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<meta name="keywords" content="C5231430, abdominal obesity-metabolic syndrome 4, aoms4, cela2a, disease or syndrome, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Abdominal obesity-metabolic syndrome-4 (AOMS4) is characterized by obesity, hypertension, and early-onset coronary artery disease. Most affected individuals meet the criteria for metabolic syndrome, including elevated triglyceride and low high-density lipoprotein levels, and type 2 diabetes (Esteghamat et al., 2019). For a discussion of the genetic heterogeneity of abdominal obesity-metabolic syndrome, see AOMS1 (605552)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=1704861
|
||
ConceptID=C5231430
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abdominal obesity-metabolic syndrome 4<span class="h1sub">(AOMS4)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1704861</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5231430</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>AOMS4</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CELA2A - ID: 63036 - NCBI Gene" href="/gene/63036" class="medgenPMinfo">CELA2A</a> (1p36.21)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0032837" target="_blank">MONDO:0032837</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/618620" target="_blank">618620</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Abdominal obesity-metabolic syndrome-4 (AOMS4) is characterized by obesity, hypertension, and early-onset coronary artery disease. Most affected individuals meet the criteria for metabolic syndrome, including elevated triglyceride and low high-density lipoprotein levels, and type 2 diabetes (Esteghamat et al., 2019). For a discussion of the genetic heterogeneity of abdominal obesity-metabolic syndrome, see AOMS1 (605552). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
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</div>
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||
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<div class="portlet mgSection" id="ID_102">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_3623"><div><strong>Coronary artery atherosclerosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3623</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010054</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3623">Feature record</a> | <a href="/medgen?term=%22Coronary%20artery%20atherosclerosis%22%5BClinical%20Features%5D%20OR%203623%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_6969"><div><strong>Hypertensive disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6969</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0020538</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of chronic increased pressure in the systemic arterial system.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6969">Feature record</a> | <a href="/medgen?term=%22Hypertensive%20disorder%22%5BClinical%20Features%5D%20OR%206969%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_10150"><div><strong>Myocardial infarction</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10150</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027051</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/10150">Feature record</a> | <a href="/medgen?term=%22Myocardial%20infarction%22%5BClinical%20Features%5D%20OR%2010150%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_376623"><div><strong>Accelerated atherosclerosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>376623</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849618</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/376623">Feature record</a> | <a href="/medgen?term=%22Accelerated%20atherosclerosis%22%5BClinical%20Features%5D%20OR%20376623%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_18127"><div><strong>Obesity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18127</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0028754</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Accumulation of substantial excess body fat.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18127">Feature record</a> | <a href="/medgen?term=%22Obesity%22%5BClinical%20Features%5D%20OR%2018127%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_892798"><div><strong>Elevated hemoglobin A1c</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892798</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4073162</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/892798">Feature record</a> | <a href="/medgen?term=%22Elevated%20hemoglobin%20A1c%22%5BClinical%20Features%5D%20OR%20892798%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_41523"><div><strong>Type 2 diabetes mellitus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41523</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0011860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">WFS1 spectrum disorder (WFS1-SD) comprises classic WFS1 spectrum disorder and nonclassic WFS1 spectrum disorder. Classic WFS1-SD, a progressive neurodegenerative disorder, is characterized by onset of diabetes mellitus and optic atrophy before age 16 years. Additional complications may include one or more of the following: variable hearing impairment / deafness, diabetes insipidus, neurologic abnormalities, neurogenic bladder, and psychiatric abnormalities. Nonclassic WFS1-SD is less common than classic WFS1-SD. Phenotypes that appear to be milder than classic WFS1-SD include: optic atrophy and hearing impairment; neonatal diabetes, profound congenital deafness, and cataracts; isolated diabetes mellitus; isolated congenital cataracts; and isolated congenital, slowly progressive, and low-frequency (<2000 Hz) sensorineural hearing loss.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41523">Feature record</a> | <a href="/medgen?term=%22Type%202%20diabetes%20mellitus%22%5BClinical%20Features%5D%20OR%2041523%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_57731"><div><strong>Decreased HDL cholesterol concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57731</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151691</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An decreased concentration of high-density lipoprotein cholesterol in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57731">Feature record</a> | <a href="/medgen?term=%22Decreased%20HDL%20cholesterol%20concentration%22%5BClinical%20Features%5D%20OR%2057731%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_154289"><div><strong>Increased LDL cholesterol concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>154289</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0549399</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An elevated concentration of low-density lipoprotein cholesterol in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/154289">Feature record</a> | <a href="/medgen?term=%22Increased%20LDL%20cholesterol%20concentration%22%5BClinical%20Features%5D%20OR%20154289%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_167238"><div><strong>Hypertriglyceridemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>167238</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0813230</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormal increase in the level of triglycerides in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/167238">Feature record</a> | <a href="/medgen?term=%22Hypertriglyceridemia%22%5BClinical%20Features%5D%20OR%20167238%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of blood and blood-forming tissues</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_892798" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated hemoglobin A1c</a></span></li></ul></li><li><span class="TLline">Abnormality of metabolism/homeostasis</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57731" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased HDL cholesterol concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_167238" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertriglyceridemia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_154289" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased LDL cholesterol concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_41523" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Type 2 diabetes mellitus</a></span></li></ul></li><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_376623" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Accelerated atherosclerosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_3623" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Coronary artery atherosclerosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6969" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertensive disorder</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10150" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myocardial infarction</a></span></li></ul></li><li><span class="TLline">Growth abnormality</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_18127" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Obesity</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27823611">Bariatric Surgery: Pathophysiology and Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Azim S,
|
||
Kashyap SR</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
|
||
2016 Dec;45(4):905-921.
|
||
Epub 2016 Oct 8
|
||
doi: 10.1016/j.ecl.2016.06.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27823611" target="_blank">27823611</a><a href="/pmc/articles/PMC9075538" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27754711">A Systematic Review on Sasang Constitutional Type-Associated Susceptibility to Disorders in Korea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee HY,
|
||
Lee WJ,
|
||
Kim HW,
|
||
Jang ES,
|
||
Ahn YC,
|
||
Ku BC,
|
||
Kang W,
|
||
Lee SW,
|
||
Son CG</span><br />
|
||
<span class="medgenPMjournal">J Altern Complement Med</span>
|
||
2016 Dec;22(12):950-956.
|
||
Epub 2016 Oct 18
|
||
doi: 10.1089/acm.2016.0177.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27754711" target="_blank">27754711</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25703677">Insulin resistance and impaired adipogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gustafson B,
|
||
Hedjazifar S,
|
||
Gogg S,
|
||
Hammarstedt A,
|
||
Smith U</span><br />
|
||
<span class="medgenPMjournal">Trends Endocrinol Metab</span>
|
||
2015 Apr;26(4):193-200.
|
||
Epub 2015 Feb 18
|
||
doi: 10.1016/j.tem.2015.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25703677" target="_blank">25703677</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20455417">Abdominal obesity, metabolic syndrome in type 1 diabetic children and adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szadkowska A,
|
||
Pietrzak I,
|
||
Szlawska J,
|
||
Kozera A,
|
||
Gadzicka A,
|
||
Młynarski W</span><br />
|
||
<span class="medgenPMjournal">Pediatr Endocrinol Diabetes Metab</span>
|
||
2009;15(4):233-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20455417" target="_blank">20455417</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17110092">The link between abdominal obesity, metabolic syndrome and cardiovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ritchie SA,
|
||
Connell JM</span><br />
|
||
<span class="medgenPMjournal">Nutr Metab Cardiovasc Dis</span>
|
||
2007 May;17(4):319-26.
|
||
Epub 2006 Nov 15
|
||
doi: 10.1016/j.numecd.2006.07.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17110092" target="_blank">17110092</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39393435">Associations between intestinal fatty-acid binding protein and clinical and metabolic characteristics of depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gawlik-Kotelnicka O,
|
||
Czarnecka-Chrebelska K,
|
||
Margulska A,
|
||
Pikus E,
|
||
Wasiak J,
|
||
Skowrońska A,
|
||
Brzeziańska-Lasota E,
|
||
Strzelecki D</span><br />
|
||
<span class="medgenPMjournal">Prog Neuropsychopharmacol Biol Psychiatry</span>
|
||
2025 Jan 10;136:111170.
|
||
Epub 2024 Oct 10
|
||
doi: 10.1016/j.pnpbp.2024.111170.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39393435" target="_blank">39393435</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25703677">Insulin resistance and impaired adipogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gustafson B,
|
||
Hedjazifar S,
|
||
Gogg S,
|
||
Hammarstedt A,
|
||
Smith U</span><br />
|
||
<span class="medgenPMjournal">Trends Endocrinol Metab</span>
|
||
2015 Apr;26(4):193-200.
|
||
Epub 2015 Feb 18
|
||
doi: 10.1016/j.tem.2015.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25703677" target="_blank">25703677</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22784553">Hypertriglyceridemic waist, cytokines and hyperglycaemia in Chinese.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu Z,
|
||
Sun L,
|
||
Qi Q,
|
||
Wu H,
|
||
Lu L,
|
||
Liu C,
|
||
Li H,
|
||
Lin X</span><br />
|
||
<span class="medgenPMjournal">Eur J Clin Invest</span>
|
||
2012 Oct;42(10):1100-11.
|
||
Epub 2012 Jul 12
|
||
doi: 10.1111/j.1365-2362.2012.02702.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22784553" target="_blank">22784553</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22370155">Measurement of waist circumference at different sites affects the detection of abdominal obesity and metabolic syndrome among psychiatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin CC,
|
||
Yu SC,
|
||
Wu BJ,
|
||
Chang DJ</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2012 May 30;197(3):322-6.
|
||
Epub 2012 Feb 25
|
||
doi: 10.1016/j.psychres.2011.09.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22370155" target="_blank">22370155</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20455417">Abdominal obesity, metabolic syndrome in type 1 diabetic children and adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szadkowska A,
|
||
Pietrzak I,
|
||
Szlawska J,
|
||
Kozera A,
|
||
Gadzicka A,
|
||
Młynarski W</span><br />
|
||
<span class="medgenPMjournal">Pediatr Endocrinol Diabetes Metab</span>
|
||
2009;15(4):233-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20455417" target="_blank">20455417</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39393435">Associations between intestinal fatty-acid binding protein and clinical and metabolic characteristics of depression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gawlik-Kotelnicka O,
|
||
Czarnecka-Chrebelska K,
|
||
Margulska A,
|
||
Pikus E,
|
||
Wasiak J,
|
||
Skowrońska A,
|
||
Brzeziańska-Lasota E,
|
||
Strzelecki D</span><br />
|
||
<span class="medgenPMjournal">Prog Neuropsychopharmacol Biol Psychiatry</span>
|
||
2025 Jan 10;136:111170.
|
||
Epub 2024 Oct 10
|
||
doi: 10.1016/j.pnpbp.2024.111170.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39393435" target="_blank">39393435</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21474823">Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Blaha MJ,
|
||
Rivera JJ,
|
||
Budoff MJ,
|
||
Blankstein R,
|
||
Agatston A,
|
||
O'Leary DH,
|
||
Cushman M,
|
||
Lakoski S,
|
||
Criqui MH,
|
||
Szklo M,
|
||
Blumenthal RS,
|
||
Nasir K</span><br />
|
||
<span class="medgenPMjournal">Arterioscler Thromb Vasc Biol</span>
|
||
2011 Jun;31(6):1430-8.
|
||
Epub 2011 Apr 7
|
||
doi: 10.1161/ATVBAHA.111.223768.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21474823" target="_blank">21474823</a><a href="/pmc/articles/PMC3130297" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17110092">The link between abdominal obesity, metabolic syndrome and cardiovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ritchie SA,
|
||
Connell JM</span><br />
|
||
<span class="medgenPMjournal">Nutr Metab Cardiovasc Dis</span>
|
||
2007 May;17(4):319-26.
|
||
Epub 2006 Nov 15
|
||
doi: 10.1016/j.numecd.2006.07.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17110092" target="_blank">17110092</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22370155">Measurement of waist circumference at different sites affects the detection of abdominal obesity and metabolic syndrome among psychiatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin CC,
|
||
Yu SC,
|
||
Wu BJ,
|
||
Chang DJ</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2012 May 30;197(3):322-6.
|
||
Epub 2012 Feb 25
|
||
doi: 10.1016/j.psychres.2011.09.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22370155" target="_blank">22370155</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15716982">Association of essential hypertension with a microsatellite marker on chromosome 17.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheung BM,
|
||
Leung RY,
|
||
Man YB,
|
||
Wong LY,
|
||
Lau CP</span><br />
|
||
<span class="medgenPMjournal">J Hum Hypertens</span>
|
||
2005 May;19(5):407-11.
|
||
doi: 10.1038/sj.jhh.1001835.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15716982" target="_blank">15716982</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32050814">Correlation between vaspin and PANSS scores in schizophrenia patients with obesity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ertekin H,
|
||
Uysal S,
|
||
Aydın M,
|
||
İlhan B,
|
||
Ertekin YH</span><br />
|
||
<span class="medgenPMjournal">Int J Psychiatry Med</span>
|
||
2020 Jul;55(4):264-280.
|
||
Epub 2020 Feb 12
|
||
doi: 10.1177/0091217420905463.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32050814" target="_blank">32050814</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23097084">Multidisciplinary therapy reduces risk factors for metabolic syndrome in obese adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bianchini JA,
|
||
da Silva DF,
|
||
Nardo CC,
|
||
Carolino ID,
|
||
Hernandes F,
|
||
Nardo N Jr</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2013 Feb;172(2):215-21.
|
||
Epub 2012 Oct 25
|
||
doi: 10.1007/s00431-012-1865-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23097084" target="_blank">23097084</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22370155">Measurement of waist circumference at different sites affects the detection of abdominal obesity and metabolic syndrome among psychiatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin CC,
|
||
Yu SC,
|
||
Wu BJ,
|
||
Chang DJ</span><br />
|
||
<span class="medgenPMjournal">Psychiatry Res</span>
|
||
2012 May 30;197(3):322-6.
|
||
Epub 2012 Feb 25
|
||
doi: 10.1016/j.psychres.2011.09.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22370155" target="_blank">22370155</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20455417">Abdominal obesity, metabolic syndrome in type 1 diabetic children and adolescents.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szadkowska A,
|
||
Pietrzak I,
|
||
Szlawska J,
|
||
Kozera A,
|
||
Gadzicka A,
|
||
Młynarski W</span><br />
|
||
<span class="medgenPMjournal">Pediatr Endocrinol Diabetes Metab</span>
|
||
2009;15(4):233-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20455417" target="_blank">20455417</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/27754711">A Systematic Review on Sasang Constitutional Type-Associated Susceptibility to Disorders in Korea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee HY,
|
||
Lee WJ,
|
||
Kim HW,
|
||
Jang ES,
|
||
Ahn YC,
|
||
Ku BC,
|
||
Kang W,
|
||
Lee SW,
|
||
Son CG</span><br />
|
||
<span class="medgenPMjournal">J Altern Complement Med</span>
|
||
2016 Dec;22(12):950-956.
|
||
Epub 2016 Oct 18
|
||
doi: 10.1089/acm.2016.0177.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27754711" target="_blank">27754711</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abdominal%20obesity-metabolic%20syndrome%204%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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