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<meta name="keywords" content="C0398650, aitp, autoimmune thrombocytopenia, autoimmune thrombocytopenias, autoimmune thrombocytopenic purpura, autoimmune thrombocytopenic purpuras, disease or syndrome, disease, werlhof, disease, werlhof's, ideopath thrombocytopenic pur, idiopathic purpura, idiopathic thrombocytopenia, idiopathic thrombocytopenia purpura, idiopathic thrombocytopenic purpura, idiopathic thrombocytopenic purpura (itp), idiopathic thrombocytopenic purpuras, immune thrombocytopenia, immune thrombocytopenias, immune thrombocytopenic purpura, immune thrombocytopenic purpuras, itp, primary immune thrombocytopenia, primary thrombocytopenic purpura, purpura, autoimmune thrombocytopenic, purpura, idiopathic thrombocytopenic, purpura, immune thrombocytopenic, purpura, thrombocytopenic, autoimmune, purpura, thrombocytopenic, idiopathic, purpuras, autoimmune thrombocytopenic, purpuras, idiopathic thrombocytopenic, purpuras, immune thrombocytopenic, thrombocytopenia, autoimmune, thrombocytopenia, immune, thrombocytopenias, autoimmune, thrombocytopenias, immune, thrombocytopenic purpura autoimmune, thrombocytopenic purpura, autoimmune, thrombocytopenic purpura, idiopathic, thrombocytopenic purpura, immune, thrombocytopenic purpuras, idiopathic, thrombocytopenic purpuras, immune, werlhof disease, werlhof's disease, werlhofs disease, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Immune thrombocytopenic purpura is characterized by a low platelet count, normal bone marrow, and the absence of other causes of thrombocytopenia. It is principally a disorder of increased platelet destruction mediated by autoantibodies to platelet-membrane antigens (George et al., 1994)." /><meta name="robots" content="index,nofollow,noarchive" />
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<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
|
||
<!--
|
||
UID=584986
|
||
ConceptID=C0398650
|
||
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|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Autoimmune thrombocytopenic purpura<span class="h1sub">(ITP)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>584986</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0398650</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Idiopathic thrombocytopenic purpura; IMMUNE THROMBOCYTOPENIA; ITP</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Werlhof's disease (13172003); Autoimmune thrombocytopenic purpura (13172003)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0008558" target="_blank">MONDO:0008558</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/188030" target="_blank">188030</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=3002">ORPHA3002</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Immune thrombocytopenic purpura is characterized by a low platelet count, normal bone marrow, and the absence of other causes of thrombocytopenia. It is principally a disorder of increased platelet destruction mediated by autoantibodies to platelet-membrane antigens (George et al., 1994). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cells called platelets that are needed for normal blood clotting.<br /><br />Affected individuals can develop red or purple spots on the skin caused by bleeding just under the skin's surface. Small spots of bleeding under the skin are called purpura and larger spots are called ecchymoses. People with immune thrombocytopenia can have significant bleeding episodes, such as nose bleeds (epistaxis) or bleeding in the moist lining (mucosae) of the mouth. In severe cases, individuals may have gastrointestinal bleeding or blood in the urine or stool, or heavy and prolonged menstrual bleeding (menorrhagia). In very rare instances, bleeding inside the skull (intracranial hemorrhage) can occur, which can be life-threatening. A greater reduction in platelet numbers is often associated with more frequent bleeding episodes and an increased risk of severe bleeding.<br /><br />While immune thrombocytopenia can be diagnosed at any age, there are two periods when the condition is most likely to develop: early childhood and late adulthood. In children, the reduction in platelets is often sudden, but platelet levels usually return to normal levels within weeks to months. Immune thrombocytopenia in children is often preceded by a minor infection, such as an upper respiratory infection, but the relationship between the infection and immune thrombocytopenia is not clear. In adults, the development of immune thrombocytopenia is usually gradual and the condition tends to persist throughout life. <a target="_blank" href="https://medlineplus.gov/genetics/condition/immune-thrombocytopenia">https://medlineplus.gov/genetics/condition/immune-thrombocytopenia</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_52737"><div><strong>Thrombocytopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52737</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040034</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction in the number of circulating thrombocytes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52737">Feature record</a> | <a href="/medgen?term=%22Thrombocytopenia%22%5BClinical%20Features%5D%20OR%2052737%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_264316"><div><strong>Abnormal bleeding</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>264316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1458140</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/264316">Feature record</a> | <a href="/medgen?term=%22Abnormal%20bleeding%22%5BClinical%20Features%5D%20OR%20264316%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_349070"><div><strong>Platelet antibody positive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349070</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858980</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Laboratory or Test Result</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence in the serum of autoantibodies directed against thrombocytes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen?term=%22Platelet%20antibody%20positive%22%5BClinical%20Features%5D%20OR%20349070%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of blood and blood-forming tissues</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_264316" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormal bleeding</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_52737" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytopenia</a></span></li></ul></li><li><span class="TLline">Abnormality of the immune system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_349070" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet antibody positive</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0242584[DISCUI]&test_type=Clinical" ref="ncbi_uid=116621">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=116621" ref="ncbi_uid=116621">V</a></span></span><span class="TLline"><a href="/medgen/116621" ref="tree=GTR&ncbi_uid=116621&link_uid=116621" title="View MedGen record for 'Autoimmune thrombocytopenia'">Autoimmune thrombocytopenia</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0398650[DISCUI]&test_type=Clinical" ref="ncbi_uid=584986">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=584986" target="_blank" href="/omim/188030">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=584986" ref="ncbi_uid=584986">V</a></span></span><span class="TLline">Autoimmune thrombocytopenic purpura</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/75773" ref="tree=GTR&ncbi_uid=75773&link_uid=75773" title="View MedGen record for 'Evans syndrome'">Evans syndrome</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4014795[DISCUI]&test_type=Clinical" ref="ncbi_uid=863232">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=863232" target="_blank" href="/omim/102582">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=863232" ref="ncbi_uid=863232">V</a></span></span><span class="TLline"><a href="/medgen/863232" ref="tree=GTR&ncbi_uid=863232&link_uid=863232" title="View MedGen record for 'STAT3-related early-onset multisystem autoimmune disease'">STAT3-related early-onset multisystem autoimmune disease</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/232638" ref="tree=MeSH" title="MedGen record for Immune System and Related Disorders">Immune System and Related Disorders</a></span><ul><li><span class="TLline"><a href="/medgen/5759" ref="tree=MeSH" title="MedGen record for Immune system disorder">Immune system disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2135" ref="tree=MeSH" title="MedGen record for Autoimmune disease">Autoimmune disease</a></span><ul><li><span class="matched_ds">Autoimmune thrombocytopenic purpura</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=784&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Autoimmune thrombocytopenic purpura</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/12103322">Treatment of severe autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balaraman R</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2002 Jun 29;359(9325):2279; author reply 2279-80.
|
||
doi: 10.1016/S0140-6736(02)09281-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12103322" target="_blank">12103322</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9111285">Treatment of chronic autoimmune thrombocytopenic purpura with monoclonal anti-D: lack of efficiency due to absence of Fc gammaR-inhibiting activity?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neppert J,
|
||
von Witzleben-Schürholz EM</span><br />
|
||
<span class="medgenPMjournal">Transfusion</span>
|
||
1997 Apr;37(4):444-5; author reply 445-6.
|
||
doi: 10.1046/j.1537-2995.1997.37497265348.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9111285" target="_blank">9111285</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2597267">Treatment of autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">N Engl J Med</span>
|
||
1989 Sep 14;321(11):760-1.
|
||
doi: 10.1056/NEJM198909143211113.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2597267" target="_blank">2597267</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22autoimmune%20thrombocytopenic%20purpura%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (28)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/12815483">Autoimmune thrombocytopenic purpura after autologous stem cell transplantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hequet O,
|
||
Salles G,
|
||
Ketterer N,
|
||
Espinouse D,
|
||
Dumontet C,
|
||
Thieblemont C,
|
||
Arnaud P,
|
||
Bouafia F,
|
||
Coiffier B</span><br />
|
||
<span class="medgenPMjournal">Bone Marrow Transplant</span>
|
||
2003 Jul;32(1):89-95.
|
||
doi: 10.1038/sj.bmt.1704073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12815483" target="_blank">12815483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11499984">Immune thrombocytopenia in the foetus and the newborn: diagnosis and therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaplan C</span><br />
|
||
<span class="medgenPMjournal">Transfus Clin Biol</span>
|
||
2001 Jun;8(3):311-4.
|
||
doi: 10.1016/s1246-7820(01)00114-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11499984" target="_blank">11499984</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7577635">Splenic irradiation for chronic autoimmune thrombocytopenic purpura in patients with contra-indications to splenectomy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caulier MT,
|
||
Darloy F,
|
||
Rose C,
|
||
Camier G,
|
||
Morel P,
|
||
Bauters F,
|
||
Fenaux P</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
1995 Sep;91(1):208-11.
|
||
doi: 10.1111/j.1365-2141.1995.tb05271.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7577635" target="_blank">7577635</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8003616">Autoimmune thrombocytopenic purpura in pregnancy: maternal risk factors predictive of neonatal thrombocytopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzucconi MG,
|
||
Petrelli V,
|
||
Gandolfo GM,
|
||
Carapella E,
|
||
Chistolini A,
|
||
Puorger CC,
|
||
De Sanctis V,
|
||
Paesano R,
|
||
Pachi A</span><br />
|
||
<span class="medgenPMjournal">Autoimmunity</span>
|
||
1993;16(3):209-14.
|
||
doi: 10.3109/08916939308993329.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8003616" target="_blank">8003616</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3115957">Hematologic complications of rheumatic disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Richert-Boe KE</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
1987 Jun;1(2):301-20.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3115957" target="_blank">3115957</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Autoimmune%20thrombocytopenic%20purpura%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (76)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/11499984">Immune thrombocytopenia in the foetus and the newborn: diagnosis and therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaplan C</span><br />
|
||
<span class="medgenPMjournal">Transfus Clin Biol</span>
|
||
2001 Jun;8(3):311-4.
|
||
doi: 10.1016/s1246-7820(01)00114-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11499984" target="_blank">11499984</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1690204">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bussel JB</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
1990 Feb;4(1):179-91.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1690204" target="_blank">1690204</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2643870">Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ratner L</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1989 Feb;86(2):194-8.
|
||
doi: 10.1016/0002-9343(89)90268-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2643870" target="_blank">2643870</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6157441">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karpatkin S</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
1980 Sep;56(3):329-43.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6157441" target="_blank">6157441</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4933874">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karpatkin S</span><br />
|
||
<span class="medgenPMjournal">Am J Med Sci</span>
|
||
1971 Mar;261(3):127-38.
|
||
doi: 10.1097/00000441-197103000-00001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4933874" target="_blank">4933874</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Autoimmune%20thrombocytopenic%20purpura%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (81)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/15224300">Clopidogrel-associated autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Best PJ,
|
||
Mathew V,
|
||
Markovic SN</span><br />
|
||
<span class="medgenPMjournal">Catheter Cardiovasc Interv</span>
|
||
2004 Jul;62(3):339-40.
|
||
doi: 10.1002/ccd.20046.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15224300" target="_blank">15224300</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7741979">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ikehara S,
|
||
Mizutani H,
|
||
Kurata Y</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
1995 Apr;19(1):33-45.
|
||
doi: 10.1016/1040-8428(94)00128-g.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7741979" target="_blank">7741979</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1690204">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bussel JB</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
1990 Feb;4(1):179-91.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1690204" target="_blank">1690204</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2413550">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karpatkin S</span><br />
|
||
<span class="medgenPMjournal">Semin Hematol</span>
|
||
1985 Oct;22(4):260-88.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2413550" target="_blank">2413550</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4933874">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Karpatkin S</span><br />
|
||
<span class="medgenPMjournal">Am J Med Sci</span>
|
||
1971 Mar;261(3):127-38.
|
||
doi: 10.1097/00000441-197103000-00001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4933874" target="_blank">4933874</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Autoimmune%20thrombocytopenic%20purpura%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (123)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/12815483">Autoimmune thrombocytopenic purpura after autologous stem cell transplantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hequet O,
|
||
Salles G,
|
||
Ketterer N,
|
||
Espinouse D,
|
||
Dumontet C,
|
||
Thieblemont C,
|
||
Arnaud P,
|
||
Bouafia F,
|
||
Coiffier B</span><br />
|
||
<span class="medgenPMjournal">Bone Marrow Transplant</span>
|
||
2003 Jul;32(1):89-95.
|
||
doi: 10.1038/sj.bmt.1704073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12815483" target="_blank">12815483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11499984">Immune thrombocytopenia in the foetus and the newborn: diagnosis and therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaplan C</span><br />
|
||
<span class="medgenPMjournal">Transfus Clin Biol</span>
|
||
2001 Jun;8(3):311-4.
|
||
doi: 10.1016/s1246-7820(01)00114-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11499984" target="_blank">11499984</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7577635">Splenic irradiation for chronic autoimmune thrombocytopenic purpura in patients with contra-indications to splenectomy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caulier MT,
|
||
Darloy F,
|
||
Rose C,
|
||
Camier G,
|
||
Morel P,
|
||
Bauters F,
|
||
Fenaux P</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
1995 Sep;91(1):208-11.
|
||
doi: 10.1111/j.1365-2141.1995.tb05271.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7577635" target="_blank">7577635</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8003616">Autoimmune thrombocytopenic purpura in pregnancy: maternal risk factors predictive of neonatal thrombocytopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzucconi MG,
|
||
Petrelli V,
|
||
Gandolfo GM,
|
||
Carapella E,
|
||
Chistolini A,
|
||
Puorger CC,
|
||
De Sanctis V,
|
||
Paesano R,
|
||
Pachi A</span><br />
|
||
<span class="medgenPMjournal">Autoimmunity</span>
|
||
1993;16(3):209-14.
|
||
doi: 10.3109/08916939308993329.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8003616" target="_blank">8003616</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1690204">Autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bussel JB</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
1990 Feb;4(1):179-91.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1690204" target="_blank">1690204</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Autoimmune%20thrombocytopenic%20purpura%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (56)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21792043">Autoimmune thrombocytopenic purpura in partial DiGeorge syndrome: case presentation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hernández-Nieto L,
|
||
Yamazaki-Nakashimada MA,
|
||
Lieberman-Hernández E,
|
||
Espinosa-Padilla SE</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2011 Aug;33(6):465-6.
|
||
doi: 10.1097/MPH.0b013e31821b0915.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21792043" target="_blank">21792043</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7717380">High-dose methylprednisolone is an alternative treatment for adults with autoimmune thrombocytopenic purpura refractory to intravenous immunoglobulins and oral corticosteroids.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Godeau B,
|
||
Zini JM,
|
||
Schaeffer A,
|
||
Bierling P</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
1995 Apr;48(4):282-4.
|
||
doi: 10.1002/ajh.2830480416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7717380" target="_blank">7717380</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8342569">Dapsone for autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Godeau B,
|
||
Oksenhendler E,
|
||
Bierling P</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
1993 Sep;44(1):70-2.
|
||
doi: 10.1002/ajh.2830440117.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8342569" target="_blank">8342569</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8217808">CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lim SH,
|
||
Hale G,
|
||
Marcus RE,
|
||
Waldmann H,
|
||
Baglin TP</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
1993 Jul;84(3):542-4.
|
||
doi: 10.1111/j.1365-2141.1993.tb03117.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8217808" target="_blank">8217808</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3597777">Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ballem PJ,
|
||
Segal GM,
|
||
Stratton JR,
|
||
Gernsheimer T,
|
||
Adamson JW,
|
||
Slichter SJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
1987 Jul;80(1):33-40.
|
||
doi: 10.1172/JCI113060.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3597777" target="_blank">3597777</a><a href="/pmc/articles/PMC442198" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Autoimmune%20thrombocytopenic%20purpura%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (68)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0398650%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
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