385 lines
42 KiB
HTML
385 lines
42 KiB
HTML
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<meta name="title" property="og:title" content="Senior Investigator, Computational Biology Branch">
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<title>NLM Intramural Research Program - Ivan Ovcharenko, PhD</title>
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<meta name="DC.Date.Issued" content="2019-10-29" />
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<meta name="DC.Date.Modified" content="2024-09-20" />
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<h1 class="forstaffpages" style="opacity: 1;">Ivan Ovcharenko, PhD</h1>
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<h2>About</h2>
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<img src="/research/img/OvcharenkoIvan.jpg" alt="Picture of Ivan Ovcharenko, PhD"/>
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<h3>Ivan Ovcharenko, PhD</h3>
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Senior Investigator, Computational Biology Branch
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<p>The current research of the Ovcharenko group focuses on deciphering the semantics and studying the evolution of the gene regulatory code in eukaryotes. The group uses comparative genomics, statistics, and machine learning to understand the DNA sequence encoding of tissue-specific regulatory elements and the links between regulatory element sequence variation and disease. </p>
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<h3>Contact Information</h3>
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<p>Building 38A, 8600 Rockville Pike MSC 6075 Bethesda, MD 20894</p>
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<p>Tel: (301) 435-8944</p>
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<p><a href="mailto:ovcharen@nih.gov">ovcharen@nih.gov</a></p>
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<h2>Research Interests</h2>
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<p><iframe src="https://www.youtube.com/embed/xSFVtOI53aY" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" width="709" height="399" frameborder="0"></iframe><p>
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My group is interested in deciphering the “second language” of the human genome. The vast landscape of the human genome hosts elements that orchestrate the dynamics of proteins in every human cell, establishes cell identity, and safeguards the defense mechanisms. These elements, known as gene regulatory elements, are encrypted in a different genomic language known as the second language of genomes. As this second language of genomes remains largely unknown, we are working on developing novel artificial intelligence methods to understand the genomic encryption of gene regulatory elements and use it to map the location of these elements in the human genome.
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<h2>Publications</h2>
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<div class="ncbi-docsum">
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<span class="authors">
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Song W, Sharan R, Ovcharenko I.
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</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31514731/">
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The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance.
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</a><span class="source">Genome Biol</span>.
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<span class="pubdate">2019 Sep 12;</span><span class="volume">20</span><span class="issue">(1)</span><span class="pages">:197</span><span>. </span><span class="doi">doi: 10.1186/s13059-019-1808-y. </span><span class="pmid">PubMed PMID:
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31514731</span><span class="pmcid">; PubMed Central PMCID:
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PMC6739990</span><span>. </span>
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<span class="authors">
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Li S, Kvon EZ, Visel A, Pennacchio LA, Ovcharenko I.
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</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31307522/">
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Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation.
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</a><span class="source">Genome Biol</span>.
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<span class="pubdate">2019 Jul 15;</span><span class="volume">20</span><span class="issue">(1)</span><span class="pages">:140</span><span>. </span><span class="doi">doi: 10.1186/s13059-019-1750-z. </span><span class="pmid">PubMed PMID:
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31307522</span><span class="pmcid">; PubMed Central PMCID:
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PMC6631995</span><span>. </span>
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<span class="authors">
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Huang D, Petrykowska HM, Miller BF, Elnitski L, Ovcharenko I.
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</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30886051/">
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Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression.
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</a><span class="source">Genome Res</span>.
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<span class="pubdate">2019 Apr;</span><span class="volume">29</span><span class="issue">(4)</span><span class="pages">:657-667</span><span>. </span><span class="doi">doi: 10.1101/gr.247007.118. </span><span class="pubstatus">Epub 2019 Mar 18. </span><span class="pmid">PubMed PMID:
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30886051</span><span class="pmcid">; PubMed Central PMCID:
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PMC6442386</span><span>. </span>
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<div class="citation-wrap">
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<div class="ncbi-docsum">
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Song W, Ovcharenko I.
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</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30563465/">
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Dichotomy in redundant enhancers points to presence of initiators of gene regulation.
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</a><span class="source">BMC Genomics</span>.
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<span class="pubdate">2018 Dec 18;</span><span class="volume">19</span><span class="issue">(1)</span><span class="pages">:947</span><span>. </span><span class="doi">doi: 10.1186/s12864-018-5335-0. </span><span class="pmid">PubMed PMID:
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30563465</span><span class="pmcid">; PubMed Central PMCID:
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PMC6299655</span><span>. </span>
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<h3><a href="https://www.ncbi.nlm.nih.gov/myncbi/ivan.ovcharenko.1/bibliography/public/">More</a></h3>
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