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<meta name="keywords" content="C5676903, disease or syndrome, hh26, hypogonadotropic hypogonadism 26 with or without anosmia, tcf12, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="HH26 is characterized by micropenis and cryptorchidism at birth in male patients, and absent puberty and anosmia in male or female patients. Some affected individuals also exhibit craniosynostosis (Davis et al., 2020). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia as well as a discussion of oligogenicity of this disorder, see 147950." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1811919
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ConceptID=C5676903
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hypogonadotropic hypogonadism 26 with or without anosmia<span class="h1sub">(HH26)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1811919</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5676903</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>HH26</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="TCF12 - ID: 6938 - NCBI Gene" href="/gene/6938" class="medgenPMinfo">TCF12</a> (15q21.3)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0030534" target="_blank">MONDO:0030534</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/619718" target="_blank">619718</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">HH26 is characterized by micropenis and cryptorchidism at birth in male patients, and absent puberty and anosmia in male or female patients. Some affected individuals also exhibit craniosynostosis (Davis et al., 2020). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia as well as a discussion of oligogenicity of this disorder, see 147950. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_8192"><div><strong>Cryptorchidism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010417</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8192">Feature record</a> | <a href="/medgen?term=%22Cryptorchidism%22%5BClinical%20Features%5D%20OR%208192%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_163083"><div><strong>Hypospadias</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0848558</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/163083">Feature record</a> | <a href="/medgen?term=%22Hypospadias%22%5BClinical%20Features%5D%20OR%20163083%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1633603"><div><strong>Micropenis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1633603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1633603">Feature record</a> | <a href="/medgen?term=%22Micropenis%22%5BClinical%20Features%5D%20OR%201633603%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1950"><div><strong>Anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1950</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003126</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1950">Feature record</a> | <a href="/medgen?term=%22Anosmia%22%5BClinical%20Features%5D%20OR%201950%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1613"><div><strong>Anxiety</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1613</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003467</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses. There is worry about the negative effects of past unpleasant experiences and future negative possibilities. Individuals may feel fearful, apprehensive, or threatened by uncertainty, and they may also have fears of falling apart or losing control.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1613">Feature record</a> | <a href="/medgen?term=%22Anxiety%22%5BClinical%20Features%5D%20OR%201613%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_96906"><div><strong>Dyslexia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>96906</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0476254</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/96906">Feature record</a> | <a href="/medgen?term=%22Dyslexia%22%5BClinical%20Features%5D%20OR%2096906%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_163547"><div><strong>Autistic behavior</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163547</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0856975</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/163547">Feature record</a> | <a href="/medgen?term=%22Autistic%20behavior%22%5BClinical%20Features%5D%20OR%20163547%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_811461"><div><strong>Intellectual disability</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811461</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3714756</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/811461">Feature record</a> | <a href="/medgen?term=%22Intellectual%20disability%22%5BClinical%20Features%5D%20OR%20811461%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_44042"><div><strong>Kyphosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44042</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022821</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Exaggerated anterior convexity of the thoracic vertebral column.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/44042">Feature record</a> | <a href="/medgen?term=%22Kyphosis%22%5BClinical%20Features%5D%20OR%2044042%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_18222"><div><strong>Osteopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18222</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0029453</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18222">Feature record</a> | <a href="/medgen?term=%22Osteopenia%22%5BClinical%20Features%5D%20OR%2018222%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_14535"><div><strong>Osteoporosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>14535</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0029456</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/14535">Feature record</a> | <a href="/medgen?term=%22Osteoporosis%22%5BClinical%20Features%5D%20OR%2014535%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_11348"><div><strong>Scoliosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>11348</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0036439</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of an abnormal lateral curvature of the spine.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/11348">Feature record</a> | <a href="/medgen?term=%22Scoliosis%22%5BClinical%20Features%5D%20OR%2011348%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_336793"><div><strong>Joint hypermobility</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>336793</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1844820</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The capability that a joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/336793">Feature record</a> | <a href="/medgen?term=%22Joint%20hypermobility%22%5BClinical%20Features%5D%20OR%20336793%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_866810"><div><strong>Bicoronal synostosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866810</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4021164</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Synostosis affecting the right and the left coronal suture.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/866810">Feature record</a> | <a href="/medgen?term=%22Bicoronal%20synostosis%22%5BClinical%20Features%5D%20OR%20866810%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_868997"><div><strong>Anterior plagiocephaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868997</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4023413</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Asymmetry of the anterior part of the skull.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/868997">Feature record</a> | <a href="/medgen?term=%22Anterior%20plagiocephaly%22%5BClinical%20Features%5D%20OR%20868997%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_3800"><div><strong>Diastema</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3800</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0011998</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Increased space between two adjacent teeth in the same dental arch.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3800">Feature record</a> | <a href="/medgen?term=%22Diastema%22%5BClinical%20Features%5D%20OR%203800%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_21210"><div><strong>Teeth, supernumerary</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21210</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040457</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of one or more teeth additional to the normal number.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21210">Feature record</a> | <a href="/medgen?term=%22Teeth%2C%20supernumerary%22%5BClinical%20Features%5D%20OR%2021210%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_66008"><div><strong>Microdontia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66008</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0240340</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/66008">Feature record</a> | <a href="/medgen?term=%22Microdontia%22%5BClinical%20Features%5D%20OR%2066008%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_866849"><div><strong>Agenesis of molar</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866849</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4021203</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Agenesis of molar tooth.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/866849">Feature record</a> | <a href="/medgen?term=%22Agenesis%20of%20molar%22%5BClinical%20Features%5D%20OR%20866849%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_46203"><div><strong>Delayed puberty</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>46203</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0034012</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/46203">Feature record</a> | <a href="/medgen?term=%22Delayed%20puberty%22%5BClinical%20Features%5D%20OR%2046203%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_82883"><div><strong>Hypogonadotropic hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82883</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271623</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82883">Feature record</a> | <a href="/medgen?term=%22Hypogonadotropic%20hypogonadism%22%5BClinical%20Features%5D%20OR%2082883%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_866849" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Agenesis of molar</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_3800" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diastema</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66008" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Microdontia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21210" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Teeth, supernumerary</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_46203" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed puberty</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82883" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cryptorchidism</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypospadias</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1633603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Micropenis</a></span></li></ul></li><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868997" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anterior plagiocephaly</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_866810" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bicoronal synostosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_336793" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Joint hypermobility</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_44042" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kyphosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_18222" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteopenia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_14535" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteoporosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_11348" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Scoliosis</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1950" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anosmia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1613" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anxiety</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163547" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autistic behavior</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_96906" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dyslexia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_811461" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35373533">International consensus statement on allergy and rhinology: Olfaction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patel ZM,
|
||
Holbrook EH,
|
||
Turner JH,
|
||
Adappa ND,
|
||
Albers MW,
|
||
Altundag A,
|
||
Appenzeller S,
|
||
Costanzo RM,
|
||
Croy I,
|
||
Davis GE,
|
||
Dehgani-Mobaraki P,
|
||
Doty RL,
|
||
Duffy VB,
|
||
Goldstein BJ,
|
||
Gudis DA,
|
||
Haehner A,
|
||
Higgins TS,
|
||
Hopkins C,
|
||
Huart C,
|
||
Hummel T,
|
||
Jitaroon K,
|
||
Kern RC,
|
||
Khanwalkar AR,
|
||
Kobayashi M,
|
||
Kondo K,
|
||
Lane AP,
|
||
Lechner M,
|
||
Leopold DA,
|
||
Levy JM,
|
||
Marmura MJ,
|
||
Mclelland L,
|
||
Miwa T,
|
||
Moberg PJ,
|
||
Mueller CA,
|
||
Nigwekar SU,
|
||
O'Brien EK,
|
||
Paunescu TG,
|
||
Pellegrino R,
|
||
Philpott C,
|
||
Pinto JM,
|
||
Reiter ER,
|
||
Roalf DR,
|
||
Rowan NR,
|
||
Schlosser RJ,
|
||
Schwob J,
|
||
Seiden AM,
|
||
Smith TL,
|
||
Soler ZM,
|
||
Sowerby L,
|
||
Tan BK,
|
||
Thamboo A,
|
||
Wrobel B,
|
||
Yan CH</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2022 Apr;12(4):327-680.
|
||
doi: 10.1002/alr.22929.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35373533" target="_blank">35373533</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32576618">Parkinson's disease: etiopathogenesis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jankovic J,
|
||
Tan EK</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Aug;91(8):795-808.
|
||
Epub 2020 Jun 23
|
||
doi: 10.1136/jnnp-2019-322338.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32576618" target="_blank">32576618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29108899">Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stamou MI,
|
||
Georgopoulos NA</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:124-134.
|
||
Epub 2017 Nov 3
|
||
doi: 10.1016/j.metabol.2017.10.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29108899" target="_blank">29108899</a><a href="/pmc/articles/PMC5934335" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (192)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
|
||
Jang SS,
|
||
Lin HC,
|
||
Ma Y,
|
||
Khanwalkar AR,
|
||
Thai A,
|
||
Patel ZM</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Jun;13(6):989-997.
|
||
Epub 2022 Dec 21
|
||
doi: 10.1002/alr.23116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36507615" target="_blank">36507615</a><a href="/pmc/articles/PMC9877663" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35633158">Neurological Sequelae of COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmad SJ,
|
||
Feigen CM,
|
||
Vazquez JP,
|
||
Kobets AJ,
|
||
Altschul DJ</span><br />
|
||
<span class="medgenPMjournal">J Integr Neurosci</span>
|
||
2022 Apr 6;21(3):77.
|
||
doi: 10.31083/j.jin2103077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35633158" target="_blank">35633158</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33638460">Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abbasi AZ,
|
||
Kiyani DA,
|
||
Hamid SM,
|
||
Saalim M,
|
||
Fahim A,
|
||
Jalal N</span><br />
|
||
<span class="medgenPMjournal">J Med Virol</span>
|
||
2021 Jul;93(7):4205-4218.
|
||
Epub 2021 Mar 18
|
||
doi: 10.1002/jmv.26911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33638460" target="_blank">33638460</a><a href="/pmc/articles/PMC8014076" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32990925">Multiple Neuroinvasive Pathways in COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bougakov D,
|
||
Podell K,
|
||
Goldberg E</span><br />
|
||
<span class="medgenPMjournal">Mol Neurobiol</span>
|
||
2021 Feb;58(2):564-575.
|
||
Epub 2020 Sep 29
|
||
doi: 10.1007/s12035-020-02152-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32990925" target="_blank">32990925</a><a href="/pmc/articles/PMC7523266" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25892327">Hormone replacement therapy and longevity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Comhaire F</span><br />
|
||
<span class="medgenPMjournal">Andrologia</span>
|
||
2016 Feb;48(1):65-8.
|
||
Epub 2015 Apr 19
|
||
doi: 10.1111/and.12419.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25892327" target="_blank">25892327</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2083)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37059509">Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siderowf A,
|
||
Concha-Marambio L,
|
||
Lafontant DE,
|
||
Farris CM,
|
||
Ma Y,
|
||
Urenia PA,
|
||
Nguyen H,
|
||
Alcalay RN,
|
||
Chahine LM,
|
||
Foroud T,
|
||
Galasko D,
|
||
Kieburtz K,
|
||
Merchant K,
|
||
Mollenhauer B,
|
||
Poston KL,
|
||
Seibyl J,
|
||
Simuni T,
|
||
Tanner CM,
|
||
Weintraub D,
|
||
Videnovic A,
|
||
Choi SH,
|
||
Kurth R,
|
||
Caspell-Garcia C,
|
||
Coffey CS,
|
||
Frasier M,
|
||
Oliveira LMA,
|
||
Hutten SJ,
|
||
Sherer T,
|
||
Marek K,
|
||
Soto C;
|
||
Parkinson's Progression Markers Initiative</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2023 May;22(5):407-417.
|
||
doi: 10.1016/S1474-4422(23)00109-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37059509" target="_blank">37059509</a><a href="/pmc/articles/PMC10627170" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36341691">Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong Y,
|
||
Li Y,
|
||
Liu K,
|
||
Han X,
|
||
Liu R,
|
||
Ren Y,
|
||
Cong L,
|
||
Zhang Q,
|
||
Hou T,
|
||
Song L,
|
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Tang S,
|
||
Shi L,
|
||
Luo Y,
|
||
Kalpouzos G,
|
||
Laukka EJ,
|
||
Winblad B,
|
||
Wang Y,
|
||
Du Y,
|
||
Qiu C</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Dement</span>
|
||
2023 Feb;19(2):589-601.
|
||
Epub 2022 Sep 15
|
||
doi: 10.1002/alz.12777.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36341691" target="_blank">36341691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35874953">Revealing the mystery of persistent smell loss in Long COVID patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park JW,
|
||
Wang X,
|
||
Xu RH</span><br />
|
||
<span class="medgenPMjournal">Int J Biol Sci</span>
|
||
2022;18(12):4795-4808.
|
||
Epub 2022 Jul 15
|
||
doi: 10.7150/ijbs.73485.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35874953" target="_blank">35874953</a><a href="/pmc/articles/PMC9305264" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35307579">Chronic Rhinosinusitis and COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marin C,
|
||
Hummel T,
|
||
Liu Z,
|
||
Mullol J</span><br />
|
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<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2022 Jun;10(6):1423-1432.
|
||
Epub 2022 Mar 17
|
||
doi: 10.1016/j.jaip.2022.03.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35307579" target="_blank">35307579</a><a href="/pmc/articles/PMC8926942" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8993065">Menstrual disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Braverman PK,
|
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Sondheimer SJ</span><br />
|
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<span class="medgenPMjournal">Pediatr Rev</span>
|
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1997 Jan;18(1):17-25; quiz 26.
|
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doi: 10.1542/pir.18-1-17.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8993065" target="_blank">8993065</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1826)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
|
||
Jang SS,
|
||
Lin HC,
|
||
Ma Y,
|
||
Khanwalkar AR,
|
||
Thai A,
|
||
Patel ZM</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Jun;13(6):989-997.
|
||
Epub 2022 Dec 21
|
||
doi: 10.1002/alr.23116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36507615" target="_blank">36507615</a><a href="/pmc/articles/PMC9877663" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34264287">Olfactory Loss and Olfactory Training.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patel ZM</span><br />
|
||
<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
|
||
2021 Sep 1;147(9):840.
|
||
doi: 10.1001/jamaoto.2021.1507.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34264287" target="_blank">34264287</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33378056">Nervous system complications of COVID-19 with a focus on stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou YL,
|
||
Lu J,
|
||
Cheng YB,
|
||
Xin N</span><br />
|
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<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2020 Dec;24(24):13044-13048.
|
||
doi: 10.26355/eurrev_202012_24210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33378056" target="_blank">33378056</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24691149">A long-acting depot formulation of testosterone (Aveed).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Med Lett Drugs Ther</span>
|
||
2014 Mar 31;56(1439):26-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24691149" target="_blank">24691149</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15629904">Index of suspicion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duong M,
|
||
Dinoulos JG,
|
||
Gupta A,
|
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Bryk T,
|
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Saps M,
|
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Di Lorenzo C,
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Sveen A,
|
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Waseem M,
|
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Kin LL</span><br />
|
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<span class="medgenPMjournal">Pediatr Rev</span>
|
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2005 Jan;26(1):23-33.
|
||
doi: 10.1542/pir.26-1-23.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15629904" target="_blank">15629904</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (968)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34853850">COVID-19 Legacy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ladani AP,
|
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Loganathan M,
|
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Kolikonda MK,
|
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Lippmann S</span><br />
|
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<span class="medgenPMjournal">South Med J</span>
|
||
2021 Dec;114(12):751-759.
|
||
doi: 10.14423/SMJ.0000000000001337.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34853850" target="_blank">34853850</a><a href="/pmc/articles/PMC8607916" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33378056">Nervous system complications of COVID-19 with a focus on stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou YL,
|
||
Lu J,
|
||
Cheng YB,
|
||
Xin N</span><br />
|
||
<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2020 Dec;24(24):13044-13048.
|
||
doi: 10.26355/eurrev_202012_24210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33378056" target="_blank">33378056</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32792262">The clinical course of COVID in pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Syeda S,
|
||
Baptiste C,
|
||
Breslin N,
|
||
Gyamfi-Bannerman C,
|
||
Miller R</span><br />
|
||
<span class="medgenPMjournal">Semin Perinatol</span>
|
||
2020 Nov;44(7):151284.
|
||
Epub 2020 Jul 21
|
||
doi: 10.1016/j.semperi.2020.151284.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32792262" target="_blank">32792262</a><a href="/pmc/articles/PMC7373055" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28531300">Anosmia-A Clinical Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boesveldt S,
|
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Postma EM,
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Boak D,
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Welge-Luessen A,
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Schöpf V,
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Mainland JD,
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Martens J,
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<span class="medgenPMjournal">Chem Senses</span>
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2017 Sep 1;42(7):513-523.
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doi: 10.1093/chemse/bjx025.
|
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<span class="bold">PMID: </span><a href="/pubmed/28531300" target="_blank">28531300</a><a href="/pmc/articles/PMC5863566" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15629904">Index of suspicion.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duong M,
|
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Dinoulos JG,
|
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Gupta A,
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Bryk T,
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Saps M,
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Di Lorenzo C,
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Sveen A,
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<span class="medgenPMjournal">Pediatr Rev</span>
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2005 Jan;26(1):23-33.
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<span class="bold">PMID: </span><a href="/pubmed/15629904" target="_blank">15629904</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (979)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38096238">Exome sequencing in 16 patients with pituitary stalk interruption syndrome: A monocentric study.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Brauner R,
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Bignon-Topalovic J,
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Bashamboo A,
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McElreavey K</span><br />
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<span class="medgenPMjournal">PLoS One</span>
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2023;18(12):e0292664.
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Epub 2023 Dec 14
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doi: 10.1371/journal.pone.0292664.
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<span class="bold">PMID: </span><a href="/pubmed/38096238" target="_blank">38096238</a><a href="/pmc/articles/PMC10721018" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37486228">Longitudinal Association of COVID-19 Hospitalization and Death with Online Search for Loss of Smell or Taste.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Toomre D,
|
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Kandula S,
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||
Shaman J</span><br />
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<span class="medgenPMjournal">Emerg Infect Dis</span>
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2023 Aug;29(8):1711-1713.
|
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doi: 10.3201/eid2908.230071.
|
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<span class="bold">PMID: </span><a href="/pubmed/37486228" target="_blank">37486228</a><a href="/pmc/articles/PMC10370832" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
|
||
Jang SS,
|
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Lin HC,
|
||
Ma Y,
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Khanwalkar AR,
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Thai A,
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Patel ZM</span><br />
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<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
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||
2023 Jun;13(6):989-997.
|
||
Epub 2022 Dec 21
|
||
doi: 10.1002/alr.23116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36507615" target="_blank">36507615</a><a href="/pmc/articles/PMC9877663" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35075664">The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
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Tian R,
|
||
Wang X,
|
||
Sun J,
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||
Zhu L,
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An X</span><br />
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<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Jun;96(6):837-846.
|
||
Epub 2022 Jan 29
|
||
doi: 10.1111/cen.14680.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35075664" target="_blank">35075664</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33560742">Olfactory and taste dysfunctions in COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rouadi PW,
|
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Idriss SA,
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Bousquet J</span><br />
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<span class="medgenPMjournal">Curr Opin Allergy Clin Immunol</span>
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||
2021 Jun 1;21(3):229-244.
|
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doi: 10.1097/ACI.0000000000000735.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33560742" target="_blank">33560742</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1578)</a></div></div>
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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|
||
<div class="nl"><a target="_blank" href="/pubmed/36725781">Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vance DE,
|
||
Del Bene VA,
|
||
Kamath V,
|
||
Frank JS,
|
||
Billings R,
|
||
Cho DY,
|
||
Byun JY,
|
||
Jacob A,
|
||
Anderson JN,
|
||
Visscher K,
|
||
Triebel K,
|
||
Martin KM,
|
||
Li W,
|
||
Puga F,
|
||
Fazeli PL</span><br />
|
||
<span class="medgenPMjournal">Neuropsychol Rev</span>
|
||
2024 Mar;34(1):155-191.
|
||
Epub 2023 Feb 2
|
||
doi: 10.1007/s11065-022-09573-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36725781" target="_blank">36725781</a><a href="/pmc/articles/PMC9891899" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35790713">Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lu Z,
|
||
Sun Y,
|
||
Zhang Y,
|
||
Chen Y,
|
||
Guo L,
|
||
Liao Y,
|
||
Kang Z,
|
||
Feng X,
|
||
Yue W</span><br />
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||
<span class="medgenPMjournal">Transl Psychiatry</span>
|
||
2022 Jul 5;12(1):267.
|
||
doi: 10.1038/s41398-022-02027-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35790713" target="_blank">35790713</a><a href="/pmc/articles/PMC9256633" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35739136">Long-COVID in children and adolescents: a systematic review and meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Leon S,
|
||
Wegman-Ostrosky T,
|
||
Ayuzo Del Valle NC,
|
||
Perelman C,
|
||
Sepulveda R,
|
||
Rebolledo PA,
|
||
Cuapio A,
|
||
Villapol S</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 23;12(1):9950.
|
||
doi: 10.1038/s41598-022-13495-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35739136" target="_blank">35739136</a><a href="/pmc/articles/PMC9226045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34463956">Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malik P,
|
||
Patel K,
|
||
Pinto C,
|
||
Jaiswal R,
|
||
Tirupathi R,
|
||
Pillai S,
|
||
Patel U</span><br />
|
||
<span class="medgenPMjournal">J Med Virol</span>
|
||
2022 Jan;94(1):253-262.
|
||
Epub 2021 Sep 7
|
||
doi: 10.1002/jmv.27309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34463956" target="_blank">34463956</a><a href="/pmc/articles/PMC8662132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32870978">COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gómez-Ochoa SA,
|
||
Franco OH,
|
||
Rojas LZ,
|
||
Raguindin PF,
|
||
Roa-Díaz ZM,
|
||
Wyssmann BM,
|
||
Guevara SLR,
|
||
Echeverría LE,
|
||
Glisic M,
|
||
Muka T</span><br />
|
||
<span class="medgenPMjournal">Am J Epidemiol</span>
|
||
2021 Jan 4;190(1):161-175.
|
||
doi: 10.1093/aje/kwaa191.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32870978" target="_blank">32870978</a><a href="/pmc/articles/PMC7499478" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (136)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C5676903%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
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<li><a href="/gtr/tests?term=C5676903%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C5676903%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=600480" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=6938[geneid]" target="_blank">View TCF12 variations in ClinVar</a></li><li><a href="https://catalog.coriell.org/Search?q=619718" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<a href="/pubmed/clinical?term=Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Hypogonadotropic%20hypogonadism%2026%20with%20or%20without%20anosmia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<div class="portlet_content DiscoveryDbLinks">
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Clear
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<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67cc3cbcb15b832ebc5400d5">C5676903[conceptid] <span class="number">(1)</span></a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67cc3cba84f3725e59987b62">Hypogonadotropic hypogonadism 22 with or without anosmia</a>
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<div class="ralinkpop offscreen_noflow">Hypogonadotropic hypogonadism 22 with or without anosmia<div class="brieflinkpopdesc"></div></div>
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<a class="htb" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67cc3cb8b15b832ebc53f046">C4014988[conceptid] <span class="number">(1)</span></a>
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