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Updated: February, 2025
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<span class="headername">Database of Clusters of Orthologous Genes (COGs)</span>
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J - Translation, ribosomal structure and biogenesis</a>
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D - Cell cycle control, cell division, chromosome partitioning</a>
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Y - Nuclear structure</a>
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V - Defense mechanisms</a>
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T - Signal transduction mechanisms</a>
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M - Cell wall/membrane/envelope biogenesis</a>
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N - Cell motility</a>
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C - Energy production and conversion</a>
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E - Amino acid transport and metabolism</a>
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F - Nucleotide transport and metabolism</a>
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I - Lipid transport and metabolism</a>
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<h1>V<span style='font-weight: 100'> - Defense mechanisms</span></h1>
<div style="float: right; clear: both;margin-top: -53px;">
<a class="usa-button" href="#" onclick="download_table_as_tsv('cog_result_table');">Download</a>
</div>
<h2>Stats</h2>
<div style="width: 60%">
<div class="ui-ncbigrid-outer-div organism_cog_table">
<div class="ui-ncbigrid-inner-div">
<table data-jig="ncbigrid">
<thead>
<tr>
<th>COG<br>definitions</th>
<th>Organims</th>
<th>Proteins</th>
<th>Median Protein<br>Length</th>
<th>Genes</th>
</tr>
</thead>
<tbody>
<tr>
<td>194</td>
<td>2,290</td>
<td>215,539</td>
<td>323.0</td>
<td>171</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="ui-ncbigrid-outer-div" style="font-size: 80%;">
<div class="ui-ncbigrid-inner-div">
<table id="cog_result_table" data-jig="ncbigrid">
<thead>
<tr>
<th>Organism</th>
<th>Protein</th>
<th>COG</th>
<th>Cat</th>
<th>Annotation</th>
</tr>
</thead>
<tbody>
<tr>
<td>2016</td>
<td>6301</td>
<td><a href="/research/cog/cog/COG0251/">COG0251</a></td>
<td>
V
</td>
<td>Enamine deaminase RidA/Endoribonuclease Rid7C, YjgF/YER057c/UK114 family</td>
</tr>
<tr>
<td>1543</td>
<td>3537</td>
<td><a href="/research/cog/cog/COG0286/">COG0286</a></td>
<td>
V
</td>
<td>Type I restriction-modification system, DNA methylase subunit</td>
</tr>
<tr>
<td>1209</td>
<td>3101</td>
<td><a href="/research/cog/cog/COG0312/">COG0312</a></td>
<td>
V
O
</td>
<td>Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family</td>
</tr>
<tr>
<td>1133</td>
<td>1522</td>
<td><a href="/research/cog/cog/COG0386/">COG0386</a></td>
<td>
V
I
</td>
<td>Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides</td>
</tr>
<tr>
<td>2043</td>
<td>6339</td>
<td><a href="/research/cog/cog/COG0388/">COG0388</a></td>
<td>
V
</td>
<td>Nitrilase/amidase YafV/Nit2, hydrolyzes deaminated glutathione</td>
</tr>
<tr>
<td>1665</td>
<td>2528</td>
<td><a href="/research/cog/cog/COG0450/">COG0450</a></td>
<td>
V
</td>
<td>Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)</td>
</tr>
<tr>
<td>2021</td>
<td>5714</td>
<td><a href="/research/cog/cog/COG0494/">COG0494</a></td>
<td>
V
</td>
<td>8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family</td>
</tr>
<tr>
<td>1860</td>
<td>6458</td>
<td><a href="/research/cog/cog/COG0534/">COG0534</a></td>
<td>
V
</td>
<td>Na+-driven multidrug efflux pump, DinF/NorM/MATE family</td>
</tr>
<tr>
<td>1662</td>
<td>6238</td>
<td><a href="/research/cog/cog/COG0577/">COG0577</a></td>
<td>
V
</td>
<td>ABC-type antimicrobial peptide transport system, permease component</td>
</tr>
<tr>
<td>1064</td>
<td>1626</td>
<td><a href="/research/cog/cog/COG0610/">COG0610</a></td>
<td>
V
</td>
<td>Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...</td>
</tr>
<tr>
<td>989</td>
<td>1405</td>
<td><a href="/research/cog/cog/COG0627/">COG0627</a></td>
<td>
V
</td>
<td>S-formylglutathione hydrolase FrmB</td>
</tr>
<tr>
<td>1632</td>
<td>3243</td>
<td><a href="/research/cog/cog/COG0693/">COG0693</a></td>
<td>
V
</td>
<td>Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids)</td>
</tr>
<tr>
<td>1029</td>
<td>1480</td>
<td><a href="/research/cog/cog/COG0701/">COG0701</a></td>
<td>
V
P
</td>
<td>Arsenite and antimonite resistance protein ArsP/YraQ, UPF0718 family</td>
</tr>
<tr>
<td>1292</td>
<td>2487</td>
<td><a href="/research/cog/cog/COG0732/">COG0732</a></td>
<td>
V
</td>
<td>Restriction endonuclease S subunit</td>
</tr>
<tr>
<td>1385</td>
<td>2701</td>
<td><a href="/research/cog/cog/COG0737/">COG0737</a></td>
<td>
V
F
</td>
<td>2&#x27;,3&#x27;-cyclic-nucleotide 2&#x27;-phosphodiesterase/5&#x27;- or 3&#x27;-nucleotidase, 5&#x27;-nucleotidase family</td>
</tr>
<tr>
<td>1663</td>
<td>1719</td>
<td><a href="/research/cog/cog/COG0756/">COG0756</a></td>
<td>
V
F
</td>
<td>dUTP pyrophosphatase (dUTPase)</td>
</tr>
<tr>
<td>1659</td>
<td>8652</td>
<td><a href="/research/cog/cog/COG0841/">COG0841</a></td>
<td>
V
</td>
<td>Multidrug efflux pump subunit AcrB</td>
</tr>
<tr>
<td>1895</td>
<td>6282</td>
<td><a href="/research/cog/cog/COG0842/">COG0842</a></td>
<td>
V
</td>
<td>ABC-type multidrug transport system, permease component</td>
</tr>
<tr>
<td>1713</td>
<td>11708</td>
<td><a href="/research/cog/cog/COG0845/">COG0845</a></td>
<td>
V
M
</td>
<td>Multidrug efflux pump subunit AcrA (membrane-fusion protein)</td>
</tr>
<tr>
<td>1341</td>
<td>2342</td>
<td><a href="/research/cog/cog/COG0861/">COG0861</a></td>
<td>
V
P
</td>
<td>Tellurite resistance membrane protein TerC</td>
</tr>
<tr>
<td>1139</td>
<td>2359</td>
<td><a href="/research/cog/cog/COG0863/">COG0863</a></td>
<td>
L
V
</td>
<td>DNA modification adenine methylase</td>
</tr>
<tr>
<td>207</td>
<td>244</td>
<td><a href="/research/cog/cog/COG1002/">COG1002</a></td>
<td>
V
</td>
<td>Type II restriction/modification system, endonuclease and methylase domains</td>
</tr>
<tr>
<td>84</td>
<td>85</td>
<td><a href="/research/cog/cog/COG1059/">COG1059</a></td>
<td>
L
V
</td>
<td>Thermostable 8-oxoguanine DNA glycosylase</td>
</tr>
<tr>
<td>2184</td>
<td>16983</td>
<td><a href="/research/cog/cog/COG1131/">COG1131</a></td>
<td>
J
V
</td>
<td>Ribosome-associated ATPase or ATPase component of an ABC-type multidrug transport system</td>
</tr>
<tr>
<td>2159</td>
<td>13012</td>
<td><a href="/research/cog/cog/COG1132/">COG1132</a></td>
<td>
V
M
</td>
<td>ABC-type multidrug and LPS transport system, ATPase and permease component MsbA</td>
</tr>
<tr>
<td>121</td>
<td>121</td>
<td><a href="/research/cog/cog/COG1133/">COG1133</a></td>
<td>
V
</td>
<td>Peptide antibiotic transporter SbmA/BacA, ABC-type permease family</td>
</tr>
<tr>
<td>763</td>
<td>996</td>
<td><a href="/research/cog/cog/COG1203/">COG1203</a></td>
<td>
V
</td>
<td>CRISPR-Cas type I system-associated endonuclease/helicase Cas3</td>
</tr>
<tr>
<td>873</td>
<td>1102</td>
<td><a href="/research/cog/cog/COG1238/">COG1238</a></td>
<td>
V
P
</td>
<td>Membrane protein YqaA involved in indium extrusion, DedA family, contains VTT domain</td>
</tr>
<tr>
<td>511</td>
<td>590</td>
<td><a href="/research/cog/cog/COG1275/">COG1275</a></td>
<td>
V
</td>
<td>Tellurite resistance protein TehA and related permeases</td>
</tr>
<tr>
<td>112</td>
<td>116</td>
<td><a href="/research/cog/cog/COG1332/">COG1332</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CSM-effector complex subunit Csm5, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>196</td>
<td>249</td>
<td><a href="/research/cog/cog/COG1336/">COG1336</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CMR-effector complex subunit Cmr4, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>229</td>
<td>467</td>
<td><a href="/research/cog/cog/COG1337/">COG1337</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CSM-effector complex subunit Csm3, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>685</td>
<td>1005</td>
<td><a href="/research/cog/cog/COG1343/">COG1343</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated endoribonuclease Cas2</td>
</tr>
<tr>
<td>289</td>
<td>384</td>
<td><a href="/research/cog/cog/COG1353/">COG1353</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain</td>
</tr>
<tr>
<td>130</td>
<td>142</td>
<td><a href="/research/cog/cog/COG1367/">COG1367</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CMR-effector complex subunit Cmr1, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>458</td>
<td>531</td>
<td><a href="/research/cog/cog/COG1401/">COG1401</a></td>
<td>
V
</td>
<td>5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB</td>
</tr>
<tr>
<td>1268</td>
<td>2515</td>
<td><a href="/research/cog/cog/COG1403/">COG1403</a></td>
<td>
V
</td>
<td>HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA</td>
</tr>
<tr>
<td>67</td>
<td>71</td>
<td><a href="/research/cog/cog/COG1421/">COG1421</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CSM-effector complex small subunit Csm2</td>
</tr>
<tr>
<td>53</td>
<td>60</td>
<td><a href="/research/cog/cog/COG1431/">COG1431</a></td>
<td>
J
V
</td>
<td>PIWI domain, catalyzes dsRNA-guided hydrolysis of ssRNA, involved in RNA silencing, RNA metabolism and antiviral defense</td>
</tr>
<tr>
<td>660</td>
<td>883</td>
<td><a href="/research/cog/cog/COG1468/">COG1468</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated exonuclease Cas4, RecB family</td>
</tr>
<tr>
<td>668</td>
<td>911</td>
<td><a href="/research/cog/cog/COG1479/">COG1479</a></td>
<td>
V
</td>
<td>DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains</td>
</tr>
<tr>
<td>846</td>
<td>2451</td>
<td><a href="/research/cog/cog/COG1487/">COG1487</a></td>
<td>
V
</td>
<td>Ribonuclease/mRNA interferase VapC, contains PIN domain</td>
</tr>
<tr>
<td>32</td>
<td>46</td>
<td><a href="/research/cog/cog/COG1517/">COG1517</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated protein Csx1, contains CARF domain</td>
</tr>
<tr>
<td>1010</td>
<td>1527</td>
<td><a href="/research/cog/cog/COG1518/">COG1518</a></td>
<td>
V
</td>
<td>CRISPR-Cas system-associated integrase Cas1</td>
</tr>
<tr>
<td>1515</td>
<td>7857</td>
<td><a href="/research/cog/cog/COG1566/">COG1566</a></td>
<td>
V
</td>
<td>Multidrug resistance efflux pump EmrA</td>
</tr>
<tr>
<td>112</td>
<td>116</td>
<td><a href="/research/cog/cog/COG1567/">COG1567</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CSM-effector complex subunit Csm4, RAMP superfamily Cas5 group</td>
</tr>
<tr>
<td>242</td>
<td>268</td>
<td><a href="/research/cog/cog/COG1578/">COG1578</a></td>
<td>
V
</td>
<td>House-cleaning carbohydrate phosphatase, DUF89 family</td>
</tr>
<tr>
<td>272</td>
<td>362</td>
<td><a href="/research/cog/cog/COG1583/">COG1583</a></td>
<td>
V
</td>
<td>CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily</td>
</tr>
<tr>
<td>666</td>
<td>1916</td>
<td><a href="/research/cog/cog/COG1598/">COG1598</a></td>
<td>
V
</td>
<td>Antitoxin component HicB of the HicAB toxin-antitoxin system</td>
</tr>
<tr>
<td>172</td>
<td>202</td>
<td><a href="/research/cog/cog/COG1604/">COG1604</a></td>
<td>
V
</td>
<td>CRISPR/Cas system CMR subunit Cmr6, Cas7 group, RAMP superfamily</td>
</tr>
<tr>
<td>205</td>
<td>208</td>
<td><a href="/research/cog/cog/COG1659/">COG1659</a></td>
<td>
V
</td>
<td>Bacteriocin, linocin/CFP29 family</td>
</tr>
<tr>
<td>1533</td>
<td>7460</td>
<td><a href="/research/cog/cog/COG1680/">COG1680</a></td>
<td>
V
</td>
<td>CubicO group peptidase, beta-lactamase class C family</td>
</tr>
<tr>
<td>137</td>
<td>150</td>
<td><a href="/research/cog/cog/COG1688/">COG1688</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated protein Cas5, RAMP superfamily</td>
</tr>
<tr>
<td>844</td>
<td>1020</td>
<td><a href="/research/cog/cog/COG1694/">COG1694</a></td>
<td>
V
</td>
<td>NTP pyrophosphatase, house-cleaning of non-canonical NTPs</td>
</tr>
<tr>
<td>78</td>
<td>80</td>
<td><a href="/research/cog/cog/COG1700/">COG1700</a></td>
<td>
V
</td>
<td>Predicted anti-virus defense system component AQ645, contains DUF2357 and PD-(D/E)xK nuclease domains</td>
</tr>
<tr>
<td>514</td>
<td>636</td>
<td><a href="/research/cog/cog/COG1715/">COG1715</a></td>
<td>
V
</td>
<td>Restriction endonuclease Mrr</td>
</tr>
<tr>
<td>64</td>
<td>105</td>
<td><a href="/research/cog/cog/COG1753/">COG1753</a></td>
<td>
V
</td>
<td>Predicted antitoxin, CopG family</td>
</tr>
<tr>
<td>1047</td>
<td>1916</td>
<td><a href="/research/cog/cog/COG1764/">COG1764</a></td>
<td>
V
</td>
<td>Organic hydroperoxide reductase OsmC/OhrA</td>
</tr>
<tr>
<td>110</td>
<td>121</td>
<td><a href="/research/cog/cog/COG1769/">COG1769</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CMR-effector complex subunit Cmr3, RAMP superfamily Cas5 group</td>
</tr>
<tr>
<td>170</td>
<td>215</td>
<td><a href="/research/cog/cog/COG1787/">COG1787</a></td>
<td>
V
</td>
<td>Endonuclease, HJR/Mrr/RecB family</td>
</tr>
<tr>
<td>915</td>
<td>1270</td>
<td><a href="/research/cog/cog/COG1842/">COG1842</a></td>
<td>
V
M
</td>
<td>Phage shock protein A involved in membrane remodeling, PspA/Vipp1/IM30 family</td>
</tr>
<tr>
<td>421</td>
<td>864</td>
<td><a href="/research/cog/cog/COG1848/">COG1848</a></td>
<td>
V
</td>
<td>VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain</td>
</tr>
<tr>
<td>141</td>
<td>158</td>
<td><a href="/research/cog/cog/COG1857/">COG1857</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily</td>
</tr>
<tr>
<td>203</td>
<td>279</td>
<td><a href="/research/cog/cog/COG1895/">COG1895</a></td>
<td>
V
</td>
<td>HEPN domain protein, predicted toxin of MNT-HEPN system</td>
</tr>
<tr>
<td>669</td>
<td>722</td>
<td><a href="/research/cog/cog/COG1912/">COG1912</a></td>
<td>
V
H
</td>
<td>Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming)</td>
</tr>
<tr>
<td>926</td>
<td>1075</td>
<td><a href="/research/cog/cog/COG1956/">COG1956</a></td>
<td>
V
T
</td>
<td>GAF domain-containing protein, putative methionine-R-sulfoxide reductase</td>
</tr>
<tr>
<td>308</td>
<td>318</td>
<td><a href="/research/cog/cog/COG1986/">COG1986</a></td>
<td>
V
F
</td>
<td>Non-canonical (house-cleaning) NTP pyrophosphatase, all-alpha NTP-PPase family</td>
</tr>
<tr>
<td>577</td>
<td>1017</td>
<td><a href="/research/cog/cog/COG2002/">COG2002</a></td>
<td>
K
B
V
</td>
<td>DNA-binding transcriptional regulator, chromatin protein or antitoxin AbrBPrlF/Sso7c4, AbrB family</td>
</tr>
<tr>
<td>684</td>
<td>1272</td>
<td><a href="/research/cog/cog/COG2026/">COG2026</a></td>
<td>
V
</td>
<td>mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system</td>
</tr>
<tr>
<td>1236</td>
<td>2350</td>
<td><a href="/research/cog/cog/COG2076/">COG2076</a></td>
<td>
V
</td>
<td>Multidrug transporter EmrE and related cation transporters</td>
</tr>
<tr>
<td>959</td>
<td>4855</td>
<td><a href="/research/cog/cog/COG2124/">COG2124</a></td>
<td>
V
Q
</td>
<td>Cytochrome P450</td>
</tr>
<tr>
<td>605</td>
<td>1011</td>
<td><a href="/research/cog/cog/COG2161/">COG2161</a></td>
<td>
V
</td>
<td>Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family</td>
</tr>
<tr>
<td>231</td>
<td>592</td>
<td><a href="/research/cog/cog/COG2250/">COG2250</a></td>
<td>
V
</td>
<td>HEPN domain protein, predicted toxin of MNT-HEPN system</td>
</tr>
<tr>
<td>352</td>
<td>461</td>
<td><a href="/research/cog/cog/COG2253/">COG2253</a></td>
<td>
V
</td>
<td>Predicted nucleotidyltransferase component of viral defense system</td>
</tr>
<tr>
<td>31</td>
<td>36</td>
<td><a href="/research/cog/cog/COG2254/">COG2254</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated endonuclease Cas3-HD</td>
</tr>
<tr>
<td>1013</td>
<td>1328</td>
<td><a href="/research/cog/cog/COG2258/">COG2258</a></td>
<td>
V
F
</td>
<td>N-hydroxylaminopurine reductase YiiM, contains MOSC domain</td>
</tr>
<tr>
<td>1163</td>
<td>2673</td>
<td><a href="/research/cog/cog/COG2274/">COG2274</a></td>
<td>
V
</td>
<td>ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain</td>
</tr>
<tr>
<td>395</td>
<td>525</td>
<td><a href="/research/cog/cog/COG2336/">COG2336</a></td>
<td>
V
</td>
<td>Antitoxin component MazE of the MazEF toxin-antitoxin module</td>
</tr>
<tr>
<td>898</td>
<td>1574</td>
<td><a href="/research/cog/cog/COG2337/">COG2337</a></td>
<td>
V
</td>
<td>mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module</td>
</tr>
<tr>
<td>444</td>
<td>859</td>
<td><a href="/research/cog/cog/COG2361/">COG2361</a></td>
<td>
V
</td>
<td>HEPN domain protein, predicted toxin of MNT-HEPN system</td>
</tr>
<tr>
<td>854</td>
<td>1382</td>
<td><a href="/research/cog/cog/COG2367/">COG2367</a></td>
<td>
V
</td>
<td>Beta-lactamase class A</td>
</tr>
<tr>
<td>226</td>
<td>495</td>
<td><a href="/research/cog/cog/COG2402/">COG2402</a></td>
<td>
V
</td>
<td>Ribonuclease VapC1, toxin component of the VapBC toxin-antitoxin module, contains PIN domain</td>
</tr>
<tr>
<td>333</td>
<td>1199</td>
<td><a href="/research/cog/cog/COG2442/">COG2442</a></td>
<td>
V
</td>
<td>Predicted antitoxin component of a toxin-antitoxin system, DUF433 family</td>
</tr>
<tr>
<td>265</td>
<td>286</td>
<td><a href="/research/cog/cog/COG2602/">COG2602</a></td>
<td>
V
</td>
<td>Beta-lactamase class D</td>
</tr>
<tr>
<td>466</td>
<td>690</td>
<td><a href="/research/cog/cog/COG2720/">COG2720</a></td>
<td>
V
</td>
<td>Vancomycin resistance protein YoaR (function unknown), contains peptidoglycan-binding and VanW domains</td>
</tr>
<tr>
<td>244</td>
<td>276</td>
<td><a href="/research/cog/cog/COG2746/">COG2746</a></td>
<td>
V
</td>
<td>Aminoglycoside N3&#x27;-acetyltransferase</td>
</tr>
<tr>
<td>81</td>
<td>85</td>
<td><a href="/research/cog/cog/COG2810/">COG2810</a></td>
<td>
V
</td>
<td>Predicted type IV restriction endonuclease</td>
</tr>
<tr>
<td>381</td>
<td>1050</td>
<td><a href="/research/cog/cog/COG2849/">COG2849</a></td>
<td>
V
</td>
<td>Antitoxin component YwqK of the YwqJK toxin-antitoxin module</td>
</tr>
<tr>
<td>478</td>
<td>538</td>
<td><a href="/research/cog/cog/COG2914/">COG2914</a></td>
<td>
V
</td>
<td>Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily</td>
</tr>
<tr>
<td>359</td>
<td>738</td>
<td><a href="/research/cog/cog/COG2929/">COG2929</a></td>
<td>
V
</td>
<td>Ribonuclease BrnT, toxin component of the BrnT-BrnA toxin-antitoxin system</td>
</tr>
<tr>
<td>191</td>
<td>208</td>
<td><a href="/research/cog/cog/COG3015/">COG3015</a></td>
<td>
V
M
</td>
<td>Uncharacterized lipoprotein NlpE involved in copper resistance</td>
</tr>
<tr>
<td>292</td>
<td>421</td>
<td><a href="/research/cog/cog/COG3041/">COG3041</a></td>
<td>
J
V
</td>
<td>mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module</td>
</tr>
<tr>
<td>120</td>
<td>154</td>
<td><a href="/research/cog/cog/COG3059/">COG3059</a></td>
<td>
V
</td>
<td>Reactive chlorine resistance protein RclC/YkgB, DUF417 family</td>
</tr>
<tr>
<td>362</td>
<td>614</td>
<td><a href="/research/cog/cog/COG3077/">COG3077</a></td>
<td>
V
</td>
<td>Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module</td>
</tr>
<tr>
<td>765</td>
<td>1295</td>
<td><a href="/research/cog/cog/COG3093/">COG3093</a></td>
<td>
V
</td>
<td>Plasmid maintenance system antidote protein VapI/HigA, contains XRE-type HTH domain</td>
</tr>
<tr>
<td>213</td>
<td>214</td>
<td><a href="/research/cog/cog/COG3155/">COG3155</a></td>
<td>
V
</td>
<td>Glyoxalase ElbB, DJ-1 superfamily</td>
</tr>
<tr>
<td>263</td>
<td>283</td>
<td><a href="/research/cog/cog/COG3183/">COG3183</a></td>
<td>
V
</td>
<td>5-methylcytosine-specific restriction endonuclease McrA</td>
</tr>
<tr>
<td>734</td>
<td>829</td>
<td><a href="/research/cog/cog/COG3217/">COG3217</a></td>
<td>
V
F
</td>
<td>N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain</td>
</tr>
<tr>
<td>289</td>
<td>354</td>
<td><a href="/research/cog/cog/COG3236/">COG3236</a></td>
<td>
V
H
</td>
<td>N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily</td>
</tr>
<tr>
<td>47</td>
<td>55</td>
<td><a href="/research/cog/cog/COG3309/">COG3309</a></td>
<td>
V
</td>
<td>Virulence-associated protein VapD, endoribonuclease</td>
</tr>
<tr>
<td>88</td>
<td>91</td>
<td><a href="/research/cog/cog/COG3337/">COG3337</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type III CMR-effector complex small subunit Cmr5</td>
</tr>
<tr>
<td>676</td>
<td>2601</td>
<td><a href="/research/cog/cog/COG3415/">COG3415</a></td>
<td>
V
</td>
<td>CRISPR-associated protein Csa3, CARF domain</td>
</tr>
<tr>
<td>59</td>
<td>65</td>
<td><a href="/research/cog/cog/COG3421/">COG3421</a></td>
<td>
V
</td>
<td>Type III restriction endonuclease</td>
</tr>
<tr>
<td>471</td>
<td>560</td>
<td><a href="/research/cog/cog/COG3440/">COG3440</a></td>
<td>
V
</td>
<td>Predicted restriction endonuclease</td>
</tr>
<tr>
<td>832</td>
<td>1481</td>
<td><a href="/research/cog/cog/COG3467/">COG3467</a></td>
<td>
V
</td>
<td>Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5&#x27;-phosphate oxidase superfamily</td>
</tr>
<tr>
<td>139</td>
<td>158</td>
<td><a href="/research/cog/cog/COG3510/">COG3510</a></td>
<td>
V
M
</td>
<td>Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family</td>
</tr>
<tr>
<td>196</td>
<td>203</td>
<td><a href="/research/cog/cog/COG3512/">COG3512</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated protein Cas2</td>
</tr>
<tr>
<td>202</td>
<td>214</td>
<td><a href="/research/cog/cog/COG3513/">COG3513</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type-II protein Cas9</td>
</tr>
<tr>
<td>279</td>
<td>466</td>
<td><a href="/research/cog/cog/COG3514/">COG3514</a></td>
<td>
V
</td>
<td>Antitoxin component of the BrnT-BrnA toxin-antitoxin system</td>
</tr>
<tr>
<td>466</td>
<td>680</td>
<td><a href="/research/cog/cog/COG3549/">COG3549</a></td>
<td>
V
</td>
<td>Plasmid maintenance system killer protein</td>
</tr>
<tr>
<td>208</td>
<td>258</td>
<td><a href="/research/cog/cog/COG3570/">COG3570</a></td>
<td>
V
</td>
<td>Streptomycin 6-kinase</td>
</tr>
<tr>
<td>92</td>
<td>109</td>
<td><a href="/research/cog/cog/COG3582/">COG3582</a></td>
<td>
V
</td>
<td>CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As/Sb toxicity)</td>
</tr>
<tr>
<td>293</td>
<td>341</td>
<td><a href="/research/cog/cog/COG3587/">COG3587</a></td>
<td>
V
</td>
<td>Restriction endonuclease, type III RM system</td>
</tr>
<tr>
<td>626</td>
<td>667</td>
<td><a href="/research/cog/cog/COG3634/">COG3634</a></td>
<td>
V
</td>
<td>Alkyl hydroperoxide reductase subunit AhpF</td>
</tr>
<tr>
<td>374</td>
<td>413</td>
<td><a href="/research/cog/cog/COG3649/">COG3649</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily</td>
</tr>
<tr>
<td>271</td>
<td>381</td>
<td><a href="/research/cog/cog/COG3657/">COG3657</a></td>
<td>
V
</td>
<td>Putative component of the toxin-antitoxin plasmid stabilization module</td>
</tr>
<tr>
<td>168</td>
<td>168</td>
<td><a href="/research/cog/cog/COG3725/">COG3725</a></td>
<td>
V
</td>
<td>Membrane protein AmpE required for beta-lactamase induction</td>
</tr>
<tr>
<td>136</td>
<td>210</td>
<td><a href="/research/cog/cog/COG3742/">COG3742</a></td>
<td>
V
</td>
<td>VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain</td>
</tr>
<tr>
<td>366</td>
<td>732</td>
<td><a href="/research/cog/cog/COG3744/">COG3744</a></td>
<td>
V
</td>
<td>PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)</td>
</tr>
<tr>
<td>105</td>
<td>107</td>
<td><a href="/research/cog/cog/COG3811/">COG3811</a></td>
<td>
V
</td>
<td>Toxin component YjhX of the YjhX-YjhQ toxin-antitoxin system, inhibitor of topoisomerase I, UPF0386/DUF2084 family</td>
</tr>
<tr>
<td>436</td>
<td>491</td>
<td><a href="/research/cog/cog/COG3853/">COG3853</a></td>
<td>
V
</td>
<td>Uncharacterized conserved protein YaaN involved in tellurite resistance</td>
</tr>
<tr>
<td>100</td>
<td>115</td>
<td><a href="/research/cog/cog/COG3896/">COG3896</a></td>
<td>
V
</td>
<td>Chloramphenicol 3-O-phosphotransferase</td>
</tr>
<tr>
<td>88</td>
<td>102</td>
<td><a href="/research/cog/cog/COG4006/">COG4006</a></td>
<td>
V
</td>
<td>CRISPR-Cas system-associated protein Csm6, contains CARF domain</td>
</tr>
<tr>
<td>567</td>
<td>747</td>
<td><a href="/research/cog/cog/COG4096/">COG4096</a></td>
<td>
V
</td>
<td>Type I site-specific restriction endonuclease, part of a restriction-modification system</td>
</tr>
<tr>
<td>103</td>
<td>123</td>
<td><a href="/research/cog/cog/COG4110/">COG4110</a></td>
<td>
V
</td>
<td>Tellurium resistance protein TerA/TerD</td>
</tr>
<tr>
<td>348</td>
<td>636</td>
<td><a href="/research/cog/cog/COG4113/">COG4113</a></td>
<td>
A
V
</td>
<td>RNA interferase (RNase) VapC, contains PIN domain</td>
</tr>
<tr>
<td>467</td>
<td>672</td>
<td><a href="/research/cog/cog/COG4115/">COG4115</a></td>
<td>
V
</td>
<td>Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family</td>
</tr>
<tr>
<td>560</td>
<td>1254</td>
<td><a href="/research/cog/cog/COG4118/">COG4118</a></td>
<td>
V
</td>
<td>Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor, Phd/VapB family</td>
</tr>
<tr>
<td>130</td>
<td>131</td>
<td><a href="/research/cog/cog/COG4167/">COG4167</a></td>
<td>
V
</td>
<td>ABC-type antimicrobial peptide export system, ATPase component SapF</td>
</tr>
<tr>
<td>122</td>
<td>122</td>
<td><a href="/research/cog/cog/COG4168/">COG4168</a></td>
<td>
V
</td>
<td>ABC-type antimicrobial peptide export system, permease component SapB</td>
</tr>
<tr>
<td>130</td>
<td>130</td>
<td><a href="/research/cog/cog/COG4170/">COG4170</a></td>
<td>
V
</td>
<td>ABC-type antimicrobial peptide export system, ATPase component SapD</td>
</tr>
<tr>
<td>142</td>
<td>142</td>
<td><a href="/research/cog/cog/COG4171/">COG4171</a></td>
<td>
V
</td>
<td>ABC-type antimicrobial peptide export system, permease component SapC</td>
</tr>
<tr>
<td>132</td>
<td>208</td>
<td><a href="/research/cog/cog/COG4200/">COG4200</a></td>
<td>
V
</td>
<td>Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family</td>
</tr>
<tr>
<td>293</td>
<td>439</td>
<td><a href="/research/cog/cog/COG4257/">COG4257</a></td>
<td>
V
</td>
<td>Streptogramin lyase</td>
</tr>
<tr>
<td>329</td>
<td>361</td>
<td><a href="/research/cog/cog/COG4268/">COG4268</a></td>
<td>
V
</td>
<td>5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC</td>
</tr>
<tr>
<td>38</td>
<td>46</td>
<td><a href="/research/cog/cog/COG4343/">COG4343</a></td>
<td>
V
</td>
<td>CRISPR/Cas system-associated exonuclease Cas4, RecB family</td>
</tr>
<tr>
<td>81</td>
<td>103</td>
<td><a href="/research/cog/cog/COG4374/">COG4374</a></td>
<td>
V
</td>
<td>PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)</td>
</tr>
<tr>
<td>169</td>
<td>271</td>
<td><a href="/research/cog/cog/COG4403/">COG4403</a></td>
<td>
V
</td>
<td>Lantibiotic modifying enzyme</td>
</tr>
<tr>
<td>112</td>
<td>156</td>
<td><a href="/research/cog/cog/COG4423/">COG4423</a></td>
<td>
V
</td>
<td>VapB family antitoxin component of VapBC type II toxin-antitoxin module</td>
</tr>
<tr>
<td>238</td>
<td>243</td>
<td><a href="/research/cog/cog/COG4452/">COG4452</a></td>
<td>
V
</td>
<td>Inner membrane protein CreD involved in colicin E2 resistance</td>
</tr>
<tr>
<td>195</td>
<td>251</td>
<td><a href="/research/cog/cog/COG4461/">COG4461</a></td>
<td>
V
</td>
<td>Lysozyme inhibitor LprI</td>
</tr>
<tr>
<td>373</td>
<td>530</td>
<td><a href="/research/cog/cog/COG4679/">COG4679</a></td>
<td>
V
X
</td>
<td>Phage-related protein gp49, toxin component of the Tad-Ata toxin-antitoxin system</td>
</tr>
<tr>
<td>268</td>
<td>374</td>
<td><a href="/research/cog/cog/COG4680/">COG4680</a></td>
<td>
J
V
</td>
<td>mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module</td>
</tr>
<tr>
<td>145</td>
<td>192</td>
<td><a href="/research/cog/cog/COG4683/">COG4683</a></td>
<td>
V
</td>
<td>HigB/gp49-like toxin component of RelE/ParE type II toxin-antitoxin system</td>
</tr>
<tr>
<td>241</td>
<td>303</td>
<td><a href="/research/cog/cog/COG4691/">COG4691</a></td>
<td>
V
</td>
<td>Plasmid stability protein StbC1, contains ribbon-helix-helix domain</td>
</tr>
<tr>
<td>74</td>
<td>91</td>
<td><a href="/research/cog/cog/COG4734/">COG4734</a></td>
<td>
V
</td>
<td>Antirestriction protein ArdA</td>
</tr>
<tr>
<td>355</td>
<td>580</td>
<td><a href="/research/cog/cog/COG4767/">COG4767</a></td>
<td>
V
</td>
<td>Glycopeptide antibiotics resistance protein</td>
</tr>
<tr>
<td>272</td>
<td>345</td>
<td><a href="/research/cog/cog/COG4823/">COG4823</a></td>
<td>
V
</td>
<td>Abortive infection bacteriophage resistance protein</td>
</tr>
<tr>
<td>283</td>
<td>297</td>
<td><a href="/research/cog/cog/COG4832/">COG4832</a></td>
<td>
V
T
</td>
<td>Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain</td>
</tr>
<tr>
<td>264</td>
<td>634</td>
<td><a href="/research/cog/cog/COG4842/">COG4842</a></td>
<td>
V
</td>
<td>Secreted virulence factor YukE/EsxA, WXG100 family</td>
</tr>
<tr>
<td>229</td>
<td>269</td>
<td><a href="/research/cog/cog/COG4845/">COG4845</a></td>
<td>
V
</td>
<td>Chloramphenicol O-acetyltransferase</td>
</tr>
<tr>
<td>145</td>
<td>155</td>
<td><a href="/research/cog/cog/COG4924/">COG4924</a></td>
<td>
V
</td>
<td>Nuclease subunit JetD of Wadjet anti-plasmid defense system, contains DUF3322 and JetD_C (DUF2220) domains</td>
</tr>
<tr>
<td>152</td>
<td>168</td>
<td><a href="/research/cog/cog/COG4951/">COG4951</a></td>
<td>
V
</td>
<td>CRISPR-associated primase-polymerase type A</td>
</tr>
<tr>
<td>397</td>
<td>546</td>
<td><a href="/research/cog/cog/COG5340/">COG5340</a></td>
<td>
V
</td>
<td>Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system</td>
</tr>
<tr>
<td>153</td>
<td>254</td>
<td><a href="/research/cog/cog/COG5428/">COG5428</a></td>
<td>
V
</td>
<td>Predicted antitoxin component YuzE of a toxin-antitoxin system, DUF2283 family</td>
</tr>
<tr>
<td>237</td>
<td>263</td>
<td><a href="/research/cog/cog/COG5441/">COG5441</a></td>
<td>
V
</td>
<td>ATP-binding helicase-inhibiting domain, Tm-1/UPF0261 family</td>
</tr>
<tr>
<td>35</td>
<td>114</td>
<td><a href="/research/cog/cog/COG5444/">COG5444</a></td>
<td>
V
</td>
<td>Predicted ribonuclease, toxin component of the YeeF-YezG toxin-antitoxin module</td>
</tr>
<tr>
<td>328</td>
<td>481</td>
<td><a href="/research/cog/cog/COG5499/">COG5499</a></td>
<td>
V
</td>
<td>Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain</td>
</tr>
<tr>
<td>129</td>
<td>129</td>
<td><a href="/research/cog/cog/COG5503/">COG5503</a></td>
<td>
K
V
</td>
<td>DNA-dependent RNA polymerase auxiliary subunit epsilon</td>
</tr>
<tr>
<td>317</td>
<td>412</td>
<td><a href="/research/cog/cog/COG5510/">COG5510</a></td>
<td>
V
</td>
<td>Entericidin EcnA/EcnB</td>
</tr>
<tr>
<td>147</td>
<td>213</td>
<td><a href="/research/cog/cog/COG5551/">COG5551</a></td>
<td>
V
</td>
<td>CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily</td>
</tr>
<tr>
<td>232</td>
<td>330</td>
<td><a href="/research/cog/cog/COG5606/">COG5606</a></td>
<td>
V
</td>
<td>Antitoxin component of the Tad-Ata toxin-antitoxin system, contains XRE-type HTH domain</td>
</tr>
<tr>
<td>234</td>
<td>269</td>
<td><a href="/research/cog/cog/COG5608/">COG5608</a></td>
<td>
V
</td>
<td>Dessication stress tolerance protein, LEA/WHy domain</td>
</tr>
<tr>
<td>241</td>
<td>334</td>
<td><a href="/research/cog/cog/COG5642/">COG5642</a></td>
<td>
V
</td>
<td>Predicted antitoxin component of a toxin-antitoxin system, contains Xre-type HTH domain</td>
</tr>
<tr>
<td>283</td>
<td>398</td>
<td><a href="/research/cog/cog/COG5654/">COG5654</a></td>
<td>
V
</td>
<td>Predicted toxin component of a toxin-antitoxin system, contains RES domain</td>
</tr>
<tr>
<td>219</td>
<td>234</td>
<td><a href="/research/cog/cog/COG5658/">COG5658</a></td>
<td>
V
</td>
<td>Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family</td>
</tr>
<tr>
<td>68</td>
<td>81</td>
<td><a href="/research/cog/cog/COG5930/">COG5930</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-D effector complex large subunit Cas10d/Csc3, contains HD superfamily nuclease domain</td>
</tr>
<tr>
<td>13</td>
<td>14</td>
<td><a href="/research/cog/cog/COG5931/">COG5931</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type-V protein Cas12a</td>
</tr>
<tr>
<td>90</td>
<td>100</td>
<td><a href="/research/cog/cog/COG5932/">COG5932</a></td>
<td>
V
</td>
<td>CRISPR-Cas type I-F system-associated endonuclease/helicase Cas3f, fused to Cas2 domain</td>
</tr>
<tr>
<td>92</td>
<td>96</td>
<td><a href="/research/cog/cog/COG5933/">COG5933</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-F effector complex subunit Cas5f/Csy2, RAMP superfamily</td>
</tr>
<tr>
<td>235</td>
<td>259</td>
<td><a href="/research/cog/cog/COG5934/">COG5934</a></td>
<td>
V
</td>
<td>CRISPR-Cas system endoribonuclease Cas6e, RAMP superfamily</td>
</tr>
<tr>
<td>96</td>
<td>104</td>
<td><a href="/research/cog/cog/COG5935/">COG5935</a></td>
<td>
V
</td>
<td>CRISPR-Cas system endoribonuclease Cas6f/Csy4, RAMP superfamily</td>
</tr>
<tr>
<td>92</td>
<td>98</td>
<td><a href="/research/cog/cog/COG5936/">COG5936</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-F effector complex subunit Cas7f/Csy3, RAMP superfamily</td>
</tr>
<tr>
<td>14</td>
<td>14</td>
<td><a href="/research/cog/cog/COG5937/">COG5937</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-A effector complex large subunit Cas8a4</td>
</tr>
<tr>
<td>119</td>
<td>129</td>
<td><a href="/research/cog/cog/COG5938/">COG5938</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-B effector complex large subunit Cas8b1</td>
</tr>
<tr>
<td>84</td>
<td>91</td>
<td><a href="/research/cog/cog/COG5939/">COG5939</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-B effector complex large subunit Cas8b2</td>
</tr>
<tr>
<td>19</td>
<td>19</td>
<td><a href="/research/cog/cog/COG5940/">COG5940</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-B effector complex large subunit Cas8b3</td>
</tr>
<tr>
<td>234</td>
<td>246</td>
<td><a href="/research/cog/cog/COG5941/">COG5941</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-C effector complex large subunit Cas8c</td>
</tr>
<tr>
<td>225</td>
<td>246</td>
<td><a href="/research/cog/cog/COG5942/">COG5942</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-E effector complex large subunit Cas8e/Cse1</td>
</tr>
<tr>
<td>89</td>
<td>92</td>
<td><a href="/research/cog/cog/COG5943/">COG5943</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-F effector complex large subunit Cas8f/Csy1</td>
</tr>
<tr>
<td>43</td>
<td>50</td>
<td><a href="/research/cog/cog/COG5944/">COG5944</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-G effector complex large subunit Cas8g1</td>
</tr>
<tr>
<td>59</td>
<td>68</td>
<td><a href="/research/cog/cog/COG5945/">COG5945</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-G effector complex subunit Csb1/Cas7u, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>59</td>
<td>71</td>
<td><a href="/research/cog/cog/COG5946/">COG5946</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-G effector complex subunit Csb5, RAMP superfamily Cas5 group</td>
</tr>
<tr>
<td>69</td>
<td>76</td>
<td><a href="/research/cog/cog/COG5947/">COG5947</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-D effector complex subunit Csc1, RAMP superfamily Cas5 group</td>
</tr>
<tr>
<td>78</td>
<td>86</td>
<td><a href="/research/cog/cog/COG5948/">COG5948</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-D effector complex subunit Csc2, RAMP superfamily Cas7 group</td>
</tr>
<tr>
<td>225</td>
<td>245</td>
<td><a href="/research/cog/cog/COG5949/">COG5949</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type I-E effector complex small subunit Cse2</td>
</tr>
<tr>
<td>140</td>
<td>162</td>
<td><a href="/research/cog/cog/COG5950/">COG5950</a></td>
<td>
V
</td>
<td>CRISPR-Cas system type II-D effector complex subunit Csx10, RAMP superfamily Cas5 group</td>
</tr>
<tr>
<td>9</td>
<td>13</td>
<td><a href="/research/cog/cog/COG5951/">COG5951</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type II-A1 protein, inhibits CRISPR-Cas type II-A system</td>
</tr>
<tr>
<td>2</td>
<td>2</td>
<td><a href="/research/cog/cog/COG5952/">COG5952</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type II-A2 protein, inhibits CRISPR-Cas type II-A system</td>
</tr>
<tr>
<td>14</td>
<td>14</td>
<td><a href="/research/cog/cog/COG5953/">COG5953</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type II-A6 protein, inhibits CRISPR-Cas type II-A system</td>
</tr>
<tr>
<td>4</td>
<td>4</td>
<td><a href="/research/cog/cog/COG5954/">COG5954</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type II-C2 protein, inhibits CRISPR-Cas type II-A system</td>
</tr>
<tr>
<td>13</td>
<td>13</td>
<td><a href="/research/cog/cog/COG5955/">COG5955</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type II-C1 protein, inhibits CRISPR-Cas type II-A system</td>
</tr>
<tr>
<td>1</td>
<td>1</td>
<td><a href="/research/cog/cog/COG5956/">COG5956</a></td>
<td>
V
X
</td>
<td>Anti-CRISPR type V-A1 protein, inhibits CRISPR-Cas12a nuclease</td>
</tr>
<tr>
<td>17</td>
<td>23</td>
<td><a href="/research/cog/cog/COG5957/">COG5957</a></td>
<td>
V
</td>
<td>Cas10-like subunit of HRAMP, derivative of type III CRISPR-Cas system</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</section>
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