>Use of Drug Name Terms Policy [Internet]. [place unknown: publisher unknown]; [cited 2018 August 14]. Available from <a href="https://www.fda.gov/Drugs/DevelopmentApprovalProcess/FormsSubmissionRequirements/ElectronicSubmissions/DataStandardsManualmonographs/ucm071638.htm" target="_blank">https://www.fda.gov/Drugs/DevelopmentApprovalProcess/FormsSubmissionRequirements/ElectronicSubmissions/DataStandardsManualmonographs/ucm071638.htm</a></p>
<div class="limboxcontent">
<h3><a class="jig-ncbitoggler">Metadata</a></h3>
<div class="sourcecontainer">
<table>
<tr>
<th>Field</th>
<th>Value</th>
</tr>
<!--<tr><td>Versioned Source Abbreviation</td><td>USP_2018_12_10_19_03_04</td></tr>
<tr><td>Source Official Name</td><td>USP Compendial Nomenclature, 2018_12_10</td></tr>
--><tr><td>Short Name</td><td>USP Compendial Nomenclature</td></tr>
<tr><td>Family</td><td>USP</td></tr>
<tr><td>Source Restriction Level</td><td>0</td></tr>
<tr><td>Language</td><td>ENG</td></tr>
<tr><td>License Contact</td><td>Jeffrey Shick<br> Director Translational Informatics<br>United States Pharmacopeia<br>12601 Twinbrook Parkway<br>Rockville<br>MD<br>US<br>20852-1790<br>1-800-227-8772<br>HealthcareQuality@usp.org<br>http://www.usp.org/health-quality-safety</td></tr>
<tr><td>Content Contact</td><td>Jeffrey Shick<br> Director Translational Informatics<br>United States Pharmacopeia<br>12601 Twinbrook Parkway<br>Rockville<br>MD<br>US<br>20852-1790<br>1-800-227-8772<br>HealthcareQuality@usp.org<br>http://www.usp.org/health-quality-safety</td></tr>
--></table>
<br>
</div>
<h3><a class="jig-ncbitoggler">Source Representation</a></h3>
<div class="sourcecontainer">
<p>This section lists specific source data elements and provides information on their representation in RxNorm.</p>
<h4>Summary of Changes</h4>
<p>There are no changes to the original data format or to RxNorm source processing.</p>
<h4>Source Provided Files: </h4>
<p>The files will be made available on the USP website later in the year.</p>
<p> The following file is used for RxNorm source processing.</p>
<table>
<tbody>
<tr>
<th>File Name</th>
<th>Description</th>
</tr>
<tr>
<td>usp-compendial-nomenclature-yyyy-mm.xlsx.xlsx</td>
<td>Excel File</td>
</tr>
</tbody>
</table>
<br />
<h4>Source-Provided Files: Details</h4>
<p>The following is a list of fields in the USP source file used in RxNorm:</p>
<h5>File name: usp-compendial-nomenclature-yyyy-mm.xlsx</h5>
<table>
<tbody>
<tr>
<th>Field Name</th>
<th>Description</th>
</tr>
<tr>
<td>monograph_identifier</td>
<td>A meaningless alphanumeric string starting with the letter m that provides encoding for the monograph.</td>
</tr>
<tr>
<td>monograph_name</td>
<td>The title of the monograph.</td>
</tr>
<tr>
<td>monograph_type</td>
<td>The monograph type represents a quality standard for either a drug “substance” (e.g. “Warfarin Sodium”) or drug “product” (e.g. “Warfarin Sodium Tablets”).</td>
</tr>
<tr>
<td>monograph_status</td>
<td>Values for this field are one of the following:
<ul>
<li>Official Monograph: The monograph is legally enforceable as of the date in the monograph_official_date field</li>
<li>Pending Official Monograph: The monograph has been finalized and will become official as of the date in the monograph_official_date field</li>
<li>Nomenclature Finalized: The name of the monograph has been balloted, but a monograph is not yet available</li>
</ul>
</td>
</tr>
<tr>
<td>monograph_official_date</td>
<td>The date when the monograph became official or will become official, depending on the value of the monograph_status field.</td>
</tr>
</tbody>
</table>
<br />
<p>USP Field Representation in RxNorm Files:</p>
<table>
<tbody>
<tr>
<th>Field</th>
<th>RxNorm Representation</th>
</tr>
<tr>
<td>monograph_identifier</td>
<td>RXNCONSO.CODE</td>
</tr>
<tr>
<td>monograph_name</td>
<td>RXNCONSO.STR</td>
</tr>
<tr>
<td>monograph_type</td>
<td>Term Type (TTY)<br />
TTY = IN when value is Substance<br />
TTY = CD when value is Product</td>
</tr>
<tr>
<td>monograph_status</td>
<td>RXNSAT.ATN = MONOGRAPH_STATUS</td>
</tr>
<tr>
<td>monograph_official_date</td>
<td>RXNSAT.ATN = MONOGRAPH_OFFICIAL_DATE</td>
</tr>
</tbody>
</table>
<br />
</div>
<h3><a class="jig-ncbitoggler">RxNorm Representation</a></h3>
<div class="sourcecontainer">
<p>This section lists RxNorm data elements and traces them back to the specific USP data that populates them.</p>
<h4>Summary of Changes</h4>
<p>There are no changes to the original data format or to RxNorm source processing.</p>
<h4>Source Provided Files: </h4>
<p>The file will be made available on the USP website later in the year. </p>
<p> The following file is used for RxNorm source processing.</p>
<table>
<tbody>
<tr>
<th>File Name</th>
<th>Description</th>
</tr>
<tr>
<td>usp-compendial-nomenclature-yyyy-mm.xlsx</td>
<td>Excel File</td>
</tr>
</tbody>
</table>
<br />
<h4>RxNorm Identifiers:</h4>
<p>Identifiers are assigned as follows:</p>
<table>
<tbody>
<tr>
<th>Identifier</th>
<th>Origin</th>
</tr>
<tr>
<td>CODE</td>
<td>monograph_identifier</td>
</tr>
<tr>
<td>SAUI</td>
<td>Not applicable</td>
</tr>
<tr>
<td>SCUI</td>
<td>Not applicable</td>
</tr>
<tr>
<td>SDUI</td>
<td>Not applicable</td>
</tr>
</tbody>
</table>
<br />
<h4>Atoms (RXNCONSO):</h4>
<table>
<tbody>
<tr>
<th>Term Type</th>
<th>Origin</th>
</tr>
<tr>
<td>IN</td>
<td>monograph_name when monograph_type = Substance</td>
</tr>
<tr>
<td>CD</td>
<td>monograph_name when monograph_type = Product</td>
</tr>
</tbody>
</table>
<br />
<h4>Relationships (RXNREL):</h4>
<p>Clinical Drug (TTY = CD):</p>
<table>
<tbody>
<tr>
<th>Atom Type 1</th>
<th>Atom Type 2</th>
<th>Relationship</th>
</tr>
<tr>
<td>Clinical Drug (CD)</td>
<td>Semantic Clinical Drug Form (SCDF)</td>
<td>product_monograph_title_of</td>
</tr>
</tbody>
</table>
<br />
<p>Semantic Clinical Drug Form (TTY = SCDF):</p>
<table>
<tbody>
<tr>
<th>Atom Type 1</th>
<th>Atom Type 2</th>
<th>Relationship</th>
</tr>
<tr>
<td>Semantic Clinical Drug Form (SCDF)</td>
<td>Clinical Drug (CD)</td>
<td>has_product_monograph_title</td>
</tr>
</tbody>
</table>
<br />
<h4>Attributes (RXNSAT):</h4>
<table>
<tbody>
<tr>
<th>ATN</th>
<th>Origin</th>
</tr>
<tr>
<td>MONOGRAPH_STATUS</td>
<td>monograph_status</td>
</tr>
<tr>
<td>MONOGRAPH_OFFICIAL_DATE</td>
<td>monograph_official_date</td>
</tr>
</tbody>
</table>
<br />
</div>
<h3><a class="jig-ncbitoggler">Data Examples with Sample Database Queries</a></h3>
<div class="sourcecontainer">
<p>This section lists source terminology specific data examples and sample database queries using Structured Query Language (SQL) to obtain the data. For more information about RxNorm data and files, see the <a href="https://www.nlm.nih.gov/research/umls/rxnorm/docs/index.html" target="_blank">RxNorm Technical Documentation</a>.</p>
<h4>Names and Codes in RXNCONSO.RRF</h4>
<p>Here are sample source terminology code, source string, RxNorm Concept Unique Identifier (RXCUI), RxNorm string, term type (TTY), and suppress values.</p>
<table>
<tbody>
<tr>
<th>SOURCE_CODE</th>
<th>SOURCE_STR</th>
<th>RXCUI</th>
<th>RXNORM_STR</th>
<th>RXNORM_TTY</th>
<th>SUPPRESS</th>
</tr>
<tr>
<td>m39860</td>
<td>Ibuprofen</td>
<td>5640</td>
<td>Ibuprofen</td>
<td>IN</td>
<td>N</td>
</tr>
</tbody>
</table>
<br/>
<p>Here is a sample database query to retrieve the data above:</p>
<p>SELECT distinct rc1.code as source_code, rc1.str as source_str, rc1.rxcui, rc2.str as rxnorm_str, rc2.tty as rxnorm_tty , rc2.suppress<br />
FROM rxnconso rc1, rxnconso rc2<br />
WHERE rc1.code = 'm39860'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc1.sab = 'USP'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc1.rxcui = rc2.rxcui<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc2.sab = 'RXNORM';<br />&nbsp;&nbsp;&nbsp;&nbsp;
</p>
<h4>Names and Relationships in RXNCONSO.RRF and RXNREL.RRF </h4>
<p>Here are sample source terminology code, source string, RXCUI, relationship name, RxNorm term type (TTY), RxNorm brand name, and suppress values.</p>
<table>
<tbody>
<tr>
<th>SOURCE_CODE</th>
<th>SOURCE_STR</th>
<th>RXCUI</th>
<th>RELA</th>
<th>RXNORM_TTY</th>
<th>RXNORM_BN</th>
<th>SUPPRESS</th>
</tr>
<tr>
<td>m39860</td>
<td>Ibuprofen</td>
<td>5640</td>
<td>has_tradename</td>
<td>BN</td>
<td>Motrin PM</td>
<td>N</td>
</tr>
<tr>
<td>m39860</td>
<td>Ibuprofen</td>
<td>5640</td>
<td>has_tradename</td>
<td>BN</td>
<td>Samson 8</td>
<td>N</td>
</tr>
<tr>
<td>m39860</td>
<td>Ibuprofen</td>
<td>5640</td>
<td>has_tradename</td>
<td>BN</td>
<td>Vicoprofen</td>
<td>N</td>
</tr>
<tr>
<td>m39860</td>
<td>Ibuprofen</td>
<td>5640</td>
<td>has_tradename</td>
<td>BN</td>
<td>Neoprofen</td>
<td>N</td>
</tr>
</tbody>
</table>
<br/>
<p>Here is a sample database query to retrieve the data above:</p>
<p>SELECT distinct rc1.code as source_code, rc1.str as source_str, rc1.rxcui, rr.rela, rc2.tty as rxnorm_tty, rc2.str as rxnorm_bn, rc2.suppress<br />
FROM rxnconso rc1, rxnrel rr, rxnconso rc2<br />
WHERE rc1.code = 'm39860'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc1.sab = 'USP'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc1.rxcui = rr.rxcui2<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rr.rela = 'has_tradename'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rr.rxcui1 = rc2.rxcui<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc2.sab = 'RXNORM'<br />&nbsp;&nbsp;&nbsp;&nbsp;
AND rc2.tty = 'BN'<br />&nbsp;&nbsp;&nbsp;&nbsp;
ORDER BY suppress;</p>
</div>
</div>
</div>
<p class=”margin-top-5”><small>Last Reviewed: January 12, 2024</small></p>
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