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<meta name="keywords" content="C2733158, cerebral microangiopathies, cerebral microangiopathy, cerebral small vessel disease, cerebral small vessel diseases, disease or syndrome, microangiopathies, cerebral, microangiopathy, cerebral, small vessel cerebrovascular disease, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=453310
|
||
ConceptID=C2733158
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Small vessel cerebrovascular disease</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>453310</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2733158</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Cerebral Microangiopathies; Cerebral Microangiopathy; Cerebral Small Vessel Disease; Cerebral Small Vessel Diseases; Microangiopathies, Cerebral; Microangiopathy, Cerebral</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Cerebral small vessel disease (443929000); Small vessel cerebrovascular disease (443929000)</td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE. [from <a title="Medical Subject Headings" href="http://www.nlm.nih.gov/pubs/factsheets/mesh.html" class="defSource" target="_blank">MeSH</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Small vessel cerebrovascular disease</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/14336" ref="tree=MeSH" title="MedGen record for Disorder of nervous system">Disorder of nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/3306" ref="tree=MeSH" title="MedGen record for Disorder of the central nervous system">Disorder of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/14214" ref="tree=MeSH" title="MedGen record for Brain disorder">Brain disorder</a></span><ul><li><span class="TLline"><a href="/medgen/858" ref="tree=MeSH" title="MedGen record for Cerebrovascular disorder">Cerebrovascular disorder</a></span><ul><li><span class="matched_ds">Small vessel cerebrovascular disease</span><ul><li><span class="TLline"><a href="/medgen/8083" ref="tree=MeSH" title="MedGen record for Angiokeratoma corporis diffusum">Angiokeratoma corporis diffusum</a></span></li><li><span class="TLline"><a href="/medgen/199687" ref="tree=MeSH" title="MedGen record for Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy">Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy</a></span><ul><li><span class="TLline"><a href="/medgen/325051" ref="tree=MeSH" title="MedGen record for CARASIL syndrome">CARASIL syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1634330" ref="tree=MeSH" title="MedGen record for Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1">Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1</a></span></li><li><span class="TLline"><a href="/medgen/895965" ref="tree=MeSH" title="MedGen record for Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2">Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/82800" ref="tree=MeSH" title="MedGen record for ITM2B amyloidosis">ITM2B amyloidosis</a></span><ul><li><span class="TLline"><a href="/medgen/1677186" ref="tree=MeSH" title="MedGen record for ABri amyloidosis">ABri amyloidosis</a></span></li><li><span class="TLline"><a href="/medgen/396208" ref="tree=MeSH" title="MedGen record for ADan amyloidosis">ADan amyloidosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/465269" ref="tree=MeSH" title="MedGen record for Lacunar stroke">Lacunar stroke</a></span><ul><li><span class="TLline"><a href="/medgen/1718709" ref="tree=MeSH" title="MedGen record for Pontine ischemic lacunes">Pontine ischemic lacunes</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/56485" ref="tree=MeSH" title="MedGen record for MELAS syndrome">MELAS syndrome</a></span></li><li><span class="TLline"><a href="/medgen/389393" ref="tree=MeSH" title="MedGen record for Microscopic polyangiitis">Microscopic polyangiitis</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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||
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<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38052680">Early Detection and Treatment of Hypertension and Obstructive Sleep Apnoea: Can We Prevent the Progression of Small Vessel Cerebrovascular Disease?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Armario P,
|
||
Avellaneda-Gómez C,
|
||
Gómez-Choco M</span><br />
|
||
<span class="medgenPMjournal">Arch Bronconeumol</span>
|
||
2024 Feb;60(2):77-79.
|
||
Epub 2023 Nov 23
|
||
doi: 10.1016/j.arbres.2023.11.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38052680" target="_blank">38052680</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22small%20vessel%20cerebrovascular%20disease%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38308344">Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morales CD,
|
||
Cotton-Samuel D,
|
||
Lao PJ,
|
||
Chang JF,
|
||
Pyne JD,
|
||
Alshikho MJ,
|
||
Lippert RV,
|
||
Bista K,
|
||
Hale C,
|
||
Edwards NC,
|
||
Igwe KC,
|
||
Deters K,
|
||
Zimmerman ME,
|
||
Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Res Ther</span>
|
||
2024 Feb 2;16(1):25.
|
||
doi: 10.1186/s13195-024-01395-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38308344" target="_blank">38308344</a><a href="/pmc/articles/PMC10836014" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34062312">Emerging Concepts in Vascular Dementia: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bir SC,
|
||
Khan MW,
|
||
Javalkar V,
|
||
Toledo EG,
|
||
Kelley RE</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2021 Aug;30(8):105864.
|
||
Epub 2021 May 29
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2021.105864.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34062312" target="_blank">34062312</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31838489">Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stamm BC,
|
||
Lao PJ,
|
||
Rizvi B,
|
||
Colon J,
|
||
Igwe K,
|
||
Chesebro AG,
|
||
Maas B,
|
||
Schupf N,
|
||
Mayeux R,
|
||
Manly JJ,
|
||
Brickman AM</span><br />
|
||
<span class="medgenPMjournal">J Gerontol A Biol Sci Med Sci</span>
|
||
2020 Oct 15;75(11):2156-2161.
|
||
doi: 10.1093/gerona/glz291.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31838489" target="_blank">31838489</a><a href="/pmc/articles/PMC7566406" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29430730">Cerebral ischemia during hemodialysis-finding the signal in the noise.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">MacEwen C,
|
||
Watkinson P,
|
||
Tarassenko L,
|
||
Pugh C</span><br />
|
||
<span class="medgenPMjournal">Semin Dial</span>
|
||
2018 May;31(3):199-203.
|
||
Epub 2018 Feb 11
|
||
doi: 10.1111/sdi.12679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29430730" target="_blank">29430730</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19501711">Subcortical ischemic cerebrovascular dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Menon U,
|
||
Kelley RE</span><br />
|
||
<span class="medgenPMjournal">Int Rev Neurobiol</span>
|
||
2009;84:21-33.
|
||
doi: 10.1016/S0074-7742(09)00402-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19501711" target="_blank">19501711</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Small%20vessel%20cerebrovascular%20disease%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (49)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38052680">Early Detection and Treatment of Hypertension and Obstructive Sleep Apnoea: Can We Prevent the Progression of Small Vessel Cerebrovascular Disease?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Armario P,
|
||
Avellaneda-Gómez C,
|
||
Gómez-Choco M</span><br />
|
||
<span class="medgenPMjournal">Arch Bronconeumol</span>
|
||
2024 Feb;60(2):77-79.
|
||
Epub 2023 Nov 23
|
||
doi: 10.1016/j.arbres.2023.11.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38052680" target="_blank">38052680</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34062312">Emerging Concepts in Vascular Dementia: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bir SC,
|
||
Khan MW,
|
||
Javalkar V,
|
||
Toledo EG,
|
||
Kelley RE</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2021 Aug;30(8):105864.
|
||
Epub 2021 May 29
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2021.105864.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34062312" target="_blank">34062312</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31932050">Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pettigrew C,
|
||
Soldan A,
|
||
Zhu Y,
|
||
Cai Q,
|
||
Wang MC,
|
||
Moghekar A,
|
||
Miller MI,
|
||
Singh B,
|
||
Martinez O,
|
||
Fletcher E,
|
||
DeCarli C,
|
||
Albert M</span><br />
|
||
<span class="medgenPMjournal">Neurobiol Aging</span>
|
||
2020 Apr;88:33-41.
|
||
Epub 2019 Dec 17
|
||
doi: 10.1016/j.neurobiolaging.2019.12.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31932050" target="_blank">31932050</a><a href="/pmc/articles/PMC7160864" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24190781">Contemplating Alzheimer's disease and the contribution of white matter hyperintensities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Curr Neurol Neurosci Rep</span>
|
||
2013 Dec;13(12):415.
|
||
doi: 10.1007/s11910-013-0415-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24190781" target="_blank">24190781</a><a href="/pmc/articles/PMC3874404" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12023434">Myelopathy from intracranial dural arteriovenous fistula.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kalamangalam GP,
|
||
Bhattacharya J,
|
||
Teasdale E,
|
||
Thomas M</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2002 Jun;72(6):816-8.
|
||
doi: 10.1136/jnnp.72.6.816.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12023434" target="_blank">12023434</a><a href="/pmc/articles/PMC1737929" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Small%20vessel%20cerebrovascular%20disease%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38308344">Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morales CD,
|
||
Cotton-Samuel D,
|
||
Lao PJ,
|
||
Chang JF,
|
||
Pyne JD,
|
||
Alshikho MJ,
|
||
Lippert RV,
|
||
Bista K,
|
||
Hale C,
|
||
Edwards NC,
|
||
Igwe KC,
|
||
Deters K,
|
||
Zimmerman ME,
|
||
Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Res Ther</span>
|
||
2024 Feb 2;16(1):25.
|
||
doi: 10.1186/s13195-024-01395-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38308344" target="_blank">38308344</a><a href="/pmc/articles/PMC10836014" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38233080">A randomized controlled trial of repetitive transcranial magnetic stimulation plus donepezil vs donepezil alone for mild to moderate cognitive impairment due to small vessel cerebrovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shou B,
|
||
Chen X,
|
||
Hou Y</span><br />
|
||
<span class="medgenPMjournal">Int J Psychiatry Med</span>
|
||
2024 Sep;59(5):556-568.
|
||
Epub 2024 Jan 17
|
||
doi: 10.1177/00912174241227513.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38233080" target="_blank">38233080</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33642856">The Efficacy of Transdermal Rivastigmine in Mild to Moderate Alzheimer's Disease with Concomitant Small Vessel Cerebrovascular Disease: Findings from an Open-Label Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yatawara C,
|
||
Zailan FZ,
|
||
Chua EV,
|
||
Lim LLH,
|
||
Silva E,
|
||
Wang JS,
|
||
Ng A,
|
||
Ng KP,
|
||
Kandiah N</span><br />
|
||
<span class="medgenPMjournal">Clin Interv Aging</span>
|
||
2021;16:301-309.
|
||
Epub 2021 Feb 19
|
||
doi: 10.2147/CIA.S290055.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33642856" target="_blank">33642856</a><a href="/pmc/articles/PMC7903964" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29430730">Cerebral ischemia during hemodialysis-finding the signal in the noise.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">MacEwen C,
|
||
Watkinson P,
|
||
Tarassenko L,
|
||
Pugh C</span><br />
|
||
<span class="medgenPMjournal">Semin Dial</span>
|
||
2018 May;31(3):199-203.
|
||
Epub 2018 Feb 11
|
||
doi: 10.1111/sdi.12679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29430730" target="_blank">29430730</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25862800">Effect of white matter lesions on manual dexterity in healthy middle-aged persons.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nyquist PA,
|
||
Yanek LR,
|
||
Bilgel M,
|
||
Cuzzocreo JL,
|
||
Becker LC,
|
||
Chevalier-Davis K,
|
||
Yousem D,
|
||
Prince J,
|
||
Kral BG,
|
||
Vaidya D,
|
||
Becker DM</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2015 May 12;84(19):1920-6.
|
||
Epub 2015 Apr 10
|
||
doi: 10.1212/WNL.0000000000001557.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25862800" target="_blank">25862800</a><a href="/pmc/articles/PMC4433457" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Small%20vessel%20cerebrovascular%20disease%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38308344">Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morales CD,
|
||
Cotton-Samuel D,
|
||
Lao PJ,
|
||
Chang JF,
|
||
Pyne JD,
|
||
Alshikho MJ,
|
||
Lippert RV,
|
||
Bista K,
|
||
Hale C,
|
||
Edwards NC,
|
||
Igwe KC,
|
||
Deters K,
|
||
Zimmerman ME,
|
||
Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Res Ther</span>
|
||
2024 Feb 2;16(1):25.
|
||
doi: 10.1186/s13195-024-01395-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38308344" target="_blank">38308344</a><a href="/pmc/articles/PMC10836014" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37092220">Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Otoki Y,
|
||
Yu D,
|
||
Shen Q,
|
||
Sahlas DJ,
|
||
Ramirez J,
|
||
Gao F,
|
||
Masellis M,
|
||
Swartz RH,
|
||
Chan PC,
|
||
Pettersen JA,
|
||
Kato S,
|
||
Nakagawa K,
|
||
Black SE,
|
||
Swardfager W,
|
||
Taha AY</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2023;93(2):665-682.
|
||
doi: 10.3233/JAD-220795.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37092220" target="_blank">37092220</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34062312">Emerging Concepts in Vascular Dementia: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bir SC,
|
||
Khan MW,
|
||
Javalkar V,
|
||
Toledo EG,
|
||
Kelley RE</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2021 Aug;30(8):105864.
|
||
Epub 2021 May 29
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2021.105864.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34062312" target="_blank">34062312</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30806767">Juxtacortical lesions are associated with seizures in cerebral small vessel disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stösser S,
|
||
Böckler S,
|
||
Ludolph AC,
|
||
Kassubek J,
|
||
Neugebauer H</span><br />
|
||
<span class="medgenPMjournal">J Neurol</span>
|
||
2019 May;266(5):1230-1235.
|
||
Epub 2019 Feb 26
|
||
doi: 10.1007/s00415-019-09253-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30806767" target="_blank">30806767</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29430730">Cerebral ischemia during hemodialysis-finding the signal in the noise.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">MacEwen C,
|
||
Watkinson P,
|
||
Tarassenko L,
|
||
Pugh C</span><br />
|
||
<span class="medgenPMjournal">Semin Dial</span>
|
||
2018 May;31(3):199-203.
|
||
Epub 2018 Feb 11
|
||
doi: 10.1111/sdi.12679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29430730" target="_blank">29430730</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Small%20vessel%20cerebrovascular%20disease%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (23)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38308344">Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer's clinical trial participants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morales CD,
|
||
Cotton-Samuel D,
|
||
Lao PJ,
|
||
Chang JF,
|
||
Pyne JD,
|
||
Alshikho MJ,
|
||
Lippert RV,
|
||
Bista K,
|
||
Hale C,
|
||
Edwards NC,
|
||
Igwe KC,
|
||
Deters K,
|
||
Zimmerman ME,
|
||
Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Res Ther</span>
|
||
2024 Feb 2;16(1):25.
|
||
doi: 10.1186/s13195-024-01395-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38308344" target="_blank">38308344</a><a href="/pmc/articles/PMC10836014" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37092220">Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Otoki Y,
|
||
Yu D,
|
||
Shen Q,
|
||
Sahlas DJ,
|
||
Ramirez J,
|
||
Gao F,
|
||
Masellis M,
|
||
Swartz RH,
|
||
Chan PC,
|
||
Pettersen JA,
|
||
Kato S,
|
||
Nakagawa K,
|
||
Black SE,
|
||
Swardfager W,
|
||
Taha AY</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2023;93(2):665-682.
|
||
doi: 10.3233/JAD-220795.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37092220" target="_blank">37092220</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33734344">Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saleh Y,
|
||
Le Heron C,
|
||
Petitet P,
|
||
Veldsman M,
|
||
Drew D,
|
||
Plant O,
|
||
Schulz U,
|
||
Sen A,
|
||
Rothwell PM,
|
||
Manohar S,
|
||
Husain M</span><br />
|
||
<span class="medgenPMjournal">Brain</span>
|
||
2021 May 7;144(4):1247-1262.
|
||
doi: 10.1093/brain/awab013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33734344" target="_blank">33734344</a><a href="/pmc/articles/PMC8240747" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32856790">Cognitive reserve and midlife vascular risk: Cognitive and clinical outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soldan A,
|
||
Pettigrew C,
|
||
Zhu Y,
|
||
Wang MC,
|
||
Gottesman RF,
|
||
DeCarli C,
|
||
Albert M;
|
||
BIOCARD Research Team</span><br />
|
||
<span class="medgenPMjournal">Ann Clin Transl Neurol</span>
|
||
2020 Aug;7(8):1307-1317.
|
||
Epub 2020 Jul 21
|
||
doi: 10.1002/acn3.51120.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32856790" target="_blank">32856790</a><a href="/pmc/articles/PMC7448143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24190781">Contemplating Alzheimer's disease and the contribution of white matter hyperintensities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brickman AM</span><br />
|
||
<span class="medgenPMjournal">Curr Neurol Neurosci Rep</span>
|
||
2013 Dec;13(12):415.
|
||
doi: 10.1007/s11910-013-0415-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24190781" target="_blank">24190781</a><a href="/pmc/articles/PMC3874404" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Small%20vessel%20cerebrovascular%20disease%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (36)</a></div></div>
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