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<meta name="keywords" content="C4020770, decreased size of premaxilla, decreased size of the primary palate bone, finding, hypoplasia of the intermaxillary bone, hypoplasia of the premaxilla, hypoplasia of the primary palate bone, premaxillary bone deficiency, premaxillary bone retrusion, premaxillary retrusion, premaxillary underdevelopment, primary palate bone deficiency, primary palate bone retrusion, small premaxilla, small primary palate bone, underdevelopment of premaxilla, underdevelopment of the premaxilla, underdevelopment of the primary palate bone, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Hypoplasia of the premaxilla (Concept Id: C4020770)
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<!--
UID=866508
ConceptID=C4020770
-->
<!--imgCountBooks = 0--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Image</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Figure 1" src="/projects/medgen/images/thumb/7180b5fd118178e6.1.thumb.jpg" src-large="/projects/medgen/images/7180b5fd118178e6.1.jpg" /></a><br /><a href="http://elementsofmorphology.nih.gov/index.cgi?tid=7180b5fd118178e6" target="_blank" title="Elements of Morphology: Human Malformation Terminology - NHGRI">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Hypoplasia of the premaxilla</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866508</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C4020770</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Decreased size of premaxilla; Decreased size of the primary palate bone; Hypoplasia of the intermaxillary bone; Hypoplasia of the primary palate bone; Premaxillary bone deficiency; Premaxillary bone retrusion; Premaxillary retrusion; Premaxillary underdevelopment; Primary palate bone deficiency; Primary palate bone retrusion; Small premaxilla; Small primary palate bone; Underdevelopment of premaxilla; Underdevelopment of the premaxilla; Underdevelopment of the primary palate bone</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0010650">HP:0010650</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Hypoplasia of the premaxilla</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/488801" ref="tree=MeSH" title="MedGen record for Abnormal skull morphology">Abnormal skull morphology</a></span><ul><li><span class="TLline"><a href="/medgen/746145" ref="tree=MeSH" title="MedGen record for Abnormal facial skeleton morphology">Abnormal facial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/905760" ref="tree=MeSH" title="MedGen record for Abnormal jaw morphology">Abnormal jaw morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871366" ref="tree=MeSH" title="MedGen record for Abnormal maxilla morphology">Abnormal maxilla morphology</a></span><ul><li><span class="TLline"><a href="/medgen/869285" ref="tree=MeSH" title="MedGen record for Abnormality of the premaxilla">Abnormality of the premaxilla</a></span><ul><li><span class="TLline"><a href="/medgen/869287" ref="tree=MeSH" title="MedGen record for Aplasia/Hypoplasia of the premaxilla">Aplasia/Hypoplasia of the premaxilla</a></span><ul><li><span class="matched_ds">Hypoplasia of the premaxilla</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_324369"><div><strong>Holoprosencephaly 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324369</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1835819</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Holoprosencephaly-9 refers to a disorder characterized by a wide phenotypic spectrum of brain developmental defects, with or without overt forebrain cleavage abnormalities. It usually includes midline craniofacial anomalies involving the first branchial arch and/or orbits, pituitary hypoplasia with panhypopituitarism, and postaxial polydactyly. The disorder shows incomplete penetrance and variable expressivity (summary by Roessler et al., 2003 and Bertolacini et al., 2012).&#13; For general phenotypic information and a discussion of genetic heterogeneity of holoprosencephaly, see HPE1 (236100).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/324369">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_372134"><div><strong>Holoprosencephaly 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>372134</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1835820</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Holoprosencephaly (HPE) is the most commonly occurring congenital structural forebrain anomaly in humans. HPE is associated with mental retardation and craniofacial malformations. Considerable heterogeneity in the genetic causes of HPE has been demonstrated (Ming et al., 2002).&#13; For general phenotypic information and a discussion of genetic heterogeneity of holoprosencephaly, see HPE1 (236100).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/372134">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_372134" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holoprosencephaly 7</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324369" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holoprosencephaly 9</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34261964">Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fariña R,
Lolas J,
Moreno E,
Alister JP,
Uribe MF,
Pantoja R,
Valladares S,
Arrué C</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2022 Mar-Apr 01;33(2):496-501.
doi: 10.1097/SCS.0000000000007973.
<span class="bold">PMID: </span><a href="/pubmed/34261964" target="_blank">34261964</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31219831">Management of the protuberant premaxilla: where does it fit in?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morris L</span><br />
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
2019 Aug;27(4):302-309.
doi: 10.1097/MOO.0000000000000558.
<span class="bold">PMID: </span><a href="/pubmed/31219831" target="_blank">31219831</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26374747">Management of the premaxilla in the treatment of bilateral cleft of lip and palate: what can the literature tell us?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bittermann GK,
de Ruiter AP,
Janssen NG,
Bittermann AJ,
van der Molen AM,
van Es RJ,
Rosenberg AJ,
Koole R</span><br />
<span class="medgenPMjournal">Clin Oral Investig</span>
2016 Mar;20(2):207-17.
Epub 2015 Sep 16
doi: 10.1007/s00784-015-1589-y.
<span class="bold">PMID: </span><a href="/pubmed/26374747" target="_blank">26374747</a><a href="/pmc/articles/PMC4762918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypoplasia%20of%20the%20premaxilla)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/34967231">Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bangun K,
Halim J,
Tania V</span><br />
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
2023 May;60(5):621-626.
Epub 2021 Dec 30
doi: 10.1177/10556656211069820.
<span class="bold">PMID: </span><a href="/pubmed/34967231" target="_blank">34967231</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34261964">Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fariña R,
Lolas J,
Moreno E,
Alister JP,
Uribe MF,
Pantoja R,
Valladares S,
Arrué C</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2022 Mar-Apr 01;33(2):496-501.
doi: 10.1097/SCS.0000000000007973.
<span class="bold">PMID: </span><a href="/pubmed/34261964" target="_blank">34261964</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33289836">Anteroposterior length of the maxillary complex and its relationship with the anterior cranial base.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Savoldi F,
Massetti F,
Tsoi JKH,
Matinlinna JP,
Yeung AWK,
Tanaka R,
Paganelli C,
Bornstein MM</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
2021 Jan 1;91(1):88-97.
doi: 10.2319/020520-82.1.
<span class="bold">PMID: </span><a href="/pubmed/33289836" target="_blank">33289836</a><a href="/pmc/articles/PMC8032287" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31420283">The arrhinias: Proboscis lateralis literature review and surgical update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Galiè M,
Clauser LC,
Tieghi R,
Kawamoto HK,
Wolfe SA,
Bianchi AE</span><br />
<span class="medgenPMjournal">J Craniomaxillofac Surg</span>
2019 Sep;47(9):1410-1413.
Epub 2018 Dec 27
doi: 10.1016/j.jcms.2018.12.013.
<span class="bold">PMID: </span><a href="/pubmed/31420283" target="_blank">31420283</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19401938">The Arrhinias.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tessier P,
Ciminello FS,
Wolfe SA</span><br />
<span class="medgenPMjournal">Scand J Plast Reconstr Surg Hand Surg</span>
2009;43(4):177-96.
doi: 10.1080/02844310802517259.
<span class="bold">PMID: </span><a href="/pubmed/19401938" target="_blank">19401938</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20premaxilla%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/32564109">Incidence and morphology of the incisive suture in CT scanning of young children and human fetuses.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nicol P,
Elmaleh-Bergès M,
Sadoine J,
Slimani L,
Vacher C</span><br />
<span class="medgenPMjournal">Surg Radiol Anat</span>
2020 Sep;42(9):1057-1062.
Epub 2020 Jun 20
doi: 10.1007/s00276-020-02521-8.
<span class="bold">PMID: </span><a href="/pubmed/32564109" target="_blank">32564109</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30904259">Is palato-premaxillary subduction a characteristic of Binder's syndrome?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Saint Hilaire T,
Nguyen DT,
Jankowski R,
Rumeau C</span><br />
<span class="medgenPMjournal">Eur Ann Otorhinolaryngol Head Neck Dis</span>
2019 Sep;136(4):241-245.
Epub 2019 Mar 21
doi: 10.1016/j.anorl.2019.03.002.
<span class="bold">PMID: </span><a href="/pubmed/30904259" target="_blank">30904259</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28658352">Premaxilla: an independent bone that can base therapeutics for middle third growth!</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Trevizan M,
Consolaro A</span><br />
<span class="medgenPMjournal">Dental Press J Orthod</span>
2017 Mar-Apr;22(2):21-26.
doi: 10.1590/2177-6709.22.2.021-026.oin.
<span class="bold">PMID: </span><a href="/pubmed/28658352" target="_blank">28658352</a><a href="/pmc/articles/PMC5484266" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27300460">Premaxillary Repositioning in the Severe Form of Bilateral Cleft Lip and Palate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Koh KS,
Han WY,
Jeong WS,
Oh TS,
Kwon SM,
Choi JW</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2016 Sep;27(6):1440-4.
doi: 10.1097/SCS.0000000000002729.
<span class="bold">PMID: </span><a href="/pubmed/27300460" target="_blank">27300460</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19401938">The Arrhinias.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tessier P,
Ciminello FS,
Wolfe SA</span><br />
<span class="medgenPMjournal">Scand J Plast Reconstr Surg Hand Surg</span>
2009;43(4):177-96.
doi: 10.1080/02844310802517259.
<span class="bold">PMID: </span><a href="/pubmed/19401938" target="_blank">19401938</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20premaxilla%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/30015740">Bilateral Cleft Lip and Palate, With Facial Dysplasia: Interdisciplinary Treatment and Long-Term Follow-Up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bennun RD,
Harfin JH</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2018 Sep;29(6):1441-1444.
doi: 10.1097/SCS.0000000000004756.
<span class="bold">PMID: </span><a href="/pubmed/30015740" target="_blank">30015740</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22677689">Advantages and limits of 3-segment (paramedian) versus 2-segment (median) surgically assisted rapid maxillary expansion (SARME).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Landes CA,
Laudemann K,
Petruchin O,
Revilla C,
Seitz O,
Kopp S,
Ludwig B,
Sader RA</span><br />
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol Oral Radiol</span>
2012 Jan;113(1):29-40.
Epub 2011 Mar 31
doi: 10.1016/j.tripleo.2011.01.013.
<span class="bold">PMID: </span><a href="/pubmed/22677689" target="_blank">22677689</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11108527">The origin and development of the upper lateral incisor and premaxilla in normal and cleft lip/palate monkeys induced with cyclophosphamide.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wei X,
Senders C,
Owiti GO,
Liu X,
Wei ZN,
Dillard-Telm L,
McClure HM,
Hendrickx AG</span><br />
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
2000 Nov;37(6):571-83.
doi: 10.1597/1545-1569_2000_037_0571_toadot_2.0.co_2.
<span class="bold">PMID: </span><a href="/pubmed/11108527" target="_blank">11108527</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9500379">Presurgical columellar elongation and primary retrograde nasal reconstruction in one-stage bilateral cleft lip and nose repair.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cutting C,
Grayson B,
Brecht L,
Santiago P,
Wood R,
Kwon S</span><br />
<span class="medgenPMjournal">Plast Reconstr Surg</span>
1998 Mar;101(3):630-9.
doi: 10.1097/00006534-199803000-00009.
<span class="bold">PMID: </span><a href="/pubmed/9500379" target="_blank">9500379</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3580160">A devitalized tooth as a complication of septorhinoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sykes JM,
Toriumi D,
Kerth JD</span><br />
<span class="medgenPMjournal">Arch Otolaryngol Head Neck Surg</span>
1987 Jul;113(7):765-7.
doi: 10.1001/archotol.1987.01860070079021.
<span class="bold">PMID: </span><a href="/pubmed/3580160" target="_blank">3580160</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20premaxilla%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/32564109">Incidence and morphology of the incisive suture in CT scanning of young children and human fetuses.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nicol P,
Elmaleh-Bergès M,
Sadoine J,
Slimani L,
Vacher C</span><br />
<span class="medgenPMjournal">Surg Radiol Anat</span>
2020 Sep;42(9):1057-1062.
Epub 2020 Jun 20
doi: 10.1007/s00276-020-02521-8.
<span class="bold">PMID: </span><a href="/pubmed/32564109" target="_blank">32564109</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23702194">Treatment algorithm for bilateral alveolar cleft based on the position of the premaxilla and the width of the alveolar gap.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Koh KS,
Kim H,
Oh TS,
Kwon SM,
Choi JW</span><br />
<span class="medgenPMjournal">J Plast Reconstr Aesthet Surg</span>
2013 Sep;66(9):1212-8.
Epub 2013 May 21
doi: 10.1016/j.bjps.2013.04.060.
<span class="bold">PMID: </span><a href="/pubmed/23702194" target="_blank">23702194</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19401938">The Arrhinias.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tessier P,
Ciminello FS,
Wolfe SA</span><br />
<span class="medgenPMjournal">Scand J Plast Reconstr Surg Hand Surg</span>
2009;43(4):177-96.
doi: 10.1080/02844310802517259.
<span class="bold">PMID: </span><a href="/pubmed/19401938" target="_blank">19401938</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16405381">Management of the prominent premaxilla in bilateral cleft lip and palate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aburezq H,
Daskalogiannakis J,
Forrest C</span><br />
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
2006 Jan;43(1):92-5.
doi: 10.1597/04-114r.1.
<span class="bold">PMID: </span><a href="/pubmed/16405381" target="_blank">16405381</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4034763">The protruding premaxilla and minimal median alveolar cleft: an unusual problem with a 12-year follow-up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Okunski WJ,
Stein A</span><br />
<span class="medgenPMjournal">Plast Reconstr Surg</span>
1985 Sep;76(3):449-50.
doi: 10.1097/00006534-198509000-00023.
<span class="bold">PMID: </span><a href="/pubmed/4034763" target="_blank">4034763</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20premaxilla%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (22)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/29652537">Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vermeij-Keers C,
Rozendaal AM,
Luijsterburg AJM,
Latief BS,
Lekkas C,
Kragt L,
Ongkosuwito EM</span><br />
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
2018 Oct;55(9):1267-1276.
Epub 2018 Apr 13
doi: 10.1177/1055665618767106.
<span class="bold">PMID: </span><a href="/pubmed/29652537" target="_blank">29652537</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27300460">Premaxillary Repositioning in the Severe Form of Bilateral Cleft Lip and Palate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Koh KS,
Han WY,
Jeong WS,
Oh TS,
Kwon SM,
Choi JW</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2016 Sep;27(6):1440-4.
doi: 10.1097/SCS.0000000000002729.
<span class="bold">PMID: </span><a href="/pubmed/27300460" target="_blank">27300460</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14760532">A re-evaluation of the premaxillary bone in humans.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barteczko K,
Jacob M</span><br />
<span class="medgenPMjournal">Anat Embryol (Berl)</span>
2004 Mar;207(6):417-37.
Epub 2004 Feb 4
doi: 10.1007/s00429-003-0366-x.
<span class="bold">PMID: </span><a href="/pubmed/14760532" target="_blank">14760532</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11887012">Development of the facial midline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Carstens MH</span><br />
<span class="medgenPMjournal">J Craniofac Surg</span>
2002 Jan;13(1):129-87; discussion 188-90.
doi: 10.1097/00001665-200201000-00032.
<span class="bold">PMID: </span><a href="/pubmed/11887012" target="_blank">11887012</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8426712">Clinical observations of cleft lip and palate.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Precious DS,
Delaire J</span><br />
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol</span>
1993 Feb;75(2):141-51.
doi: 10.1016/0030-4220(93)90084-h.
<span class="bold">PMID: </span><a href="/pubmed/8426712" target="_blank">8426712</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypoplasia%20of%20the%20premaxilla%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Hypoplasia%20of%20the%20premaxilla" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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