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<meta name="description" content="We found little evidence around the benefits of psychosocial interventions provided to reduce fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent. Additional studies with larger samples are required to assess whether psychosocial interventions are benefi …"><meta name="keywords" content="pmid:28708236, PMC6408929, doi:10.1002/14651858.CD012030.pub2, Meta-Analysis, Review, Systematic Review, Hanneke Poort, Marlies Peters, Hans Knoop, Activities of Daily Living, Adult, Cognition, Fatigue / etiology, Fatigue / physiopathology, Fatigue / psychology, Fatigue / therapy*, Female, Humans, Male, Middle Aged, Neoplasms / complications*, Neoplasms / physiopathology, Neoplasms / psychology, Neoplasms / therapy, Palliative Care / methods*, Psychotherapy / methods*, Quality of Life, Randomized Controlled Trials as Topic, Social Skills, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Psychosocial interventions for fatigue during cancer treatment with palliative intent - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/28708236/"><meta property="og:description" content="We found little evidence around the benefits of psychosocial interventions provided to reduce fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent. Additional studies with larger samples are required to assess whether psychosocial interventions are benefi …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Psychosocial interventions for fatigue during cancer treatment with palliative intent - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/28708236/"><meta name="twitter:description" content="We found little evidence around the benefits of psychosocial interventions provided to reduce fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent. Additional studies with larger samples are required to assess whether psychosocial interventions are benefi …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">
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<option value="abstract-text">Abstract (text)</option>
</select>
</div>
<div class="include-supplemental-container">
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
</div>
<div class="form-field recaptcha ">
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
</div>
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="send">
Send email
</button>
<button class="action-panel-cancel"
aria-label="Close 'Email citations' panel"
ref="linksrc=close_email_panel"
aria-controls="email-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="cancel">
Cancel
</button>
</div>
<input type="hidden" name="email-search-details" value="" />
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
</form>
</div>
</div>
<div id="collections-action-panel"
class="collections-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-collections-open-panel-enabled="false"
data-collections-open-panel-url-hash="#open-collections-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to Collections
</h3>
<form id="collections-action-panel-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-myncbi-max-collection-name-length="100"
data-add-to-collection-max-amount="1000"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
<input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li>
<input type="radio"
id="collections-action-panel-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_new">
<label for="collections-action-panel-new">Create a new collection</label>
</li>
<li>
<input type="radio"
id="collections-action-panel-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_existing">
<label for="collections-action-panel-existing">Add to an existing collection</label>
</li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls">
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label>
<input
type="text"
name="add-to-new-collection"
id="collections-action-panel-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="save_share"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection">
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div>
</div>
<div class="action-panel-control-wrap existing-collections-controls">
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
Choose a collection:
</label>
<select id="collections-action-panel-add-to-existing"
class="action-panel-selector collections-action-add-to-existing"
data-ga-category="save_share"
data-ga-action="select_collection"
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
</select>
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your collection due to an error<br>
<a href="#">Please try again</a>
</div>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="add">
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to Collections' panel"
ref="linksrc=close_collections_panel"
aria-controls="collections-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="bibliography-action-panel"
class="bibliography-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-bibliography-open-panel-enabled="false"
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to My Bibliography
</h3>
<form id="bibliography-action-panel-form"
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-add-to-bibliography-max-amount="100"
data-add-to-bibliography-batch-size="10"
data-bibliography-delegates-url="/list-bibliography-delegates/"
data-add-to-bibliography-url="/add-to-bibliography/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
<input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO">
<div class="action-panel-control-wrap bibliographies-controls">
<div class="choice-group">
<ul class="bibliographies-action-add radio-group-items">
<li>
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
<label for="my-bibliography">My Bibliography</label>
</li>
</ul>
</div>
</div>
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your delegates due to an error<br>
<a href="#">Please try again</a>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore>
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to bibliography' panel"
ref="linksrc=close_bibliography_panel"
aria-controls="bibliography-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="mybib"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
data-saved-search-open-panel-enabled="false"
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your saved search
</h2>
<form id="saved-search-action-panel-form"
class="saved-search-action-panel-form action-panel-content action-form"
data-create-saved-search-url="/create-saved-search/"
data-try-search-terms-url="/try-search-term/"
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
<input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO">
<div class="action-panel-control-wrap">
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
Name of saved search:
</label>
<input maxlength="200"
type="text"
name="saved-search-name"
id="saved-search-name"
class="saved-search-name"
value=""
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
Search terms:
</label>
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
</div>
<div class="test-search-term-wrap">
<a href="#" class="try-search-term">Test search terms</a>
</div>
<div class="choice-group action-panel-extra-margin-top">
<span class="action-panel-label" id="fieldset-label">
Would you like email updates of new search results?
</span>
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
<ul class="radio-group-items">
<li>
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
</li>
<li>
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
<label for="saved-search-alert-no" class="action-panel-label">No</label>
</li>
</ul>
</fieldset>
</div>
<div class="alert-schedule-wrap">
<div class="action-panel-control-wrap">
<label class="action-panel-label">
Email:
</label>
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
</div>
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="saved-search-frequency" class="action-panel-label">
Frequency:
</label>
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
<option value="monthly">Monthly</option>
<option value="weekly">Weekly</option>
<option value="daily">Daily</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-monthly-additional">
<label for="saved-search-monthly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
<option value="Sunday">The first Sunday</option>
<option value="Monday">The first Monday</option>
<option value="Tuesday">The first Tuesday</option>
<option value="Wednesday">The first Wednesday</option>
<option value="Thursday">The first Thursday</option>
<option value="Friday">The first Friday</option>
<option value="Saturday">The first Saturday</option>
<option value="day">The first day</option>
<option value="weekday">The first weekday</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-weekly-additional">
<label for="saved-search-weekly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
<option value="Sunday">Sunday</option>
<option value="Monday">Monday</option>
<option value="Tuesday">Tuesday</option>
<option value="Wednesday">Wednesday</option>
<option value="Thursday">Thursday</option>
<option value="Friday">Friday</option>
<option value="Saturday">Saturday</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-report" class="action-panel-label">
Report format:
</label>
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
<option value="DocSum">Summary</option>
<option value="DocSumText">Summary (text)</option>
<option value="Abstract">Abstract</option>
<option value="AbstractText">Abstract (text)</option>
<option value="MEDLINE">PubMed</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-amount" class="action-panel-label">
Send at most:
</label>
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
<option value="1">1 item</option>
<option value="5" selected>5 items</option>
<option value="10">10 items</option>
<option value="20">20 items</option>
<option value="50">50 items</option>
<option value="100">100 items</option>
<option value="200">200 items</option>
</select>
</div>
<div>
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
Send even when there aren't any new results
</label>
</div>
<div class="action-panel-control-wrap option-text-in-email-wrap">
<label for="saved-search-email-text" class="action-panel-label">
Optional text in email:
</label>
<textarea name="saved-search-email-text"
id="saved-search-email-text"
class="saved-search-email-text"></textarea>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Saving..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Save
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your saved search' panel"
ref="linksrc=close_saved_search_panel"
aria-controls="saved-search-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Create a file for external citation management software
</h2>
<form id="citation-manager-action-panel-form"
class="action-panel-content action-form"
action="/results-export-ids/"
data-by-search-action="/results-export-search-data/"
data-by-ids-action="/results-export-ids/"
method="post"
data-by-search-method="post"
data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO">
<input name="results-format" type="hidden" value="pubmed"/>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="save">
Create file
</button>
<button class="action-panel-cancel"
aria-label="Close 'Send citations to citation manager' panel"
ref="linksrc=close_citation_manager_panel"
aria-controls="citation-manager-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your RSS Feed
</h2>
<form id="rss-action-panel-form"
class="rss-action-panel-form action-panel-content action-form"
data-create-rss-feed-url="/create-rss-feed-url/"
data-search-form-term-value="">
<input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO">
<div class="action-panel-control-wrap">
<label for="rss-name" class="action-panel-label required-field-asterisk">
Name of RSS Feed:
</label>
<input maxlength="200"
placeholder="Name"
type="text"
name="rss-name"
id="rss-name"
class="rss-name"
value=''
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="rss-limit-wrap">
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="rss-limit" class="action-panel-label">
Number of items displayed:
</label>
<select id="rss-limit" class="no-border-panel-selector rss-limit">
<option value="5">5</option>
<option value="10">10</option>
<option value="15" selected="selected">15</option>
<option value="20">20</option>
<option value="50">50</option>
<option value="100">100</option>
</select>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Creating..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Create RSS
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your RSS' panel"
ref="linksrc=close_rss_panel"
aria-controls="rss-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
<div class="action-panel-control-wrap rss-link-copy-wrap">
<label for="rss-link" class="usa-sr-only">RSS Link</label>
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
<button
type="button"
disabled
class="rss-link-copy-button disabled"
data-ga-category="save_share"
data-ga-action="rss"
data-ga-label="copy">
Copy
</button>
</div>
</form>
</div>
</div>
</div>
</div>
<div class="article-page" id="article-page" data-article-pmid="28708236">
<aside class="page-sidebar">
<div class="inner-wrap">
<div class="full-text-links">
<div class="full-view">
<h3 class="title">
Full text links
</h3>
<div class="full-text-links-list">
<a class="link-item
dialog-focus"
href="https://doi.org/10.1002/14651858.CD012030.pub2"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=False&amp;PrId=3058&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=28708236&amp;db=pubmed&amp;nlmid=100909747"
title="See full text options at Wiley"
data-ga-category="full_text"
data-ga-action="Wiley"
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><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7331-42-Cochrane_Library_Logo_RGB_120x30.jpg" alt="Wiley full text link"><span class="text">
Wiley
</span></a><a class="link-item
pmc
"
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/28708236/"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=True&amp;PrId=3494&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=28708236&amp;db=pubmed&amp;nlmid=100909747"
title="Free full text at PubMed Central"
data-ga-category="full_text"
data-ga-action="PMC"
data-ga-label="28708236"
><span class="text">
Free PMC article
</span></a>
</div>
</div>
<div class="short-view">
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
Full text links
</a>
</div>
</div>
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
aria-label="Open dialog with citation text in different styles"
data-ga-category="save_share"
data-ga-action="cite"
data-ga-label="open"
data-all-citations-url="/28708236/citations/"
data-citation-style="nlm"
data-pubmed-format-link="/28708236/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="28708236" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
aria-label="Save article in MyNCBI collections."
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_button"
data-collections-open-dialog-enabled="false"
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F28708236%2F%23open-collections-dialog"
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
class="dialog collections-dialog"
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-myncbi-max-collection-name-length="100"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="GLJFum0H0MYzdbYLMFmZqcgSCoOqBjSuXytK7ct3AnL37C4BpYZ1UkMwaswCuUqO"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
id="collections-action-dialog-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
id="collections-action-dialog-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label><input
type="text"
name="add-to-new-collection"
id="collections-action-dialog-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="collections_button"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
Choose a collection:
</label><select id="collections-action-dialog-add-to-existing"
class="action-panel-selector collections-action-add-to-existing"
data-ga-category="collections_button"
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<div class="abstract" id="abstract">
<h2 class="title">
Abstract
</h2>
<div class="abstract-content selected"
id="eng-abstract">
<p>
<strong class="sub-title">
Background:
</strong>
Fatigue is a prevalent and burdensome symptom for patients with incurable cancer receiving cancer treatment with palliative intent and is associated with reduced quality of life. Psychosocial interventions seem promising for management of fatigue among cancer patients.
</p>
<p>
<strong class="sub-title">
Objectives:
</strong>
To assess the effects of psychosocial interventions for fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent.
</p>
<p>
<strong class="sub-title">
Search methods:
</strong>
We searched the following databases: CENTRAL, MEDLINE, Embase, CINAHL, PsycINFO, and seven clinical trial registries; we also searched the reference lists of articles. The date of our most recent search was 29 November 2016.
</p>
<p>
<strong class="sub-title">
Selection criteria:
</strong>
We included randomised controlled trials that compared psychosocial interventions in adults aged 18 years or over undergoing cancer treatment with palliative intent for incurable cancer versus usual care or other controls. Psychosocial interventions were defined as various kinds of interventions provided to influence or change cognitions, emotions, behaviours, social interactions, or a combination of these. Psychosocial interventions of interest to this review had to involve at least two interactions between the patient and the care provider in which the care provider gave the patient personal feedback concerning changes sought by these interventions. We included trials that reported fatigue as an outcome of interest.
</p>
<p>
<strong class="sub-title">
Data collection and analysis:
</strong>
We used standard methodological procedures expected by Cochrane. Two review authors independently considered trials for inclusion in the review, assessed risk of bias, and extracted data, including information on adverse events. We assessed the quality of evidence using GRADE (Grading of Recommendations Assessment, Development, and Evaluation) and created a 'Summary of findings' table.
</p>
<p>
<strong class="sub-title">
Main results:
</strong>
We identified 14 studies (16 reports) that met inclusion criteria for this review and involved 3077 randomised participants in total. Most of these studies included a mixed sample of participants; we obtained data for the subset of interest for this review (diagnosis of incurable cancer and receiving cancer treatment) from the study investigators of 12 studies, for which we included 535 participants in the subset meta-analysis for fatigue post intervention. Researchers investigated a broad range of psychosocial interventions with different intervention aims and durations. We identified sources of potential bias, including lack of description of methods of blinding and allocation concealment and inclusion of small study populations.Findings from our meta-analysis do not support the effectiveness of psychosocial interventions for reducing fatigue post intervention (standardised mean difference (SMD) -0.25, 95% confidence interval (CI) -0.50 to 0.00; not significant; 535 participants, 12 studies; very low-quality evidence). First follow-up findings on fatigue suggested benefit for participants assigned to the psychosocial intervention compared with control (SMD -0.66, 95% CI -1.00 to -0.32; 147 participants, four studies; very low-quality evidence), which was not sustained at second follow-up (SMD -0.41, 95% CI -1.12 to 0.30; not significant; very low-quality evidence).Results for our secondary outcomes revealed very low-quality evidence for the efficacy of psychosocial interventions in improving physical functioning post intervention (SMD 0.32, 95% CI 0.01 to 0.63; 307 participants, seven studies). These findings were not sustained at first follow-up (SMD 0.37, 95% CI -0.20 to 0.94; not significant; 122 participants, two studies; very low-quality evidence). Findings do not support the effectiveness of psychosocial interventions for improving social functioning (mean difference (MD) 4.16, 95% CI -11.20 to 19.53; not significant; 141 participants, four studies), role functioning (MD 3.49, 95% CI -12.78 to 19.76; not significant; 143 participants, four studies), emotional functioning (SMD -0.11, 95% CI -0.56 to 0.35; not significant; 115 participants, three studies), or cognitive functioning (MD -2.23, 95% CI -12.52 to 8.06; not significant; 86 participants, two studies) post intervention. Only three studies evaluated adverse events. These studies found no difference between the number of adverse events among participants in the intervention versus control group.Using GRADE, we considered the overall quality of evidence for our primary and secondary outcomes to be very low. Therefore, we have very little confidence in the effect estimate, and the true effect is likely to be substantially different from the estimate of effect. Limitations in study quality and imprecision due to sparse data resulted in downgrading of the quality of data. Additionally, most studies were at high risk of bias owing to their small sample size for the subset of patients with incurable cancer (fewer than 50 participants per arm), leading to uncertainty about effect estimates.
</p>
<p>
<strong class="sub-title">
Authors&#x27; conclusions:
</strong>
We found little evidence around the benefits of psychosocial interventions provided to reduce fatigue in adult patients with incurable cancer receiving cancer treatment with palliative intent. Additional studies with larger samples are required to assess whether psychosocial interventions are beneficial for addressing fatigue in patients with incurable cancer.
</p>
</div>
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<div class="conflict-of-interest" id="conflict-of-interest">
<h2 class="title">
Conflict of interest statement
</h2>
<div class="statement">
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">HP: none known. HP is the coordinating investigator on a study included in the 'ongoing studies' section (Poort).</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">MP: none known. MP is coinvestigator on a study included in the 'ongoing studies' section (Poort).</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">GB: none known. GB is coinvestigator on a study included in the 'ongoing studies' section (Poort).</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">MFMG: none known.</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">MMG: none known.</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">PJ has been involved in the development of cancerrelated fatigue guidelines for the American Society of Clinical Oncology and the National Comprehensive Cancer Network. He has also consulted with Onyx Pharmaceuticals, Inc. (20122014) and On Q Health, Inc. (2014Sep 2016) about quality of life and quality of care issues in people with cancer.</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">SV: none known. SV is principal investigator on a study included in the 'ongoing studies' section (Poort). SV is a medical oncologist and manages patients with incurable cancer.</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">HK: none known. HK is principal investigator on a study included in the 'ongoing studies' section (Poort). HK is a clinical psychologist and manages patients with incurable cancer.</p>
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<h2 class="title">
Figures
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<div class="figure-caption-contents">Risk of bias summary: review authors' judgements about each risk of bias item for each included study.</div>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Fatigue, outcome: 1.1 Post intervention. </p></div>
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<div class="figure-caption-contents">Forest plot of comparison: 1 Fatigue, outcome: 1.1 Post intervention.</div>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Fatigue,… </p></div>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Fatigue, outcome: 1.2 First followup. </p></div>
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<div class="figure-caption-contents">Forest plot of comparison: 1 Fatigue, outcome: 1.2 First followup.</div>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Fatigue,… </p></div>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Fatigue, outcome: 1.3 Second followup. </p></div>
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<div class="figure-caption-contents">Forest plot of comparison: 1 Fatigue, outcome: 1.3 Second followup.</div>
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<p> 1.1. Analysis </p>
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<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 1… </p></div>
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<p> 1.1. Analysis </p>
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<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 1 Post intervention. </p></div>
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1.1. Analysis
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<div class="figure-caption-contents">Comparison 1 Fatigue, Outcome 1 Post intervention.</div>
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<p> 1.2. Analysis </p>
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<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 2… </p></div>
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<p> 1.2. Analysis </p>
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<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 2 First followup. </p></div>
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1.2. Analysis
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<div class="figure-caption-contents">Comparison 1 Fatigue, Outcome 2 First followup.</div>
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<p> 1.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 3… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 1.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 1 Fatigue, Outcome 3 Second followup. </p></div>
</div>
<figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
1.3. Analysis
</strong>
<div class="figure-caption-contents">Comparison 1 Fatigue, Outcome 3 Second followup.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="9"
data-label-slug="21">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/d24d3ba35b79/nCD012030-CMP-002-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-9"
role="button"
data-image-width="566"
data-image-height="217"
data-image-alt="2.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0010">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-9"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/01d2c56cac07/nCD012030-CMP-002-01.gif"
alt="2.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="217">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 2.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 2 Physical functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 2.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 2 Physical functioning, Outcome 1 Post intervention. </p></div>
</div>
<figcaption id="figure-caption-9" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
2.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 2 Physical functioning, Outcome 1 Post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="10"
data-label-slug="22">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/a546d2bcb1c2/nCD012030-CMP-002-02.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-10"
role="button"
data-image-width="566"
data-image-height="157"
data-image-alt="2.2"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0011">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-10"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/6892fd667ca8/nCD012030-CMP-002-02.gif"
alt="2.2" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="157">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 2.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 2 Physical functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 2.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 2 Physical functioning, Outcome 2 First followup. </p></div>
</div>
<figcaption id="figure-caption-10" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
2.2. Analysis
</strong>
<div class="figure-caption-contents">Comparison 2 Physical functioning, Outcome 2 First followup.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="11"
data-label-slug="31">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/3fcd436e0097/nCD012030-CMP-003-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-11"
role="button"
data-image-width="566"
data-image-height="181"
data-image-alt="3.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0012">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-11"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/a239ead905dc/nCD012030-CMP-003-01.gif"
alt="3.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="181">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 3.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 3 Social functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 3.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 3 Social functioning, Outcome 1 Post intervention. </p></div>
</div>
<figcaption id="figure-caption-11" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
3.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 3 Social functioning, Outcome 1 Post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="12"
data-label-slug="41">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/7a257c74ffdc/nCD012030-CMP-004-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-12"
role="button"
data-image-width="566"
data-image-height="181"
data-image-alt="4.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0013">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-12"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/060cb9f32b74/nCD012030-CMP-004-01.gif"
alt="4.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="181">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 4.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 4 Role functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 4.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 4 Role functioning, Outcome 1 Post intervention. </p></div>
</div>
<figcaption id="figure-caption-12" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
4.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 4 Role functioning, Outcome 1 Post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="13"
data-label-slug="51">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/2c63cc7d8589/nCD012030-CMP-005-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-13"
role="button"
data-image-width="566"
data-image-height="169"
data-image-alt="5.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0014">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-13"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/e823e5c9779e/nCD012030-CMP-005-01.gif"
alt="5.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="169">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 5.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 5 Emotional functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 5.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 5 Emotional functioning, Outcome 1 Post intervention. </p></div>
</div>
<figcaption id="figure-caption-13" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
5.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 5 Emotional functioning, Outcome 1 Post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="14"
data-label-slug="61">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/0765e0565d47/nCD012030-CMP-006-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-14"
role="button"
data-image-width="566"
data-image-height="157"
data-image-alt="6.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0015">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-14"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/032a710bea7a/nCD012030-CMP-006-01.gif"
alt="6.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="157">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 6.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 6 Cognitive functioning, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 6.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 6 Cognitive functioning, Outcome 1 Post intervention. </p></div>
</div>
<figcaption id="figure-caption-14" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
6.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 6 Cognitive functioning, Outcome 1 Post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="15"
data-label-slug="71">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/35e9a9288045/nCD012030-CMP-007-01.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-15"
role="button"
data-image-width="566"
data-image-height="344"
data-image-alt="7.1"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0016">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-15"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/86dd249acdd9/nCD012030-CMP-007-01.gif"
alt="7.1" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="344">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 1 Fatigue post intervention. </p></div>
</div>
<figcaption id="figure-caption-15" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 1 Fatigue post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="16"
data-label-slug="72">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/1324fe9c426d/nCD012030-CMP-007-02.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-16"
role="button"
data-image-width="566"
data-image-height="332"
data-image-alt="7.2"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0017">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-16"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/6d401d1fddf0/nCD012030-CMP-007-02.gif"
alt="7.2" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="332">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 2 Fatigue post intervention. </p></div>
</div>
<figcaption id="figure-caption-16" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.2. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 2 Fatigue post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="17"
data-label-slug="73">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/2fc8aded9d02/nCD012030-CMP-007-03.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-17"
role="button"
data-image-width="566"
data-image-height="344"
data-image-alt="7.3"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0018">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-17"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/c8b49ba0bf70/nCD012030-CMP-007-03.gif"
alt="7.3" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="344">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 3 Fatigue post intervention. </p></div>
</div>
<figcaption id="figure-caption-17" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.3. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 3 Fatigue post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="18"
data-label-slug="74">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/a2f407263afe/nCD012030-CMP-007-04.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-18"
role="button"
data-image-width="566"
data-image-height="344"
data-image-alt="7.4"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0019">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-18"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/847eb1e57d9e/nCD012030-CMP-007-04.gif"
alt="7.4" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="344">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.4. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.4. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 4 Fatigue post intervention. </p></div>
</div>
<figcaption id="figure-caption-18" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.4. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 4 Fatigue post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="19"
data-label-slug="75">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/3a3a9fb159c0/nCD012030-CMP-007-05.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-19"
role="button"
data-image-width="566"
data-image-height="284"
data-image-alt="7.5"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0020">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-19"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/1d2c75a3d2e4/nCD012030-CMP-007-05.gif"
alt="7.5" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="284">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.5. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.5. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 5 Fatigue first followup. </p></div>
</div>
<figcaption id="figure-caption-19" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.5. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 5 Fatigue first followup.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
itemscope itemtype="http://schema.org/ImageObject"
itemprop="associatedMedia"
data-slide-index="20"
data-label-slug="76">
<a class="figure-link"
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/39c9316a92ef/nCD012030-CMP-007-06.jpg"
itemprop="contentUrl"
aria-describedby="figure-caption-20"
role="button"
data-image-width="566"
data-image-height="260"
data-image-alt="7.6"
data-pmc-id="PMC6408929"
data-figure-id="CD012030-fig-0021">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-20"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/4e0c637e1b47/nCD012030-CMP-007-06.gif"
alt="7.6" />
</a>
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="566">
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="260">
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
<div class="caption-wrap">
<strong class="figure-label">
<p> 7.6. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 7.6. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 7 Subgroup analyses, Outcome 6 Fatigue second followup. </p></div>
</div>
<figcaption id="figure-caption-20" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
7.6. Analysis
</strong>
<div class="figure-caption-contents">Comparison 7 Subgroup analyses, Outcome 6 Fatigue second followup.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
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data-figure-id="CD012030-fig-0022">
<img class="figure-thumb" itemprop="thumbnail"
id="article-image-21"
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/733b/6408929/5d30cfa2ac2d/nCD012030-CMP-008-01.gif"
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<strong class="figure-label">
<p> 8.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 8.1. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome 1 Fatigue post intervention. </p></div>
</div>
<figcaption id="figure-caption-21" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
8.1. Analysis
</strong>
<div class="figure-caption-contents">Comparison 8 Sensitivity analyses, Outcome 1 Fatigue post intervention.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
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<strong class="figure-label">
<p> 8.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 8.2. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome 2 Fatigue first followup. </p></div>
</div>
<figcaption id="figure-caption-22" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
8.2. Analysis
</strong>
<div class="figure-caption-contents">Comparison 8 Sensitivity analyses, Outcome 2 Fatigue first followup.</div>
</figcaption>
</figure>
<figure class="figure-item tail"
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data-slide-index="23"
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aria-describedby="figure-caption-23"
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<img class="figure-thumb" itemprop="thumbnail"
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<strong class="figure-label">
<p> 8.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome… </p></div>
</div>
</div>
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
<strong class="figure-label">
<p> 8.3. Analysis </p>
</strong>
<div class="figure-caption-contents"><p> Comparison 8 Sensitivity analyses, Outcome 3 Fatigue second followup. </p></div>
</div>
<figcaption id="figure-caption-23" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
<strong class="figure-label">
8.3. Analysis
</strong>
<div class="figure-caption-contents">Comparison 8 Sensitivity analyses, Outcome 3 Fatigue second followup.</div>
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References
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<h4 class="refs-list-title">References to studies included in this review</h4>
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<h5 class="refs-list-title">Armes 2007 {published data only}</h5>
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<li>
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<li
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value="1">
Armes J, Chalder T, AddingtonHall J, Richardson A, Hotopf M. A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancerrelated fatigue. Cancer 2007;110(6):138595. [DOI: 10.1002/cncr.22923]
-
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<h5 class="refs-list-title">Barsevick 2004 {published data only}</h5>
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<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Barsevick AM, Dudley W, Beck S, Sweeney C, Whitmer K, Nail L. A randomized clinical trial of energy conservation for patients with cancerrelated fatigue. Cancer 2004;100(6):130210. [DOI: 10.1002/cncr.20111]
-
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<h5 class="refs-list-title">Barsevick 2010 {published data only}</h5>
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<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Barsevick A, Beck SL, Dudley WN, Wong B, Berger AM, Whitmer K, et al. Efficacy of an intervention for fatigue and sleep disturbance during cancer chemotherapy. Journal of Pain and Symptom Management 2010;40(2):20016. [DOI: 10.1016/j.jpainsymman.2009.12.020]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.jpainsymman.2009.12.020"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.jpainsymman.2009.12.020"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2921542/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2921542"
>
PMC
</a>
-
<a
class="reference-link"
href="/20705231/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="20705231"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bordeleau 2003 {published data only}</h5>
<ol id="top-references-list-5" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bordeleau L, Szalai JP, Ennis M, Leszcz M, Speca M, Sela R, et al. Quality of life in a randomized trial of group psychosocial support in metastatic breast cancer: overall effects of the intervention and an exploration of missing data. Journal of Clinical Oncology 2003;21(10):194451. [DOI: 10.1200/jco.2003.04.080]
-
<a
class="reference-link"
href="https://doi.org/10.1200/jco.2003.04.080"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1200/jco.2003.04.080"
>
DOI
</a>
-
<a
class="reference-link"
href="/12743147/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12743147"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bruera 2013 {published data only}</h5>
<ol id="top-references-list-6" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bruera E, Yennurajalingam S, Palmer JL, PerezCruz PE, FrisbeeHume S, Allo JA, et al. Methylphenidate and/or a nursing telephone intervention for fatigue in patients with advanced cancer: a randomized, placebocontrolled, phase II trial. Journal of Clinical Oncology 2013;31(19):24217. [DOI: 10.1200/JCO.2012.45.3696]
-
<a
class="reference-link"
href="https://doi.org/10.1200/jco.2012.45.3696"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1200/JCO.2012.45.3696"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3691358/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC3691358"
>
PMC
</a>
-
<a
class="reference-link"
href="/23690414/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="23690414"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Chan 2011 {published data only}</h5>
<ol id="top-references-list-7" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Chan CW, Richardson A, Richardson J. Managing symptoms in patients with advanced lung cancer during radiotherapy: results of a psychoeducational randomized controlled trial. Journal of Pain and Symptom Management 2011;41(2):34757. [DOI: 10.1016/j.jpainsymman.2010.04.024]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.jpainsymman.2010.04.024"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.jpainsymman.2010.04.024"
>
DOI
</a>
-
<a
class="reference-link"
href="/21131165/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="21131165"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Classen 2001 {published data only}</h5>
<ol id="top-references-list-8" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Classen C, Butlet LD, Koopman C, DiMiceli S, GieseDavis J, Fobair P, et al. Supportiveexpressive group therapy and distress in patients with metastatic breast cancer: a randomized clinical intervention trial. Archives of General Psychiatry 2001;58(5):494501.
-
<a
class="reference-link"
href="/11343530/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="11343530"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Palesh OG, Collie K, Batiuchok D, Tilston J, Koopman C, Perlis ML, et al. A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer. Biological Psychology 2007;75(1):3744. [DOI: 10.1016/j.biopsycho.2006.11.002]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.biopsycho.2006.11.002"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.biopsycho.2006.11.002"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1894689/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC1894689"
>
PMC
</a>
-
<a
class="reference-link"
href="/17166646/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="17166646"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Edelman 1999 {published data only}</h5>
<ol id="top-references-list-9" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Edelman S, Bell DR, Kidman AD. A group cognitive behaviour therapy programme with metastatic breast cancer patients. Psychooncology 1999;8(4):295305. [DOI: 10.1002/(SICI)1099-1611(199907/08)8:4%3C295::AID-PON386%<a class="external-link-urlize" href="http://3E3.0.CO" rel="nofollow noopener" target="_blank">3E3.0.CO</a>;2-Y]
-
<a
class="reference-link"
href="https://doi.org/10.1002/(sici)1099-1611(199907/08)8:4%3c295::aid-pon386%3e3.0.co;2-y"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/(SICI)1099-1611(199907/08)8:4%3C295::AID-PON386%3E3.0.CO;2-Y"
>
DOI
</a>
-
<a
class="reference-link"
href="/10474848/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="10474848"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Johansson 2008 {published data only}</h5>
<ol id="top-references-list-10" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Johansson B, Brandberg Y, Hellbom M, Persson C, Petersson LM, Berglund G, et al. Healthrelated quality of life and distress in cancer patients: results from a large randomised study. British Journal of Cancer 2008;99(12):197583. [DOI: 10.1038/sj.bjc.6604789]
-
<a
class="reference-link"
href="https://doi.org/10.1038/sj.bjc.6604789"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1038/sj.bjc.6604789"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2607225/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2607225"
>
PMC
</a>
-
<a
class="reference-link"
href="/19018255/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="19018255"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Persson CR, Johansson BB, Sjöden PO, Glimelius BL. A randomized study of nutritional support in patients with colorectal and gastric cancer. Nutrition and Cancer 2002;42(1):4858. [DOI: 10.1207/S15327914NC421_7]
-
<a
class="reference-link"
href="https://doi.org/10.1207/s15327914nc421_7"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1207/S15327914NC421_7"
>
DOI
</a>
-
<a
class="reference-link"
href="/12235650/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12235650"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Savard 2006 {published data only}</h5>
<ol id="top-references-list-11" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Savard J, Simard S, Giguère I, Ivers H, Morin CM, Maunsell E, et al. Randomized clinical trial on cognitive therapy for depression in women with metastatic breast cancer: psychological and immunological effects. Palliative &amp; Supportive Care 2006;4(3):21937.
-
<a
class="reference-link"
href="/17066964/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17066964"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Sharpe 2014 {published data only}</h5>
<ol id="top-references-list-12" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Sharpe M, Walker J, Holm Hansen C, Martin P, Symeonides S, Gourley C, et al. Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology2): a multicentre randomised controlled effectiveness trial. Lancet 2014;384(9948):1099108. [DOI: 10.1016/s0140-6736(14)61231-9]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0140-6736(14)61231-9"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/s0140-6736(14)61231-9"
>
DOI
</a>
-
<a
class="reference-link"
href="/25175478/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="25175478"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Spiegel 1981 {published data only}</h5>
<ol id="top-references-list-13" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Spiegel D, Bloom JR, Yalom I. Group support for patients with metastatic cancer. A randomized outcome study. Archives of General Psychiatry 1981;38(5):52733.
-
<a
class="reference-link"
href="/7235853/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="7235853"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Steel 2016 {published data only}</h5>
<ol id="top-references-list-14" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Steel JL, Geller DA, Kim KH, Butterfield LH, Spring M, Grady J, et al. Webbased collaborative care intervention to manage cancerrelated symptoms in the palliative care setting. Cancer 2016;122(8):127082. [DOI: 10.1002/cncr.29906]
-
<a
class="reference-link"
href="https://doi.org/10.1002/cncr.29906"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/cncr.29906"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4828258/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4828258"
>
PMC
</a>
-
<a
class="reference-link"
href="/26970434/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26970434"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Walker 2014 {published data only}</h5>
<ol id="top-references-list-15" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Walker J, Hansen CH, Martin P, Symeonides S, Gourley C, Wall L, et al. Integrated collaborative care for major depression comorbid with a poor prognosis cancer (SMaRT Oncology3): a multicentre randomised controlled trial in patients with lung cancer. Lancet Oncology 2014;15(10):116876. [DOI: 10.1016/S1470-2045(14)70343-2]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s1470-2045(14)70343-2"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S1470-2045(14)70343-2"
>
DOI
</a>
-
<a
class="reference-link"
href="/25175097/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="25175097"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">References to studies excluded from this review</h4>
<div class="refs-list">
<h5 class="refs-list-title">Adamsen 2009 {published data only}</h5>
<ol id="top-references-list-17" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Adamsen L, Quist M, Andersen C, Møller T, Herrstedt J, Kronborg D, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ 2009;339(b3410):111. [DOI: 10.1136/bmj.b3410]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmj.b3410"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmj.b3410"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2762035/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2762035"
>
PMC
</a>
-
<a
class="reference-link"
href="/19826172/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="19826172"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Andersen C, Rørth M, Ejlertsen B, Stage M, Møller T, Midtgaard J, et al. The effects of a sixweek supervised multimodal exercise intervention during chemotherapy on cancerrelated fatigue. European Journal of Oncology Nursing 2013;17(3):3319. [DOI: 10.1016/j.ejon.2012.09.003]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.ejon.2012.09.003"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.ejon.2012.09.003"
>
DOI
</a>
-
<a
class="reference-link"
href="/23084254/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="23084254"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Anderson 2015 {published data only}</h5>
<ol id="top-references-list-18" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Anderson KO, Palos GR, Mendoza TR, Cleeland CS, Liao KP, Fisch MJ, et al. Automated pain intervention for underserved minority women with breast cancer. Cancer 2015;121(11):188290. [DOI: 10.1002/cncr.29204]
-
<a
class="reference-link"
href="https://doi.org/10.1002/cncr.29204"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/cncr.29204"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4527331/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4527331"
>
PMC
</a>
-
<a
class="reference-link"
href="/25711974/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="25711974"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Berglund 2007 {published data only}</h5>
<ol id="top-references-list-19" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Berglund G, Petersson LM, Eriksson KC, Wallenius I, Roshanai A, Nordin KM, et al. "Between Men": a psychosocial rehabilitation programme for men with prostate cancer. Acta Oncologica 2007;46(1):839. [PUBMED: 17438709 ]
-
<a
class="reference-link"
href="/17438709/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17438709"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bigatao 2016 {published data only}</h5>
<ol id="top-references-list-20" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bigatao MR, Peria FM, Tirapelli DPC, Carlotti Junior CG. Educational program on fatigue for brain tumor patients: possibility strategy?. Arquivos de NeuroPsiquiatria 2016;74(2):15560. [DOI: 10.1590/0004-282X20160007]
-
<a
class="reference-link"
href="https://doi.org/10.1590/0004-282x20160007"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1590/0004-282X20160007"
>
DOI
</a>
-
<a
class="reference-link"
href="/26982993/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="26982993"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Brown 2006 {published data only}</h5>
<ol id="top-references-list-21" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Brown P, Clark MM, Atherton P, Huschka M, Sloan JA, Gamble G, et al. Will improvement in quality of life (QOL) impact fatigue in patients receiving radiation therapy for advanced cancer?. American Journal of Clinical Oncology 2006;29(1):528. [DOI: 10.1097/01.coc.0000190459.14841.55]
-
<a
class="reference-link"
href="https://doi.org/10.1097/01.coc.0000190459.14841.55"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1097/01.coc.0000190459.14841.55"
>
DOI
</a>
-
<a
class="reference-link"
href="/16462503/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="16462503"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Cheville AL, Girardi J, Clark MM, Rummans TA, Pittelkow T, Brown P, et al. Therapeutic exercise during outpatient radiation therapy for advanced cancer: feasibility and impact on physical wellbeing. American Journal of Physical Medicine &amp; Rehabilitation 2010;89(8):6119. [DOI: 10.1097/PHM.0b013e3181d3e782]
-
<a
class="reference-link"
href="https://doi.org/10.1097/phm.0b013e3181d3e782"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1097/PHM.0b013e3181d3e782"
>
DOI
</a>
-
<a
class="reference-link"
href="/20531162/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="20531162"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Cunningham 1989 {published data only}</h5>
<ol id="top-references-list-22" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Cunningham AJ, Tocco EK. A randomized trial of group psychoeducational therapy for cancer patients. Patient Education and Counseling 1989;14:10114.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Decker 1992 {published data only}</h5>
<ol id="top-references-list-23" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Decker TW, ClineElsen J, Gallagher M. Relaxation therapy as an adjunct in radiation oncology. Journal of Clinical Psychology 1992;48(3):38893.
-
<a
class="reference-link"
href="/1602030/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="1602030"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">De Moor 2001 {published data only}</h5>
<ol id="top-references-list-24" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moor C, Sterner J, Hall M, Warneke C, Gilani Z, Amato R, et al. A pilot study of the effects of expressive writing on psychological and behavioral adjustment in patients enrolled in a Phase II trial of vaccine therapy for metastatic renal cell carcinoma. Health Psychology 2002;21(6):6159. [PUBMED: 12433015 ]
-
<a
class="reference-link"
href="/12433015/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="12433015"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">De Raaf 2013 {published data only}</h5>
<ol id="top-references-list-25" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Raaf PJ, Klerk C, Timman R, Busschbach JJ, Oldenmenger WH, Rijt CC. Systematic monitoring and treatment of physical symptoms to alleviate fatigue in patients with advanced cancer: a randomized controlled trial. Journal of Clinical Oncology 2013;31(6):71623. [DOI: 10.1200/JCO.2012.44.4216]
-
<a
class="reference-link"
href="https://doi.org/10.1200/jco.2012.44.4216"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1200/JCO.2012.44.4216"
>
DOI
</a>
-
<a
class="reference-link"
href="/23284036/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="23284036"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Fernandez 2011 {published data only}</h5>
<ol id="top-references-list-26" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Fernández C, Villoria E, Amigo I, Padierna C, Gracia JM, Fernández R, et al. Behavioral activation treatment for cancer patients [Terapia de activación conductual en pacientes con cáncer]. Anales de Psicología 2011;27(2):27891.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Focan 2015 {published data only}</h5>
<ol id="top-references-list-27" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Focan C, Houbiers G, Gilles L, Steeland T, Georges N, Maniglia A, et al. Dietetic and psychological mindfulness workshops for the management of cachectic cancer patients. A randomized study. Anticancer Research 2015;35:63116.
-
<a
class="reference-link"
href="/26504068/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="26504068"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Forester 1985 {published data only}</h5>
<ol id="top-references-list-28" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Forester B, Kornfeld DS, Fleiss JL. Psychotherapy during radiotherapy: effects on emotional and physical distress. American Journal of Psychiatry 1985;142:227.
-
<a
class="reference-link"
href="/3966583/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="3966583"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">GastonJohansson 2000 {published data only}</h5>
<ol id="top-references-list-29" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
GastonJohansson F, FallDickson JM, Nanda J, Ohly KV, Stillman S, Krumm S, et al. The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation. Cancer Nursing 2000;23(4):27785. [PUBMED: 10939175 ]
-
<a
class="reference-link"
href="/10939175/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10939175"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Given 2002 {published data only}</h5>
<ol id="top-references-list-30" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Given B, Given CW, McCorkle R, Kozachik S, Cimprich B, Rahbar MH, et al. Pain and fatigue management: results of a nursing randomized clinical trial. Oncology Nursing Forum 2002;29(6):94956. [DOI: 10.1188/02.ONF.949-956]
-
<a
class="reference-link"
href="https://doi.org/10.1188/02.onf.949-956"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1188/02.ONF.949-956"
>
DOI
</a>
-
<a
class="reference-link"
href="/12096292/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12096292"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Godino 2006 {published data only}</h5>
<ol id="top-references-list-31" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Godino C, Jodar L, Durán A, Martínez I, Schiaffino A. Nursing education as an intervention to decrease fatigue perception in oncology patients. European Journal of Oncology Nursing 2006;10(2):1505. [DOI: 10.1016/j.ejon.2005.03.004]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.ejon.2005.03.004"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.ejon.2005.03.004"
>
DOI
</a>
-
<a
class="reference-link"
href="/16618589/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="16618589"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Oh 2010 {published data only}</h5>
<ol id="top-references-list-32" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Oh B, Butow P, Mullan B, Clarke S, Beale P, Pavlakis N, et al. Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial. Annals of Oncology 2010;21(3):60814. [DOI: 10.1093/annonc/mdp479]
-
<a
class="reference-link"
href="https://doi.org/10.1093/annonc/mdp479"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1093/annonc/mdp479"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2826100/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2826100"
>
PMC
</a>
-
<a
class="reference-link"
href="/19880433/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="19880433"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Ream 2006 {published data only}</h5>
<ol id="top-references-list-33" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ream E, Richardson A, AlexanderDann C. Supportive intervention for fatigue in patients undergoing chemotherapy: a randomized controlled trial. Journal of Pain and Symptom Management 2006;31(2):14861. [DOI: 10.1016/j.jpainsymman.2005.07.003]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.jpainsymman.2005.07.003"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.jpainsymman.2005.07.003"
>
DOI
</a>
-
<a
class="reference-link"
href="/16488348/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="16488348"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Ream 2015 {published data only}</h5>
<ol id="top-references-list-34" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ream E, Gargaro G, Barsevick A, Richardson A. Management of cancerrelated fatigue during chemotherapy through telephone motivational interviewing: modeling and randomized exploratory trial. Patient Education and Counseling 2015;98(2):199206. [DOI: 10.1016/j.pec.2014.10.012]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.pec.2014.10.012"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.pec.2014.10.012"
>
DOI
</a>
-
<a
class="reference-link"
href="/25468398/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="25468398"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Serfaty 2012 {published data only}</h5>
<ol id="top-references-list-35" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Serfaty M, Wilkinson S, Freeman C, Mannix K, King M. The ToT study: helping with Touch or Talk (ToT): a pilot randomised controlled trial to examine the clinical effectiveness of aromatherapy massage versus cognitive behaviour therapy for emotional distress in patients in cancer/palliative care. PsychoOncology 2012;21(5):5639. [DOI: 10.1002/pon.1921]
-
<a
class="reference-link"
href="https://doi.org/10.1002/pon.1921"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/pon.1921"
>
DOI
</a>
-
<a
class="reference-link"
href="/21370309/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="21370309"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Strong 2008 {published data only}</h5>
<ol id="top-references-list-36" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Strong V, Waters R, Hibberd C, Murray G, Wall L, Walker J, et al. Management of depression for people with cancer (SMaRT oncology 1): a randomised trial. Lancet 2008;372(9632):408. [DOI: 10.1016/S0140-6736(08)60991-5]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0140-6736(08)60991-5"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0140-6736(08)60991-5"
>
DOI
</a>
-
<a
class="reference-link"
href="/18603157/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="18603157"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Yorke 2015 {published data only}</h5>
<ol id="top-references-list-37" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Yorke J, LloydWilliams M, Smith J, Blackhall F, Harle A, Warden J, et al. Management of the respiratory distress symptom cluster in lung cancer: a randomised controlled feasibility trial. Supportive Care in Cancer 2015;23(11):337384. [DOI: 10.1007/s00520-015-2810-x]
-
<a
class="reference-link"
href="https://doi.org/10.1007/s00520-015-2810-x"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/s00520-015-2810-x"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4584102/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4584102"
>
PMC
</a>
-
<a
class="reference-link"
href="/26111954/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26111954"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">References to ongoing studies</h4>
<div class="refs-list">
<h5 class="refs-list-title">Poort {published and unpublished data}</h5>
<ol id="top-references-list-39" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
TIRED study.. Ongoing study January 2013, recruitment ongoing..
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Serfaty {published and unpublished data}</h5>
<ol id="top-references-list-40" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
CanTalk study.. Ongoing study July 2012, recruitment completed..
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">Additional references</h4>
<div class="refs-list">
<h5 class="refs-list-title">Authier 1975</h5>
<ol id="top-references-list-42" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Authier J, Gustafson K, Guerney B Jr, Kasdorf J. The psychological practitioner as teacher: a theoreticalhistorical and practical review. Counseling Psychologist 1975;5(2):3150.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bandura 1969</h5>
<ol id="top-references-list-43" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bandura A. Principles of Behavior Modification. New York: Holt, Rinehart &amp; Winston, 1969.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bandura 1997</h5>
<ol id="top-references-list-44" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bandura A. Selfefficacy: The Exercise of Control. New York: W.H. Freeman, 1997.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Barnes 2002</h5>
<ol id="top-references-list-45" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Barnes EA, Bruera E. Fatigue in patients with advanced cancer: a review. International Journal of Gynecological Cancer 2002;12(5):4248.
-
<a
class="reference-link"
href="/12366656/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="12366656"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Beck 1970</h5>
<ol id="top-references-list-46" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Beck AT. Cognitive therapy: nature and relation to behavior therapy. Behavior Therapy 1970;1(2):184200.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Beck 1976</h5>
<ol id="top-references-list-47" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Beck AT. Cognitive Therapy and the Emotional Disorders. New York: International Universities Press, 1976.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Beck 2011</h5>
<ol id="top-references-list-48" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Beck JS. Introduction to cognitive behavior therapy. In: Beck JS editor(s). Cognitive Behavior Therapy: Basics and Beyond. 2nd Edition. New York: The Guilford Press, 2011:114.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Berman 1985</h5>
<ol id="top-references-list-49" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Berman JS, Miller RC, Massman PJ. Cognitive therapy versus systematic desensitization: is one treatment superior?. Psychological Bulletin 1985;97:45161.
-
<a
class="reference-link"
href="/2860682/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="2860682"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bordin 1979</h5>
<ol id="top-references-list-50" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bordin ES. The generalizability of the psychoanalytic concept of the working alliance. Psychotherapy: Theory Research and Practice 1979;16(3):25260.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bower 2014</h5>
<ol id="top-references-list-51" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bower JE, Bak K, Breitbart W, Escalante CP, Ganz PA, Schnipper HH, et al. American Society of Clinical Oncology. Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. Journal of Clinical Oncology 2014;32(17):184050.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4039870/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC4039870"
>
PMC
</a>
-
<a
class="reference-link"
href="/24733803/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="24733803"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Butt 2008</h5>
<ol id="top-references-list-52" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Butt Z, Rosenbloom SK, Abernethy AP, Beaumont JL, Paul D, Hampton D, et al. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. Journal of the National Comprehensive Cancer Network: JNCCN 2008;6(5):44855.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5089809/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC5089809"
>
PMC
</a>
-
<a
class="reference-link"
href="/18492460/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="18492460"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Chalder 2015</h5>
<ol id="top-references-list-53" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Chalder T, Goldsmith KA, White PD, Sharpe M, Pickless AR. Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial. Lancet Psychiatry 2015;2(2):14152.
-
<a
class="reference-link"
href="/26359750/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="26359750"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Cramp 2012</h5>
<ol id="top-references-list-54" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Cramp F, ByronDaniel J. Exercise for the management of cancerrelated fatigue in adults. Cochrane Database of Systematic Reviews 2012, Issue 11. [DOI: 10.1002/14651858.CD006145.pub3]
-
<a
class="reference-link"
href="https://doi.org/10.1002/14651858.cd006145.pub3"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/14651858.CD006145.pub3"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8480137/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC8480137"
>
PMC
</a>
-
<a
class="reference-link"
href="/23152233/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="23152233"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Dragioti 2015</h5>
<ol id="top-references-list-55" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Dragioti E, Dimoliatis I, Evangelou E. Disclosure of researcher allegiance in metaanalyses and randomised controlled trials of psychotherapy: a systematic appraisal. BMJ Open 2015;5:e007206. [DOI: 10.1136/bmjopen-2014-007206]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmjopen-2014-007206"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmjopen-2014-007206"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4458582/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4458582"
>
PMC
</a>
-
<a
class="reference-link"
href="/26033943/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26033943"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Frank 1990</h5>
<ol id="top-references-list-56" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Frank AF, Gunderson JG. The role of the therapeutic alliance in the treatment of schizophrenia: relationship to course and outcome. Archives of General Psychiatry 1990;47:22836.
-
<a
class="reference-link"
href="/1968329/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="1968329"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Gaston 1990</h5>
<ol id="top-references-list-57" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Gaston L. The concept of the alliance and its role in psychotherapy: theoretical and empirical considerations. Psychotherapy 1990;27:14353.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Gielissen 2006</h5>
<ol id="top-references-list-58" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Gielissen MF, Verhagen S, Witjes F, Bleijenberg G. Effects of cognitive behavior therapy in severely fatigued diseasefree cancer patients compared with patients waiting for cognitive behavior therapy: a randomized controlled trial. Journal of Clinical Oncology 2006;24(30):48827.
-
<a
class="reference-link"
href="/17050873/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17050873"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Gielissen 2012</h5>
<ol id="top-references-list-59" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Gielissen MF, Wiborg JF, Verhagen CA, Knoop H, Bleijenberg G. Examining the role of physical activity in reducing postcancer fatigue. Supportive Care in Cancer 2012;20(7):14417.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3360858/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC3360858"
>
PMC
</a>
-
<a
class="reference-link"
href="/21773676/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="21773676"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">GRADEpro 2015 [Computer program]</h5>
<ol id="top-references-list-60" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Brozek J, Oxman A, Schünemann H. GRADEpro Guideline Development Tool [Software]. McMaster University (developed by Evidence Prime, Inc.), 2015.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hauser 2008</h5>
<ol id="top-references-list-61" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hauser K, Walsh D, Rybicki LA, Davis MP, SeyidovaKhoshknabi D. Fatigue in advanced cancer: a prospective study. American Journal of Hospice &amp; Palliative Care 2008;25(5):3728.
-
<a
class="reference-link"
href="/18539763/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="18539763"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Higgins 2011</h5>
<ol id="top-references-list-62" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. www.cochrane<a class="external-link-urlize" href="http://handbook.org" rel="nofollow noopener" target="_blank">handbook.org</a>. Vol. 5.1.0, London, UK: The Cochrane Collaboration, 2009 [Updated 2011].
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hofman 2007</h5>
<ol id="top-references-list-63" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hofman M, Ryan JL, FigueroaMoseley CD, JeanPierre P, Morrow GR. Cancerrelated fatigue: the scale of the problem. Oncologist 2007;12(Suppl 1):410.
-
<a
class="reference-link"
href="/17573451/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17573451"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Italiano 2008</h5>
<ol id="top-references-list-64" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Italiano A, Massard C, Bahleda R, Vataire AL, Deutsch E, Magné N, et al. Treatment outcome and survival in participants of phase I oncology trials carried out from 2003 to 2006 at Institut Gustave Roussy. Annals of Oncology 2008;19(4):78792.
-
<a
class="reference-link"
href="/18042834/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="18042834"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Knoop 2012</h5>
<ol id="top-references-list-65" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Knoop H, Kessel K, MossMorris R. Which cognitions and behaviours mediate the positive effect of cognitive behavioural therapy on fatigue in patients with multiple sclerosis?. Psychological Medicine 2012;42(1):20513.
-
<a
class="reference-link"
href="/21672300/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="21672300"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Lynn 2003</h5>
<ol id="top-references-list-66" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Lynn J, Adamson DM. Living Well at the End of Life. Adapting Health Care to Serious Chronic Illness in Old Age. Washington: Rand Health. 2003.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Martin 2000</h5>
<ol id="top-references-list-67" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Martin DJ, Garske JP, Davis MK. Relation of the therapeutic alliance with outcome and other variables. A metaanalytic review. Journal of Consulting and Clinical Psychology 2000;68:43850.
-
<a
class="reference-link"
href="/10883561/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10883561"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Miller 2008</h5>
<ol id="top-references-list-68" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Miller FG, Joffe S. Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option?. Clinical Trials 2008;5(6):61723.
-
<a
class="reference-link"
href="/19029210/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="19029210"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Minton 2009</h5>
<ol id="top-references-list-69" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Minton O, Stone P. A systematic review of the scales used for the measurement of cancerrelated fatigue (CRF). Annals of Oncology 2009;20:1725.
-
<a
class="reference-link"
href="/18678767/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="18678767"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Minton 2013</h5>
<ol id="top-references-list-70" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Minton O, Berger A, Barsevick A, Cramp F, Goedendorp M, Mitchell SA, et al. Cancerrelated fatigue and its impact on functioning. Cancer 2013;119(S11):212430.
-
<a
class="reference-link"
href="/23695924/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="23695924"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mock 2000</h5>
<ol id="top-references-list-71" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mock V, Atkinson A, Barsevick A, Cella D, Cimprich B, Cleeland C, et al. NCCN Practice Guidelines for CancerRelated Fatigue. Oncology (Williston Park) 2000;14(11A):15161.
-
<a
class="reference-link"
href="/11195408/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="11195408"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moher 2009</h5>
<ol id="top-references-list-72" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moher D, Liberati A, Tetzlaff J, Altman DG, the PRISMA Group. Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. PLoS Medicine 2009;6(7):e1000097.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2707599/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC2707599"
>
PMC
</a>
-
<a
class="reference-link"
href="/19621072/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="19621072"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mücke 2015</h5>
<ol id="top-references-list-73" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mücke M, Mochamat, Cuhls H, PeuckmannPost V, Minton O, Stone P, et al. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database of Systematic Reviews 2015, Issue 5. [DOI: 10.1002/14651858.CD006788.pub3]
-
<a
class="reference-link"
href="https://doi.org/10.1002/14651858.cd006788.pub3"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/14651858.CD006788.pub3"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6483317/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC6483317"
>
PMC
</a>
-
<a
class="reference-link"
href="/26026155/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26026155"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Orlinsky 2004</h5>
<ol id="top-references-list-74" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Orlinsky DE, Ronnestad MH, Willutski U. Fifty years of psychotherapy processoutcome research. Continuity and change. In: Lambert MJ editor(s). Bergin and Garfield's Handbook of Psychotherapy and Behavior Change. 5th Edition. New York: Wiley, 2004:30790.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Paiva 2013</h5>
<ol id="top-references-list-75" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Paiva CE, Paiva BS. Prevalence, predictors, and prognostic impact of fatigue among Brazilian outpatients with advanced cancers. Supportive Care in Cancer 2013;21(4):105360.
-
<a
class="reference-link"
href="/23052924/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="23052924"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Peters 2014</h5>
<ol id="top-references-list-76" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Peters MEWJ, Goedendorp MM, Verhagen CAHHVM, Graaf WTA, Bleijenberg G. Exploring the contribution of psychosocial factors to fatigue in patients with advanced incurable cancer. Psychooncology 2014;23(7):7739.
-
<a
class="reference-link"
href="/24458595/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="24458595"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Peyrot 2007</h5>
<ol id="top-references-list-77" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Peyrot M, Rubin RR. Behavioral and psychosocial interventions in diabetes: a conceptual review. Diabetes Care 2007;30(10):243340.
-
<a
class="reference-link"
href="/17666457/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17666457"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Prinsen 2013</h5>
<ol id="top-references-list-78" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Prinsen H, Bleijenberg G, Heijmen L, Zwarts MJ, Leer JW, Heerschap A, et al. The role of physical activity and physical fitness in postcancer fatigue: a randomized controlled trial. Supportive Care in Cancer 2013;21(8):227988.
-
<a
class="reference-link"
href="/23519566/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="23519566"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Radbruch 2008</h5>
<ol id="top-references-list-79" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Radbruch L, Strasser F, Elsner F, Goncalves JF, Loge J, Kaasa S, et al. the Research Steering Committee of the EAPC. Fatigue in palliative care patients an EAPC approach. Palliative Medicine 2008;22:1332.
-
<a
class="reference-link"
href="/18216074/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="18216074"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">RevMan 2014 [Computer program]</h5>
<ol id="top-references-list-80" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Stone 1999</h5>
<ol id="top-references-list-81" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Stone P, Hardy J, Broadley K, Tookman AJ, Kurowska A, A'Hern R. Fatigue in advanced cancer: a prospective controlled crosssectional study. British Journal of Cancer 1999;79:147986.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2362706/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC2362706"
>
PMC
</a>
-
<a
class="reference-link"
href="/10188894/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="10188894"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Stone 2008</h5>
<ol id="top-references-list-82" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Stone PC, Minton O. Cancerrelated fatigue. European Journal of Cancer 2008;44(8):1097104.
-
<a
class="reference-link"
href="/18381237/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="18381237"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Tanaka 2002</h5>
<ol id="top-references-list-83" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Tanaka K, Akechi T, Okuyama T, Nishiwaki Y, Uchitomi Y. Impact of dyspnea, pain, and fatigue on daily life activities in ambulatory patients with advanced lung cancer. Journal of Pain and Symptom Management 2002;23(5):41723.
-
<a
class="reference-link"
href="/12007759/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="12007759"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Teunissen 2007</h5>
<ol id="top-references-list-84" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Teunissen SCCM, Wesker W, Kruitwagen C, Haes HCJM, Voest EE, Graeff A. Symptom prevalence in patients with incurable cancer: a systematic review. Journal of Pain and Symptom Management 2007;34(1):94104.
-
<a
class="reference-link"
href="/17509812/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="17509812"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Wampold 2001</h5>
<ol id="top-references-list-85" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Wampold BE. The Great Psychotherapy Debate: Models, Methods, and Findings. Mahwah, NJ: Lawrence Erlbaum Associates, 2001.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Wanrooij 2010</h5>
<ol id="top-references-list-86" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
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Wanrooij BS, Graeff A, Koopmans RTCM, Leget CJW, Prins JB, Vissers KCP, et al. Palliative Zorg in de Dagelijkse Praktijk. Houten: Bohn Stafleu van Loghum, 2003.
</li>
</ol>
</li>
</ol>
</div>
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<li
class="skip-numbering"
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Wiborg JF, Knoop H, Prins JB, Bleijenberg G. Does a decrease in avoidance behavior and focusing on fatigue mediate the effect of cognitive behavior therapy for chronic fatigue syndrome?. Journal of Psychosomatic Research 2011;70(4):30610.
-
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Wiborg JF, Knoop H, Frank LE, Bleijenberg G. Towards an evidencebased treatment model for cognitive behavioral interventions focusing on chronic fatigue syndrome. Journal of Psychosomatic Research 2012;72(5):399404.
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<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Yates SL, Morley S, Eccleston C, Williams ACdeC. A scale for rating the quality of psychological trials for pain. Pain 2005;117(3):31425.
-
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<h4 class="refs-list-title">References to other published versions of this review</h4>
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<h5 class="refs-list-title">Goedendorp 2009</h5>
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Goedendorp M, Gielissen MFM, Verhagen CAHHVM, Bleijenberg G. Psychosocial interventions for reducing fatigue during cancer treatment in adults. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD006953.pub2]
-
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