259 lines
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NLM’s statistical methods research focuses on understanding the function and evolution of biological molecules, their involvement in the mechanisms of disease, and the experimental methods used to investigate them. This research studies DNA, protein molecules and the genomes of viruses, microbes, and higher organisms.
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<div class="image-wrapper"><a href="/research/researchstaff/AltschulStephenF.html"><img src="/research/img/AltschulStephen.jpg" alt="Image of Stephen Altschul, PhD" /></a>
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<h3><a href="/research/researchstaff/AltschulStephenF.html">Stephen Altschul, PhD</a></h3>
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Senior Investigator, Computational Biology Branch, NCBI</div>
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<div class="detail-wrapper"> <h4>Stephen Altschul, PhD</h4>
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<li>Investigating the automated construction of hierarchical multiple alignments and HMMs for elucidating protein subfamily functions and their sequence determinants</li>
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<li>Developing the LogOddsLogo program and website</li>
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<li>Integrating the hierarchical and direct-coupling formalisms for describing correlations among protein positions</li>
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<h3><a href="/research/researchstaff/YuYiKuo.html">Yi-Kuo Yu, PhD</a></h3>
|
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Senior Investigator, Computational Biology Branch</div>
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<div class="detail-wrapper"> <h4>Yi-Kuo Yu, PhD</h4>
|
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<ul>
|
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<li>Developing protein knowledge databases and mass spectrometry-based pathogen identification and metaproteomics methods</li>
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<li>Investigating green energy production using microbes</li>
|
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<li>Developing rigorous methods for understanding long-range molecular interactions</li></ul>
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</article>
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