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<meta name="keywords" content="C3463824, asxl1, dysmyelopoiesis, dysmyelopoietic syndrome, dysmyelopoietic syndromes, gata2, gnb1, hematopoeitic - myelodysplastic syndrome (mds), mds, mds - myelodysplastic syndrome, mds, unclassifiable, mds-u, myelodysplasia, myelodysplastic neoplasm, myelodysplastic syndrome, myelodysplastic syndrome (clinical), myelodysplastic syndrome (mds), myelodysplastic syndrome, somatic, myelodysplastic syndrome, susceptibility to, myelodysplastic syndrome, susceptibility, gata2-related, myelodysplastic syndrome, unclassifiable, myelodysplastic syndrome/neoplasm, myelodysplastic syndromes, neoplastic process, oligoblastic leukaemia, oligoblastic leukemia, preleukemia, sf3b1, smoldering leukemia, smouldering leukaemia, syndrome, dysmyelopoietic, syndrome, myelodysplastic, syndromes, dysmyelopoietic, syndromes, myelodysplastic, tet2, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic stem cell disorders characterized by ineffective hematopoiesis resulting in low blood counts, most commonly anemia, and a risk of progression to acute myeloid leukemia (AML; 601626). Blood smears and bone marrow biopsies show dysplastic changes in myeloid cells, with abnormal proliferation and differentiation of 1 or more lineages (erythroid, myeloid, megakaryocytic). MDS can be subdivided into several categories based on morphologic characteristics, such as low-grade refractory anemia (RA) or high-grade refractory anemia with excess blasts (RAEB). Bone marrow biopsies of some patients show ringed sideroblasts (RARS), which reflects abnormal iron staining in mitochondria surrounding the nucleus of erythrocyte progenitors (summary by Delhommeau et al., 2009 and Papaemmanuil et al., 2011)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=483005
|
||
ConceptID=C3463824
|
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-->
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Myelodysplastic syndrome<span class="h1sub">(MDS)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>483005</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C3463824</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>MDS; Myelodysplastic syndrome, somatic; MYELODYSPLASTIC SYNDROME, SUSCEPTIBILITY TO; Myelodysplastic Syndrome, Susceptibility, GATA2-Related; Myelodysplastic syndromes</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Myelodysplastic syndrome (128623006); MDS - Myelodysplastic syndrome (109995007); Dysmyelopoietic syndrome (128623006); Myelodysplastic syndrome (clinical) (109995007); Myelodysplastic syndrome (109995007); Myelodysplastic neoplasm (128623006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="ASXL1 - ID: 171023 - NCBI Gene" href="/gene/171023" class="medgenPMinfo">ASXL1</a> (20q11.21); <a target="_blank" title="GATA2 - ID: 2624 - NCBI Gene" href="/gene/2624" class="medgenPMinfo">GATA2</a> (3q21.3); <a target="_blank" title="GNB1 - ID: 2782 - NCBI Gene" href="/gene/2782" class="medgenPMinfo">GNB1</a> (1p36.33); <a target="_blank" title="SF3B1 - ID: 23451 - NCBI Gene" href="/gene/23451" class="medgenPMinfo">SF3B1</a> (2q33.1); <a target="_blank" title="TET2 - ID: 54790 - NCBI Gene" href="/gene/54790" class="medgenPMinfo">TET2</a> (4q24)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018881" target="_blank">MONDO:0018881</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/614286" target="_blank">614286</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=52688">ORPHA52688</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic stem cell disorders characterized by ineffective hematopoiesis resulting in low blood counts, most commonly anemia, and a risk of progression to acute myeloid leukemia (AML; 601626). Blood smears and bone marrow biopsies show dysplastic changes in myeloid cells, with abnormal proliferation and differentiation of 1 or more lineages (erythroid, myeloid, megakaryocytic). MDS can be subdivided into several categories based on morphologic characteristics, such as low-grade refractory anemia (RA) or high-grade refractory anemia with excess blasts (RAEB). Bone marrow biopsies of some patients show ringed sideroblasts (RARS), which reflects abnormal iron staining in mitochondria surrounding the nucleus of erythrocyte progenitors (summary by Delhommeau et al., 2009 and Papaemmanuil et al., 2011). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
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<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_10231"><div><strong>Myelodysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10231</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0026985</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/10231">Feature record</a> | <a href="/medgen?term=%22Myelodysplasia%22%5BClinical%20Features%5D%20OR%2010231%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10231" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Myelodysplasia</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3463824[DISCUI]&test_type=Clinical" ref="ncbi_uid=483005">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C3463824[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=483005">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=483005" target="_blank" href="/omim/614286">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=483005" ref="ncbi_uid=483005">V</a></span></span><span class="TLline">Myelodysplastic syndrome</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2311" ref="tree=MeSH" title="MedGen record for Bone marrow disorder">Bone marrow disorder</a></span><ul><li><span class="TLline"><a href="/medgen/129203" ref="tree=MeSH" title="MedGen record for Bone marrow neoplasm">Bone marrow neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/438070" ref="tree=MeSH" title="MedGen record for Bone marrow cancer">Bone marrow cancer</a></span><ul><li><span class="matched_ds">Myelodysplastic syndrome</span><ul><li><span class="TLline"><a href="/medgen/859692" ref="tree=MeSH" title="MedGen record for Adult Myelodysplastic Syndrome">Adult Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/389541" ref="tree=MeSH" title="MedGen record for Childhood myelodysplastic syndrome">Childhood myelodysplastic syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/417430" ref="tree=MeSH" title="MedGen record for Refractory cytopenia of childhood">Refractory cytopenia of childhood</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79122" ref="tree=MeSH" title="MedGen record for de novo Myelodysplastic Syndrome">de novo Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1826116" ref="tree=MeSH" title="MedGen record for Familial monosomy 7 syndrome">Familial monosomy 7 syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/381529" ref="tree=MeSH" title="MedGen record for Monosomy 7 myelodysplasia and leukemia syndrome 1">Monosomy 7 myelodysplasia and leukemia syndrome 1</a></span></li><li><span class="TLline"><a href="/medgen/1762901" ref="tree=MeSH" title="MedGen record for Monosomy 7 myelodysplasia and leukemia syndrome 2">Monosomy 7 myelodysplasia and leukemia syndrome 2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1711283" ref="tree=MeSH" title="MedGen record for Hereditary Myelodysplastic Syndrome">Hereditary Myelodysplastic Syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/1710410" ref="tree=MeSH" title="MedGen record for SAMD9-Associated Hereditary Myelodysplastic Syndrome">SAMD9-Associated Hereditary Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1719321" ref="tree=MeSH" title="MedGen record for SAMD9L-Associated Hereditary Myelodysplastic Syndrome">SAMD9L-Associated Hereditary Myelodysplastic Syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/481660" ref="tree=MeSH" title="MedGen record for Monocytopenia with susceptibility to infections">Monocytopenia with susceptibility to infections</a></span></li><li><span class="TLline"><a href="/medgen/196625" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome associated with isolated del(5q)">Myelodysplastic syndrome associated with isolated del(5q)</a></span></li><li><span class="TLline"><a href="/medgen/226950" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with del(5q)">Myelodysplastic Syndrome with del(5q)</a></span></li><li><span class="TLline"><a href="/medgen/8066" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome with excess blasts">Myelodysplastic syndrome with excess blasts</a></span><ul><li><span class="TLline"><a href="/medgen/417429" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Excess Blasts and Fibrosis">Myelodysplastic Syndrome with Excess Blasts and Fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/231145" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome with excess blasts-1">Myelodysplastic syndrome with excess blasts-1</a></span></li><li><span class="TLline"><a href="/medgen/962564" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome with excess blasts-2">Myelodysplastic syndrome with excess blasts-2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/208726" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome with multilineage dysplasia">Myelodysplastic syndrome with multilineage dysplasia</a></span><ul><li><span class="TLline"><a href="/medgen/639969" ref="tree=MeSH" title="MedGen record for Aregenerative anemia">Aregenerative anemia</a></span></li><li><span class="TLline"><a href="/medgen/1799320" ref="tree=MeSH" title="MedGen record for Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome">Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome</a></span></li><li><span class="TLline"><a href="/medgen/415300" ref="tree=MeSH" title="MedGen record for Refractory cytopenia with unilineage dysplasia">Refractory cytopenia with unilineage dysplasia</a></span><ul><li><span class="TLline"><a href="/medgen/286" ref="tree=MeSH" title="MedGen record for Refractory anemia">Refractory anemia</a></span></li><li><span class="TLline"><a href="/medgen/414877" ref="tree=MeSH" title="MedGen record for Refractory Neutropenia">Refractory Neutropenia</a></span></li><li><span class="TLline"><a href="/medgen/443195" ref="tree=MeSH" title="MedGen record for Refractory Thrombocytopenia">Refractory Thrombocytopenia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1842914" ref="tree=MeSH" title="MedGen record for Unclassified myelodysplastic syndrome">Unclassified myelodysplastic syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/865038" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome with ring sideroblasts">Myelodysplastic syndrome with ring sideroblasts</a></span></li><li><span class="TLline"><a href="/medgen/1716049" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Somatic Mutation">Myelodysplastic Syndrome with Somatic Mutation</a></span></li><li><span class="TLline"><a href="/medgen/692784" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome, Unclassifiable">Myelodysplastic Syndrome, Unclassifiable</a></span><ul><li><span class="TLline"><a href="/medgen/1718320" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts">Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts</a></span></li><li><span class="TLline"><a href="/medgen/1711583" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome, Unclassifiable, with Defining Cytogenetic Abnormality">Myelodysplastic Syndrome, Unclassifiable, with Defining Cytogenetic Abnormality</a></span></li><li><span class="TLline"><a href="/medgen/1719622" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia">Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9205" ref="tree=MeSH" title="MedGen record for Paroxysmal Hemoglobinuria">Paroxysmal Hemoglobinuria</a></span></li><li><span class="TLline"><a href="/medgen/1651993" ref="tree=MeSH" title="MedGen record for Recurrent Myelodysplastic Syndrome">Recurrent Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/124692" ref="tree=MeSH" title="MedGen record for Refractory anemia with excess blasts in transformation">Refractory anemia with excess blasts in transformation</a></span></li><li><span class="TLline"><a href="/medgen/220394" ref="tree=MeSH" title="MedGen record for Refractory anemia with ringed sideroblasts">Refractory anemia with ringed sideroblasts</a></span><ul><li><span class="TLline"><a href="/medgen/226982" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia">Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia</a></span></li><li><span class="TLline"><a href="/medgen/1378167" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia">Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1656162" ref="tree=MeSH" title="MedGen record for Refractory Myelodysplastic Syndrome">Refractory Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/76156" ref="tree=MeSH" title="MedGen record for Secondary Myelodysplastic Syndrome">Secondary Myelodysplastic Syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/224863" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome Post Cytotoxic Therapy">Myelodysplastic Syndrome Post Cytotoxic Therapy</a></span><ul><li><span class="TLline"><a href="/medgen/272300" ref="tree=MeSH" title="MedGen record for Alkylating Agent-Related Myelodysplastic Syndrome">Alkylating Agent-Related Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/232463" ref="tree=MeSH" title="MedGen record for Epipodophyllotoxin-Related Myelodysplastic Syndrome">Epipodophyllotoxin-Related Myelodysplastic Syndrome</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/8067" ref="tree=MeSH" title="MedGen record for Sideroblastic anemia">Sideroblastic anemia</a></span><ul><li><span class="TLline"><a href="/medgen/75771" ref="tree=MeSH" title="MedGen record for Pyridoxine-responsive sideroblastic anemia">Pyridoxine-responsive sideroblastic anemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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<div class="portlet mgSection" id="ID_105">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/38160120">VEXAS syndrome: Clinical manifestations, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Loeza-Uribe MP,
|
||
Hinojosa-Azaola A,
|
||
Sánchez-Hernández BE,
|
||
Crispín JC,
|
||
Apodaca-Chávez E,
|
||
Ferrada MA,
|
||
Martín-Nares E</span><br />
|
||
<span class="medgenPMjournal">Reumatol Clin (Engl Ed)</span>
|
||
2024 Jan;20(1):47-56.
|
||
Epub 2023 Dec 29
|
||
doi: 10.1016/j.reumae.2023.12.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38160120" target="_blank">38160120</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29544767">Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ullmann AJ,
|
||
Aguado JM,
|
||
Arikan-Akdagli S,
|
||
Denning DW,
|
||
Groll AH,
|
||
Lagrou K,
|
||
Lass-Flörl C,
|
||
Lewis RE,
|
||
Munoz P,
|
||
Verweij PE,
|
||
Warris A,
|
||
Ader F,
|
||
Akova M,
|
||
Arendrup MC,
|
||
Barnes RA,
|
||
Beigelman-Aubry C,
|
||
Blot S,
|
||
Bouza E,
|
||
Brüggemann RJM,
|
||
Buchheidt D,
|
||
Cadranel J,
|
||
Castagnola E,
|
||
Chakrabarti A,
|
||
Cuenca-Estrella M,
|
||
Dimopoulos G,
|
||
Fortun J,
|
||
Gangneux JP,
|
||
Garbino J,
|
||
Heinz WJ,
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||
Herbrecht R,
|
||
Heussel CP,
|
||
Kibbler CC,
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||
Klimko N,
|
||
Kullberg BJ,
|
||
Lange C,
|
||
Lehrnbecher T,
|
||
Löffler J,
|
||
Lortholary O,
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||
Maertens J,
|
||
Marchetti O,
|
||
Meis JF,
|
||
Pagano L,
|
||
Ribaud P,
|
||
Richardson M,
|
||
Roilides E,
|
||
Ruhnke M,
|
||
Sanguinetti M,
|
||
Sheppard DC,
|
||
Sinkó J,
|
||
Skiada A,
|
||
Vehreschild MJGT,
|
||
Viscoli C,
|
||
Cornely OA</span><br />
|
||
<span class="medgenPMjournal">Clin Microbiol Infect</span>
|
||
2018 May;24 Suppl 1:e1-e38.
|
||
Epub 2018 Mar 12
|
||
doi: 10.1016/j.cmi.2018.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29544767" target="_blank">29544767</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29141943">Anemia at older age: etiologies, clinical implications, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stauder R,
|
||
Valent P,
|
||
Theurl I</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2018 Feb 1;131(5):505-514.
|
||
Epub 2017 Nov 15
|
||
doi: 10.1182/blood-2017-07-746446.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29141943" target="_blank">29141943</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22myelodysplastic%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (637)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/mds.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myelodysplastic Syndromes, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36445482">The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rudelius M,
|
||
Weinberg OK,
|
||
Niemeyer CM,
|
||
Shimamura A,
|
||
Calvo KR</span><br />
|
||
<span class="medgenPMjournal">Virchows Arch</span>
|
||
2023 Jan;482(1):113-130.
|
||
Epub 2022 Nov 29
|
||
doi: 10.1007/s00428-022-03447-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36445482" target="_blank">36445482</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34907099">Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jain AG,
|
||
Zhang L,
|
||
Bennett JM,
|
||
Komrokji R</span><br />
|
||
<span class="medgenPMjournal">Ann Lab Med</span>
|
||
2022 May 1;42(3):299-305.
|
||
doi: 10.3343/alm.2022.42.3.299.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34907099" target="_blank">34907099</a><a href="/pmc/articles/PMC8677477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34638574">Molecular Targeted Therapy and Immunotherapy for Myelodysplastic Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee P,
|
||
Yim R,
|
||
Yung Y,
|
||
Chu HT,
|
||
Yip PK,
|
||
Gill H</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 Sep 23;22(19)
|
||
doi: 10.3390/ijms221910232.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34638574" target="_blank">34638574</a><a href="/pmc/articles/PMC8508686" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30041243">Myelodysplastic Syndrome Updated.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hasserjian RP</span><br />
|
||
<span class="medgenPMjournal">Pathobiology</span>
|
||
2019;86(1):7-13.
|
||
Epub 2018 Jul 24
|
||
doi: 10.1159/000489702.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30041243" target="_blank">30041243</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29791902">The Molecular Pathology of Myelodysplastic Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haferlach T</span><br />
|
||
<span class="medgenPMjournal">Pathobiology</span>
|
||
2019;86(1):24-29.
|
||
Epub 2018 May 23
|
||
doi: 10.1159/000488712.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29791902" target="_blank">29791902</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4896)</a></div><h3 class="subhead">Diagnosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/37865508">Childhood Myelodysplastic Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chisholm KM,
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2023 Dec;43(4):639-655.
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<span class="bold">PMID: </span><a href="/pubmed/37865508" target="_blank">37865508</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36445482">The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rudelius M,
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Weinberg OK,
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Niemeyer CM,
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Shimamura A,
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Calvo KR</span><br />
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<span class="medgenPMjournal">Virchows Arch</span>
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2023 Jan;482(1):113-130.
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<span class="bold">PMID: </span><a href="/pubmed/36445482" target="_blank">36445482</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34304779">Pediatric Myelodysplastic Syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Patel SS</span><br />
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2021 Sep;41(3):517-528.
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Epub 2021 Jun 24
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doi: 10.1016/j.cll.2021.03.015.
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<span class="bold">PMID: </span><a href="/pubmed/34304779" target="_blank">34304779</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30041243">Myelodysplastic Syndrome Updated.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hasserjian RP</span><br />
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<span class="medgenPMjournal">Pathobiology</span>
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<span class="bold">PMID: </span><a href="/pubmed/30041243" target="_blank">30041243</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29791902">The Molecular Pathology of Myelodysplastic Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Haferlach T</span><br />
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<span class="medgenPMjournal">Pathobiology</span>
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2019;86(1):24-29.
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Epub 2018 May 23
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doi: 10.1159/000488712.
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<span class="bold">PMID: </span><a href="/pubmed/29791902" target="_blank">29791902</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4129)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38987076">Current landscape of CD3 bispecific antibodies in hematologic malignancies.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kassner J,
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Kaner J</span><br />
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<span class="medgenPMjournal">Trends Cancer</span>
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2024 Aug;10(8):708-732.
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<span class="bold">PMID: </span><a href="/pubmed/38987076" target="_blank">38987076</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38814537">Treatment of Anemia in Lower-Risk Myelodysplastic Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Battaglia MR,
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Cannova J,
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<span class="bold">PMID: </span><a href="/pubmed/38814537" target="_blank">38814537</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35617104">Treosulfan compared with reduced-intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Beelen DW,
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<div class="portlet_content ln"><span class="medgenPMauthor">Jiang Z,
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<span class="bold">PMID: </span><a href="/pubmed/34717705" target="_blank">34717705</a><a href="/pmc/articles/PMC8557524" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29177643">Iron overload in myelodysplastic syndromes (MDS).</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gattermann N</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/29177643" target="_blank">29177643</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4201)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/34793718">(177)Lu-Dotatate plus long-acting octreotide versus high‑dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival and long-term safety results from an open-label, randomised, controlled, phase 3 trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Strosberg JR,
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Seregni E,
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Mariani MF,
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Demange A,
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Mutevelic S,
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<span class="bold">PMID: </span><a href="/pubmed/34793718" target="_blank">34793718</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32948844">Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hoeks M,
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Bagguley T,
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Smith A,
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<span class="bold">PMID: </span><a href="/pubmed/32948844" target="_blank">32948844</a><a href="/pmc/articles/PMC8179850" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31419568">Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cordeiro A,
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Turtle CJ,
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<span class="bold">PMID: </span><a href="/pubmed/31419568" target="_blank">31419568</a><a href="/pmc/articles/PMC6953906" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30091023">Autoimmune manifestations associated with myelodysplastic syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Grignano E,
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Jachiet V,
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<span class="bold">PMID: </span><a href="/pubmed/30091023" target="_blank">30091023</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24095584">Income and outcome in myelodysplastic syndrome: the prognostic impact of SES in a single-payer system.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">England JT,
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Zhang L,
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Buckstein R,
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Lenis M,
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<span class="bold">PMID: </span><a href="/pubmed/24095584" target="_blank">24095584</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3977)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/34907099">Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jain AG,
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<span class="bold">PMID: </span><a href="/pubmed/34907099" target="_blank">34907099</a><a href="/pmc/articles/PMC8677477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31568568">How we manage adults with myelodysplastic syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fenaux P,
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<span class="bold">PMID: </span><a href="/pubmed/31568568" target="_blank">31568568</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29791902">The Molecular Pathology of Myelodysplastic Syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Haferlach T</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/29791902" target="_blank">29791902</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29128070">Flow Cytometric Assessment of Chronic Myeloid Neoplasms.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Shi M,
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2017 Dec;37(4):803-819.
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Epub 2017 Sep 20
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<span class="bold">PMID: </span><a href="/pubmed/29128070" target="_blank">29128070</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28760300">First-line Therapeutic Strategies for Myelodysplastic Syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Santini V</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/28760300" target="_blank">28760300</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3005)</a></div></div>
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</div>
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|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/38906261">Investigating historic cases of pyoderma gangrenosum in myelodysplastic syndrome and chronic myelomonocytic leukemia for possible VEXAS syndrome: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Croitoru DO,
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Huang RS,
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McMullen EP,
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Maazi M,
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Piguet V</span><br />
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<span class="medgenPMjournal">J Am Acad Dermatol</span>
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2024 Oct;91(4):712-714.
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Epub 2024 Jun 19
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<span class="bold">PMID: </span><a href="/pubmed/38906261" target="_blank">38906261</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38423375">Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Shahzad M,
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Iqbal Q,
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Tariq E,
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Ammad-Ud-Din M,
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Butt A,
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Mushtaq AH,
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Ali F,
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Chaudhary SG,
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Anwar I,
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Gonzalez-Lugo JD,
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Abdelhakim H,
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Ahmed N,
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Hematti P,
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Singh AK,
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McGuirk JP,
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Mushtaq MU</span><br />
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<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
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2024 Apr;196:104310.
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<span class="bold">PMID: </span><a href="/pubmed/38423375" target="_blank">38423375</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37233149">How to treat VEXAS syndrome: a systematic review on effectiveness and safety of current treatment strategies.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Boyadzhieva Z,
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Ruffer N,
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Kötter I,
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Krusche M</span><br />
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<span class="medgenPMjournal">Rheumatology (Oxford)</span>
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2023 Nov 2;62(11):3518-3525.
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<span class="bold">PMID: </span><a href="/pubmed/37233149" target="_blank">37233149</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37036307">The efficacy and safety of venetoclax and azacytidine combination treatment in patients with acute myeloid leukemia and myelodysplastic syndrome: systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Du Y,
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Li C,
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Yan J</span><br />
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<span class="medgenPMjournal">Hematology</span>
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<span class="bold">PMID: </span><a href="/pubmed/37036307" target="_blank">37036307</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33030550">Comparison of Antifungal Prophylaxis Drugs in Patients With Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
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Zhou M,
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Xu JY,
|
||
Zhou RF,
|
||
Chen B,
|
||
Wan Y</span><br />
|
||
<span class="medgenPMjournal">JAMA Netw Open</span>
|
||
2020 Oct 1;3(10):e2017652.
|
||
doi: 10.1001/jamanetworkopen.2020.17652.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33030550" target="_blank">33030550</a><a href="/pmc/articles/PMC7545296" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Myelodysplastic%20syndrome%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (83)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
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<div class=" bottom">
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</div>
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</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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</div>
|
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|
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<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (57)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (16)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&test_type=Research" target="_blank">Research (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (10)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (69)</a></li>
|
||
<li><a href="/gtr/tests?term=C3463824%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (53)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3463824%5bDISCUI%5d" target="_blank">See all (157)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=614286" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=52688" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Myelodysplastic%20syndrome" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22myelodysplastic%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Myelodysplastic%20syndrome%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/mds.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myelodysplastic Syndromes, 2024</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=137295%20139380%20605590%20612839%20612990" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=2624[geneid]" target="_blank">View GATA2 variations in ClinVar</a></li><li><a href="/clinvar/?term=2782[geneid]" target="_blank">View GNB1 variations in ClinVar</a></li><li><a href="/clinvar/?term=23451[geneid]" target="_blank">View SF3B1 variations in ClinVar</a></li><li><a href="/clinvar/?term=54790[geneid]" target="_blank">View TET2 variations in ClinVar</a></li><li><a href="/clinvar/?term=171023[geneid]" target="_blank">View ASXL1 variations in ClinVar</a></li><li><a href="/nuccore/311210846,325651828" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=614286" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
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|
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|
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|
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Myelodysplastic+syndromes/5021" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/myelodysplastic_syndrome" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Myelodysplastic%20syndrome" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/7132/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
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|
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|
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<li>
|
||
<a href="/pubmed/clinical?term=Myelodysplastic%20syndrome" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
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|
||
<li>
|
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<a href="/pubmed?term=Myelodysplastic%20syndrome%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
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|
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|
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<h3>Related information</h3>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=483005" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=483005" ref="log$=recordlinks">Gene</a>
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<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
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<li class="brieflinkpopper">
|
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3463824[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
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|
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3463824[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cc450584f3725e59c14e50">Myelodysplastic syndrome</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67cc450384f3725e59c13f3d">C1834752[trait identifier] AND "Fulgent Genetics, Fulgent Genetic... <span class="number">(13)</span></a>
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<div class="ralinkpop offscreen_noflow">C1834752[trait identifier] AND "Fulgent Genetics, Fulgent Genetics"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<div class="tertiary">ClinVar</div>
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