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<p><a id="headshot" href="/core/assets/cbb/images/hth.jpg"><img src="/core/assets/cbb/images/hth_sm.jpg" alt="A small version of the helix-turn-helix domain" /></a>
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<strong>Contact Information</strong><br />
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Building 38A, Room 5N503<br />
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8600 Rockville Pike<br />
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MSC 6075<br />
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Bethesda, MD 20894-6075<br />
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Tel: 301-594-2445<br />
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Fax: 301-435-7794 or 301-480-9241<br />
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<a href="mailto:aravind@ncbi.nlm.nih.gov">aravind@ncbi.nlm.nih.gov</a></p>
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<p>This is the official webpage of L. Aravind. Any other webpage, blog (other than one linked below), social networking page claiming to belong to or represent L. Aravind/Aravind L. Iyer or his views or opinions is either some other person or the work of imposters. L. Aravind is also not associated with any other email address than the one provided here.</p>
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</section>
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<div id="ncbi-content-block-main">
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<h1 id="l-aravind-phd">L. Aravind, PhD</h1>
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<p>Computational Biology Branch<br />
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<a href="/">NCBI</a>, <a href="https://www.nlm.nih.gov/">NLM</a>, <a href="https://www.nih.gov/">NIH</a></p>
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<h2 id="research-interests">Research Interests</h2>
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<ul>
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<li>Evolutionary classification of proteins.</li>
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<li>Understanding large-scale evolutionary trends in genome evolution.</li>
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<li>Reconstruction of functional networks of regulatory proteins and metabolic enzyme pathways from genome sequence.</li>
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<li>Prediction of novel biochemical activities and biological functions of proteins, and inference of organismal biology from comparative sequence and genome analysis.</li>
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<li>Understanding the fundamental interactions between natural selection and structural/genomic constraints in shaping protein domain diversity.</li>
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</ul>
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<h2 id="announcements">Announcements</h2>
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<ul>
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<li><a href="http://jivarahasya.blogspot.com/">Latest research highlights from our group</a></li>
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</ul>
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<h2 id="publications">Publications</h2>
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<ul>
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<li>Publications appearing in <a href="/pubmed/?term=aravind+l%5Bau%5D"><span class="SpellE">Entrez.</span></a> My current <a href="http://scholar.google.com/citations?user=aS_TLX4AAAAJ&hl=en">h-index</a>. To learn more about the h-index see this <a href="http://www.pnas.org/cgi/content/abstract/102/46/16569">paper</a></li>
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<li>Reprints available for certain publications in <a href="/pmc/?term=aravind+l%5Bau%5D">PDF format</a>.</li>
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<li><a href="/CBBresearch/Lakshmin/supplementary_material.html">Supplementary material for previously published papers</a>.</li>
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</ul>
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<h2 id="brief-biography">Brief Biography</h2>
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<ul>
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<li><a href="/CBBresearch/Aravind/CV_aravind_official.htm">My official CV</a></li>
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</ul>
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<p>I obtained a Masters Degree in Biotechnology from the University of Pune and subsequently moved to Texas A & M University, USA, for my doctoral studies in computational and evolutionary biology. I conducted most of my doctoral research at the National Center for Biotechnology Information/NIH, Maryland and graduated with a Doctorate in Biology from TAMU in December 1999. Currently, I work at the National Center for Biotechnology as a Principal Investigator, and with my group study a variety of problems related to protein-superfamily- and genome- evolution. My research group comprises of two post-doctoral fellows, two Staff Scientists and one graduate student. My most important scientific achievements include:</p>
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<ol>
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<li>Establishment of the deep events in the evolution of topoisomerases and primases, the DNA repair system and diverse DNA binding proteins.</li>
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<li>Discovery of new domains involved in small molecule binding and elucidation of the evolutionary principles that determine their architectures.</li>
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<li>The first quantitative estimates of the role of horizontal gene transfer in evolution.</li>
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<li>Identification of the principal evolutionary events that determined the origin of multicellularity in eukaryotes.</li>
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<li>Reconstruction of the earliest events that occurred close to the origin of the protein universe.</li>
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<li>Establishment of the role of lineage specific gene expansions in the emergence of biological diversity.</li>
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<li>Determination of the principal evolutionary events involved in the emergence of specialized Apicomplexan parasites from a generalized parasitic common ancestor.</li>
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<li>Elucidating origins of the eukaryotic nonsense mediated RNA degradation system.</li>
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<li>Elucidating origins of the ubiquitin conjugation system.</li>
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</ol>
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<h2 id="select-recent-publications">Select Recent Publications</h2>
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<ul>
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<li>Iyer LM, Zhang D, Rogozin IB, Aravind L. <a href="/pubmed/21890906">Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems.</a> Nucleic Acids Res 2011 Sep 3. PMID:21890906.</li>
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<li>Oakley MS, Gerald N, McCutchan TF, Aravind L, Kumar S. <a href="/pubmed/21795115">Clinical and molecular aspects of malaria fever.</a> Trends Parasitol. 2011 Jul 25. [Epub ahead of print] PubMed PMID: 21795115.</li>
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<li>Nguitragool W, Bokhari AA, Pillai AD, Rayavara K, Sharma P, Turpin B, Aravind L, Desai SA. <a href="/pubmed/21620134">Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells.</a> Cell. 2011 May 27;145(5):665-77. PubMed PMID: 21620134; PubMed Central PMCID: <a href="/pmc/articles/PMC3105333/">PMC3105333</a>.</li>
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<li>Iyer LM, Abhiman S, Aravind L. <a href="/pubmed/21507349">Natural history of eukaryotic DNA methylation systems.</a> Prog Mol Biol Transl Sci. 2011;101:25-104. PubMed PMID: 21507349.</li>
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<li>Aravind L, Abhiman S, Iyer LM. <a href="/pubmed/21507350">Natural history of the eukaryotic chromatin protein methylation system.</a> Prog Mol Biol Transl Sci. 2011;101:105-76. PubMed PMID: 21507350.</li>
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<li>Burroughs AM, Iyer LM, Aravind L. <a href="/pubmed/21547297">Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system.</a> Mol Biosyst. 2011 Jul;7(7):2261-77. Epub 2011 May 6. PubMed PMID: 21547297.</li>
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<li>Zhang D, Iyer LM, Aravind L. <a href="/pubmed/21306995">A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.</a> Nucleic Acids Res. 2011 Jun;39(11):4532-52. Epub 2011 Feb 8. PubMed PMID: 21306995; PubMed Central PMCID: <a href="/pmc/articles/PMC3113570/">PMC3113570</a>.</li>
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<li>Anantharaman V, Abhiman S, de Souza RF, Aravind L. <a href="/pubmed/21182906">Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system.</a> Gene. 2011 Apr 15;475(2):63-78. Epub 2010 Dec 20. PubMed PMID: 21182906.</li>
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<li>Zhang D, Aravind L. <a href="/pubmed/20713135">Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.</a> Gene. 2010 Dec 1;469(1-2):18-30. Epub 2010 Aug 14. PubMed PMID: 20713135; PubMed Central PMCID: <a href="/pmc/articles/PMC2965036/">PMC2965036</a>.</li>
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<li>Aravind L, de Souza RF, Iyer LM. <a href="/pubmed/20678224">Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis.</a> Biol Direct. 2010 Aug 2;5:48. PubMed PMID: 20678224; PubMed Central PMCID: <a href="/pmc/articles/PMC2922099/">PMC2922099</a>.</li>
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<li>Venancio TM, Balaji S, Geetha S, Aravind L. <a href="/pubmed/20517567">Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions.</a> Mol Biosyst. 2010 Aug;6(8):1475-91. Epub 2010 Jun 2. PubMed PMID: 20517567.</li>
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<li>Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. <a href="/pubmed/19372391">Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.</a> Science. 2009 May 15;324(5929):930-5. Epub 2009 Apr 16. PubMed PMID: 19372391; PubMed Central PMCID: <a href="/pmc/articles/PMC2715015/">PMC2715015</a>.</li>
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<li>Iyer LM, Tahiliani M, Rao A, Aravind L. <a href="/pubmed/19411852">Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids.</a> Cell Cycle. 2009 Jun 1;8(11):1698-710. Epub 2009 Jun 27. PubMed PMID: 19411852; PubMed Central PMCID: <a href="/pmc/articles/PMC2995806/">PMC2995806</a>.</li>
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<li>de Souza RF, Iyer LM, Aravind L. <a href="/pubmed/19878744">Diversity and evolution of chromatin proteins encoded by DNA viruses.</a> Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):302-18. Epub 2009 Oct 28. Review. PubMed PMID: 19878744.</li>
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<li>Burroughs AM, Iyer LM, Aravind L. <a href="/pubmed/19089947">Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation.</a> Proteins. 2009 Jun;75(4):895-910. PubMed PMID: 19089947; PubMed Central PMCID: <a href="/pmc/articles/PMC2732565/">PMC2732565</a>.</li>
|
|
<li>Balaji S, Iyer LM, Aravind L. <a href="/pubmed/19225618">HPC2 and ubinuclein define a novel family of histone chaperones conserved throughout eukaryotes.</a> Mol Biosyst. 2009 Mar;5(3):269-75. Epub 2009 Jan 21. PubMed PMID: 19225618.</li>
|
|
<li>Burroughs AM, Iyer LM, Aravind L. <a href="/pubmed/18753784">Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems.</a> Genome Dyn. 2007;3:48-65. Review. PubMed PMID: 18753784.</li>
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<li>Burroughs AM, Balaji S, Iyer LM, Aravind L. <a href="/pubmed/17605815">Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold.</a> Biol Direct. 2007 Jul 2;2:18. PubMed PMID: 17605815; PubMed Central PMCID: <a href="/pmc/articles/PMC1949818/">PMC1949818</a>.</li>
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<li>Anantharaman V, Balaji S, Aravind L. <a href="/pubmed/16953892">The signaling helix: a common functional theme in diverse signaling proteins.</a> Biol Direct. 2006 Sep 5;1:25. PubMed PMID: 16953892; PubMed Central PMCID: <a href="/pmc/articles/PMC1592074/">PMC1592074</a>.</li>
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</ul>
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<h2 id="research-group">Research Group</h2>
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<ul>
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<li><a href="mailto:ananthar@ncbi.nlm.nih.gov">Vivek Anantharaman</a></li>
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<li><a href="mailto:desouza@ncbi.nlm.nih.gov">Robson de Souza</a></li>
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<li><a href="/CBBresearch/Lakshmin/">Lakshminarayan Iyer</a></li>
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<li><a href="/research/staff/zhangd3">Dapeng Zhang</a></li>
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