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<meta name="keywords" content="C2931456, brca2, chek2, familial malignant neoplasm of prostate, familial prostate cancer, hereditary prostate cancer, klf6, mad1l1, mxi1, neoplastic process, prostate cancer, familial, prostate cancer, hereditary, pten, zfhx3, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. \n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nProstate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=419810
|
||
ConceptID=C2931456
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Familial prostate cancer</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419810</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2931456</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Hereditary Prostate Cancer</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Familial malignant neoplasm of prostate (715412008); Familial prostate cancer (715412008)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="BRCA2 - ID: 675 - NCBI Gene" href="/gene/675" class="medgenPMinfo">BRCA2</a> (13q13.1); <a target="_blank" title="CHEK2 - ID: 11200 - NCBI Gene" href="/gene/11200" class="medgenPMinfo">CHEK2</a> (22q12.1); <a target="_blank" title="KLF6 - ID: 1316 - NCBI Gene" href="/gene/1316" class="medgenPMinfo">KLF6</a> (10p15.2); <a target="_blank" title="MAD1L1 - ID: 8379 - NCBI Gene" href="/gene/8379" class="medgenPMinfo">MAD1L1</a> (7p22.3); <a target="_blank" title="MXI1 - ID: 4601 - NCBI Gene" href="/gene/4601" class="medgenPMinfo">MXI1</a> (10q25.2); <a target="_blank" title="PTEN - ID: 5728 - NCBI Gene" href="/gene/5728" class="medgenPMinfo">PTEN</a> (10q23.31); <a target="_blank" title="ZFHX3 - ID: 463 - NCBI Gene" href="/gene/463" class="medgenPMinfo">ZFHX3</a> (16q22.2-22.3)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0700275" target="_blank">MONDO:0700275</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/176807" target="_blank">176807</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=1331">ORPHA1331</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases.<br /><br />Some cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. <br /><br />The severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.<br /><br />Early prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.<br /><br />Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_138169"><div><strong>Malignant tumor of prostate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>138169</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0376358</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A cancer of the prostate.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/138169">Feature record</a> | <a href="/medgen?term=%22Malignant%20tumor%20of%20prostate%22%5BClinical%20Features%5D%20OR%20138169%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_138169" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Malignant tumor of prostate</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0042065[DISCUI]&test_type=Clinical" ref="ncbi_uid=22583">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/22583" ref="tree=GTR&ncbi_uid=22583&link_uid=22583" title="View MedGen record for 'Neoplasm of the genitourinary tract'">Neoplasm of the genitourinary tract</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0474809[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=105374">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/105374" ref="tree=GTR&ncbi_uid=105374&link_uid=105374" title="View MedGen record for 'Endometrioid tumor'">Endometrioid tumor</a></span></li><li class="TLclosed"><span class="TLline"><a href="/medgen/69146" ref="tree=GTR&ncbi_uid=69146&link_uid=69146" title="View MedGen record for 'Kidney angiomyolipoma'">Kidney angiomyolipoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0376358[DISCUI]&test_type=Clinical" ref="ncbi_uid=138169">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=138169" target="_blank" href="/omim/176807">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=138169" ref="ncbi_uid=138169">V</a></span></span><span class="TLline"><a href="/medgen/138169" ref="tree=GTR&ncbi_uid=138169&link_uid=138169" title="View MedGen record for 'Malignant tumor of prostate'">Malignant tumor of prostate</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2931456[DISCUI]&test_type=Clinical" ref="ncbi_uid=419810">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=419810" ref="ncbi_uid=419810">V</a></span></span><span class="TLline">Familial prostate cancer</span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0153594[DISCUI]&test_type=Clinical" ref="ncbi_uid=56313">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=56313" ref="ncbi_uid=56313">V</a></span></span><span class="TLline"><a href="/medgen/56313" ref="tree=GTR&ncbi_uid=56313&link_uid=56313" title="View MedGen record for 'Malignant tumor of testis'">Malignant tumor of testis</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1336708[DISCUI]&test_type=Clinical" ref="ncbi_uid=277809">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=277809" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=277809" ref="ncbi_uid=277809">V</a></span></span><span class="TLline"><a href="/medgen/277809" ref="tree=GTR&ncbi_uid=277809&link_uid=277809" title="View MedGen record for 'Germ cell tumor of testis'">Germ cell tumor of testis</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=11371" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/11371" ref="tree=GTR&ncbi_uid=11371&link_uid=11371" title="View MedGen record for 'Seminoma'">Seminoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=68669" target="_blank" href="/omim/273300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/68669" ref="tree=GTR&ncbi_uid=68669&link_uid=68669" title="View MedGen record for 'Testicular teratoma'">Testicular teratoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=102281" target="_blank" href="/omim/191600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/102281" ref="tree=GTR&ncbi_uid=102281&link_uid=102281" title="View MedGen record for 'Malignant tumor of ureter'">Malignant tumor of ureter</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0005684[DISCUI]&test_type=Clinical" ref="ncbi_uid=14150">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=14150" target="_blank" href="/omim/109800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=14150" ref="ncbi_uid=14150">V</a></span></span><span class="TLline"><a href="/medgen/14150" ref="tree=GTR&ncbi_uid=14150&link_uid=14150" title="View MedGen record for 'Malignant tumor of urinary bladder'">Malignant tumor of urinary bladder</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0699885[DISCUI]&test_type=Clinical" ref="ncbi_uid=147071">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/147071" ref="tree=GTR&ncbi_uid=147071&link_uid=147071" title="View MedGen record for 'Urinary bladder carcinoma'">Urinary bladder carcinoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0015558[DISCUI]&test_type=Clinical" ref="ncbi_uid=8775">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/8775" ref="tree=GTR&ncbi_uid=8775&link_uid=8775" title="View MedGen record for 'Neoplasm of fallopian tube'">Neoplasm of fallopian tube</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0042138[DISCUI]&test_type=Clinical" ref="ncbi_uid=12030">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=12030" ref="ncbi_uid=12030">V</a></span></span><span class="TLline"><a href="/medgen/12030" ref="tree=GTR&ncbi_uid=12030&link_uid=12030" title="View MedGen record for 'Neoplasm of uterus'">Neoplasm of uterus</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014170[DISCUI]&test_type=Clinical" ref="ncbi_uid=8619">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/8619" ref="tree=GTR&ncbi_uid=8619&link_uid=8619" title="View MedGen record for 'Endometrium neoplasm'">Endometrium neoplasm</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007873[DISCUI]&test_type=Clinical" ref="ncbi_uid=40201">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/40201" ref="tree=GTR&ncbi_uid=40201&link_uid=40201" title="View MedGen record for 'Neoplasm of uterine cervix'">Neoplasm of uterine cervix</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/91094" ref="tree=GTR&ncbi_uid=91094&link_uid=91094" title="View MedGen record for 'Oncocytoma of kidney'">Oncocytoma of kidney</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0919267[DISCUI]&test_type=Clinical" ref="ncbi_uid=181539">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=181539" ref="ncbi_uid=181539">V</a></span></span><span class="TLline"><a href="/medgen/181539" ref="tree=GTR&ncbi_uid=181539&link_uid=181539" title="View MedGen record for 'Ovarian neoplasm'">Ovarian neoplasm</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1333992[DISCUI]&test_type=Clinical" ref="ncbi_uid=272713">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=272713" ref="ncbi_uid=272713">V</a></span></span><span class="TLline"><a href="/medgen/272713" ref="tree=GTR&ncbi_uid=272713&link_uid=272713" title="View MedGen record for 'Familial ovarian carcinoma'">Familial ovarian carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1140680[DISCUI]&test_type=Clinical" ref="ncbi_uid=216027">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=216027" target="_blank" href="/omim/167000">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=216027" ref="ncbi_uid=216027">V</a></span></span><span class="TLline"><a href="/medgen/216027" ref="tree=GTR&ncbi_uid=216027&link_uid=216027" title="View MedGen record for 'Ovarian cancer'">Ovarian cancer</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1868358[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=358303">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=358303" target="_blank" href="/omim/171834">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=358303" ref="ncbi_uid=358303">V</a></span></span><span class="TLline"><a href="/medgen/358303" ref="tree=GTR&ncbi_uid=358303&link_uid=358303" title="View MedGen record for 'OVARIAN CANCER, EPITHELIAL, SOMATIC'">OVARIAN CANCER, EPITHELIAL, SOMATIC</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1336839[DISCUI]&test_type=Clinical" ref="ncbi_uid=237026">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=237026" target="_blank" href="/omim/164860">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=237026" ref="ncbi_uid=237026">V</a></span></span><span class="TLline"><a href="/medgen/237026" ref="tree=GTR&ncbi_uid=237026&link_uid=237026" title="View MedGen record for 'Papillary renal cell carcinoma type 1'">Papillary renal cell carcinoma type 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1266142[DISCUI]&test_type=Clinical" ref="ncbi_uid=690113">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/690113" ref="tree=GTR&ncbi_uid=690113&link_uid=690113" title="View MedGen record for 'Renal hamartoma'">Renal hamartoma</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/508335" ref="tree=MeSH" title="MedGen record for Disorder of the genitourinary system">Disorder of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/1783801" ref="tree=MeSH" title="MedGen record for Diseases, Genital">Diseases, Genital</a></span><ul><li><span class="TLline"><a href="/medgen/42195" ref="tree=MeSH" title="MedGen record for Disorder of male genital organ">Disorder of male genital organ</a></span><ul><li><span class="TLline"><a href="/medgen/42196" ref="tree=MeSH" title="MedGen record for Male reproductive system neoplasm">Male reproductive system neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/102279" ref="tree=MeSH" title="MedGen record for Male reproductive organ cancer">Male reproductive organ cancer</a></span><ul><li><span class="TLline"><a href="/medgen/138169" ref="tree=MeSH" title="MedGen record for Malignant tumor of prostate">Malignant tumor of prostate</a></span><ul><li><span class="matched_ds">Familial prostate cancer</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=903&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Familial prostate cancer</span> in Orphanet.</div></div></div>
|
||
</div>
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|
||
<div class="portlet mgSection" id="ID_105">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34003610">Available evidence on HIFU for focal treatment of prostate cancer: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bakavicius A,
|
||
Marra G,
|
||
Macek P,
|
||
Robertson C,
|
||
Abreu AL,
|
||
George AK,
|
||
Malavaud B,
|
||
Coloby P,
|
||
Rischmann P,
|
||
Moschini M,
|
||
Rastinehad AR,
|
||
Sidana A,
|
||
Stabile A,
|
||
Tourinho-Barbosa R,
|
||
de la Rosette J,
|
||
Ahmed H,
|
||
Polascik T,
|
||
Cathelineau X,
|
||
Sanchez-Salas R</span><br />
|
||
<span class="medgenPMjournal">Int Braz J Urol</span>
|
||
2022 Mar-Apr;48(2):263-274.
|
||
doi: 10.1590/S1677-5538.IBJU.2021.0091.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34003610" target="_blank">34003610</a><a href="/pmc/articles/PMC8932027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33284538">Consensus on diagnosis and management of non-metastatic castration resistant prostate cancer in Brazil: focus on patient, selection, treatment efficacy, side effects and physician's perception according to patient comorbidities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maluf F,
|
||
Soares A,
|
||
Avanço G,
|
||
Hada AL,
|
||
Cardoso APG,
|
||
Carneiro A,
|
||
Herchenhorn D,
|
||
Jardim DLF,
|
||
Schutz FA,
|
||
Kater FR,
|
||
Pereira FMT,
|
||
Monteiro FSM,
|
||
Morbeck IAP,
|
||
Reolon JFN,
|
||
da Trindade KM,
|
||
Andrade LMQDS,
|
||
Nogueira LM,
|
||
Furoni R,
|
||
Natel RA,
|
||
Dos Reis RB,
|
||
Fogace RN,
|
||
Souza VC</span><br />
|
||
<span class="medgenPMjournal">Int Braz J Urol</span>
|
||
2021 Mar-Apr;47(2):359-373.
|
||
doi: 10.1590/S1677-5538.IBJU.2020.0249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33284538" target="_blank">33284538</a><a href="/pmc/articles/PMC7857750" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24881167">Optimising the management of early prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kirby R</span><br />
|
||
<span class="medgenPMjournal">Practitioner</span>
|
||
2014 Apr;258(1770):15-8, 2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24881167" target="_blank">24881167</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20prostate%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (7)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Prostate Cancer, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng131" target="_blank">UK NICE Guideline NG131, Prostate cancer: diagnosis and management, 2021</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389227">Genetics of Prostate Cancer (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389227" target="_blank">26389227</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34903604">Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boonen RACM,
|
||
Wiegant WW,
|
||
Celosse N,
|
||
Vroling B,
|
||
Heijl S,
|
||
Kote-Jarai Z,
|
||
Mijuskovic M,
|
||
Cristea S,
|
||
Solleveld-Westerink N,
|
||
van Wezel T,
|
||
Beerenwinkel N,
|
||
Eeles R,
|
||
Devilee P,
|
||
Vreeswijk MPG,
|
||
Marra G,
|
||
van Attikum H</span><br />
|
||
<span class="medgenPMjournal">Cancer Res</span>
|
||
2022 Feb 15;82(4):615-631.
|
||
doi: 10.1158/0008-5472.CAN-21-1845.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34903604" target="_blank">34903604</a><a href="/pmc/articles/PMC9359737" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27899188">Familial prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giri VN,
|
||
Beebe-Dimmer JL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
2016 Oct;43(5):560-565.
|
||
Epub 2016 Aug 18
|
||
doi: 10.1053/j.seminoncol.2016.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27899188" target="_blank">27899188</a><a href="/pmc/articles/PMC6986340" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26074382">Prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Attard G,
|
||
Parker C,
|
||
Eeles RA,
|
||
Schröder F,
|
||
Tomlins SA,
|
||
Tannock I,
|
||
Drake CG,
|
||
de Bono JS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jan 2;387(10013):70-82.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1016/S0140-6736(14)61947-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26074382" target="_blank">26074382</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9088268">Familial prostate cancer studies in Utah.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neuhausen SL,
|
||
Skolnick MH,
|
||
Cannon-Albright L</span><br />
|
||
<span class="medgenPMjournal">Br J Urol</span>
|
||
1997 Mar;79 Suppl 1:15-20.
|
||
doi: 10.1111/j.1464-410x.1997.tb00796.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9088268" target="_blank">9088268</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9088267">Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eeles RA,
|
||
Dearnaley DP,
|
||
Ardern-Jones A,
|
||
Shearer RJ,
|
||
Easton DF,
|
||
Ford D,
|
||
Edwards S,
|
||
Dowe A</span><br />
|
||
<span class="medgenPMjournal">Br J Urol</span>
|
||
1997 Mar;79 Suppl 1:8-14.
|
||
doi: 10.1111/j.1464-410x.1997.tb00795.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9088267" target="_blank">9088267</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (166)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35855555">Novel germline mutations for active surveillance and imaging strategies in prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mondschein R,
|
||
Taylor R,
|
||
Thorne H,
|
||
Bolton D</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Urol</span>
|
||
2022 Sep 1;32(5):456-461.
|
||
Epub 2022 Jul 18
|
||
doi: 10.1097/MOU.0000000000001024.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35855555" target="_blank">35855555</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35286517">Splice-disrupt genomic variants in prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alanazi IO,
|
||
Alamery SF,
|
||
Ebrahimie E,
|
||
Mohammadi-Dehcheshmeh M</span><br />
|
||
<span class="medgenPMjournal">Mol Biol Rep</span>
|
||
2022 Jun;49(6):4237-4246.
|
||
Epub 2022 Mar 14
|
||
doi: 10.1007/s11033-022-07257-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35286517" target="_blank">35286517</a><a href="/pmc/articles/PMC9262760" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33486571">Genetic predisposition to prostate cancer: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ni Raghallaigh H,
|
||
Eeles R</span><br />
|
||
<span class="medgenPMjournal">Fam Cancer</span>
|
||
2022 Jan;21(1):101-114.
|
||
Epub 2021 Jan 24
|
||
doi: 10.1007/s10689-021-00227-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33486571" target="_blank">33486571</a><a href="/pmc/articles/PMC8799539" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27899188">Familial prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giri VN,
|
||
Beebe-Dimmer JL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
2016 Oct;43(5):560-565.
|
||
Epub 2016 Aug 18
|
||
doi: 10.1053/j.seminoncol.2016.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27899188" target="_blank">27899188</a><a href="/pmc/articles/PMC6986340" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26074382">Prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Attard G,
|
||
Parker C,
|
||
Eeles RA,
|
||
Schröder F,
|
||
Tomlins SA,
|
||
Tannock I,
|
||
Drake CG,
|
||
de Bono JS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jan 2;387(10013):70-82.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1016/S0140-6736(14)61947-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26074382" target="_blank">26074382</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (90)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26074382">Prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Attard G,
|
||
Parker C,
|
||
Eeles RA,
|
||
Schröder F,
|
||
Tomlins SA,
|
||
Tannock I,
|
||
Drake CG,
|
||
de Bono JS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jan 2;387(10013):70-82.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1016/S0140-6736(14)61947-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26074382" target="_blank">26074382</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22974436">Prostate cancer: germline prediction for a commonly variable malignancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bambury RM,
|
||
Gallagher DJ</span><br />
|
||
<span class="medgenPMjournal">BJU Int</span>
|
||
2012 Dec;110(11 Pt C):E809-18.
|
||
Epub 2012 Sep 14
|
||
doi: 10.1111/j.1464-410X.2012.11450.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22974436" target="_blank">22974436</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21507186">Clinical and histopathological characteristics of familial prostate cancer in Finland.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pakkanen S,
|
||
Kujala PM,
|
||
Ha N,
|
||
Matikainen MP,
|
||
Schleutker J,
|
||
Tammela TL</span><br />
|
||
<span class="medgenPMjournal">BJU Int</span>
|
||
2012 Feb;109(4):557-63.
|
||
Epub 2011 Apr 20
|
||
doi: 10.1111/j.1464-410X.2011.10198.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21507186" target="_blank">21507186</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18368555">Role of hormonal and other factors in human prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wigle DT,
|
||
Turner MC,
|
||
Gomes J,
|
||
Parent ME</span><br />
|
||
<span class="medgenPMjournal">J Toxicol Environ Health B Crit Rev</span>
|
||
2008 Mar;11(3-4):242-59.
|
||
doi: 10.1080/10937400701873548.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18368555" target="_blank">18368555</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15535435">The role of inflammation in the pathogenesis of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nelson WG,
|
||
De Marzo AM,
|
||
DeWeese TL,
|
||
Isaacs WB</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
2004 Nov;172(5 Pt 2):S6-11; discussion S11-2.
|
||
doi: 10.1097/01.ju.0000142058.99614.ff.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15535435" target="_blank">15535435</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35286517">Splice-disrupt genomic variants in prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alanazi IO,
|
||
Alamery SF,
|
||
Ebrahimie E,
|
||
Mohammadi-Dehcheshmeh M</span><br />
|
||
<span class="medgenPMjournal">Mol Biol Rep</span>
|
||
2022 Jun;49(6):4237-4246.
|
||
Epub 2022 Mar 14
|
||
doi: 10.1007/s11033-022-07257-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35286517" target="_blank">35286517</a><a href="/pmc/articles/PMC9262760" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33447865">Benefit finding in long-term prostate cancer survivors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lassmann I,
|
||
Dinkel A,
|
||
Marten-Mittag B,
|
||
Jahnen M,
|
||
Schulwitz H,
|
||
Gschwend JE,
|
||
Herkommer K</span><br />
|
||
<span class="medgenPMjournal">Support Care Cancer</span>
|
||
2021 Aug;29(8):4451-4460.
|
||
Epub 2021 Jan 15
|
||
doi: 10.1007/s00520-020-05971-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33447865" target="_blank">33447865</a><a href="/pmc/articles/PMC8236447" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32251286">8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dupont WD,
|
||
Breyer JP,
|
||
Plummer WD,
|
||
Chang SS,
|
||
Cookson MS,
|
||
Smith JA;
|
||
University of Washington Center for Mendelian Genomics,
|
||
Blue EE,
|
||
Bamshad MJ,
|
||
Smith JR</span><br />
|
||
<span class="medgenPMjournal">Nat Commun</span>
|
||
2020 Mar 23;11(1):1523.
|
||
doi: 10.1038/s41467-020-15122-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32251286" target="_blank">32251286</a><a href="/pmc/articles/PMC7089954" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27899188">Familial prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giri VN,
|
||
Beebe-Dimmer JL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
2016 Oct;43(5):560-565.
|
||
Epub 2016 Aug 18
|
||
doi: 10.1053/j.seminoncol.2016.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27899188" target="_blank">27899188</a><a href="/pmc/articles/PMC6986340" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26074382">Prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Attard G,
|
||
Parker C,
|
||
Eeles RA,
|
||
Schröder F,
|
||
Tomlins SA,
|
||
Tannock I,
|
||
Drake CG,
|
||
de Bono JS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jan 2;387(10013):70-82.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1016/S0140-6736(14)61947-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26074382" target="_blank">26074382</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33486571">Genetic predisposition to prostate cancer: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ni Raghallaigh H,
|
||
Eeles R</span><br />
|
||
<span class="medgenPMjournal">Fam Cancer</span>
|
||
2022 Jan;21(1):101-114.
|
||
Epub 2021 Jan 24
|
||
doi: 10.1007/s10689-021-00227-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33486571" target="_blank">33486571</a><a href="/pmc/articles/PMC8799539" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31664733">Clinical and pathologic characteristics of familial prostate cancer in Asian population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim M,
|
||
Kim JK,
|
||
Ye C,
|
||
Lee H,
|
||
Oh JJ,
|
||
Lee S,
|
||
Jeong SJ,
|
||
Lee SE,
|
||
Hong SK,
|
||
Byun SS</span><br />
|
||
<span class="medgenPMjournal">Prostate</span>
|
||
2020 Jan;80(1):57-64.
|
||
Epub 2019 Oct 30
|
||
doi: 10.1002/pros.23917.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31664733" target="_blank">31664733</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27899188">Familial prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giri VN,
|
||
Beebe-Dimmer JL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
2016 Oct;43(5):560-565.
|
||
Epub 2016 Aug 18
|
||
doi: 10.1053/j.seminoncol.2016.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27899188" target="_blank">27899188</a><a href="/pmc/articles/PMC6986340" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26074382">Prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Attard G,
|
||
Parker C,
|
||
Eeles RA,
|
||
Schröder F,
|
||
Tomlins SA,
|
||
Tannock I,
|
||
Drake CG,
|
||
de Bono JS</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jan 2;387(10013):70-82.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1016/S0140-6736(14)61947-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26074382" target="_blank">26074382</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22974436">Prostate cancer: germline prediction for a commonly variable malignancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bambury RM,
|
||
Gallagher DJ</span><br />
|
||
<span class="medgenPMjournal">BJU Int</span>
|
||
2012 Dec;110(11 Pt C):E809-18.
|
||
Epub 2012 Sep 14
|
||
doi: 10.1111/j.1464-410X.2012.11450.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22974436" target="_blank">22974436</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (99)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/12780833">A systematic review and meta-analysis of familial prostate cancer risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johns LE,
|
||
Houlston RS</span><br />
|
||
<span class="medgenPMjournal">BJU Int</span>
|
||
2003 Jun;91(9):789-94.
|
||
doi: 10.1046/j.1464-410x.2003.04232.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12780833" target="_blank">12780833</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20prostate%20cancer%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C2931456%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (16)</a></li>
|
||
<li><a href="/gtr/tests?term=C2931456%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C2931456%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (26)</a></li>
|
||
<li><a href="/gtr/tests?term=C2931456%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C2931456%5bDISCUI%5d" target="_blank">See all (32)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=176807" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=1331" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Familial%20prostate%20cancer" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20prostate%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Familial%20prostate%20cancer%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Prostate Cancer, 2024</div></li><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng131">NICE, 2021</a><div>UK NICE Guideline NG131, Prostate cancer: diagnosis and management, 2021</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=104155%20600020%20600185%20601728%20602053%20602686%20604373" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=463[geneid]" target="_blank">View ZFHX3 variations in ClinVar</a></li><li><a href="/clinvar/?term=675[geneid]" target="_blank">View BRCA2 variations in ClinVar</a></li><li><a href="/clinvar/?term=1316[geneid]" target="_blank">View KLF6 variations in ClinVar</a></li><li><a href="/clinvar/?term=4601[geneid]" target="_blank">View MXI1 variations in ClinVar</a></li><li><a href="/clinvar/?term=5728[geneid]" target="_blank">View PTEN variations in ClinVar</a></li><li><a href="/clinvar/?term=8379[geneid]" target="_blank">View MAD1L1 variations in ClinVar</a></li><li><a href="/clinvar/?term=11200[geneid]" target="_blank">View CHEK2 variations in ClinVar</a></li><li><a href="/nuccore/170650628,193290109,224809358,237858726,239582780,256574794,261598996" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=176807" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/prostate_cancer_hereditary_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Familial%20prostate%20cancer" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/prostate-cancer" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Familial%20prostate%20cancer" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Familial%20prostate%20cancer%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=419810" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=419810" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2931456[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2931456[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=419810" ref="log$=recordlinks">MeSH</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=419810" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=419810" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=419810" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=419810" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
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