nih-gov/www.nibib.nih.gov/labs-at-nibib/ideas-lab/projects/virtual-reality-system-study-neural-processes-underlying-self-agency

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<meta name="description" content="An IDEAS project to develop a virtual reality system for studying neural processes in aging." />
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<title>Virtual Reality System for the Study of Neural Processes Underlying Self-Agency | National Institute of Biomedical Imaging and Bioengineering</title>
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<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/labs-at-nibib/ideas-lab/projects/virtual-reality-system-study-neural-processes-underlying-self-agency" data-a2a-title="Virtual Reality System for the Study of Neural Processes Underlying Self-Agency"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
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<span>Virtual Reality System for the Study of Neural Processes Underlying Self-Agency</span>
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<article data-history-node-id="136421" about="/labs-at-nibib/ideas-lab/projects/virtual-reality-system-study-neural-processes-underlying-self-agency" class="ideas-projects node--ideas-projects node--type-ideas-projects">
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<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Mark Hallett, M.D.</span></div>
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Human Motor Control Section, Medical Neurology Branch, NINDS</div>
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<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Fatta Nahab, M.D.</span></div>
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Human Motor Control Section, Medical Neurology Branch, NINDS</div>
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<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Suk Yun Kang, M.D., Ph.D.</span></div>
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Human Motor Control Section, Medical Neurology Branch, NINDS</div>
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>For voluntary motor control to occur, normal individuals must have a sense of ownership over the effector (i.e. their hand in a voluntary grasp), and a sense of agency (i.e. the hand movement was initiated by them). In cases such as orticobasal degeneration, alien limb syndrome, and various other psychogenic movement disorders, patients experience various movements which they judge to be involuntary, or performed by an outside agent (referred to as passivity phenomenon in the setting of schizophrenia and manifests as auditory or visual hallucinations). Such pathologic conditions are hypothesized to occur due to an impaired sense of agency (SA). Our collaborators in NINDS initiated a study to identify the underlying network for self-agency by altering a normal subject's sense of control or agency with the use of a virtual reality device (Cyberglove, Immersion Corp) in the fMRI environment. While wearing the Cyberglove and undergoing fMRI scans, the subject would touch their fingers together while watching the virtual hand on a computer monitor. The virtual hand movements would be modified by varying degrees such that the virtual hand motions do not match the actual hand motions, thus modulating the subjects sense of self-agency.</p>
<p>However, the MRI environment induces significant noise on the electronics of the virtual reality glove system, causing the virtual hand to display constant tremors and unnatural finger motions. These anomalies in the displayed virtual hand needed to be eliminated to help ensure the subjects sense of agency was maintained, especially when viewing the unmodified (i.e., subjects actual finger position or motion) virtual hand. &nbsp;SPIS engineers evaluated the noise and developed signal processing algorithms to remove the MRI-induced noise allowing the virtual hand to more accurately reflect actual hand motions or display realistic modified hand motions. In addition, SPIS engineers developed the software to modulate the virtual hand motions per the needs of the researchers. The success of the fMRI study led to a follow-up study by another NINDS researcher which used EEG in place of fMRI.</p>
<p>&nbsp;</p>
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<img alt="Example of the modulated motion vs actual motion for a single sensor" data-entity-type="file" data-entity-uuid="24234a2e-f728-4ead-8432-a72bbdd4bb4e" src="/sites/default/files/inline-images/Virtual1.png" width="875" height="574" loading="lazy">
<figcaption>Demonstration of virtual reality paradigm showing the joint angle data from one of 18 total sensors while the subject performs the sequential finger movements. The level of SA is modulated based on the relative contribution of the subjects actual data with a prerecorded set of movements to produce the rendered model hand displayed to the subject. Note the actual paradigm performs these modulations on all 18 sensors simultaneously.</figcaption>
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<div class="field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536203/">Brain Networks Responsible for Sense of Agency: An EEG Study</a></p>
<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557977/">Correction: Brain Networks Responsible for Sense of Agency: An EEG Study</a></p>
<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000563/">The neural processes underlying self-agency</a></p>
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<div class="field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p>Non-Disclosure Agreement: Signed with Immersion Corp</p>
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