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<p class="tableOfContents"><strong>Table of Contents: <a href="/pubs/techbull/so22/so22_issue_cover.html">2022 SEPTEMBER–OCTOBER No. 448</a></strong></p>
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<h1 class="articleH1">Updated PubMed E-utilities Launching on November 15, 2022</h1>
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<p class="tbyearmonth">Updated PubMed E-utilities Launching on November 15, 2022. NLM Tech Bull. 2022 Sep-Oct;(448):e4.</p>
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<div class="articleactions">2022 September 14 <span class="status">[posted]</span>
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<p>PubMed will be moving to an updated version of the <a href="https://www.ncbi.nlm.nih.gov/books/NBK25501/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=pubmed-api-delay-20220622">E-utilities API</a> on November 15, 2022. As previously announced, this updated version of E-utilities will use the same technology as the <a href="https://pubmed.ncbi.nlm.nih.gov/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link2">web version of PubMed</a> released in 2020. For example, search results returned by the updated <a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link3#chapter4.ESearch">ESearch E-utility</a> will now match those of the PubMed.gov website.<br /><br />This update only affects E-utility calls with &db=pubmed. There are no changes to the E-utilities for other databases. You can refer to our <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/10/05/updated-pubmed-api/">previous post</a> or watch our <a href="https://www.youtube.com/watch?v=aETx4MyXukk">recorded webinar</a> for more details on this update. <br /><br /><strong>Do I need to do anything to prepare? </strong></p>
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<ul>
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<li>If you manage code that creates PubMed E-utility requests, review the changes below to ensure that your code will continue to function after the update.</li>
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<li>Up until launch, you can also verify your code on the public test server, available through the following URL: https://eutilspreview.ncbi.nlm.nih.gov/entrez/eutils/. To use the test server, replace the standard E-Utilities URL (eutils.ncbi.nlm.nih.gov/entrez/eutils/) in your requests with the test URL.</li>
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</ul>
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<p><strong>What will happen to the current version of the PubMed E-utilities after the release on November 15, 2022?</strong><br /><br />The current E-utility URLs for PubMed (&db=pubmed) will continue to function after the E-utilities update is released, with only a few exceptions:</p>
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<ul>
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<li><a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link4#chapter4.ESearch"><strong>ESearch</strong></a> will only be able to access the first 10,000 records retrieved by the search query (&retmax <= 10,000; &retstart + &retmax <= 10,000).</li>
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<li><a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link5#chapter4.EPost"><strong>EPost</strong></a> will only be able to accept up to 10,000 PubMed IDs (PMIDs) in a single URL request.</li>
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<li><a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link6#chapter4.EFetch"><strong>EFetch</strong></a> will no longer support returns in ASN.1 format.</li>
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</ul>
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<p><strong>Will the output of PubMed E-utility calls be changing?</strong><br /><br />Again, in almost all cases, no. Here are the exceptions:</p>
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<ul>
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<li><a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link7#chapter4.ESearch"><strong>ESearch</strong></a> will now return exactly the same PMIDs that are currently returned by web PubMed.</li>
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<li><a href="https://www.ncbi.nlm.nih.gov/books/NBK25499/?utm_source=blog&utm_medium=referral&utm_campaign=pubmed-api&utm_term=post1&utm_content=20210929link8#chapter4.EFetch"><strong>EFetch</strong> </a>will now return XML data by default (&retmode is not set) rather than ASN.1. In other words, the default value of &retmode will become "xml."</li>
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</ul>
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<p><strong>How can I keep in touch?<br /><br /></strong>Please write to us at <a href="mailto:info@ncbi.nlm.nih.gov?subject=NCBI%20Insights%20PubMed%20API%2020210929">info@ncbi.nlm.nih.gov</a> if you have any questions or concerns.<strong><br /><br /></strong>You can also <a href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?topic_id=USNLMOCPL_44">follow the NCBI Insights Blog</a> and subscribe to the <a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/utilities-announce/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=pubmed-api-delay-20220622">E-Utilities Announcement Mailing List</a> for updates. </p>
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