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<meta name="keywords" content="C5561949, disease or syndrome, gnb2, sick sinus syndrome 4, sss4, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=1794159
|
||
ConceptID=C5561949
|
||
-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Sick sinus syndrome 4<span class="h1sub">(SSS4)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794159</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5561949</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>SSS4</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="GNB2 - ID: 2783 - NCBI Gene" href="/gene/2783" class="medgenPMinfo">GNB2</a> (7q22.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0859173" target="_blank">MONDO:0859173</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/619464" target="_blank">619464</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
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</div>
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||
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<div class="portlet mgSection" id="ID_102">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_38841"><div><strong>Sudden cardiac death</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>38841</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085298</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/38841">Feature record</a> | <a href="/medgen?term=%22Sudden%20cardiac%20death%22%5BClinical%20Features%5D%20OR%2038841%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_13956"><div><strong>Atrioventricular block</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>13956</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004245</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/13956">Feature record</a> | <a href="/medgen?term=%22Atrioventricular%20block%22%5BClinical%20Features%5D%20OR%2013956%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_19984"><div><strong>Sinoatrial block</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>19984</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0037188</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/19984">Feature record</a> | <a href="/medgen?term=%22Sinoatrial%20block%22%5BClinical%20Features%5D%20OR%2019984%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_21443"><div><strong>Syncope</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21443</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0039070</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Syncope is a syndrome in which loss of consciousness is of relatively sudden onset, temporary (usually less than 1 to 2 minutes), self-terminating, and of usually rapid recovery. Syncope leads to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21443">Feature record</a> | <a href="/medgen?term=%22Syncope%22%5BClinical%20Features%5D%20OR%2021443%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_39316"><div><strong>Sinus bradycardia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085610</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bradycardia related to a mean resting sinus rate of less than 50 beats per minute.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/39316">Feature record</a> | <a href="/medgen?term=%22Sinus%20bradycardia%22%5BClinical%20Features%5D%20OR%2039316%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_115990"><div><strong>Paroxysmal atrial fibrillation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>115990</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0235480</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/115990">Feature record</a> | <a href="/medgen?term=%22Paroxysmal%20atrial%20fibrillation%22%5BClinical%20Features%5D%20OR%20115990%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_745001"><div><strong>Chronotropic incompetence</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>745001</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1997984</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Inability of the heart to increase its rate commensurate with increased activity or demand.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/745001">Feature record</a> | <a href="/medgen?term=%22Chronotropic%20incompetence%22%5BClinical%20Features%5D%20OR%20745001%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1370423"><div><strong>Abnormal QRS complex</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1370423</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4476580</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1370423">Feature record</a> | <a href="/medgen?term=%22Abnormal%20QRS%20complex%22%5BClinical%20Features%5D%20OR%201370423%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1620328"><div><strong>Abnormal QT interval</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1620328</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4531051</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any anomaly of the time interval between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1620328">Feature record</a> | <a href="/medgen?term=%22Abnormal%20QT%20interval%22%5BClinical%20Features%5D%20OR%201620328%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1634800"><div><strong>Abnormal PR interval</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1634800</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4703431</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1634800">Feature record</a> | <a href="/medgen?term=%22Abnormal%20PR%20interval%22%5BClinical%20Features%5D%20OR%201634800%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1634800" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormal PR interval</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1370423" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormal QRS complex</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1620328" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormal QT interval</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_13956" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrioventricular block</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_745001" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chronotropic incompetence</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_115990" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paroxysmal atrial fibrillation</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_19984" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sinoatrial block</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_39316" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sinus bradycardia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21443" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Syncope</a></span></li></ul></li><li><span class="TLline">Constitutional symptom</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_38841" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sudden cardiac death</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/1490698">The prevalence of diabetes mellitus and other risk factors of atherosclerosis in bradycardia requiring pacemaker treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Podlaha R,
|
||
Falk A</span><br />
|
||
<span class="medgenPMjournal">Horm Metab Res Suppl</span>
|
||
1992;26:84-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1490698" target="_blank">1490698</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22sick%20sinus%20syndrome%204%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36282123">Genetic insight into sick sinus syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thorolfsdottir RB,
|
||
Sveinbjornsson G,
|
||
Aegisdottir HM,
|
||
Benonisdottir S,
|
||
Stefansdottir L,
|
||
Ivarsdottir EV,
|
||
Halldorsson GH,
|
||
Sigurdsson JK,
|
||
Torp-Pedersen C,
|
||
Weeke PE,
|
||
Brunak S,
|
||
Westergaard D,
|
||
Pedersen OB,
|
||
Sorensen E,
|
||
Nielsen KR,
|
||
Burgdorf KS,
|
||
Banasik K,
|
||
Brumpton B,
|
||
Zhou W,
|
||
Oddsson A,
|
||
Tragante V,
|
||
Hjorleifsson KE,
|
||
Davidsson OB,
|
||
Rajamani S,
|
||
Jonsson S,
|
||
Torfason B,
|
||
Valgardsson AS,
|
||
Thorgeirsson G,
|
||
Frigge ML,
|
||
Thorleifsson G,
|
||
Norddahl GL,
|
||
Helgadottir A,
|
||
Gretarsdottir S,
|
||
Sulem P,
|
||
Jonsdottir I,
|
||
Willer CJ,
|
||
Hveem K,
|
||
Bundgaard H,
|
||
Ullum H,
|
||
Arnar DO,
|
||
Thorsteinsdottir U,
|
||
Gudbjartsson DF,
|
||
Holm H,
|
||
Stefansson K;
|
||
DBDS Genomic Consortium</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2021 May 21;42(20):1959-1971.
|
||
doi: 10.1093/eurheartj/ehaa1108.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36282123" target="_blank">36282123</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30893006">Pacemaker exteriorization.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dupont J,
|
||
Koch A,
|
||
Vonck A,
|
||
Sarens T</span><br />
|
||
<span class="medgenPMjournal">Acta Cardiol</span>
|
||
2020 Aug;75(4):375-376.
|
||
Epub 2019 Mar 20
|
||
doi: 10.1080/00015385.2019.1587139.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30893006" target="_blank">30893006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28805625">Congenital sick sinus syndrome: Prenatal diagnosis and postnatal follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tseng JJ,
|
||
Lin MC</span><br />
|
||
<span class="medgenPMjournal">Taiwan J Obstet Gynecol</span>
|
||
2017 Aug;56(4):573-575.
|
||
doi: 10.1016/j.tjog.2016.09.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28805625" target="_blank">28805625</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26407606">An uncommon cause of syncope.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campagna D,
|
||
Amaradio MD,
|
||
Battaglia E,
|
||
Demma S,
|
||
Russo C,
|
||
Polosa R</span><br />
|
||
<span class="medgenPMjournal">Intern Emerg Med</span>
|
||
2016 Apr;11(3):425-9.
|
||
Epub 2015 Sep 25
|
||
doi: 10.1007/s11739-015-1317-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26407606" target="_blank">26407606</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1423381">Survival in patients with permanent pacemakers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosenqvist M,
|
||
Nordlander R</span><br />
|
||
<span class="medgenPMjournal">Cardiol Clin</span>
|
||
1992 Nov;10(4):691-703.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1423381" target="_blank">1423381</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sick%20sinus%20syndrome%204%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (512)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38104955">Potential consequences of cardioneuroablation for vasovagal syncope: A call for appropriately designed, sham-controlled clinical trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chakraborty P,
|
||
Chen PS,
|
||
Gollob MH,
|
||
Olshansky B,
|
||
Po SS</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2024 Apr;21(4):464-470.
|
||
Epub 2023 Dec 16
|
||
doi: 10.1016/j.hrthm.2023.12.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38104955" target="_blank">38104955</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34689892">Sinus Node Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sathnur N,
|
||
Ebin E,
|
||
Benditt DG</span><br />
|
||
<span class="medgenPMjournal">Card Electrophysiol Clin</span>
|
||
2021 Dec;13(4):641-659.
|
||
Epub 2021 Sep 23
|
||
doi: 10.1016/j.ccep.2021.06.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34689892" target="_blank">34689892</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30893006">Pacemaker exteriorization.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dupont J,
|
||
Koch A,
|
||
Vonck A,
|
||
Sarens T</span><br />
|
||
<span class="medgenPMjournal">Acta Cardiol</span>
|
||
2020 Aug;75(4):375-376.
|
||
Epub 2019 Mar 20
|
||
doi: 10.1080/00015385.2019.1587139.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30893006" target="_blank">30893006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29798782">Clinical Spectrum of SCN5A Mutations: Long QT Syndrome, Brugada Syndrome, and Cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wilde AAM,
|
||
Amin AS</span><br />
|
||
<span class="medgenPMjournal">JACC Clin Electrophysiol</span>
|
||
2018 May;4(5):569-579.
|
||
Epub 2018 May 2
|
||
doi: 10.1016/j.jacep.2018.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29798782" target="_blank">29798782</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26485000">Sick Sinus Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Walsh-Irwin C,
|
||
Hannibal GB</span><br />
|
||
<span class="medgenPMjournal">AACN Adv Crit Care</span>
|
||
2015 Oct-Dec;26(4):376-80.
|
||
doi: 10.1097/NCI.0000000000000099.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26485000" target="_blank">26485000</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sick%20sinus%20syndrome%204%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (308)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36282123">Genetic insight into sick sinus syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thorolfsdottir RB,
|
||
Sveinbjornsson G,
|
||
Aegisdottir HM,
|
||
Benonisdottir S,
|
||
Stefansdottir L,
|
||
Ivarsdottir EV,
|
||
Halldorsson GH,
|
||
Sigurdsson JK,
|
||
Torp-Pedersen C,
|
||
Weeke PE,
|
||
Brunak S,
|
||
Westergaard D,
|
||
Pedersen OB,
|
||
Sorensen E,
|
||
Nielsen KR,
|
||
Burgdorf KS,
|
||
Banasik K,
|
||
Brumpton B,
|
||
Zhou W,
|
||
Oddsson A,
|
||
Tragante V,
|
||
Hjorleifsson KE,
|
||
Davidsson OB,
|
||
Rajamani S,
|
||
Jonsson S,
|
||
Torfason B,
|
||
Valgardsson AS,
|
||
Thorgeirsson G,
|
||
Frigge ML,
|
||
Thorleifsson G,
|
||
Norddahl GL,
|
||
Helgadottir A,
|
||
Gretarsdottir S,
|
||
Sulem P,
|
||
Jonsdottir I,
|
||
Willer CJ,
|
||
Hveem K,
|
||
Bundgaard H,
|
||
Ullum H,
|
||
Arnar DO,
|
||
Thorsteinsdottir U,
|
||
Gudbjartsson DF,
|
||
Holm H,
|
||
Stefansson K;
|
||
DBDS Genomic Consortium</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2021 May 21;42(20):1959-1971.
|
||
doi: 10.1093/eurheartj/ehaa1108.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36282123" target="_blank">36282123</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32350766">The culprit was inside myocardium.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sweeney MO,
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Greenspon AJ,
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<div class="nl"><a target="_blank" href="/pubmed/36193871">Interesting phenomena during threshold testing of conduction system pacing: What is the mechanism?</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36282123">Genetic insight into sick sinus syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Thorolfsdottir RB,
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Benonisdottir S,
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Weeke PE,
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Brunak S,
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Westergaard D,
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Pedersen OB,
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Nielsen KR,
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Burgdorf KS,
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Banasik K,
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Brumpton B,
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Zhou W,
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Oddsson A,
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Hjorleifsson KE,
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Davidsson OB,
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Rajamani S,
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Torfason B,
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Thorgeirsson G,
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Thorleifsson G,
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Norddahl GL,
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Helgadottir A,
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Jonsdottir I,
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Willer CJ,
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Hveem K,
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Bundgaard H,
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Ullum H,
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Arnar DO,
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Thorsteinsdottir U,
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Gudbjartsson DF,
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Holm H,
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Stefansson K;
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<div class="nl"><a target="_blank" href="/pubmed/33580673">Genetic insight into sick sinus syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Thorolfsdottir RB,
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Sveinbjornsson G,
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Aegisdottir HM,
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Benonisdottir S,
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Stefansdottir L,
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Ivarsdottir EV,
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Halldorsson GH,
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Sigurdsson JK,
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Torp-Pedersen C,
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Weeke PE,
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Brunak S,
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Westergaard D,
|
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Pedersen OB,
|
||
Sorensen E,
|
||
Nielsen KR,
|
||
Burgdorf KS,
|
||
Banasik K,
|
||
Brumpton B,
|
||
Zhou W,
|
||
Oddsson A,
|
||
Tragante V,
|
||
Hjorleifsson KE,
|
||
Davidsson OB,
|
||
Rajamani S,
|
||
Jonsson S,
|
||
Torfason B,
|
||
Valgardsson AS,
|
||
Thorgeirsson G,
|
||
Frigge ML,
|
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Thorleifsson G,
|
||
Norddahl GL,
|
||
Helgadottir A,
|
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Gretarsdottir S,
|
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Sulem P,
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Jonsdottir I,
|
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Willer CJ,
|
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Hveem K,
|
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Bundgaard H,
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Ullum H,
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Arnar DO,
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Thorsteinsdottir U,
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Gudbjartsson DF,
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Holm H,
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Stefansson K;
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DBDS Genomic Consortium</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/31516082">The expanding phenotypes of cohesinopathies: one ring to rule them all!</a></div>
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Pucéat M,
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|
||
<div class="nl"><a target="_blank" href="/pubmed/12782566">Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Sweeney MO,
|
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Hellkamp AS,
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Ellenbogen KA,
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Greenspon AJ,
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Freedman RA,
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Lee KL,
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Lamas GA;
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MOde Selection Trial Investigators</span><br />
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<span class="medgenPMjournal">Circulation</span>
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2003 Jun 17;107(23):2932-7.
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Epub 2003 Jun 2
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||
doi: 10.1161/01.CIR.0000072769.17295.B1.
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||
<span class="bold">PMID: </span><a href="/pubmed/12782566" target="_blank">12782566</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sick%20sinus%20syndrome%204%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (278)</a></div></div>
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||
</div>
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||
<div class="portlet mgSection" id="ID_104">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37480376">Epicardial Versus Endocardial Pacing in Paediatric Patients with Atrioventricular Block or Sinus Node Dysfunction: A Systematic Review and Meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Patsiou V,
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Haidich AB,
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Baroutidou A,
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Giannopoulos A,
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Giannakoulas G</span><br />
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<span class="medgenPMjournal">Pediatr Cardiol</span>
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2023 Dec;44(8):1641-1648.
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Epub 2023 Jul 22
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||
doi: 10.1007/s00246-023-03213-x.
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<span class="bold">PMID: </span><a href="/pubmed/37480376" target="_blank">37480376</a><a href="/pmc/articles/PMC10520152" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34081789">Tricuspid regurgitation associated with implantable electrical device insertion: A systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tatum R,
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Maynes EJ,
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Wood CT,
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Deb AK,
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Austin MA,
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O'Malley TJ,
|
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Choi JH,
|
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Massey HT,
|
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Morris RJ,
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Pavri BB,
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Tchantchaleishvili V</span><br />
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<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
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2021 Aug;44(8):1297-1302.
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||
Epub 2021 Jul 1
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||
doi: 10.1111/pace.14287.
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||
<span class="bold">PMID: </span><a href="/pubmed/34081789" target="_blank">34081789</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/30610455">Comparison of survival for cardiac resynchronization therapy in atrial fibrillation patients with or without atrio-ventricular junction ablation and patients in sinus rhythm: a systematic review and network meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Xue Y,
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Wang J,
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Wang J,
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Thapa S,
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Huang K,
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Peng Y,
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Qian L,
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Li J,
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Ji K</span><br />
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<span class="medgenPMjournal">Heart Fail Rev</span>
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2019 May;24(3):335-342.
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doi: 10.1007/s10741-018-9761-5.
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<span class="bold">PMID: </span><a href="/pubmed/30610455" target="_blank">30610455</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26219620">Chronic Arrhythmias in the Setting of Heterotaxy: Differences between Right and Left Isomerism.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Loomba RS,
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Willes RJ,
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Kovach JR,
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Anderson RH</span><br />
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<span class="medgenPMjournal">Congenit Heart Dis</span>
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2016 Jan-Feb;11(1):7-18.
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Epub 2015 Jul 29
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<span class="bold">PMID: </span><a href="/pubmed/26219620" target="_blank">26219620</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sick%20sinus%20syndrome%204%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22sick%20sinus%20syndrome%204%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Sick%20sinus%20syndrome%204%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a href="/pubmed/clinical?term=Sick%20sinus%20syndrome%204" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cd42e1f4a390645e29f857">Sick sinus syndrome 4</a>
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<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67cd42dfb15b832ebce20f8b">C5561949[conceptid] <span class="number">(1)</span></a>
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<div class="tertiary">ClinVar</div>
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<a class="htb" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67cd42de84f3725e591d12c1">C1834144[trait identifier] AND "OMIM"[submitter] <span class="number">(8)</span></a>
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<div class="tertiary">ClinVar</div>
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<li class="ra_qry two_line">
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<a class="htb" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67cd42ddb15b832ebce2014c">C1837845[trait identifier] AND "OMIM"[submitter] <span class="number">(19)</span></a>
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<div class="tertiary">ClinVar</div>
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