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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p id="tagline">Transforming the understanding
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and treatment of mental illnesses.
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="m-0 text-small text-right d-none d-lg-block"><a href="/">Home</a> | <a href="/site-info/contact-nimh" data-entity-type="node" data-entity-uuid="3b82dd34-6040-4763-a9ff-db0c3d5b6a38" data-entity-substitution="canonical">Contact Us</a> | <a href="/health/find-help" data-entity-type="node" data-entity-uuid="95a25c22-6bc4-4ac3-ad7b-d3aca76eaed0" data-entity-substitution="canonical">Help for Mental Illnesses</a></p><div class="mobile-helper-icons"><span class="hidden-md hidden-lg"><i class="fas fa-search search_icon"></i></span> <span class="menu_icon sb-toggle-right hidden-md hidden-lg"><i class="fas fa-bars"></i></span></div><form class="search-in-banner" accept-charset="UTF-8" action="/search-nimh" id="search_form" method="get" name="Search" role="search"><p class="mt-2 mb-1"><label for="query"><span class="hidden">Search the NIMH Website: </span></label><input class="searchbox usagov-search-autocomplete ui-autocomplete-input" aria-label="Search the NIMH website" autocomplete="off" id="query" name="query" placeholder="Search the NIMH website" type="text"> <input type="submit" value="Search"></p></form><div class="hidden-xs hidden-sm"><p class="small text-right m-0"><a href="/health/topics/espanol" data-entity-type="node" data-entity-uuid="d6df42f3-6876-496e-918c-cc34cc7681f7" data-entity-substitution="canonical" lang="es">Información en español</a></p></div></div>
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<h2>Health Topics</h2>
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<p>NIMH offers expert-reviewed information on mental disorders and a range of topics.</p>
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<p>NIMH statistics pages include statistics on the prevalence, treatment, and costs of mental illness for the population of the United States.</p>
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<p>Download, read, and order free NIMH brochures and fact sheets about mental disorders and related topics.</p>
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<h2>Help for Mental Illnesses</h2>
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<p>If you or someone you know has a mental illness, there are ways to get help. Use these resources to find help for yourself, a friend, or a family member.</p>
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<h2>Clinical Trials</h2>
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<p>If you or a friend or family member are thinking about taking part in clinical research, this page contains basic information about clinical trials.</p>
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<h2>Stakeholder Engagement</h2>
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<p>Find out how NIMH engages a range of stakeholder organizations as part of its efforts to ensure the greatest public health impact of the research we support.</p>
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<h2>Connect with NIMH</h2>
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<p>Learn more about NIMH newsletters, public participation in grant reviews, research funding, clinical trials, the NIMH Gift Fund, and connecting with NIMH on social media. </p>
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<h2>Digital Shareables</h2>
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<p>Use these free education and outreach materials in your community and on social media to spread the word about mental health and related topics.</p>
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<a class="megamenu_nav_i" href="/get-involved/science-education">
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<h2>Science Education</h2>
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<p>Use these free digital, outreach materials in your community and on social media to spread the word about mental health.</p>
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</a>
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<h2>Upcoming Observances and Related Events</h2>
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<p>Get Involved observances calendar</p>
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<h2>Research Funded by NIMH</h2>
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<p>NIMH supports research at universities, medical centers, and other institutions via grants, contracts, and cooperative agreements. Learn more about NIMH research areas, policies, resources, and initiatives.</p>
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<h2>Research Conducted at NIMH (Intramural Research Program)</h2>
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<p>The Division of Intramural Research Programs (IRP) is the internal research division of the NIMH. Over 40 research groups conduct basic neuroscience research and clinical investigations of mental illnesses, brain function, and behavior at the NIH campus in Bethesda, Maryland. Learn more about research conducted at NIMH.</p>
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<a class="megamenu_nav_i" href="/research/priority-research-areas">
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<h2>Priority Research Areas</h2>
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<p>Learn about NIMH priority areas for research and funding that have the potential to improve mental health care over the short, medium, and long term.</p>
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<h2>Resources for Researchers</h2>
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<p>Information about resources such as data, tissue, model organisms and imaging resources to support the NIMH research community.</p>
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<h2>Opportunities & Announcements</h2>
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<p>Find all NIMH and cross-NIH funding opportunities.</p>
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<a class="megamenu_nav_i" href="/funding/funding-strategy-for-research-grants">
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<h2>Funding Strategy for Grants</h2>
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<p>Read more about the NIMH Strategic Plan for Research, Strategic Research Priorities, the anatomy of NIMH funding, and our yearly funding strategy for research grants.</p>
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<a class="megamenu_nav_i" href="/funding/grant-writing-and-application-process">
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<h2>Application Process</h2>
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<p>Explore the NIMH grant application process, including how to write your grant, how to submit your grant, and how the review process works.</p>
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<a class="megamenu_nav_i" href="/funding/managing-your-grant">
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<h2>Managing Grants</h2>
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<p>Learn about how NIMH manages research grants, including policies and reporting requirements.</p>
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<div class="menu_inner">
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<a class="megamenu_nav_i" href="/funding/clinical-research">
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<h2>Clinical Research</h2>
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<p>Find the latest NIH and NIMH policies, guidance, and resources for clinical research.</p>
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<div class="menu_flexbox_span3">
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<a class="megamenu_nav_i" href="/funding/training">
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<h2>Training</h2>
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<p>Explore NIMH research training and career development opportunities.</p>
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<div class="menu_inner">
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<a class="megamenu_nav_i" href="/funding/sbir">
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<h2>Small Business Research</h2>
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<p>Learn about funding opportunities for small businesses.</p>
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<h3>Quick Links</h3>
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<p><a href="/funding/opportunities-announcements/funding-grant-news">Funding & Grant News</a></p>
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<p><a href="/funding/opportunities-announcements/clinical-trials-foas">Support for Clinical Trials at NIMH</a></p>
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<h1 class="splashBanner__title" >Grant Writing Assistance</h1>
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<p><strong>Principal Investigator:</strong><br> The Principal Investigator (PI) is responsible for the scientific conduct of the work and usually prepares the grant application. Projects may have one or more scientists designated as Co-Principal Investigators (Co-PIs), but NIH does not formally recognize Co-PIs. NIH does not award grants directly to individuals; grants are awarded to institutions that are responsible for the administration, especially the financial aspects, of the grant award. Grant applications must be approved and signed by a responsible institutional official. See <a href="http://grants2.nih.gov/grants/multi_pi/" rel="external">Multiple PI Information Update <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a> for further information on applications with multiple PIs.</p>
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<p>There are no guarantees for successful funding of your application, but the following material should prove helpful as you prepare your application. While this information is applicable to preparing grant applications in general, it is written specifically with preparation of an R01 application in mind. Be sure to read the Review Criteria found in Step 3 for further guidance. For help with applications that are under training mechanisms, please see <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="85516581-f4ab-423d-8641-4eb5814e9f0c" href="/funding/training">Research Training, Career Development and Related Programs</a></p>
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<p>Most grant applications are reviewed according to five major criteria: significance, approach, innovation, investigator, and environment. Addressing each of these elements adequately is fundamental to writing a successful application. For more information on the criteria see <a href="https://public.csr.nih.gov/ForApplicants" rel="external">Center for Scientific Review (CSR) Advice to Investigators <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>. Aspects of the grant application are:</p>
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<ol>
|
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<li>Essentials
|
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<ul>
|
||
<li>Significance,</li>
|
||
<li>Sound hypotheses,</li>
|
||
<li>Productivity and demonstration of feasibility - high quality results and figures,</li>
|
||
<li>Logical development of experimental design,</li>
|
||
<li>Can you do everything you propose to do in the time requested; "overly ambitious" is one of the most common criticisms of new investigators,</li>
|
||
<li>Clear writing; an overview and tips can be found by visiting <a href="http://grants.nih.gov/grants/plain_language.htm" rel="external">Communicating Research Intent and Value <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>,</li>
|
||
<li>Plan ahead and don't rush - give yourself 2-3 months to prepare the grant application.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Specific aims
|
||
<ul>
|
||
<li>Do the aims address interesting and significant issues?</li>
|
||
<li>Are they hypothesis-based?</li>
|
||
<li>Are they "win-win" - will an outcome consistent with the null hypothesis still be a contribution to the field?</li>
|
||
<li>Arrange with colleagues or mentors to review a first draft of your specific aims early (6 weeks or so) just to make sure you are on the mark.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Background
|
||
<ul>
|
||
<li>Clear, well organized - use subheadings where possible; make sure the significance of the topic is explicitly stated,</li>
|
||
<li>State clearly where the gaps in knowledge exist in the field that your results will address,</li>
|
||
<li>Make sure your references reflect an updated knowledge of the field.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Preliminary results
|
||
<ul>
|
||
<li>Draw as much as possible on your past productivity; emphasize how your previous work leads up to the present proposal or at least demonstrates feasibility of methods to be used,</li>
|
||
<li>Do not show preliminary results that are not of high quality - this is your chance to represent yourself,</li>
|
||
<li>Make sure that the major methods to be used in the proposed work are reflected by preliminary results; if you do not have expertise or preliminary results with a technique, make sure you list a solid, experienced consultant or collaborator and include a letter agreeing to the collaboration, and specifically stating just what the collaborator will contribute,</li>
|
||
<li>Show detailed numbers and representative raw data where necessary, especially if this is work that is unpublished,</li>
|
||
<li>Put time and effort into preparing meticulous figures, graphs, or tables; this is your chance to demonstrate rigor and organization that will increase the reviewer's confidence that you can carry out the project.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Experimental design
|
||
<ul>
|
||
<li>This is one of the most common places where the text is insufficient; this is not just a place to list group sizes, detailed methods, etc., this is the place to demonstrate your ability to think knowledgeably and logically,</li>
|
||
<li>Develop your aims; of all the sections this may well be the part of the grant application upon which you spend the most time,</li>
|
||
<li>What happens if your first specific aim doesn't work out as you have predicted? Will aims 2, 3, and 4 then be rendered useless? Where do you go if the first step fails? Have multiple working hypotheses.</li>
|
||
<li>One method that often works is to divide this section into subheadings after each specific aim is restated, as follows:
|
||
<ul>
|
||
<li>Specific Aim #
|
||
<ul>
|
||
<li>Rationale: How does this design relate to your hypotheses? What is your reasoning (in detail)?</li>
|
||
<li>Methods: List general approaches first, explaining why the methods you propose are the best available for your questions. (Caveat: if you realize that you do not have the best, most direct methods for your questions, you need to rethink your aims or incorporate collaborators or new preliminary data showing feasibility with the necessary techniques.) -Don't forget to address statistical analysis.</li>
|
||
<li>Anticipated results: You need to show that a great deal of thought has gone into predicting potential outcomes and their likelihood. Explain how you will interpret the different outcome scenarios and how these results relate back to your hypotheses. This is an opportunity to demonstrate creativity and enthusiasm for the data to be obtained, and show that they will be competently addressed.</li>
|
||
<li>Problems and pitfalls: All experiments have pitfalls, but extraordinarily large pitfalls are likely to be unreasonable; hence, this section should serve as a reality test. Explain the pitfalls, and how alternate approaches will be used to overcome them if they occur. Do not think that avoiding mentioning a pitfall is a good strategy-it usually doesn't work. The reviewer will very likely notice the pitfall and believe that you are not aware of it, decreasing confidence in your ability to manage the data.</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li>Timetable
|
||
<ul>
|
||
<li>Charting out who will do what, by whom, can provide a helpful reality check; this does not need to take up an inordinate amount of space,</li>
|
||
<li>Remember, this is a required element of the grant application, and the reviewers will use it to gauge your commitment, time resources, and planning ability.</li>
|
||
</ul>
|
||
</li>
|
||
<li>Budget
|
||
<ul>
|
||
<li>For <a href="http://grants.nih.gov/grants/policy/nihgps_2013/nihgps_ch13.htm#_Toc271265241" rel="external">modular budgets <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>:</li>
|
||
<li>A budget of $250,000 or less in direct costs should be submitted in modules (or increments) of $25,000.</li>
|
||
<li>A typical modular budget will have the same number of modules in each year. If they are not the same, an additional narrative budget justification should be provided.</li>
|
||
<li>Consortium/contractual costs should be estimated based on total costs and rounded to the nearest $1,000 and must be included in the overall requested modular direct cost amount.
|
||
<h3><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d581e16f-fa7b-4ee1-ac20-084085283e5b" href="/funding/grant-writing-and-application-process/step-2-applying-for-funding">Back to Step 2</a></h3>
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</li>
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