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<meta name="keywords" content="C4023155, impaired arachidonic acid-induced platelet aggregation, pathologic function, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=868750
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ConceptID=C4023155
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Impaired arachidonic acid-induced platelet aggregation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868750</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4023155</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011870">HP:0011870</a></td></tr>
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<div class="portlet_content ln">Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Impaired arachidonic acid-induced platelet aggregation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/57492" ref="tree=MeSH" title="MedGen record for Abnormality of thrombocytes">Abnormality of thrombocytes</a></span><ul><li><span class="TLline"><a href="/medgen/488944" ref="tree=MeSH" title="MedGen record for Abnormal platelet function">Abnormal platelet function</a></span><ul><li><span class="TLline"><a href="/medgen/154224" ref="tree=MeSH" title="MedGen record for Abnormal platelet aggregation">Abnormal platelet aggregation</a></span><ul><li><span class="TLline"><a href="/medgen/383786" ref="tree=MeSH" title="MedGen record for Impaired platelet aggregation">Impaired platelet aggregation</a></span><ul><li><span class="matched_ds">Impaired arachidonic acid-induced platelet aggregation</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_321945"><div><strong>Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321945</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832388</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy. RUNX1-FPDMM is characterized by thrombocytopenia with normal platelet size; bleeding is often greater than expected due to qualitative platelet dysfunction. Myeloid malignancies are the most common, including acute myelogenous leukemia and myelodysplastic syndrome. T- and B-cell acute lymphoblastic leukemias and lymphomas have also been reported, as well as skin manifestations (e.g., eczema, psoriasis).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/321945">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_481244"><div><strong>Bleeding disorder, platelet-type, 13, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481244</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3279614</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Susceptibility to platelet-type bleeding disorder-13 (BDPLT13) is due to a defective thromboxane A2 receptor on platelets. The susceptibility is inherited in an autosomal dominant pattern, but clinical features, including mild mucocutaneous bleeding, occur only in the presence of a 'second hit' affecting platelet function; this second hit may be either in the TBXA2R gene or in another gene affecting the coagulation cascade (summary by Mumford et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/481244">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_854714"><div><strong>Hermansky-Pudlak syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854714</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3888007</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/854714">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1673822"><div><strong>Bleeding disorder, platelet-type, 22</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1673822</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193111</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-22 (BDPLT22) is an autosomal recessive bleeding disorder resulting from impaired platelet aggregation due to intracellular signaling defects. Patients present in the first decade with spontaneous subcutaneous bleeding and excessive bleeding after minor injuries. Platelet counts are usually normal, although platelets show abnormal morphology (summary by Berrou et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1673822">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1768257"><div><strong>Thrombocytopenia 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1768257</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436874</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Thrombocytopenia-7 (THC7) is an autosomal dominant disorder characterized by reduced peripheral platelet count. The expression and severity of the disorder is highly variable: some patients have no bleeding symptoms, whereas other have recurrent petechiae, epistaxis, or more severe bleeding episodes. A common finding is decreased alpha-granules in the platelets. There are variable findings on light and electron microscopic analysis: some patients have normal platelet morphology, whereas others show abnormal platelet morphology with cytoskeletal defects. Flow cytometric studies may show reduced expression of platelet membrane glycoproteins and activation markers (summary by Lentaigne et al., 2019 and Leinoe et al., 2021). For a general phenotypic description and a discussion of genetic heterogeneity of thrombocytopenia, see 313900.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1768257">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1785711"><div><strong>Bleeding disorder, platelet-type, 24</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1785711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543280</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Platelet-type bleeding disorder-24 (BDPLT24) is an autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities (summary by Kunishima et al., 2011 and Nurden et al., 2011). For a discussion of genetic heterogeneity of Glanzmann thrombasthenia-like with macrothrombocytopenia, see 187800.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1785711">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481244" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 13, susceptibility to</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1673822" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 22</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1785711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bleeding disorder, platelet-type, 24</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854714" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1768257" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytopenia 7</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36463859">High On-Treatment Platelet Reactivity: Aspirin versus Clopidogrel.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">M'Pembele R,
|
||
Ahlbrecht S,
|
||
Helten C,
|
||
Mourikis P,
|
||
Naguib D,
|
||
Zako S,
|
||
Trojovsky K,
|
||
Huhn R,
|
||
Petzold T,
|
||
Hohlfeld T,
|
||
Zeus T,
|
||
Kelm M,
|
||
Dannenberg L,
|
||
Polzin A</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(1):83-89.
|
||
Epub 2022 Dec 2
|
||
doi: 10.1159/000527816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36463859" target="_blank">36463859</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(impaired%20arachidonic%20acid-induced%20platelet%20aggregation)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36463859">High On-Treatment Platelet Reactivity: Aspirin versus Clopidogrel.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">M'Pembele R,
|
||
Ahlbrecht S,
|
||
Helten C,
|
||
Mourikis P,
|
||
Naguib D,
|
||
Zako S,
|
||
Trojovsky K,
|
||
Huhn R,
|
||
Petzold T,
|
||
Hohlfeld T,
|
||
Zeus T,
|
||
Kelm M,
|
||
Dannenberg L,
|
||
Polzin A</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(1):83-89.
|
||
Epub 2022 Dec 2
|
||
doi: 10.1159/000527816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36463859" target="_blank">36463859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28556061">Acetylsalicylic acid in critically ill patients: a cross-sectional and a randomized trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schoergenhofer C,
|
||
Hobl EL,
|
||
Schwameis M,
|
||
Gelbenegger G,
|
||
Staudinger T,
|
||
Heinz G,
|
||
Speidl WS,
|
||
Zauner C,
|
||
Reiter B,
|
||
Lang I,
|
||
Jilma B</span><br />
|
||
<span class="medgenPMjournal">Eur J Clin Invest</span>
|
||
2017 Jul;47(7):504-512.
|
||
Epub 2017 Jun 20
|
||
doi: 10.1111/eci.12771.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28556061" target="_blank">28556061</a><a href="/pmc/articles/PMC5519937" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26644261">Antiplatelet effects of aspirin in chronic kidney disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Sansone R,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T</span><br />
|
||
<span class="medgenPMjournal">J Thromb Haemost</span>
|
||
2016 Feb;14(2):375-80.
|
||
Epub 2016 Jan 25
|
||
doi: 10.1111/jth.13211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26644261" target="_blank">26644261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22691184">Monitoring of acetyl salicylic acid-induced platelet inhibition with impedance aggregometry in children with systemic-to-pulmonary shunts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Romlin BS,
|
||
Wåhlander H,
|
||
Strömvall-Larsson E,
|
||
Synnergren M,
|
||
Baghaei F,
|
||
Jeppsson A</span><br />
|
||
<span class="medgenPMjournal">Cardiol Young</span>
|
||
2013 Apr;23(2):225-32.
|
||
Epub 2012 Jun 12
|
||
doi: 10.1017/S1047951112000753.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22691184" target="_blank">22691184</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20arachidonic%20acid-induced%20platelet%20aggregation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30355919">Malondialdehyde Assay in the Evaluation of Aspirin Antiplatelet Effects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Schneider T,
|
||
Knoop B,
|
||
Naguib D,
|
||
Helten C,
|
||
Pöhl M,
|
||
Kelm M,
|
||
Zeus T,
|
||
Hohlfeld T</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2019;103(1-2):23-29.
|
||
Epub 2018 Oct 24
|
||
doi: 10.1159/000493754.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30355919" target="_blank">30355919</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26644261">Antiplatelet effects of aspirin in chronic kidney disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Sansone R,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T</span><br />
|
||
<span class="medgenPMjournal">J Thromb Haemost</span>
|
||
2016 Feb;14(2):375-80.
|
||
Epub 2016 Jan 25
|
||
doi: 10.1111/jth.13211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26644261" target="_blank">26644261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17519543">Variable platelet response to aspirin in patients with ischemic stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hohlfeld T,
|
||
Weber AA,
|
||
Junghans U,
|
||
Schumacher M,
|
||
Boucher M,
|
||
Schrör K,
|
||
Siebler M</span><br />
|
||
<span class="medgenPMjournal">Cerebrovasc Dis</span>
|
||
2007;24(1):43-50.
|
||
Epub 2007 May 22
|
||
doi: 10.1159/000103115.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17519543" target="_blank">17519543</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20arachidonic%20acid-induced%20platelet%20aggregation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36463859">High On-Treatment Platelet Reactivity: Aspirin versus Clopidogrel.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">M'Pembele R,
|
||
Ahlbrecht S,
|
||
Helten C,
|
||
Mourikis P,
|
||
Naguib D,
|
||
Zako S,
|
||
Trojovsky K,
|
||
Huhn R,
|
||
Petzold T,
|
||
Hohlfeld T,
|
||
Zeus T,
|
||
Kelm M,
|
||
Dannenberg L,
|
||
Polzin A</span><br />
|
||
<span class="medgenPMjournal">Pharmacology</span>
|
||
2023;108(1):83-89.
|
||
Epub 2022 Dec 2
|
||
doi: 10.1159/000527816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36463859" target="_blank">36463859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30778625">Metamizole inhibits arachidonic acid-induced platelet aggregation after surgery and impairs the effect of aspirin in hospitalized patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pfrepper C,
|
||
Deters S,
|
||
Metze M,
|
||
Siegemund R,
|
||
Gockel I,
|
||
Petros S</span><br />
|
||
<span class="medgenPMjournal">Eur J Clin Pharmacol</span>
|
||
2019 Jun;75(6):777-784.
|
||
Epub 2019 Feb 18
|
||
doi: 10.1007/s00228-019-02646-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30778625" target="_blank">30778625</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28556061">Acetylsalicylic acid in critically ill patients: a cross-sectional and a randomized trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schoergenhofer C,
|
||
Hobl EL,
|
||
Schwameis M,
|
||
Gelbenegger G,
|
||
Staudinger T,
|
||
Heinz G,
|
||
Speidl WS,
|
||
Zauner C,
|
||
Reiter B,
|
||
Lang I,
|
||
Jilma B</span><br />
|
||
<span class="medgenPMjournal">Eur J Clin Invest</span>
|
||
2017 Jul;47(7):504-512.
|
||
Epub 2017 Jun 20
|
||
doi: 10.1111/eci.12771.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28556061" target="_blank">28556061</a><a href="/pmc/articles/PMC5519937" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27301652">Dipyrone comedication in aspirin treated stroke patients impairs outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dannenberg L,
|
||
Erschoff V,
|
||
Bönner F,
|
||
Gliem M,
|
||
Jander S,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T,
|
||
Polzin A</span><br />
|
||
<span class="medgenPMjournal">Vascul Pharmacol</span>
|
||
2016 Dec;87:66-69.
|
||
Epub 2016 Jun 11
|
||
doi: 10.1016/j.vph.2016.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27301652" target="_blank">27301652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26644261">Antiplatelet effects of aspirin in chronic kidney disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Sansone R,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T</span><br />
|
||
<span class="medgenPMjournal">J Thromb Haemost</span>
|
||
2016 Feb;14(2):375-80.
|
||
Epub 2016 Jan 25
|
||
doi: 10.1111/jth.13211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26644261" target="_blank">26644261</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20arachidonic%20acid-induced%20platelet%20aggregation%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26644261">Antiplatelet effects of aspirin in chronic kidney disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Sansone R,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T</span><br />
|
||
<span class="medgenPMjournal">J Thromb Haemost</span>
|
||
2016 Feb;14(2):375-80.
|
||
Epub 2016 Jan 25
|
||
doi: 10.1111/jth.13211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26644261" target="_blank">26644261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23527528">Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lundström A,
|
||
Laska AC,
|
||
Von Arbin M,
|
||
Jörneskog G,
|
||
Wallén H</span><br />
|
||
<span class="medgenPMjournal">Platelets</span>
|
||
2014;25(2):102-10.
|
||
Epub 2013 Mar 25
|
||
doi: 10.3109/09537104.2013.777951.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23527528" target="_blank">23527528</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19215991">Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lordkipanidzé M,
|
||
Diodati JG,
|
||
Turgeon J,
|
||
Schampaert E,
|
||
Palisaitis DA,
|
||
Pharand C</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2010 Aug 6;143(1):43-50.
|
||
Epub 2009 Feb 11
|
||
doi: 10.1016/j.ijcard.2009.01.037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19215991" target="_blank">19215991</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20arachidonic%20acid-induced%20platelet%20aggregation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27301652">Dipyrone comedication in aspirin treated stroke patients impairs outcome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dannenberg L,
|
||
Erschoff V,
|
||
Bönner F,
|
||
Gliem M,
|
||
Jander S,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T,
|
||
Polzin A</span><br />
|
||
<span class="medgenPMjournal">Vascul Pharmacol</span>
|
||
2016 Dec;87:66-69.
|
||
Epub 2016 Jun 11
|
||
doi: 10.1016/j.vph.2016.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27301652" target="_blank">27301652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26644261">Antiplatelet effects of aspirin in chronic kidney disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polzin A,
|
||
Dannenberg L,
|
||
Sansone R,
|
||
Levkau B,
|
||
Kelm M,
|
||
Hohlfeld T,
|
||
Zeus T</span><br />
|
||
<span class="medgenPMjournal">J Thromb Haemost</span>
|
||
2016 Feb;14(2):375-80.
|
||
Epub 2016 Jan 25
|
||
doi: 10.1111/jth.13211.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26644261" target="_blank">26644261</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25975006">Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wand S,
|
||
Schneider S,
|
||
Meybohm P,
|
||
Zacharowski K,
|
||
Weber CF</span><br />
|
||
<span class="medgenPMjournal">Clin Lab</span>
|
||
2015;61(3-4):379-87.
|
||
doi: 10.7754/clin.lab.2014.140931.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25975006" target="_blank">25975006</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22691184">Monitoring of acetyl salicylic acid-induced platelet inhibition with impedance aggregometry in children with systemic-to-pulmonary shunts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Romlin BS,
|
||
Wåhlander H,
|
||
Strömvall-Larsson E,
|
||
Synnergren M,
|
||
Baghaei F,
|
||
Jeppsson A</span><br />
|
||
<span class="medgenPMjournal">Cardiol Young</span>
|
||
2013 Apr;23(2):225-32.
|
||
Epub 2012 Jun 12
|
||
doi: 10.1017/S1047951112000753.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22691184" target="_blank">22691184</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19215991">Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lordkipanidzé M,
|
||
Diodati JG,
|
||
Turgeon J,
|
||
Schampaert E,
|
||
Palisaitis DA,
|
||
Pharand C</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2010 Aug 6;143(1):43-50.
|
||
Epub 2009 Feb 11
|
||
doi: 10.1016/j.ijcard.2009.01.037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19215991" target="_blank">19215991</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Impaired%20arachidonic%20acid-induced%20platelet%20aggregation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
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