2376 lines
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|
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<article data-history-node-id="136371" about="/labs-at-nibib/ideas-lab/projects/prime-physiological-recording-mri-environment" class="ideas-projects node--ideas-projects node--type-ideas-projects">
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||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Robert Lederman, M.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
||
</div>
|
||
</span>
|
||
<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
|
||
|
||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Anthony Faranesh, Ph.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
||
</div>
|
||
</span>
|
||
<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
|
||
|
||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Daniel Herzka, Ph.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
||
</div>
|
||
</span>
|
||
<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
|
||
|
||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Kanishka Ratnayaka, M.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
||
</div>
|
||
</span>
|
||
<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
|
||
|
||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Toby Rogers, M.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
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</div>
|
||
</span>
|
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<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
|
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|
||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Adrienne Campbell, Ph.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Cardiovascular Intervention Program, NHLBI</div>
|
||
|
||
</div>
|
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</span>
|
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<span class="grid-col flex-auto"> <div class="paragraph paragraph--type--collaborators paragraph--view-mode--default">
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||
|
||
<div class="field field--name-field-collaborator field--type-link field--label-hidden field__item"><span>Josh Kanter, M.D.</span></div>
|
||
|
||
|
||
<div class="field field--name-field-institution field--type-string field--label-hidden field__item">Interventional Pediatric Cardiology, Children's National Medical Center</div>
|
||
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|
||
|
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|
||
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|
||
<div class="ideas-project-section-title">
|
||
<h2>Project Brief</h2>
|
||
</div>
|
||
|
||
|
||
<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A multidisciplinary intramural team led by CIT in collaboration with the NHLBI Cardiovascular Intervention Program developed and implemented a fundamental electronics and signal processing tool facilitating MRI catheterization procedure innovation. As an alternative to surgical techniques in the treatment of cardiovascular disease, NHLBI is developing innovative techniques in cardiovascular catheterization with the use of real-time MRI. The use of MRI greatly reduces the patient’s exposure to ionizing radiation from X-ray imaging, which is typically used in catheterization procedures. During these procedures, the cardiology staff must continuously monitor the patient’s physiological signals (i.e., ECG and IBP (invasive blood pressure)) for both patient safety and diagnostic purposes. Due to the lack of commercial solutions, SPIS staff developed a high fidelity physiological signal recording system that operates in the hostile (e.g., electromagnetic interference) environment of MRI, which allows physicians to safely navigate catheters through the heart using MRI. The Physiological Recording in MRI Environment (PRiME) system includes custom electronics which are resilient to MRI-induced noise (e.g., filtering, digitization, data transmission, fabrication methods tailored to mitigate the effects of a noise-rich environment), an adaptive filter software algorithm which removes additional noise, and an interface to a commercial hemodynamic recording system which allows the cardiology staff to use their existing workflow. In a license-free form, SPIS is <a href="https://nhlbi-mr.github.io/PRiME/">publicly disseminating</a> the PRiME system design documents for other research hospitals to duplicate the PRiME system, allowing more research groups to contribute to the field of MRI-guided cardiovascular interventions. With NHLBI, SPIS deployed the PRiME system to the Children’s National Medical Center in Washington, D.C., where it has been successfully used in over 40 pediatric procedures. Within NHLBI at the NIH Clinical Center, the PRiME system has been used in over a half dozen adult procedures and numerous animal experiments.</p>
|
||
<p> </p>
|
||
|
||
<figure role="group" class="align-center">
|
||
<img alt="Workflow of the PRiME system." data-entity-type="file" data-entity-uuid="4ac3c872-e20d-4193-8341-98ba9617e874" height="546" src="/sites/default/files/inline-images/PRiME1.png" width="757" loading="lazy">
|
||
<figcaption>Workflow of the PRiME system. The patient is first prepared in the X-Ray room, including the initial insertion of the catheter, which requires some minor X-ray imaging. The patient may require additional procedures, which cannot be performed in the MRI room. These procedures, and associated X-ray imaging, may take place before or after the MRI-guided catheterization procedures. Once the patient is placed in the MRI bore, the ECG will change to varying degrees due to the MRI magnet effects on the blood flow (known as hemodynamic effects). Once real-time MRI imaging starts (to help the cardiologist guide the catheter to various parts of the heart), the MRI system will induce further noise on the ECG signals. The PRiME system, under the control of a PC in the control room, can significantly reduce this MRI-induced noise, allowing the cardiologist to clearly see important features of the ECG signal. All signals collected are sent to an existing medical record system, which allows the staff to use their normal interventional workflow.</figcaption>
|
||
</figure>
|
||
<p> </p>
|
||
|
||
<figure role="group" class="align-center">
|
||
<img alt="Example of printed circuit boards designed by IDEAS" data-entity-type="file" data-entity-uuid="558c6fc8-04cf-40df-8e16-7feadd1d8d5c" src="/sites/default/files/inline-images/PRiME2.png" width="523" height="304" loading="lazy">
|
||
<figcaption>The printed circuit boards within the Physiological Signal Acquisition module of the PRiME system. Each of the submodules labeled in the figure can be easily removed for debugging or upgrading.</figcaption>
|
||
</figure>
|
||
<p> </p>
|
||
|
||
<figure role="group" class="align-center">
|
||
<img alt="Application software developed by IDEAS" data-entity-type="file" data-entity-uuid="7f06dcb0-abd6-4762-9b74-9f1ed1fc43e2" height="451" src="/sites/default/files/inline-images/PRiME3.png" width="759" loading="lazy">
|
||
<figcaption>Screenshot of the PRiME application software which was developed in LabView. The application provides the user control of the adaptive filtering parameters, as well as various displays and controls for system troubleshooting.</figcaption>
|
||
</figure>
|
||
<p> </p>
|
||
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<div class="field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849467/">Physiological Recording in the MRI Environment (PRiME): MRI-compatible hemodynamic recording system</a></p>
|
||
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<div class="field field--name-field-card-text field--type-text-long field--label-hidden field__item"><ul>
|
||
<li>Public Distribution of <a href="https://github.com/NHLBI-MR/PRiME">Design Files</a> on GitHub</li>
|
||
<li>System duplication and deployment to Children’s National Medical Center, Washington D.C.</li>
|
||
<li>System duplication and deployment to Children’s Health, Dallas, TX</li>
|
||
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<div class="field field--name-field-card-title field--type-string field--label-hidden field__item">Awards</div>
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<div class="field field--name-field-card-text field--type-text-long field--label-hidden field__item"><ul>
|
||
<li>2016 NIH Director’s Award: The Development of Physiological Recording in MRI Environment (PRiME) for the Implementation of Radiation-Free MRI-Guided Right Heart Catheterization</li>
|
||
<li>2015 NHLBI Director's Award: Outstanding Clinical Research Award For the Implementation of Radiation -Free, MRI-Guided Right Heart Catheterization in Pediatric Patients</li>
|
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