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<span class="headername">Database of Clusters of Orthologous Genes (COGs)</span>
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J - Translation, ribosomal structure and biogenesis</a>
<a href="/research/cog/cogcategory/A/" title="COG Categories"
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A - RNA processing and modification</a>
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K - Transcription</a>
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L - Replication, recombination and repair</a>
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B - Chromatin structure and dynamics</a>
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D - Cell cycle control, cell division, chromosome partitioning</a>
<a href="/research/cog/cogcategory/Y/" title="COG Categories"
class="uppercase"
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Y - Nuclear structure</a>
<a href="/research/cog/cogcategory/V/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
V - Defense mechanisms</a>
<a href="/research/cog/cogcategory/T/" title="COG Categories"
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T - Signal transduction mechanisms</a>
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M - Cell wall/membrane/envelope biogenesis</a>
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N - Cell motility</a>
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Z - Cytoskeleton</a>
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W - Extracellular structures</a>
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U - Intracellular trafficking, secretion, and vesicular transport</a>
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O - Posttranslational modification, protein turnover, chaperones</a>
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X - nan</a>
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C - Energy production and conversion</a>
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G - Carbohydrate transport and metabolism</a>
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E - Amino acid transport and metabolism</a>
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F - Nucleotide transport and metabolism</a>
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class="uppercase"
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H - Coenzyme transport and metabolism</a>
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class="uppercase"
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I - Lipid transport and metabolism</a>
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class="uppercase"
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P - Inorganic ion transport and metabolism</a>
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Q - Secondary metabolites biosynthesis, transport and catabolism</a>
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S - Function unknown</a>
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<section class="usa-section cog_top_section">
<div class="usa-grid">
<h1>H<span style='font-weight: 100'> - Coenzyme transport and metabolism</span></h1>
<div style="float: right; clear: both;margin-top: -53px;">
<a class="usa-button" href="#" onclick="download_table_as_tsv('cog_result_table');">Download</a>
</div>
<h2>Stats</h2>
<div style="width: 60%">
<div class="ui-ncbigrid-outer-div organism_cog_table">
<div class="ui-ncbigrid-inner-div">
<table data-jig="ncbigrid">
<thead>
<tr>
<th>COG<br>definitions</th>
<th>Organims</th>
<th>Proteins</th>
<th>Median Protein<br>Length</th>
<th>Genes</th>
</tr>
</thead>
<tbody>
<tr>
<td>267</td>
<td>2,294</td>
<td>396,416</td>
<td>295.0</td>
<td>262</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="ui-ncbigrid-outer-div" style="font-size: 80%;">
<div class="ui-ncbigrid-inner-div">
<table id="cog_result_table" data-jig="ncbigrid">
<thead>
<tr>
<th>Organism</th>
<th>Protein</th>
<th>COG</th>
<th>Cat</th>
<th>Annotation</th>
</tr>
</thead>
<tbody>
<tr>
<td>1714</td>
<td>2498</td>
<td><a href="/research/cog/cog/COG0001/">COG0001</a></td>
<td>
H
</td>
<td>Glutamate-1-semialdehyde aminotransferase</td>
</tr>
<tr>
<td>1634</td>
<td>2474</td>
<td><a href="/research/cog/cog/COG0007/">COG0007</a></td>
<td>
H
</td>
<td>Uroporphyrinogen-III methylase (siroheme synthase)</td>
</tr>
<tr>
<td>705</td>
<td>797</td>
<td><a href="/research/cog/cog/COG0011/">COG0011</a></td>
<td>
H
</td>
<td>Thiamin-binding stress-response protein YqgV, UPF0045 family</td>
</tr>
<tr>
<td>1982</td>
<td>5797</td>
<td><a href="/research/cog/cog/COG0028/">COG0028</a></td>
<td>
E
H
</td>
<td>Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme</td>
</tr>
<tr>
<td>1539</td>
<td>1704</td>
<td><a href="/research/cog/cog/COG0029/">COG0029</a></td>
<td>
H
</td>
<td>Aspartate oxidase</td>
</tr>
<tr>
<td>1098</td>
<td>1392</td>
<td><a href="/research/cog/cog/COG0043/">COG0043</a></td>
<td>
H
</td>
<td>3-polyprenyl-4-hydroxybenzoate decarboxylase</td>
</tr>
<tr>
<td>1934</td>
<td>2062</td>
<td><a href="/research/cog/cog/COG0054/">COG0054</a></td>
<td>
H
</td>
<td>6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)</td>
</tr>
<tr>
<td>1880</td>
<td>1948</td>
<td><a href="/research/cog/cog/COG0059/">COG0059</a></td>
<td>
E
H
</td>
<td>Ketol-acid reductoisomerase</td>
</tr>
<tr>
<td>2178</td>
<td>2516</td>
<td><a href="/research/cog/cog/COG0061/">COG0061</a></td>
<td>
H
</td>
<td>NAD kinase</td>
</tr>
<tr>
<td>980</td>
<td>1511</td>
<td><a href="/research/cog/cog/COG0095/">COG0095</a></td>
<td>
H
</td>
<td>Lipoate-protein ligase A</td>
</tr>
<tr>
<td>1915</td>
<td>2165</td>
<td><a href="/research/cog/cog/COG0108/">COG0108</a></td>
<td>
H
</td>
<td>3,4-dihydroxy-2-butanone 4-phosphate synthase</td>
</tr>
<tr>
<td>1464</td>
<td>1584</td>
<td><a href="/research/cog/cog/COG0109/">COG0109</a></td>
<td>
H
I
</td>
<td>Polyprenyltransferase (heme O synthase)</td>
</tr>
<tr>
<td>2036</td>
<td>5765</td>
<td><a href="/research/cog/cog/COG0111/">COG0111</a></td>
<td>
H
</td>
<td>Phosphoglycerate dehydrogenase or related dehydrogenase</td>
</tr>
<tr>
<td>1868</td>
<td>1915</td>
<td><a href="/research/cog/cog/COG0113/">COG0113</a></td>
<td>
H
</td>
<td>Delta-aminolevulinic acid dehydratase, porphobilinogen synthase</td>
</tr>
<tr>
<td>2079</td>
<td>4990</td>
<td><a href="/research/cog/cog/COG0115/">COG0115</a></td>
<td>
E
H
</td>
<td>Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</td>
</tr>
<tr>
<td>1782</td>
<td>1835</td>
<td><a href="/research/cog/cog/COG0117/">COG0117</a></td>
<td>
H
</td>
<td>Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain</td>
</tr>
<tr>
<td>1194</td>
<td>1297</td>
<td><a href="/research/cog/cog/COG0132/">COG0132</a></td>
<td>
H
</td>
<td>Dethiobiotin synthetase</td>
</tr>
<tr>
<td>2196</td>
<td>4701</td>
<td><a href="/research/cog/cog/COG0142/">COG0142</a></td>
<td>
H
</td>
<td>Geranylgeranyl pyrophosphate synthase</td>
</tr>
<tr>
<td>1952</td>
<td>3586</td>
<td><a href="/research/cog/cog/COG0147/">COG0147</a></td>
<td>
E
H
</td>
<td>Anthranilate/para-aminobenzoate synthases component I</td>
</tr>
<tr>
<td>1676</td>
<td>3219</td>
<td><a href="/research/cog/cog/COG0156/">COG0156</a></td>
<td>
H
</td>
<td>7-keto-8-aminopelargonate synthetase or related enzyme</td>
</tr>
<tr>
<td>1716</td>
<td>1876</td>
<td><a href="/research/cog/cog/COG0157/">COG0157</a></td>
<td>
H
</td>
<td>Nicotinate-nucleotide pyrophosphorylase</td>
</tr>
<tr>
<td>1440</td>
<td>2987</td>
<td><a href="/research/cog/cog/COG0161/">COG0161</a></td>
<td>
H
</td>
<td>Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</td>
</tr>
<tr>
<td>1070</td>
<td>1164</td>
<td><a href="/research/cog/cog/COG0163/">COG0163</a></td>
<td>
H
</td>
<td>Flavin prenyltransferase UbiX</td>
</tr>
<tr>
<td>2153</td>
<td>2421</td>
<td><a href="/research/cog/cog/COG0171/">COG0171</a></td>
<td>
H
</td>
<td>NH3-dependent NAD+ synthetase</td>
</tr>
<tr>
<td>1566</td>
<td>3102</td>
<td><a href="/research/cog/cog/COG0175/">COG0175</a></td>
<td>
E
H
</td>
<td>Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme</td>
</tr>
<tr>
<td>1881</td>
<td>1919</td>
<td><a href="/research/cog/cog/COG0181/">COG0181</a></td>
<td>
H
</td>
<td>Porphobilinogen deaminase</td>
</tr>
<tr>
<td>1589</td>
<td>3446</td>
<td><a href="/research/cog/cog/COG0189/">COG0189</a></td>
<td>
J
E
H
Q
</td>
<td>Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily</td>
</tr>
<tr>
<td>2155</td>
<td>2367</td>
<td><a href="/research/cog/cog/COG0190/">COG0190</a></td>
<td>
H
</td>
<td>5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase</td>
</tr>
<tr>
<td>2039</td>
<td>2238</td>
<td><a href="/research/cog/cog/COG0192/">COG0192</a></td>
<td>
H
</td>
<td>S-adenosylmethionine synthetase</td>
</tr>
<tr>
<td>2006</td>
<td>2084</td>
<td><a href="/research/cog/cog/COG0196/">COG0196</a></td>
<td>
H
</td>
<td>FAD synthase</td>
</tr>
<tr>
<td>1932</td>
<td>2076</td>
<td><a href="/research/cog/cog/COG0212/">COG0212</a></td>
<td>
H
</td>
<td>5-formyltetrahydrofolate cyclo-ligase</td>
</tr>
<tr>
<td>722</td>
<td>746</td>
<td><a href="/research/cog/cog/COG0214/">COG0214</a></td>
<td>
H
</td>
<td>Pyridoxal 5&#x27;-phosphate synthase subunit PdxS</td>
</tr>
<tr>
<td>2212</td>
<td>2273</td>
<td><a href="/research/cog/cog/COG0237/">COG0237</a></td>
<td>
H
</td>
<td>Dephospho-CoA kinase</td>
</tr>
<tr>
<td>1182</td>
<td>1350</td>
<td><a href="/research/cog/cog/COG0259/">COG0259</a></td>
<td>
H
</td>
<td>Pyridoxine/pyridoxamine 5&#x27;-phosphate oxidase</td>
</tr>
<tr>
<td>1714</td>
<td>3789</td>
<td><a href="/research/cog/cog/COG0262/">COG0262</a></td>
<td>
H
</td>
<td>Dihydrofolate reductase</td>
</tr>
<tr>
<td>1577</td>
<td>1682</td>
<td><a href="/research/cog/cog/COG0276/">COG0276</a></td>
<td>
H
</td>
<td>Protoheme ferro-lyase (ferrochelatase)</td>
</tr>
<tr>
<td>2079</td>
<td>2241</td>
<td><a href="/research/cog/cog/COG0285/">COG0285</a></td>
<td>
H
</td>
<td>Folylpolyglutamate synthase/Dihydropteroate synthase</td>
</tr>
<tr>
<td>1998</td>
<td>2471</td>
<td><a href="/research/cog/cog/COG0294/">COG0294</a></td>
<td>
H
</td>
<td>Dihydropteroate synthase</td>
</tr>
<tr>
<td>780</td>
<td>822</td>
<td><a href="/research/cog/cog/COG0301/">COG0301</a></td>
<td>
J
H
</td>
<td>Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis)</td>
</tr>
<tr>
<td>1514</td>
<td>1793</td>
<td><a href="/research/cog/cog/COG0302/">COG0302</a></td>
<td>
H
</td>
<td>GTP cyclohydrolase I</td>
</tr>
<tr>
<td>1701</td>
<td>3036</td>
<td><a href="/research/cog/cog/COG0303/">COG0303</a></td>
<td>
H
</td>
<td>Molybdopterin Mo-transferase (molybdopterin biosynthesis)</td>
</tr>
<tr>
<td>1866</td>
<td>1938</td>
<td><a href="/research/cog/cog/COG0307/">COG0307</a></td>
<td>
H
</td>
<td>Riboflavin synthase alpha chain</td>
</tr>
<tr>
<td>674</td>
<td>682</td>
<td><a href="/research/cog/cog/COG0311/">COG0311</a></td>
<td>
H
</td>
<td>Pyridoxal 5&#x27;-phosphate synthase subunit PdxT (glutamine amidotransferase)</td>
</tr>
<tr>
<td>1502</td>
<td>1541</td>
<td><a href="/research/cog/cog/COG0314/">COG0314</a></td>
<td>
H
</td>
<td>Molybdopterin synthase catalytic subunit MoaE</td>
</tr>
<tr>
<td>1666</td>
<td>1692</td>
<td><a href="/research/cog/cog/COG0315/">COG0315</a></td>
<td>
H
</td>
<td>Molybdenum cofactor biosynthesis enzyme MoaC</td>
</tr>
<tr>
<td>1711</td>
<td>1846</td>
<td><a href="/research/cog/cog/COG0320/">COG0320</a></td>
<td>
H
</td>
<td>Lipoate synthase</td>
</tr>
<tr>
<td>1469</td>
<td>1500</td>
<td><a href="/research/cog/cog/COG0321/">COG0321</a></td>
<td>
H
</td>
<td>Lipoate-protein ligase B (lipoyltransferase)</td>
</tr>
<tr>
<td>1942</td>
<td>2023</td>
<td><a href="/research/cog/cog/COG0325/">COG0325</a></td>
<td>
H
</td>
<td>Pyridoxal 5&#x27;-phosphate homeostasis protein YggS, UPF0001 family</td>
</tr>
<tr>
<td>1569</td>
<td>1710</td>
<td><a href="/research/cog/cog/COG0327/">COG0327</a></td>
<td>
H
</td>
<td>Putative GTP cyclohydrolase 1 type 2, NIF3 family</td>
</tr>
<tr>
<td>2119</td>
<td>2284</td>
<td><a href="/research/cog/cog/COG0340/">COG0340</a></td>
<td>
H
</td>
<td>Biotin-protein ligase</td>
</tr>
<tr>
<td>1706</td>
<td>2044</td>
<td><a href="/research/cog/cog/COG0351/">COG0351</a></td>
<td>
H
</td>
<td>Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</td>
</tr>
<tr>
<td>1732</td>
<td>2632</td>
<td><a href="/research/cog/cog/COG0352/">COG0352</a></td>
<td>
H
</td>
<td>Thiamine monophosphate synthase</td>
</tr>
<tr>
<td>1206</td>
<td>1230</td>
<td><a href="/research/cog/cog/COG0368/">COG0368</a></td>
<td>
H
</td>
<td>Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase)</td>
</tr>
<tr>
<td>1582</td>
<td>1663</td>
<td><a href="/research/cog/cog/COG0373/">COG0373</a></td>
<td>
H
</td>
<td>Glutamyl-tRNA reductase</td>
</tr>
<tr>
<td>1580</td>
<td>1617</td>
<td><a href="/research/cog/cog/COG0379/">COG0379</a></td>
<td>
H
</td>
<td>Quinolinate synthase</td>
</tr>
<tr>
<td>1719</td>
<td>2871</td>
<td><a href="/research/cog/cog/COG0382/">COG0382</a></td>
<td>
H
</td>
<td>4-hydroxybenzoate polyprenyltransferase</td>
</tr>
<tr>
<td>1018</td>
<td>1175</td>
<td><a href="/research/cog/cog/COG0391/">COG0391</a></td>
<td>
G
H
</td>
<td>Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family</td>
</tr>
<tr>
<td>1705</td>
<td>2640</td>
<td><a href="/research/cog/cog/COG0407/">COG0407</a></td>
<td>
H
</td>
<td>Uroporphyrinogen-III decarboxylase HemE</td>
</tr>
<tr>
<td>959</td>
<td>977</td>
<td><a href="/research/cog/cog/COG0408/">COG0408</a></td>
<td>
H
</td>
<td>Coproporphyrinogen-III oxidase HemH, oxygen-dependent</td>
</tr>
<tr>
<td>1723</td>
<td>1832</td>
<td><a href="/research/cog/cog/COG0413/">COG0413</a></td>
<td>
H
</td>
<td>Ketopantoate hydroxymethyltransferase</td>
</tr>
<tr>
<td>1622</td>
<td>1653</td>
<td><a href="/research/cog/cog/COG0414/">COG0414</a></td>
<td>
H
</td>
<td>Panthothenate synthetase</td>
</tr>
<tr>
<td>1360</td>
<td>1482</td>
<td><a href="/research/cog/cog/COG0422/">COG0422</a></td>
<td>
H
</td>
<td>4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC</td>
</tr>
<tr>
<td>1436</td>
<td>2495</td>
<td><a href="/research/cog/cog/COG0425/">COG0425</a></td>
<td>
J
O
H
</td>
<td>Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)</td>
</tr>
<tr>
<td>1252</td>
<td>1646</td>
<td><a href="/research/cog/cog/COG0432/">COG0432</a></td>
<td>
H
</td>
<td>Thiamin phosphate synthase YjbQ, UPF0047 family</td>
</tr>
<tr>
<td>1456</td>
<td>2863</td>
<td><a href="/research/cog/cog/COG0446/">COG0446</a></td>
<td>
H
</td>
<td>Coenzyme A disulfide reductase or related oxidoreductase, NAD(P)H-disulfide oxidoreductase family</td>
</tr>
<tr>
<td>837</td>
<td>875</td>
<td><a href="/research/cog/cog/COG0447/">COG0447</a></td>
<td>
H
</td>
<td>1,4-Dihydroxy-2-naphthoyl-CoA synthase</td>
</tr>
<tr>
<td>2083</td>
<td>2328</td>
<td><a href="/research/cog/cog/COG0452/">COG0452</a></td>
<td>
H
</td>
<td>Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC</td>
</tr>
<tr>
<td>1832</td>
<td>2756</td>
<td><a href="/research/cog/cog/COG0476/">COG0476</a></td>
<td>
H
</td>
<td>Molybdopterin or thiamine biosynthesis adenylyltransferase</td>
</tr>
<tr>
<td>1600</td>
<td>1742</td>
<td><a href="/research/cog/cog/COG0499/">COG0499</a></td>
<td>
H
</td>
<td>S-adenosylhomocysteine hydrolase</td>
</tr>
<tr>
<td>1451</td>
<td>1721</td>
<td><a href="/research/cog/cog/COG0502/">COG0502</a></td>
<td>
H
</td>
<td>Biotin synthase or related enzyme</td>
</tr>
<tr>
<td>606</td>
<td>838</td>
<td><a href="/research/cog/cog/COG0510/">COG0510</a></td>
<td>
H
</td>
<td>Thiamine kinase or a related kinase</td>
</tr>
<tr>
<td>1937</td>
<td>2515</td>
<td><a href="/research/cog/cog/COG0512/">COG0512</a></td>
<td>
E
H
</td>
<td>Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase)</td>
</tr>
<tr>
<td>1631</td>
<td>1838</td>
<td><a href="/research/cog/cog/COG0521/">COG0521</a></td>
<td>
H
</td>
<td>Molybdopterin adenylyltransferase MoaB/MogA</td>
</tr>
<tr>
<td>1548</td>
<td>4743</td>
<td><a href="/research/cog/cog/COG0535/">COG0535</a></td>
<td>
D
H
</td>
<td>Radical SAM superfamily maturase, SkfB/NifB/PqqE family</td>
</tr>
<tr>
<td>1343</td>
<td>2441</td>
<td><a href="/research/cog/cog/COG0543/">COG0543</a></td>
<td>
C
H
</td>
<td>NAD(P)H-flavin reductase</td>
</tr>
<tr>
<td>1605</td>
<td>4596</td>
<td><a href="/research/cog/cog/COG0561/">COG0561</a></td>
<td>
H
R
</td>
<td>Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases</td>
</tr>
<tr>
<td>2096</td>
<td>22530</td>
<td><a href="/research/cog/cog/COG0596/">COG0596</a></td>
<td>
H
R
</td>
<td>2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL</td>
</tr>
<tr>
<td>1575</td>
<td>1883</td>
<td><a href="/research/cog/cog/COG0602/">COG0602</a></td>
<td>
H
</td>
<td>Organic radical activating enzyme, includes 7-carboxy-7-deazaguanine synthase NrdG/QueE</td>
</tr>
<tr>
<td>1578</td>
<td>1601</td>
<td><a href="/research/cog/cog/COG0611/">COG0611</a></td>
<td>
H
</td>
<td>Thiamine monophosphate kinase</td>
</tr>
<tr>
<td>1170</td>
<td>2545</td>
<td><a href="/research/cog/cog/COG0619/">COG0619</a></td>
<td>
H
</td>
<td>ECF-type transporter transmembrane protein EcfT</td>
</tr>
<tr>
<td>1979</td>
<td>3392</td>
<td><a href="/research/cog/cog/COG0635/">COG0635</a></td>
<td>
H
</td>
<td>Coproporphyrinogen-III oxidase HemN (oxygen-independent) or related Fe-S oxidoreductase</td>
</tr>
<tr>
<td>1361</td>
<td>6530</td>
<td><a href="/research/cog/cog/COG0654/">COG0654</a></td>
<td>
C
H
</td>
<td>2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases</td>
</tr>
<tr>
<td>1608</td>
<td>2608</td>
<td><a href="/research/cog/cog/COG0661/">COG0661</a></td>
<td>
T
H
</td>
<td>Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family</td>
</tr>
<tr>
<td>1757</td>
<td>8211</td>
<td><a href="/research/cog/cog/COG0667/">COG0667</a></td>
<td>
H
R
</td>
<td>Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family</td>
</tr>
<tr>
<td>1986</td>
<td>2025</td>
<td><a href="/research/cog/cog/COG0669/">COG0669</a></td>
<td>
H
</td>
<td>Phosphopantetheine adenylyltransferase</td>
</tr>
<tr>
<td>1524</td>
<td>2053</td>
<td><a href="/research/cog/cog/COG0720/">COG0720</a></td>
<td>
H
</td>
<td>6-pyruvoyl-tetrahydropterin synthase</td>
</tr>
<tr>
<td>1555</td>
<td>1662</td>
<td><a href="/research/cog/cog/COG0746/">COG0746</a></td>
<td>
H
</td>
<td>Molybdopterin-guanine dinucleotide biosynthesis protein A</td>
</tr>
<tr>
<td>1367</td>
<td>1924</td>
<td><a href="/research/cog/cog/COG0775/">COG0775</a></td>
<td>
F
H
</td>
<td>Nucleoside phosphorylase/nucleosidase, includes 5&#x27;-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB</td>
</tr>
<tr>
<td>1836</td>
<td>2078</td>
<td><a href="/research/cog/cog/COG0801/">COG0801</a></td>
<td>
H
</td>
<td>7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis)</td>
</tr>
<tr>
<td>1804</td>
<td>2505</td>
<td><a href="/research/cog/cog/COG0807/">COG0807</a></td>
<td>
H
</td>
<td>GTP cyclohydrolase II</td>
</tr>
<tr>
<td>584</td>
<td>762</td>
<td><a href="/research/cog/cog/COG0819/">COG0819</a></td>
<td>
H
</td>
<td>Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway)</td>
</tr>
<tr>
<td>1150</td>
<td>1196</td>
<td><a href="/research/cog/cog/COG0853/">COG0853</a></td>
<td>
H
</td>
<td>Aspartate 1-decarboxylase</td>
</tr>
<tr>
<td>1200</td>
<td>1212</td>
<td><a href="/research/cog/cog/COG0854/">COG0854</a></td>
<td>
H
</td>
<td>Pyridoxine 5&#x27;-phosphate synthase PdxJ</td>
</tr>
<tr>
<td>851</td>
<td>902</td>
<td><a href="/research/cog/cog/COG1010/">COG1010</a></td>
<td>
H
</td>
<td>Precorrin-3B methylase</td>
</tr>
<tr>
<td>1903</td>
<td>5365</td>
<td><a href="/research/cog/cog/COG1011/">COG1011</a></td>
<td>
H
</td>
<td>FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)</td>
</tr>
<tr>
<td>149</td>
<td>167</td>
<td><a href="/research/cog/cog/COG1019/">COG1019</a></td>
<td>
H
</td>
<td>Phosphopantetheine adenylyltransferase</td>
</tr>
<tr>
<td>1573</td>
<td>3063</td>
<td><a href="/research/cog/cog/COG1052/">COG1052</a></td>
<td>
C
H
R
</td>
<td>Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase</td>
</tr>
<tr>
<td>465</td>
<td>539</td>
<td><a href="/research/cog/cog/COG1056/">COG1056</a></td>
<td>
H
</td>
<td>Nicotinamide mononucleotide adenylyltransferase</td>
</tr>
<tr>
<td>1958</td>
<td>2056</td>
<td><a href="/research/cog/cog/COG1057/">COG1057</a></td>
<td>
H
</td>
<td>Nicotinate-nucleotide adenylyltransferase NadD</td>
</tr>
<tr>
<td>989</td>
<td>1856</td>
<td><a href="/research/cog/cog/COG1060/">COG1060</a></td>
<td>
H
</td>
<td>2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE</td>
</tr>
<tr>
<td>641</td>
<td>830</td>
<td><a href="/research/cog/cog/COG1072/">COG1072</a></td>
<td>
H
</td>
<td>Pantothenate kinase</td>
</tr>
<tr>
<td>1754</td>
<td>4229</td>
<td><a href="/research/cog/cog/COG1120/">COG1120</a></td>
<td>
H
P
</td>
<td>ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component</td>
</tr>
<tr>
<td>1794</td>
<td>1913</td>
<td><a href="/research/cog/cog/COG1154/">COG1154</a></td>
<td>
H
I
</td>
<td>Deoxyxylulose-5-phosphate synthase</td>
</tr>
<tr>
<td>778</td>
<td>792</td>
<td><a href="/research/cog/cog/COG1165/">COG1165</a></td>
<td>
H
</td>
<td>2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</td>
</tr>
<tr>
<td>830</td>
<td>921</td>
<td><a href="/research/cog/cog/COG1169/">COG1169</a></td>
<td>
H
Q
</td>
<td>Isochorismate synthase EntC</td>
</tr>
<tr>
<td>973</td>
<td>1352</td>
<td><a href="/research/cog/cog/COG1232/">COG1232</a></td>
<td>
H
</td>
<td>Protoporphyrinogen oxidase HemY/PPOX</td>
</tr>
<tr>
<td>1579</td>
<td>2350</td>
<td><a href="/research/cog/cog/COG1235/">COG1235</a></td>
<td>
H
P
</td>
<td>Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase</td>
</tr>
<tr>
<td>683</td>
<td>1048</td>
<td><a href="/research/cog/cog/COG1239/">COG1239</a></td>
<td>
H
</td>
<td>Mg-chelatase subunit ChlI</td>
</tr>
<tr>
<td>1025</td>
<td>1189</td>
<td><a href="/research/cog/cog/COG1268/">COG1268</a></td>
<td>
H
</td>
<td>Biotin transporter BioY</td>
</tr>
<tr>
<td>1168</td>
<td>1288</td>
<td><a href="/research/cog/cog/COG1270/">COG1270</a></td>
<td>
H
</td>
<td>Cobalamin biosynthesis protein CobD/CbiB</td>
</tr>
<tr>
<td>1776</td>
<td>4907</td>
<td><a href="/research/cog/cog/COG1335/">COG1335</a></td>
<td>
H
R
</td>
<td>Nicotinamidase-related amidase</td>
</tr>
<tr>
<td>189</td>
<td>194</td>
<td><a href="/research/cog/cog/COG1339/">COG1339</a></td>
<td>
H
</td>
<td>Archaeal CTP-dependent riboflavin kinase</td>
</tr>
<tr>
<td>452</td>
<td>679</td>
<td><a href="/research/cog/cog/COG1348/">COG1348</a></td>
<td>
H
P
</td>
<td>Nitrogenase ATPase subunit NifH/coenzyme F430 biosynthesis subunit CfbC</td>
</tr>
<tr>
<td>837</td>
<td>1351</td>
<td><a href="/research/cog/cog/COG1402/">COG1402</a></td>
<td>
H
</td>
<td>Creatinine amidohydrolase/FAPy deformylase (formamide hydrolase)</td>
</tr>
<tr>
<td>60</td>
<td>61</td>
<td><a href="/research/cog/cog/COG1424/">COG1424</a></td>
<td>
H
</td>
<td>Pimeloyl-CoA synthetase</td>
</tr>
<tr>
<td>334</td>
<td>336</td>
<td><a href="/research/cog/cog/COG1427/">COG1427</a></td>
<td>
H
</td>
<td>Chorismate dehydratase (menaquinone biosynthesis, futalosine pathway)</td>
</tr>
<tr>
<td>657</td>
<td>992</td>
<td><a href="/research/cog/cog/COG1429/">COG1429</a></td>
<td>
H
</td>
<td>Cobalamin biosynthesis protein CobN, Mg-chelatase</td>
</tr>
<tr>
<td>126</td>
<td>126</td>
<td><a href="/research/cog/cog/COG1441/">COG1441</a></td>
<td>
H
</td>
<td>O-succinylbenzoate synthase</td>
</tr>
<tr>
<td>657</td>
<td>698</td>
<td><a href="/research/cog/cog/COG1469/">COG1469</a></td>
<td>
H
</td>
<td>GTP cyclohydrolase FolE2</td>
</tr>
<tr>
<td>1342</td>
<td>1972</td>
<td><a href="/research/cog/cog/COG1477/">COG1477</a></td>
<td>
O
H
</td>
<td>FAD:protein FMN transferase ApbE</td>
</tr>
<tr>
<td>382</td>
<td>450</td>
<td><a href="/research/cog/cog/COG1478/">COG1478</a></td>
<td>
H
</td>
<td>F420-0:Gamma-glutamyl ligase (F420 biosynthesis)</td>
</tr>
<tr>
<td>1635</td>
<td>1785</td>
<td><a href="/research/cog/cog/COG1488/">COG1488</a></td>
<td>
H
</td>
<td>Nicotinic acid phosphoribosyltransferase</td>
</tr>
<tr>
<td>1122</td>
<td>1197</td>
<td><a href="/research/cog/cog/COG1492/">COG1492</a></td>
<td>
H
</td>
<td>Cobyric acid synthase</td>
</tr>
<tr>
<td>1524</td>
<td>1597</td>
<td><a href="/research/cog/cog/COG1521/">COG1521</a></td>
<td>
H
</td>
<td>Pantothenate kinase type III</td>
</tr>
<tr>
<td>1630</td>
<td>1794</td>
<td><a href="/research/cog/cog/COG1539/">COG1539</a></td>
<td>
H
</td>
<td>Dihydroneopterin aldolase</td>
</tr>
<tr>
<td>1191</td>
<td>2514</td>
<td><a href="/research/cog/cog/COG1541/">COG1541</a></td>
<td>
H
</td>
<td>Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family</td>
</tr>
<tr>
<td>1958</td>
<td>2159</td>
<td><a href="/research/cog/cog/COG1546/">COG1546</a></td>
<td>
H
</td>
<td>Nicotinamide mononucleotide (NMN) deamidase PncC</td>
</tr>
<tr>
<td>144</td>
<td>145</td>
<td><a href="/research/cog/cog/COG1548/">COG1548</a></td>
<td>
H
</td>
<td>Methanofuran synthetase MfnF, hydantoinase/oxoprolinase family</td>
</tr>
<tr>
<td>665</td>
<td>671</td>
<td><a href="/research/cog/cog/COG1564/">COG1564</a></td>
<td>
H
</td>
<td>Thiamine pyrophosphokinase</td>
</tr>
<tr>
<td>1083</td>
<td>1258</td>
<td><a href="/research/cog/cog/COG1575/">COG1575</a></td>
<td>
H
</td>
<td>1,4-dihydroxy-2-naphthoate polyprenyltransferase</td>
</tr>
<tr>
<td>1910</td>
<td>2346</td>
<td><a href="/research/cog/cog/COG1587/">COG1587</a></td>
<td>
H
</td>
<td>Uroporphyrinogen-III synthase</td>
</tr>
<tr>
<td>1268</td>
<td>1347</td>
<td><a href="/research/cog/cog/COG1612/">COG1612</a></td>
<td>
H
</td>
<td>Heme A synthase</td>
</tr>
<tr>
<td>166</td>
<td>168</td>
<td><a href="/research/cog/cog/COG1634/">COG1634</a></td>
<td>
H
</td>
<td>6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE (tetrahydrofolate and tetrahydromethanopterin biosynthesis)</td>
</tr>
<tr>
<td>180</td>
<td>188</td>
<td><a href="/research/cog/cog/COG1635/">COG1635</a></td>
<td>
G
H
</td>
<td>Thiazole synthase/Archaeal ribulose 1,5-bisphosphate synthetase</td>
</tr>
<tr>
<td>583</td>
<td>663</td>
<td><a href="/research/cog/cog/COG1641/">COG1641</a></td>
<td>
H
</td>
<td>CTP-dependent cyclometallase, nickel-pincer nucleotide (NPN) cofactor biosynthesis</td>
</tr>
<tr>
<td>1317</td>
<td>1459</td>
<td><a href="/research/cog/cog/COG1648/">COG1648</a></td>
<td>
H
</td>
<td>Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)</td>
</tr>
<tr>
<td>157</td>
<td>159</td>
<td><a href="/research/cog/cog/COG1701/">COG1701</a></td>
<td>
H
</td>
<td>Archaeal phosphopantothenate synthetase</td>
</tr>
<tr>
<td>74</td>
<td>74</td>
<td><a href="/research/cog/cog/COG1731/">COG1731</a></td>
<td>
H
</td>
<td>Archaeal riboflavin synthase</td>
</tr>
<tr>
<td>832</td>
<td>893</td>
<td><a href="/research/cog/cog/COG1763/">COG1763</a></td>
<td>
H
</td>
<td>Molybdopterin-guanine dinucleotide biosynthesis protein</td>
</tr>
<tr>
<td>467</td>
<td>536</td>
<td><a href="/research/cog/cog/COG1767/">COG1767</a></td>
<td>
H
</td>
<td>Triphosphoribosyl-dephospho-CoA synthetase</td>
</tr>
<tr>
<td>1017</td>
<td>1175</td>
<td><a href="/research/cog/cog/COG1797/">COG1797</a></td>
<td>
H
</td>
<td>Cobyrinic acid a,c-diamide synthase</td>
</tr>
<tr>
<td>191</td>
<td>206</td>
<td><a href="/research/cog/cog/COG1809/">COG1809</a></td>
<td>
H
</td>
<td>Phosphosulfolactate synthase, CoM biosynthesis protein A</td>
</tr>
<tr>
<td>205</td>
<td>215</td>
<td><a href="/research/cog/cog/COG1812/">COG1812</a></td>
<td>
H
</td>
<td>Archaeal S-adenosylmethionine synthetase</td>
</tr>
<tr>
<td>125</td>
<td>128</td>
<td><a href="/research/cog/cog/COG1821/">COG1821</a></td>
<td>
H
</td>
<td>Tyramine-glutamate ligase MfnD (methanofuran biosynthesis), ATP-grasp superfamily</td>
</tr>
<tr>
<td>255</td>
<td>284</td>
<td><a href="/research/cog/cog/COG1827/">COG1827</a></td>
<td>
K
H
</td>
<td>Transcriptional regulator of NAD metabolism, contains HTH and 3H domains</td>
</tr>
<tr>
<td>168</td>
<td>175</td>
<td><a href="/research/cog/cog/COG1829/">COG1829</a></td>
<td>
H
</td>
<td>Archaeal pantoate kinase</td>
</tr>
<tr>
<td>1249</td>
<td>2657</td>
<td><a href="/research/cog/cog/COG1840/">COG1840</a></td>
<td>
G
H
</td>
<td>ABC-type transport systems for B6 and hexose phosphate, periplasmic component</td>
</tr>
<tr>
<td>315</td>
<td>348</td>
<td><a href="/research/cog/cog/COG1865/">COG1865</a></td>
<td>
H
</td>
<td>Adenosylcobinamide amidohydrolase</td>
</tr>
<tr>
<td>151</td>
<td>151</td>
<td><a href="/research/cog/cog/COG1891/">COG1891</a></td>
<td>
H
</td>
<td>4-(hydroxymethyl)-2-furancarboxaldehyde phosphate synthase MfnB</td>
</tr>
<tr>
<td>1226</td>
<td>1922</td>
<td><a href="/research/cog/cog/COG1893/">COG1893</a></td>
<td>
H
</td>
<td>Ketopantoate reductase</td>
</tr>
<tr>
<td>642</td>
<td>649</td>
<td><a href="/research/cog/cog/COG1903/">COG1903</a></td>
<td>
H
</td>
<td>Cobalt-precorrin-5B methyltransferase</td>
</tr>
<tr>
<td>233</td>
<td>255</td>
<td><a href="/research/cog/cog/COG1907/">COG1907</a></td>
<td>
H
</td>
<td>Beta-ribofuranosylaminobenzene 5&#x27;-phosphate synthase (methanopterin biosynthesis)</td>
</tr>
<tr>
<td>178</td>
<td>178</td>
<td><a href="/research/cog/cog/COG1909/">COG1909</a></td>
<td>
H
</td>
<td>Archaeal dephospho-CoA kinase</td>
</tr>
<tr>
<td>669</td>
<td>722</td>
<td><a href="/research/cog/cog/COG1912/">COG1912</a></td>
<td>
V
H
</td>
<td>Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming)</td>
</tr>
<tr>
<td>306</td>
<td>316</td>
<td><a href="/research/cog/cog/COG1920/">COG1920</a></td>
<td>
H
</td>
<td>2-phospho-L-lactate guanylyltransferase, coenzyme F420 biosynthesis enzyme, CobY/MobA/RfbA family</td>
</tr>
<tr>
<td>1487</td>
<td>1548</td>
<td><a href="/research/cog/cog/COG1932/">COG1932</a></td>
<td>
E
H
</td>
<td>Phosphoserine aminotransferase</td>
</tr>
<tr>
<td>329</td>
<td>430</td>
<td><a href="/research/cog/cog/COG1953/">COG1953</a></td>
<td>
F
H
</td>
<td>Cytosine/uracil/thiamine/allantoin permease</td>
</tr>
<tr>
<td>67</td>
<td>89</td>
<td><a href="/research/cog/cog/COG1962/">COG1962</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit H</td>
</tr>
<tr>
<td>277</td>
<td>309</td>
<td><a href="/research/cog/cog/COG1964/">COG1964</a></td>
<td>
H
I
</td>
<td>Archaeal tetraether lipid synthase/C-terminal domain of the GTP 3&#x27;,8&#x27;-cyclase MoaA, radical SAM superfamily</td>
</tr>
<tr>
<td>1537</td>
<td>2208</td>
<td><a href="/research/cog/cog/COG1977/">COG1977</a></td>
<td>
H
</td>
<td>Molybdopterin synthase sulfur carrier subunit MoaD</td>
</tr>
<tr>
<td>846</td>
<td>918</td>
<td><a href="/research/cog/cog/COG1981/">COG1981</a></td>
<td>
H
</td>
<td>Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY)</td>
</tr>
<tr>
<td>1973</td>
<td>2531</td>
<td><a href="/research/cog/cog/COG1985/">COG1985</a></td>
<td>
H
</td>
<td>Pyrimidine reductase, riboflavin biosynthesis</td>
</tr>
<tr>
<td>178</td>
<td>283</td>
<td><a href="/research/cog/cog/COG1992/">COG1992</a></td>
<td>
H
</td>
<td>Thiamin biosynthesis enzyme, contains thiamin monophosphate synthase domain</td>
</tr>
<tr>
<td>1368</td>
<td>1631</td>
<td><a href="/research/cog/cog/COG1995/">COG1995</a></td>
<td>
H
</td>
<td>4-hydroxy-L-threonine phosphate dehydrogenase PdxA</td>
</tr>
<tr>
<td>1258</td>
<td>1286</td>
<td><a href="/research/cog/cog/COG2022/">COG2022</a></td>
<td>
H
</td>
<td>Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis)</td>
</tr>
<tr>
<td>1189</td>
<td>1294</td>
<td><a href="/research/cog/cog/COG2038/">COG2038</a></td>
<td>
H
</td>
<td>NaMN:DMB phosphoribosyltransferase</td>
</tr>
<tr>
<td>463</td>
<td>497</td>
<td><a href="/research/cog/cog/COG2045/">COG2045</a></td>
<td>
H
</td>
<td>Phosphosulfolactate phosphohydrolase or related enzyme</td>
</tr>
<tr>
<td>147</td>
<td>147</td>
<td><a href="/research/cog/cog/COG2054/">COG2054</a></td>
<td>
H
</td>
<td>5-(aminomethyl)-3-furanmethanol-phosphate kinase MfnE (methanofuran biosynthesis)</td>
</tr>
<tr>
<td>1057</td>
<td>1174</td>
<td><a href="/research/cog/cog/COG2068/">COG2068</a></td>
<td>
H
</td>
<td>CTP:molybdopterin cytidylyltransferase MocA</td>
</tr>
<tr>
<td>661</td>
<td>724</td>
<td><a href="/research/cog/cog/COG2073/">COG2073</a></td>
<td>
H
</td>
<td>Cobalt-precorrin 5A hydrolase</td>
</tr>
<tr>
<td>854</td>
<td>952</td>
<td><a href="/research/cog/cog/COG2082/">COG2082</a></td>
<td>
H
</td>
<td>Precorrin-8X methylmutase CbiC/CobH</td>
</tr>
<tr>
<td>1046</td>
<td>1139</td>
<td><a href="/research/cog/cog/COG2087/">COG2087</a></td>
<td>
H
</td>
<td>Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase</td>
</tr>
<tr>
<td>961</td>
<td>1196</td>
<td><a href="/research/cog/cog/COG2091/">COG2091</a></td>
<td>
H
</td>
<td>Phosphopantetheinyl transferase</td>
</tr>
<tr>
<td>1305</td>
<td>1411</td>
<td><a href="/research/cog/cog/COG2096/">COG2096</a></td>
<td>
H
</td>
<td>Cob(II)alamin adenosyltransferase</td>
</tr>
<tr>
<td>122</td>
<td>123</td>
<td><a href="/research/cog/cog/COG2098/">COG2098</a></td>
<td>
H
</td>
<td>7,8-dihydroneopterin aldolase MptD (tetrahydrofolate and tetrahydromethanopterin biosynthesis)</td>
</tr>
<tr>
<td>664</td>
<td>687</td>
<td><a href="/research/cog/cog/COG2099/">COG2099</a></td>
<td>
H
</td>
<td>Precorrin-6x reductase</td>
</tr>
<tr>
<td>1394</td>
<td>1531</td>
<td><a href="/research/cog/cog/COG2104/">COG2104</a></td>
<td>
J
H
</td>
<td>Sulfur carrier protein ThiS/TtuB (thiamine biosynthesis, tRNA 2-thiouridylation)</td>
</tr>
<tr>
<td>313</td>
<td>321</td>
<td><a href="/research/cog/cog/COG2107/">COG2107</a></td>
<td>
H
</td>
<td>1,4-dihydroxy-6-naphtoate synthase (menaquinone biosynthesis, futalosine pathway)</td>
</tr>
<tr>
<td>1119</td>
<td>1341</td>
<td><a href="/research/cog/cog/COG2109/">COG2109</a></td>
<td>
H
</td>
<td>ATP:corrinoid adenosyltransferase</td>
</tr>
<tr>
<td>861</td>
<td>1136</td>
<td><a href="/research/cog/cog/COG2138/">COG2138</a></td>
<td>
H
</td>
<td>Sirohydrochlorin ferrochelatase</td>
</tr>
<tr>
<td>1245</td>
<td>8519</td>
<td><a href="/research/cog/cog/COG2141/">COG2141</a></td>
<td>
H
R
</td>
<td>Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)</td>
</tr>
<tr>
<td>680</td>
<td>708</td>
<td><a href="/research/cog/cog/COG2145/">COG2145</a></td>
<td>
H
</td>
<td>Hydroxyethylthiazole kinase, sugar kinase family</td>
</tr>
<tr>
<td>438</td>
<td>510</td>
<td><a href="/research/cog/cog/COG2149/">COG2149</a></td>
<td>
H
</td>
<td>Membrane protein YidH involved in molybdoenzyme production, DUF202 family</td>
</tr>
<tr>
<td>1226</td>
<td>1400</td>
<td><a href="/research/cog/cog/COG2154/">COG2154</a></td>
<td>
H
</td>
<td>Pterin-4a-carbinolamine dehydratase</td>
</tr>
<tr>
<td>2207</td>
<td>18977</td>
<td><a href="/research/cog/cog/COG2226/">COG2226</a></td>
<td>
J
H
</td>
<td>Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9</td>
</tr>
<tr>
<td>1933</td>
<td>7828</td>
<td><a href="/research/cog/cog/COG2227/">COG2227</a></td>
<td>
H
</td>
<td>2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase</td>
</tr>
<tr>
<td>711</td>
<td>798</td>
<td><a href="/research/cog/cog/COG2236/">COG2236</a></td>
<td>
H
</td>
<td>Hypoxanthine phosphoribosyltransferase</td>
</tr>
<tr>
<td>542</td>
<td>596</td>
<td><a href="/research/cog/cog/COG2240/">COG2240</a></td>
<td>
H
</td>
<td>Pyridoxal/pyridoxine/pyridoxamine kinase</td>
</tr>
<tr>
<td>877</td>
<td>915</td>
<td><a href="/research/cog/cog/COG2241/">COG2241</a></td>
<td>
H
</td>
<td>Precorrin-6Y C5,15-methylase subunit CbiE</td>
</tr>
<tr>
<td>974</td>
<td>1243</td>
<td><a href="/research/cog/cog/COG2242/">COG2242</a></td>
<td>
H
</td>
<td>Precorrin-6Y C5,15-methylase subunit CbiT</td>
</tr>
<tr>
<td>848</td>
<td>1048</td>
<td><a href="/research/cog/cog/COG2243/">COG2243</a></td>
<td>
H
</td>
<td>Precorrin-2 methylase</td>
</tr>
<tr>
<td>194</td>
<td>200</td>
<td><a href="/research/cog/cog/COG2266/">COG2266</a></td>
<td>
H
</td>
<td>GTP:adenosylcobinamide-phosphate guanylyltransferase</td>
</tr>
<tr>
<td>985</td>
<td>1547</td>
<td><a href="/research/cog/cog/COG2329/">COG2329</a></td>
<td>
H
</td>
<td>Heme-degrading monooxygenase HmoA and related ABM domain proteins</td>
</tr>
<tr>
<td>217</td>
<td>232</td>
<td><a href="/research/cog/cog/COG2503/">COG2503</a></td>
<td>
H
</td>
<td>Secreted acid phosphatase/5&#x27;-nucleotidase, lipoprotein e(P4) family</td>
</tr>
<tr>
<td>520</td>
<td>592</td>
<td><a href="/research/cog/cog/COG2510/">COG2510</a></td>
<td>
H
</td>
<td>Riboflavin transporter RibN, EamA domain</td>
</tr>
<tr>
<td>371</td>
<td>1657</td>
<td><a href="/research/cog/cog/COG2710/">COG2710</a></td>
<td>
H
P
</td>
<td>Nitrogenase Mo-Fe protein NifD/coenzyme F430 biosynthesis subunit CfbD</td>
</tr>
<tr>
<td>858</td>
<td>897</td>
<td><a href="/research/cog/cog/COG2875/">COG2875</a></td>
<td>
H
</td>
<td>Precorrin-4 methylase</td>
</tr>
<tr>
<td>1689</td>
<td>1925</td>
<td><a href="/research/cog/cog/COG2896/">COG2896</a></td>
<td>
H
</td>
<td>GTP 3&#x27;,8-cyclase (molybdenum cofactor biosynthesis protein MoaA)</td>
</tr>
<tr>
<td>421</td>
<td>439</td>
<td><a href="/research/cog/cog/COG2918/">COG2918</a></td>
<td>
H
</td>
<td>Gamma-glutamylcysteine synthetase</td>
</tr>
<tr>
<td>384</td>
<td>410</td>
<td><a href="/research/cog/cog/COG2941/">COG2941</a></td>
<td>
H
</td>
<td>Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis)</td>
</tr>
<tr>
<td>678</td>
<td>680</td>
<td><a href="/research/cog/cog/COG2960/">COG2960</a></td>
<td>
H
</td>
<td>Ubiquinone biosynthesis accessory factor UbiK</td>
</tr>
<tr>
<td>324</td>
<td>446</td>
<td><a href="/research/cog/cog/COG2978/">COG2978</a></td>
<td>
H
</td>
<td>p-Aminobenzoyl-glutamate transporter AbgT</td>
</tr>
<tr>
<td>299</td>
<td>302</td>
<td><a href="/research/cog/cog/COG3154/">COG3154</a></td>
<td>
H
</td>
<td>Ubiquinone biosynthesis accessory factor UbiT, lipid carrier SCP2 domain</td>
</tr>
<tr>
<td>522</td>
<td>530</td>
<td><a href="/research/cog/cog/COG3161/">COG3161</a></td>
<td>
H
</td>
<td>4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)</td>
</tr>
<tr>
<td>452</td>
<td>457</td>
<td><a href="/research/cog/cog/COG3165/">COG3165</a></td>
<td>
H
</td>
<td>Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain</td>
</tr>
<tr>
<td>397</td>
<td>431</td>
<td><a href="/research/cog/cog/COG3172/">COG3172</a></td>
<td>
H
</td>
<td>Nicotinamide riboside kinase</td>
</tr>
<tr>
<td>640</td>
<td>735</td>
<td><a href="/research/cog/cog/COG3201/">COG3201</a></td>
<td>
H
</td>
<td>Nicotinamide riboside transporter PnuC</td>
</tr>
<tr>
<td>289</td>
<td>354</td>
<td><a href="/research/cog/cog/COG3236/">COG3236</a></td>
<td>
V
H
</td>
<td>N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily</td>
</tr>
<tr>
<td>210</td>
<td>215</td>
<td><a href="/research/cog/cog/COG3252/">COG3252</a></td>
<td>
H
</td>
<td>Methenyltetrahydromethanopterin cyclohydrolase</td>
</tr>
<tr>
<td>504</td>
<td>514</td>
<td><a href="/research/cog/cog/COG3253/">COG3253</a></td>
<td>
H
P
</td>
<td>Coproheme decarboxylase/chlorite dismutase</td>
</tr>
<tr>
<td>375</td>
<td>377</td>
<td><a href="/research/cog/cog/COG3442/">COG3442</a></td>
<td>
M
H
</td>
<td>Glutaminase/glutamine amidotransferase domain of CobB, CobQ, and lipid II isoglutaminyl synthase</td>
</tr>
<tr>
<td>97</td>
<td>98</td>
<td><a href="/research/cog/cog/COG3445/">COG3445</a></td>
<td>
H
</td>
<td>Autonomous glycyl radical cofactor GrcA</td>
</tr>
<tr>
<td>468</td>
<td>492</td>
<td><a href="/research/cog/cog/COG3572/">COG3572</a></td>
<td>
H
</td>
<td>Gamma-glutamylcysteine synthetase</td>
</tr>
<tr>
<td>666</td>
<td>890</td>
<td><a href="/research/cog/cog/COG3585/">COG3585</a></td>
<td>
H
</td>
<td>Molybdopterin-binding protein MopI</td>
</tr>
<tr>
<td>338</td>
<td>357</td>
<td><a href="/research/cog/cog/COG3601/">COG3601</a></td>
<td>
H
</td>
<td>Riboflavin transporter FmnP/RibU</td>
</tr>
<tr>
<td>159</td>
<td>171</td>
<td><a href="/research/cog/cog/COG3697/">COG3697</a></td>
<td>
H
I
</td>
<td>Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)</td>
</tr>
<tr>
<td>111</td>
<td>119</td>
<td><a href="/research/cog/cog/COG3721/">COG3721</a></td>
<td>
H
P
</td>
<td>Heme degradation regulator ChuX/HutX</td>
</tr>
<tr>
<td>233</td>
<td>234</td>
<td><a href="/research/cog/cog/COG3840/">COG3840</a></td>
<td>
H
</td>
<td>ABC-type thiamine transport system, ATPase component ThiQ</td>
</tr>
<tr>
<td>246</td>
<td>255</td>
<td><a href="/research/cog/cog/COG3859/">COG3859</a></td>
<td>
H
</td>
<td>Thiamine transporter ThiT</td>
</tr>
<tr>
<td>181</td>
<td>239</td>
<td><a href="/research/cog/cog/COG3862/">COG3862</a></td>
<td>
H
</td>
<td>Molybdopterin oxidoreductase Fe4S4 domain, DUF1667 family</td>
</tr>
<tr>
<td>245</td>
<td>280</td>
<td><a href="/research/cog/cog/COG3961/">COG3961</a></td>
<td>
G
H
R
</td>
<td>TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase</td>
</tr>
<tr>
<td>14</td>
<td>14</td>
<td><a href="/research/cog/cog/COG4016/">COG4016</a></td>
<td>
H
</td>
<td>Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF, CinA family</td>
</tr>
<tr>
<td>13</td>
<td>13</td>
<td><a href="/research/cog/cog/COG4017/">COG4017</a></td>
<td>
H
</td>
<td>Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, methyltransferase HcgC</td>
</tr>
<tr>
<td>14</td>
<td>14</td>
<td><a href="/research/cog/cog/COG4018/">COG4018</a></td>
<td>
H
</td>
<td>Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, fibrillarin family</td>
</tr>
<tr>
<td>13</td>
<td>13</td>
<td><a href="/research/cog/cog/COG4019/">COG4019</a></td>
<td>
H
</td>
<td>Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgB, guanylyltransferase</td>
</tr>
<tr>
<td>173</td>
<td>199</td>
<td><a href="/research/cog/cog/COG4032/">COG4032</a></td>
<td>
H
</td>
<td>Sulfopyruvate decarboxylase, TPP-binding subunit (coenzyme M biosynthesis)</td>
</tr>
<tr>
<td>45</td>
<td>56</td>
<td><a href="/research/cog/cog/COG4054/">COG4054</a></td>
<td>
H
</td>
<td>Methyl coenzyme M reductase, beta subunit</td>
</tr>
<tr>
<td>44</td>
<td>55</td>
<td><a href="/research/cog/cog/COG4055/">COG4055</a></td>
<td>
H
</td>
<td>Methyl coenzyme M reductase, subunit D</td>
</tr>
<tr>
<td>45</td>
<td>46</td>
<td><a href="/research/cog/cog/COG4056/">COG4056</a></td>
<td>
H
</td>
<td>Methyl coenzyme M reductase, subunit C</td>
</tr>
<tr>
<td>45</td>
<td>57</td>
<td><a href="/research/cog/cog/COG4057/">COG4057</a></td>
<td>
H
</td>
<td>Methyl coenzyme M reductase, gamma subunit</td>
</tr>
<tr>
<td>45</td>
<td>59</td>
<td><a href="/research/cog/cog/COG4058/">COG4058</a></td>
<td>
H
</td>
<td>Methyl coenzyme M reductase, alpha subunit</td>
</tr>
<tr>
<td>36</td>
<td>36</td>
<td><a href="/research/cog/cog/COG4059/">COG4059</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit E</td>
</tr>
<tr>
<td>35</td>
<td>35</td>
<td><a href="/research/cog/cog/COG4060/">COG4060</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit D</td>
</tr>
<tr>
<td>36</td>
<td>36</td>
<td><a href="/research/cog/cog/COG4061/">COG4061</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit C</td>
</tr>
<tr>
<td>36</td>
<td>36</td>
<td><a href="/research/cog/cog/COG4062/">COG4062</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit B</td>
</tr>
<tr>
<td>63</td>
<td>89</td>
<td><a href="/research/cog/cog/COG4063/">COG4063</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit A</td>
</tr>
<tr>
<td>25</td>
<td>25</td>
<td><a href="/research/cog/cog/COG4064/">COG4064</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit G</td>
</tr>
<tr>
<td>362</td>
<td>419</td>
<td><a href="/research/cog/cog/COG4094/">COG4094</a></td>
<td>
H
P
</td>
<td>Zeta-carotene isomerase/dentrification protein, Z-ISO/NnrU family</td>
</tr>
<tr>
<td>543</td>
<td>716</td>
<td><a href="/research/cog/cog/COG4111/">COG4111</a></td>
<td>
H
</td>
<td>ATP-responsive regulator of NAD biosynthesis</td>
</tr>
<tr>
<td>74</td>
<td>76</td>
<td><a href="/research/cog/cog/COG4138/">COG4138</a></td>
<td>
H
</td>
<td>ABC-type cobalamin transport system, ATPase component BtuD</td>
</tr>
<tr>
<td>98</td>
<td>101</td>
<td><a href="/research/cog/cog/COG4139/">COG4139</a></td>
<td>
H
</td>
<td>ABC-type cobalamin transport system, permease component BtuC</td>
</tr>
<tr>
<td>459</td>
<td>476</td>
<td><a href="/research/cog/cog/COG4143/">COG4143</a></td>
<td>
H
</td>
<td>ABC-type thiamine transport system, periplasmic component TbpA</td>
</tr>
<tr>
<td>259</td>
<td>281</td>
<td><a href="/research/cog/cog/COG4145/">COG4145</a></td>
<td>
H
</td>
<td>Na+/panthothenate symporter</td>
</tr>
<tr>
<td>979</td>
<td>3721</td>
<td><a href="/research/cog/cog/COG4206/">COG4206</a></td>
<td>
H
</td>
<td>Outer membrane cobalamin receptor protein BtuB</td>
</tr>
<tr>
<td>29</td>
<td>29</td>
<td><a href="/research/cog/cog/COG4218/">COG4218</a></td>
<td>
H
</td>
<td>Tetrahydromethanopterin S-methyltransferase, subunit F</td>
</tr>
<tr>
<td>337</td>
<td>365</td>
<td><a href="/research/cog/cog/COG4256/">COG4256</a></td>
<td>
K
H
</td>
<td>RNA-binding regulator of hemin uptake HemP/HmuP</td>
</tr>
<tr>
<td>400</td>
<td>433</td>
<td><a href="/research/cog/cog/COG4547/">COG4547</a></td>
<td>
H
</td>
<td>Cobalamin biosynthesis cobaltochelatase CobT subunit</td>
</tr>
<tr>
<td>472</td>
<td>564</td>
<td><a href="/research/cog/cog/COG4635/">COG4635</a></td>
<td>
H
</td>
<td>Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)</td>
</tr>
<tr>
<td>294</td>
<td>389</td>
<td><a href="/research/cog/cog/COG4720/">COG4720</a></td>
<td>
H
</td>
<td>Membrane component of ECF-type riboflavin transportert</td>
</tr>
<tr>
<td>221</td>
<td>236</td>
<td><a href="/research/cog/cog/COG4721/">COG4721</a></td>
<td>
H
</td>
<td>ABC-type thiamine/hydroxymethylpyrimidine transport system, permease component</td>
</tr>
<tr>
<td>151</td>
<td>151</td>
<td><a href="/research/cog/cog/COG4732/">COG4732</a></td>
<td>
H
</td>
<td>Membrane component ThiW of ECF-type thiazole transporter</td>
</tr>
<tr>
<td>311</td>
<td>316</td>
<td><a href="/research/cog/cog/COG4769/">COG4769</a></td>
<td>
O
H
</td>
<td>Protein flavinylation system FAD exporter subunit EetB</td>
</tr>
<tr>
<td>225</td>
<td>282</td>
<td><a href="/research/cog/cog/COG4822/">COG4822</a></td>
<td>
H
</td>
<td>Cobalamin biosynthesis protein CbiK, Co2+ chelatase</td>
</tr>
<tr>
<td>114</td>
<td>198</td>
<td><a href="/research/cog/cog/COG5031/">COG5031</a></td>
<td>
H
</td>
<td>Ubiquinone biosynthesis protein Coq4</td>
</tr>
<tr>
<td>50</td>
<td>50</td>
<td><a href="/research/cog/cog/COG5146/">COG5146</a></td>
<td>
H
</td>
<td>Pantothenate kinase</td>
</tr>
<tr>
<td>201</td>
<td>253</td>
<td><a href="/research/cog/cog/COG5398/">COG5398</a></td>
<td>
H
</td>
<td>Heme oxygenase</td>
</tr>
<tr>
<td>376</td>
<td>471</td>
<td><a href="/research/cog/cog/COG5424/">COG5424</a></td>
<td>
H
</td>
<td>Pyrroloquinoline quinone (PQQ) synthase PqqC, TenA/Thi4/PqqC family</td>
</tr>
<tr>
<td>198</td>
<td>208</td>
<td><a href="/research/cog/cog/COG5590/">COG5590</a></td>
<td>
H
</td>
<td>Ubiquinone biosynthesis protein COQ9</td>
</tr>
<tr>
<td>175</td>
<td>678</td>
<td><a href="/research/cog/cog/COG5598/">COG5598</a></td>
<td>
H
</td>
<td>Trimethylamine:corrinoid methyltransferase</td>
</tr>
<tr>
<td>193</td>
<td>276</td>
<td><a href="/research/cog/cog/COG5746/">COG5746</a></td>
<td>
H
</td>
<td>Light-independent protochlorophyllide reductase subunit B, BchB (=ChlB)</td>
</tr>
<tr>
<td>155</td>
<td>155</td>
<td><a href="/research/cog/cog/COG5747/">COG5747</a></td>
<td>
H
</td>
<td>Light-independent protochlorophyllide reductase subunit N, BchN (=ChlN)</td>
</tr>
<tr>
<td>581</td>
<td>1094</td>
<td><a href="/research/cog/cog/COG5748/">COG5748</a></td>
<td>
H
</td>
<td>Light-dependent NADPH-protochlorophyllide oxidoreductase</td>
</tr>
<tr>
<td>579</td>
<td>1406</td>
<td><a href="/research/cog/cog/COG5749/">COG5749</a></td>
<td>
H
</td>
<td>Chlorophyllide a oxygenase/letal leaf spot protein</td>
</tr>
<tr>
<td>82</td>
<td>82</td>
<td><a href="/research/cog/cog/COG5753/">COG5753</a></td>
<td>
H
</td>
<td>Bacteriochlorophyllide reductase subunit BchX</td>
</tr>
<tr>
<td>81</td>
<td>81</td>
<td><a href="/research/cog/cog/COG5754/">COG5754</a></td>
<td>
H
</td>
<td>Bacteriochlorophyllide reductase subunit BchY</td>
</tr>
<tr>
<td>82</td>
<td>82</td>
<td><a href="/research/cog/cog/COG5755/">COG5755</a></td>
<td>
H
</td>
<td>Bacteriochlorophyllide reductase subunit BchZ</td>
</tr>
<tr>
<td>131</td>
<td>184</td>
<td><a href="/research/cog/cog/COG5759/">COG5759</a></td>
<td>
H
</td>
<td>Mg-protoporphyrin IX monomethyl ester cyclase BchE, aerobic (=Ycf59)</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</section>
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