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<meta name="keywords" content="C5436498, disease or syndrome, ifng, ifng deficiency, autosomal recessive, imd69, immunodeficiency 69, immunodeficiency 69, mycobacteriosis, immunodeficiency 69, mycobacteriosis, autosomal recessive, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Immunodeficiency-69 (IMD69) is an autosomal recessive disorder characterized by increased susceptibility to disseminated mycobacterial infection, including after BCG (bacille Calmette-Guerin) vaccination. Affected individuals develop fever, hepatosplenomegaly, leukocytosis, and thrombocytosis during the acute infection. There appears to be normal immunologic function against other pathogens, including viruses and bacteria. Immunologic work-up shows normal parameters, but patient T and NK cells fail to produce gamma-interferon (IFNG) when stimulated in vitro (summary by Kerner et al., 2020).&#13; IMD69 is a form of mendelian susceptibility to mycobacterial disease (MSMD) (see, e.g., IMD27A; 209950)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=1735911
ConceptID=C5436498
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Immunodeficiency 69<span class="h1sub">(IMD69)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1735911</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C5436498</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>IFNG DEFICIENCY, AUTOSOMAL RECESSIVE; IMMUNODEFICIENCY 69, MYCOBACTERIOSIS, AUTOSOMAL RECESSIVE</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="IFNG - ID: 3458 - NCBI Gene" href="/gene/3458" class="medgenPMinfo">IFNG</a> (12q15)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0033541" target="_blank">MONDO:0033541</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/618963" target="_blank">618963</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Immunodeficiency-69 (IMD69) is an autosomal recessive disorder characterized by increased susceptibility to disseminated mycobacterial infection, including after BCG (bacille Calmette-Guerin) vaccination. Affected individuals develop fever, hepatosplenomegaly, leukocytosis, and thrombocytosis during the acute infection. There appears to be normal immunologic function against other pathogens, including viruses and bacteria. Immunologic work-up shows normal parameters, but patient T and NK cells fail to produce gamma-interferon (IFNG) when stimulated in vitro (summary by Kerner et al., 2020).&#13; IMD69 is a form of mendelian susceptibility to mycobacterial disease (MSMD) (see, e.g., IMD27A; 209950). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
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<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_746019"><div><strong>Failure to thrive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>746019</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2315100</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/746019">Feature record</a> | <a href="/medgen?term=%22Failure%20to%20thrive%22%5BClinical%20Features%5D%20OR%20746019%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_8360"><div><strong>Diarrhea</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8360</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0011991</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/8360">Feature record</a> | <a href="/medgen?term=%22Diarrhea%22%5BClinical%20Features%5D%20OR%208360%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_9225"><div><strong>Hepatosplenomegaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9225</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0019214</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">Simultaneous enlargement of the liver and spleen.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/9225">Feature record</a> | <a href="/medgen?term=%22Hepatosplenomegaly%22%5BClinical%20Features%5D%20OR%209225%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1526"><div><strong>Anemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1526</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0002871</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A reduction in erythrocytes volume or hemoglobin concentration.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1526">Feature record</a> | <a href="/medgen?term=%22Anemia%22%5BClinical%20Features%5D%20OR%201526%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_18281"><div><strong>Pancytopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18281</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0030312</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/18281">Feature record</a> | <a href="/medgen?term=%22Pancytopenia%22%5BClinical%20Features%5D%20OR%2018281%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_163397"><div><strong>Thrombocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163397</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0836924</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Increased numbers of platelets in the peripheral blood.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/163397">Feature record</a> | <a href="/medgen?term=%22Thrombocytosis%22%5BClinical%20Features%5D%20OR%20163397%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_9736"><div><strong>Leukocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9736</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0023518</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An abnormal increase in the number of leukocytes in the blood.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/9736">Feature record</a> | <a href="/medgen?term=%22Leukocytosis%22%5BClinical%20Features%5D%20OR%209736%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_52469"><div><strong>Splenomegaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52469</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0038002</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Abnormal increased size of the spleen.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/52469">Feature record</a> | <a href="/medgen?term=%22Splenomegaly%22%5BClinical%20Features%5D%20OR%2052469%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_163750"><div><strong>Hemophagocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163750</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0876991</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/163750">Feature record</a> | <a href="/medgen?term=%22Hemophagocytosis%22%5BClinical%20Features%5D%20OR%20163750%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_823215"><div><strong>BCGosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>823215</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3830467</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/823215">Feature record</a> | <a href="/medgen?term=%22BCGosis%22%5BClinical%20Features%5D%20OR%20823215%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1684722"><div><strong>BCGitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684722</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5139070</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Local or regional infection with Bacillus Calmette-Guerin (BCG) following vaccination.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1684722">Feature record</a> | <a href="/medgen?term=%22BCGitis%22%5BClinical%20Features%5D%20OR%201684722%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1830322"><div><strong>Skin rash</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1830322</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5779628</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">A red eruption of the skin.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1830322">Feature record</a> | <a href="/medgen?term=%22Skin%20rash%22%5BClinical%20Features%5D%20OR%201830322%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_5169"><div><strong>Fever</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5169</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0015967</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">Body temperature elevated above the normal range.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/5169">Feature record</a> | <a href="/medgen?term=%22Fever%22%5BClinical%20Features%5D%20OR%205169%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_69130"><div><strong>Increased circulating ferritin concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>69130</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0241013</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Increased concentration of ferritin in the blood circulation.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/69130">Feature record</a> | <a href="/medgen?term=%22Increased%20circulating%20ferritin%20concentration%22%5BClinical%20Features%5D%20OR%2069130%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of blood and blood-forming tissues</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anemia</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_18281" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pancytopenia</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163397" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytosis</a></span></li></ul></li><li><span class="TLline">Abnormality of metabolism/homeostasis</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_5169" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fever</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_69130" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased circulating ferritin concentration</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8360" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diarrhea</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9225" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hepatosplenomegaly</a></span></li></ul></li><li><span class="TLline">Abnormality of the immune system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1684722" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BCGitis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_823215" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BCGosis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163750" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hemophagocytosis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9736" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukocytosis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1830322" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Skin rash</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_52469" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Splenomegaly</a></span></li></ul></li><li><span class="TLline">Growth abnormality</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_746019" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Failure to thrive</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/39134019">HIV-1 resistance and virological failure to treatment with the integrase inhibitors bictegravir, cabotegravir, and dolutegravir: a systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Blanco-Arévalo JL,
García-Deltoro M,
Torralba M,
Vélez-Díaz-Pallarés M,
Castro A,
Rubio-Rodríguez D,
Rubio-Terrés C</span><br />
<span class="medgenPMjournal">AIDS Rev</span>
2024;26(2):67-79.
doi: 10.24875/AIDSRev.24000011.
<span class="bold">PMID: </span><a href="/pubmed/39134019" target="_blank">39134019</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37352885">Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thakar MS,
Logan BR,
Puck JM,
Dunn EA,
Buckley RH,
Cowan MJ,
O'Reilly RJ,
Kapoor N,
Satter LF,
Pai SY,
Heimall J,
Chandra S,
Ebens CL,
Chellapandian D,
Williams O,
Burroughs LM,
Saldana BD,
Rayes A,
Madden LM,
Chandrakasan S,
Bednarski JJ 2nd,
DeSantes KB,
Cuvelier GDE,
Teira P,
Gillio AP,
Eissa H,
Knutsen AP,
Goldman FD,
Aquino VM,
Shereck EB,
Moore TB,
Caywood EH,
Lugt MTV,
Rozmus J,
Broglie L,
Yu LC,
Shah AJ,
Andolina JR,
Liu X,
Parrott RE,
Dara J,
Prockop S,
Martinez CA,
Kapadia M,
Jyonouchi SC,
Sullivan KE,
Bleesing JJ,
Chaudhury S,
Petrovic A,
Keller MD,
Quigg TC,
Parikh S,
Shenoy S,
Seroogy C,
Rubin T,
Decaluwe H,
Routes JM,
Torgerson TR,
Leiding JW,
Pulsipher MA,
Kohn DB,
Griffith LM,
Haddad E,
Dvorak CC,
Notarangelo LD</span><br />
<span class="medgenPMjournal">Lancet</span>
2023 Jul 8;402(10396):129-140.
Epub 2023 Jun 20
doi: 10.1016/S0140-6736(23)00731-6.
<span class="bold">PMID: </span><a href="/pubmed/37352885" target="_blank">37352885</a><a href="/pmc/articles/PMC10386791" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4564039">Treatment of immune deficiency.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fudenberg HH,
Spitler LE,
Levin AS</span><br />
<span class="medgenPMjournal">Am J Pathol</span>
1972 Dec;69(3):529-36.
<span class="bold">PMID: </span><a href="/pubmed/4564039" target="_blank">4564039</a><a href="/pmc/articles/PMC2032800" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(immunodeficiency%2069)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (838)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37545942">Effect of nutrition education on dietary diversity among HIV Patients in Southeast, Nigeria.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ezenwosu IL,
Ezenwosu OU</span><br />
<span class="medgenPMjournal">Afr Health Sci</span>
2023 Mar;23(1):170-177.
doi: 10.4314/ahs.v23i1.19.
<span class="bold">PMID: </span><a href="/pubmed/37545942" target="_blank">37545942</a><a href="/pmc/articles/PMC10398481" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36149115">Exploring the clinical variables among drug-dependent HIV-Positive patients: Implications for treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Quraishi R,
Sarkar S,
Parmar A,
Jain R,
Das BK,
Ambekar A</span><br />
<span class="medgenPMjournal">Indian J Public Health</span>
2022 Jul-Sep;66(3):331-333.
doi: 10.4103/ijph.ijph_1317_21.
<span class="bold">PMID: </span><a href="/pubmed/36149115" target="_blank">36149115</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35760476">Rectal tuberculosis: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chaudhary P,
Nagpal A,
Padala SB,
Mukund M,
Bansal LK,
Lal R</span><br />
<span class="medgenPMjournal">Indian J Tuberc</span>
2022 Jul;69(3):268-276.
Epub 2021 Jun 16
doi: 10.1016/j.ijtb.2021.06.009.
<span class="bold">PMID: </span><a href="/pubmed/35760476" target="_blank">35760476</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28057253">HIV and Ischemic Heart Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vachiat A,
McCutcheon K,
Tsabedze N,
Zachariah D,
Manga P</span><br />
<span class="medgenPMjournal">J Am Coll Cardiol</span>
2017 Jan 3;69(1):73-82.
doi: 10.1016/j.jacc.2016.09.979.
<span class="bold">PMID: </span><a href="/pubmed/28057253" target="_blank">28057253</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22042269">New frontiers of primary antibody deficiencies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">van der Burg M,
van Zelm MC,
Driessen GJ,
van Dongen JJ</span><br />
<span class="medgenPMjournal">Cell Mol Life Sci</span>
2012 Jan;69(1):59-73.
Epub 2011 Nov 1
doi: 10.1007/s00018-011-0836-x.
<span class="bold">PMID: </span><a href="/pubmed/22042269" target="_blank">22042269</a><a href="/pmc/articles/PMC11114824" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7245)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36149115">Exploring the clinical variables among drug-dependent HIV-Positive patients: Implications for treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Quraishi R,
Sarkar S,
Parmar A,
Jain R,
Das BK,
Ambekar A</span><br />
<span class="medgenPMjournal">Indian J Public Health</span>
2022 Jul-Sep;66(3):331-333.
doi: 10.4103/ijph.ijph_1317_21.
<span class="bold">PMID: </span><a href="/pubmed/36149115" target="_blank">36149115</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35760476">Rectal tuberculosis: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chaudhary P,
Nagpal A,
Padala SB,
Mukund M,
Bansal LK,
Lal R</span><br />
<span class="medgenPMjournal">Indian J Tuberc</span>
2022 Jul;69(3):268-276.
Epub 2021 Jun 16
doi: 10.1016/j.ijtb.2021.06.009.
<span class="bold">PMID: </span><a href="/pubmed/35760476" target="_blank">35760476</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30548598">Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Heidary M,
Nasiri MJ,
Mirsaeidi M,
Jazi FM,
Khoshnood S,
Drancourt M,
Darban-Sarokhalil D</span><br />
<span class="medgenPMjournal">J Cell Physiol</span>
2019 Jul;234(7):9994-10001.
Epub 2018 Dec 12
doi: 10.1002/jcp.27859.
<span class="bold">PMID: </span><a href="/pubmed/30548598" target="_blank">30548598</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25264161">Recent advances in chronic granulomatous disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goldblatt D</span><br />
<span class="medgenPMjournal">J Infect</span>
2014 Nov;69 Suppl 1:S32-5.
Epub 2014 Sep 26
doi: 10.1016/j.jinf.2014.07.013.
<span class="bold">PMID: </span><a href="/pubmed/25264161" target="_blank">25264161</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3925260">Immunodeficiencies associated with errors in purine metabolism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Edwards NL</span><br />
<span class="medgenPMjournal">Med Clin North Am</span>
1985 May;69(3):505-18.
doi: 10.1016/s0025-7125(16)31029-x.
<span class="bold">PMID: </span><a href="/pubmed/3925260" target="_blank">3925260</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3901)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37232940">Single High Dose of Liposomal Amphotericin B in Human Immunodeficiency Virus/AIDS-Related Disseminated Histoplasmosis: A Randomized Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pasqualotto AC,
Lana DD,
Godoy CSM,
Leitão TDMJS,
Bay MB,
Damasceno LS,
Soares RBA,
Kist R,
Silva LR,
Wiltgen D,
Melo M,
Guimarães TF,
Guimarães MR,
Vechi HT,
de Mesquita JRL,
Monteiro GRG,
Adenis A,
Bahr NC,
Spec A,
Boulware DR,
Israelski D,
Chiller T,
Falci DR</span><br />
<span class="medgenPMjournal">Clin Infect Dis</span>
2023 Oct 13;77(8):1126-1132.
doi: 10.1093/cid/ciad313.
<span class="bold">PMID: </span><a href="/pubmed/37232940" target="_blank">37232940</a><a href="/pmc/articles/PMC10573726" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36149115">Exploring the clinical variables among drug-dependent HIV-Positive patients: Implications for treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Quraishi R,
Sarkar S,
Parmar A,
Jain R,
Das BK,
Ambekar A</span><br />
<span class="medgenPMjournal">Indian J Public Health</span>
2022 Jul-Sep;66(3):331-333.
doi: 10.4103/ijph.ijph_1317_21.
<span class="bold">PMID: </span><a href="/pubmed/36149115" target="_blank">36149115</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33108035">Network meta-analysis of post-exposure prophylaxis randomized clinical trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fernández I,
de Lazzari E,
Inciarte A,
Diaz-Brito V,
Milinkovic A,
Arenas-Pinto A,
Etcheverrry F,
García F,
Leal L;
HIV-PEP Group</span><br />
<span class="medgenPMjournal">HIV Med</span>
2021 Mar;22(3):218-224.
Epub 2020 Oct 27
doi: 10.1111/hiv.12964.
<span class="bold">PMID: </span><a href="/pubmed/33108035" target="_blank">33108035</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28118533">Efficacy and Safety of Subcutaneous Belimumab in Systemic Lupus Erythematosus: A Fifty-Two-Week Randomized, Double-Blind, Placebo-Controlled Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stohl W,
Schwarting A,
Okada M,
Scheinberg M,
Doria A,
Hammer AE,
Kleoudis C,
Groark J,
Bass D,
Fox NL,
Roth D,
Gordon D</span><br />
<span class="medgenPMjournal">Arthritis Rheumatol</span>
2017 May;69(5):1016-1027.
Epub 2017 Apr 7
doi: 10.1002/art.40049.
<span class="bold">PMID: </span><a href="/pubmed/28118533" target="_blank">28118533</a><a href="/pmc/articles/PMC5434872" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2671931">Azidothymidine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Oksenhendler E</span><br />
<span class="medgenPMjournal">Nouv Rev Fr Hematol (1978)</span>
1989;31(2):69-72.
<span class="bold">PMID: </span><a href="/pubmed/2671931" target="_blank">2671931</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4550)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/33910425">Retention in HIV care and factors associated with loss to follow-up in Oman: a countrywide study from the Middle East.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elgalib A,
Shah S,
Al-Wahaibi A,
Al-Habsi Z,
Al-Fouri M,
Lau R,
Al-Kindi H,
Al-Rawahi B,
Al-Abri S</span><br />
<span class="medgenPMjournal">AIDS Care</span>
2022 May;34(5):568-574.
Epub 2021 Apr 29
doi: 10.1080/09540121.2021.1916871.
<span class="bold">PMID: </span><a href="/pubmed/33910425" target="_blank">33910425</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34337741">The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bakhtiar S,
Salzmann-Manrique E,
Donath H,
Woelke S,
Duecker RP,
Fritzemeyer S,
Schubert R,
Huenecke S,
Kieslich M,
Klingebiel T,
Bader P,
Zielen S</span><br />
<span class="medgenPMjournal">Br J Haematol</span>
2021 Sep;194(5):879-887.
Epub 2021 Aug 1
doi: 10.1111/bjh.17736.
<span class="bold">PMID: </span><a href="/pubmed/34337741" target="_blank">34337741</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28057253">HIV and Ischemic Heart Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vachiat A,
McCutcheon K,
Tsabedze N,
Zachariah D,
Manga P</span><br />
<span class="medgenPMjournal">J Am Coll Cardiol</span>
2017 Jan 3;69(1):73-82.
doi: 10.1016/j.jacc.2016.09.979.
<span class="bold">PMID: </span><a href="/pubmed/28057253" target="_blank">28057253</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17132052">Projections of global mortality and burden of disease from 2002 to 2030.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mathers CD,
Loncar D</span><br />
<span class="medgenPMjournal">PLoS Med</span>
2006 Nov;3(11):e442.
doi: 10.1371/journal.pmed.0030442.
<span class="bold">PMID: </span><a href="/pubmed/17132052" target="_blank">17132052</a><a href="/pmc/articles/PMC1664601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7671917">A review of endocarditis in acquired immunodeficiency syndrome and human immunodeficiency virus infection.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Currie PF,
Sutherland GR,
Jacob AJ,
Bell JE,
Brettle RP,
Boon NA</span><br />
<span class="medgenPMjournal">Eur Heart J</span>
1995 Apr;16 Suppl B:15-8.
doi: 10.1093/eurheartj/16.suppl_b.15.
<span class="bold">PMID: </span><a href="/pubmed/7671917" target="_blank">7671917</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3009)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38129705">Clinical and Immunological Features, Genetic Variants, and Outcomes of Patients with CD40 Deficiency.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Banday AZ,
Nisar R,
Patra PK,
Kaur A,
Sadanand R,
Chaudhry C,
Bukhari STA,
Banday SZ,
Bhattarai D,
Notarangelo LD</span><br />
<span class="medgenPMjournal">J Clin Immunol</span>
2023 Dec 22;44(1):17.
doi: 10.1007/s10875-023-01633-1.
<span class="bold">PMID: </span><a href="/pubmed/38129705" target="_blank">38129705</a><a href="/pmc/articles/PMC11252661" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34779941">Factors Influencing Rapid Antiretroviral Therapy Initiation at Four eThekwini Clinics, KwaZulu-Natal, South Africa.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Govere SM,
Kalinda C,
Chimbari MJ</span><br />
<span class="medgenPMjournal">AIDS Behav</span>
2022 Jun;26(6):1821-1828.
Epub 2021 Nov 15
doi: 10.1007/s10461-021-03530-3.
<span class="bold">PMID: </span><a href="/pubmed/34779941" target="_blank">34779941</a><a href="/pmc/articles/PMC9046140" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28118533">Efficacy and Safety of Subcutaneous Belimumab in Systemic Lupus Erythematosus: A Fifty-Two-Week Randomized, Double-Blind, Placebo-Controlled Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stohl W,
Schwarting A,
Okada M,
Scheinberg M,
Doria A,
Hammer AE,
Kleoudis C,
Groark J,
Bass D,
Fox NL,
Roth D,
Gordon D</span><br />
<span class="medgenPMjournal">Arthritis Rheumatol</span>
2017 May;69(5):1016-1027.
Epub 2017 Apr 7
doi: 10.1002/art.40049.
<span class="bold">PMID: </span><a href="/pubmed/28118533" target="_blank">28118533</a><a href="/pmc/articles/PMC5434872" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24903787">Isoniazid/acetylisoniazid urine concentrations: markers of adherence to isoniazid preventive therapy in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Amlabu V,
Mulligan C,
Jele N,
Evans A,
Gray D,
Zar HJ,
McIlleron H,
Smith P</span><br />
<span class="medgenPMjournal">Int J Tuberc Lung Dis</span>
2014 May;18(5):528-30.
doi: 10.5588/ijtld.13.0730.
<span class="bold">PMID: </span><a href="/pubmed/24903787" target="_blank">24903787</a><a href="/pmc/articles/PMC4229494" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8174818">Transfusion-associated (T-A)-AIDS in the United States.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ward JW</span><br />
<span class="medgenPMjournal">Dev Biol Stand</span>
1993;81:41-3.
<span class="bold">PMID: </span><a href="/pubmed/8174818" target="_blank">8174818</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3769)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/35760476">Rectal tuberculosis: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chaudhary P,
Nagpal A,
Padala SB,
Mukund M,
Bansal LK,
Lal R</span><br />
<span class="medgenPMjournal">Indian J Tuberc</span>
2022 Jul;69(3):268-276.
Epub 2021 Jun 16
doi: 10.1016/j.ijtb.2021.06.009.
<span class="bold">PMID: </span><a href="/pubmed/35760476" target="_blank">35760476</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33930583">A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Oblak L,
van der Zaag J,
Higgins-Chen AT,
Levine ME,
Boks MP</span><br />
<span class="medgenPMjournal">Ageing Res Rev</span>
2021 Aug;69:101348.
Epub 2021 Apr 28
doi: 10.1016/j.arr.2021.101348.
<span class="bold">PMID: </span><a href="/pubmed/33930583" target="_blank">33930583</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33141449">Phlebotonics for venous insufficiency.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martinez-Zapata MJ,
Vernooij RW,
Simancas-Racines D,
Uriona Tuma SM,
Stein AT,
Moreno Carriles RMM,
Vargas E,
Bonfill Cosp X</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2020 Nov 3;11(11):CD003229.
doi: 10.1002/14651858.CD003229.pub4.
<span class="bold">PMID: </span><a href="/pubmed/33141449" target="_blank">33141449</a><a href="/pmc/articles/PMC8094625" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32479781">Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Del Corpo O,
Butler-Laporte G,
Sheppard DC,
Cheng MP,
McDonald EG,
Lee TC</span><br />
<span class="medgenPMjournal">Clin Microbiol Infect</span>
2020 Sep;26(9):1137-1143.
Epub 2020 May 30
doi: 10.1016/j.cmi.2020.05.024.
<span class="bold">PMID: </span><a href="/pubmed/32479781" target="_blank">32479781</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27121755">Corticosteroids for managing tuberculous meningitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prasad K,
Singh MB,
Ryan H</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2016 Apr 28;4(4):CD002244.
doi: 10.1002/14651858.CD002244.pub4.
<span class="bold">PMID: </span><a href="/pubmed/27121755" target="_blank">27121755</a><a href="/pmc/articles/PMC4916936" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Immunodeficiency%2069%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (281)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=618963" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Immunodeficiency%2069" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(immunodeficiency%2069)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=147570" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=3458[geneid]" target="_blank">View IFNG variations in ClinVar</a></li><li><a href="/nuccore/267844874" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=618963" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/immunodeficiency_69" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Immunodeficiency%2069" target="_blank">MedlinePlus</a></li></ul></div>
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