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<meta name="keywords" content="C0751900, motor 'tics', motor tic, motor tics, sign or symptom, tic, motor, tics, motor, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Movement-based tics affecting discrete muscle groups." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=199761
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ConceptID=C0751900
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Motor tics</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>199761</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0751900</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Motor Tic; Motor Tics; Tic, Motor; Tics, Motor</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100034">HP:0100034</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Movement-based tics affecting discrete muscle groups. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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||
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Motor tics</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1053648" ref="tree=MeSH" title="MedGen record for Abnormal volitional state">Abnormal volitional state</a></span><ul><li><span class="TLline"><a href="/medgen/1853215" ref="tree=MeSH" title="MedGen record for Abnormally increased volition">Abnormally increased volition</a></span><ul><li><span class="TLline"><a href="/medgen/5769" ref="tree=MeSH" title="MedGen record for Impulse control disorder">Impulse control disorder</a></span><ul><li><span class="TLline"><a href="/medgen/43850" ref="tree=MeSH" title="MedGen record for Impulsivity">Impulsivity</a></span><ul><li><span class="TLline"><a href="/medgen/109373" ref="tree=MeSH" title="MedGen record for Compulsive behaviors">Compulsive behaviors</a></span><ul><li><span class="TLline"><a href="/medgen/853666" ref="tree=MeSH" title="MedGen record for Tics">Tics</a></span><ul><li><span class="matched_ds">Motor tics</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_6708"><div><strong>Pigmentary pallidal degeneration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6708</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0018523</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pantothenate kinase-associated neurodegeneration (PKAN) is a type of neurodegeneration with brain iron accumulation (NBIA). The phenotypic spectrum of PKAN includes classic PKAN and atypical PKAN. Classic PKAN is characterized by early-childhood onset of progressive dystonia, dysarthria, rigidity, and choreoathetosis. Pigmentary retinal degeneration is common. Atypical PKAN is characterized by later onset (age >10 years), prominent speech defects, psychiatric disturbances, and more gradual progression of disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6708">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_21219"><div><strong>Tourette syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21219</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040517</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tourette syndrome is a neurobehavioral disorder manifest particularly by motor and vocal tics and associated with behavioral abnormalities. Tics are sudden, brief, intermittent, involuntary or semi-voluntary movements (motor tics) or sounds (phonic or vocal tics). They typically consist of simple, coordinated, repetitive movements, gestures, or utterances that mimic fragments of normal behavior. Motor tics may range from simple blinking, nose twitching, and head jerking to more complex throwing, hitting, or making rude gestures. Phonic tics include sniffling, throat clearing, blowing, coughing, echolalia, or coprolalia. Males are affected about 3 times more often than females, and onset usually occurs between 3 and 8 years of age. By age 18 years, more than half of affected individuals are free of tics, but they may persist into adulthood (review by Jankovic, 2001).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21219">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_162886"><div><strong>Autism, susceptibility to, X-linked 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>162886</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0795888</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). Levy et al. (2009) provided a general review of autism and autism spectrum disorder, including epidemiology, characteristics of the disorder, diagnosis, neurobiologic hypotheses for the etiology, genetics, and treatment options.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/162886">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_374113"><div><strong>Striatonigral degeneration, infantile, mitochondrial</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374113</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839022</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374113">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766800"><div><strong>Microcephaly 9, primary, autosomal recessive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766800</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553886</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary microcephaly (MCPH) is a clinical diagnosis made when an individual has a head circumference more than 3 standard deviations below the age- and sex-matched population mean and impaired intellectual development, with no other associated malformations and with no apparent etiology. Most cases of primary microcephaly show an autosomal recessive mode of inheritance (Woods et al., 2005). For a general phenotypic description and a discussion of genetic heterogeneity of primary microcephaly, see MCPH1 (251200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766800">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815975"><div><strong>Basal ganglia calcification, idiopathic, 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815975</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809645</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary familial brain calcification (PFBC) is a neurodegenerative disorder with characteristic calcium deposits in the basal ganglia and other brain areas visualized on neuroimaging. Most affected individuals are in good health during childhood and young adulthood and typically present in the fourth to fifth decade with a gradually progressive movement disorder and neuropsychiatric symptoms. The movement disorder first manifests as clumsiness, fatigability, unsteady gait, slow or slurred speech, dysphagia, involuntary movements, or muscle cramping. Neuropsychiatric symptoms, often the first or most prominent manifestations, range from mild difficulty with concentration and memory to changes in personality and/or behavior, to psychosis and dementia. Seizures of various types occur frequently, some individuals experience chronic headache and vertigo; urinary urgency or incontinence may be present.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815975">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934741"><div><strong>Intellectual disability, autosomal dominant 42</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934741</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310774</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GNB1 encephalopathy (GNB1-E) is characterized by moderate-to-severe developmental delay / intellectual disability, structural brain abnormalities, and often infantile hypotonia and seizures. Other less common findings include dystonia, reduced vision, behavior issues, growth delay, gastrointestinal (GI) problems, genitourinary (GU) abnormalities in males, and cutaneous mastocytosis.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934741">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1387791"><div><strong>Neurodegeneration with brain iron accumulation 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1387791</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4517377</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurodegeneration with brain iron accumulation refers to a group of neurodegenerative disorders characterized by progressive motor and cognitive dysfunction beginning in childhood or young adulthood. Patients show extrapyramidal motor signs, such as spasticity, dystonia, and parkinsonism. Brain imaging shows iron accumulation in the basal ganglia (summary by Dusi et al., 2014). For a general phenotypic description and a discussion of genetic heterogeneity of NBIA, see NBIA1 (234200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1387791">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1802087"><div><strong>Neurodevelopmental disorder with or without variable movement or behavioral abnormalities</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1802087</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676908</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurodevelopmental disorder with or without variable movement or behavioral abnormalities (NEDMAB) is an autosomal dominant disorder characterized by mildly to severely impaired intellectual development and, in some patients, movement abnormalities consisting of tremors, cerebellar ataxia, or extrapyramidal symptoms. Movement abnormalities have onset in childhood or adolescence. Other variable features include autism spectrum disorder or autistic features and epilepsy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1802087">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1805690"><div><strong>Intellectual developmental disorder, autosomal dominant 67</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1805690</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5677006</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant intellectual developmental disorder-67 (MRD67) is characterized by global developmental delay with variably impaired intellectual development apparent from infancy or early childhood. Additional features may include behavioral abnormalities, such as autism spectrum disorder (ASD) and ADHD, as well as language and sleeping difficulties. Brain imaging is normal (Ismail et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1805690">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1845603"><div><strong>Intellectual developmental disorder, autosomal dominant 74</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1845603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882749</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant intellectual developmental disorder-74 (MRD74) is characterized by global developmental delay, including delay of gross and fine motor skills and speech delay, and variable subtle dysmorphic facial features (Niggl et al., 2023).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1845603">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_162886" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autism, susceptibility to, X-linked 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815975" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Basal ganglia calcification, idiopathic, 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1805690" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, autosomal dominant 67</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1845603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, autosomal dominant 74</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934741" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual disability, autosomal dominant 42</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (11)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766800" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Microcephaly 9, primary, autosomal recessive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1387791" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodegeneration with brain iron accumulation 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1802087" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with or without variable movement or behavioral abnormalities</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_6708" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pigmentary pallidal degeneration</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_374113" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Striatonigral degeneration, infantile, mitochondrial</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_21219" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tourette syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39034647">An update on the pharmacological management of Tourette syndrome and emerging treatment paradigms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lenka A,
|
||
Jankovic J</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Neurother</span>
|
||
2024 Oct;24(10):1025-1033.
|
||
Epub 2024 Jul 21
|
||
doi: 10.1080/14737175.2024.2382463.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39034647" target="_blank">39034647</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38760282">French guidelines for the diagnosis and management of Tourette syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hartmann A,
|
||
Ansquer S,
|
||
Brefel-Courbon C,
|
||
Burbaud P,
|
||
Castrioto A,
|
||
Czernecki V,
|
||
Damier P,
|
||
Deniau E,
|
||
Drapier S,
|
||
Jalenques I,
|
||
Marechal O,
|
||
Priou T,
|
||
Spodenkiewicz M,
|
||
Thobois S,
|
||
Roubertie A,
|
||
Witjas T,
|
||
Anheim M</span><br />
|
||
<span class="medgenPMjournal">Rev Neurol (Paris)</span>
|
||
2024 Oct;180(8):818-827.
|
||
Epub 2024 May 17
|
||
doi: 10.1016/j.neurol.2024.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38760282" target="_blank">38760282</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19170198">The management of tics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shprecher D,
|
||
Kurlan R</span><br />
|
||
<span class="medgenPMjournal">Mov Disord</span>
|
||
2009 Jan 15;24(1):15-24.
|
||
doi: 10.1002/mds.22378.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19170198" target="_blank">19170198</a><a href="/pmc/articles/PMC2701289" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22motor%20tics%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (19)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36738982">Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsetsos F,
|
||
Topaloudi A,
|
||
Jain P,
|
||
Yang Z,
|
||
Yu D,
|
||
Kolovos P,
|
||
Tumer Z,
|
||
Rizzo R,
|
||
Hartmann A,
|
||
Depienne C,
|
||
Worbe Y,
|
||
Müller-Vahl KR,
|
||
Cath DC,
|
||
Boomsma DI,
|
||
Wolanczyk T,
|
||
Zekanowski C,
|
||
Barta C,
|
||
Nemoda Z,
|
||
Tarnok Z,
|
||
Padmanabhuni SS,
|
||
Buxbaum JD,
|
||
Grice D,
|
||
Glennon J,
|
||
Stefansson H,
|
||
Hengerer B,
|
||
Yannaki E,
|
||
Stamatoyannopoulos JA,
|
||
Benaroya-Milshtein N,
|
||
Cardona F,
|
||
Hedderly T,
|
||
Heyman I,
|
||
Huyser C,
|
||
Mir P,
|
||
Morer A,
|
||
Mueller N,
|
||
Munchau A,
|
||
Plessen KJ,
|
||
Porcelli C,
|
||
Roessner V,
|
||
Walitza S,
|
||
Schrag A,
|
||
Martino D;
|
||
PGC TS Working Group;
|
||
TSAICG;
|
||
TSGeneSEE Initiative;
|
||
EMTICS Collaborative Group;
|
||
TS-EUROTRAIN Network;
|
||
TIC Genetics Collaborative Group,
|
||
Tischfield JA,
|
||
Heiman GA,
|
||
Willsey AJ,
|
||
Dietrich A,
|
||
Davis LK,
|
||
Crowley JJ,
|
||
Mathews CA,
|
||
Scharf JM,
|
||
Georgitsi M,
|
||
Hoekstra PJ,
|
||
Paschou P</span><br />
|
||
<span class="medgenPMjournal">Biol Psychiatry</span>
|
||
2024 Jul 15;96(2):114-124.
|
||
Epub 2023 Feb 2
|
||
doi: 10.1016/j.biopsych.2023.01.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36738982" target="_blank">36738982</a><a href="/pmc/articles/PMC10783199" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36823209">Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jain P,
|
||
Miller-Fleming T,
|
||
Topaloudi A,
|
||
Yu D,
|
||
Drineas P,
|
||
Georgitsi M,
|
||
Yang Z,
|
||
Rizzo R,
|
||
Müller-Vahl KR,
|
||
Tumer Z,
|
||
Mol Debes N,
|
||
Hartmann A,
|
||
Depienne C,
|
||
Worbe Y,
|
||
Mir P,
|
||
Cath DC,
|
||
Boomsma DI,
|
||
Roessner V,
|
||
Wolanczyk T,
|
||
Janik P,
|
||
Szejko N,
|
||
Zekanowski C,
|
||
Barta C,
|
||
Nemoda Z,
|
||
Tarnok Z,
|
||
Buxbaum JD,
|
||
Grice D,
|
||
Glennon J,
|
||
Stefansson H,
|
||
Hengerer B,
|
||
Benaroya-Milshtein N,
|
||
Cardona F,
|
||
Hedderly T,
|
||
Heyman I,
|
||
Huyser C,
|
||
Morer A,
|
||
Mueller N,
|
||
Munchau A,
|
||
Plessen KJ,
|
||
Porcelli C,
|
||
Walitza S,
|
||
Schrag A,
|
||
Martino D;
|
||
Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS);
|
||
EMTICS collaborative group,
|
||
Dietrich A;
|
||
TS-EUROTRAIN Network,
|
||
Mathews CA,
|
||
Scharf JM,
|
||
Hoekstra PJ,
|
||
Davis LK,
|
||
Paschou P</span><br />
|
||
<span class="medgenPMjournal">Transl Psychiatry</span>
|
||
2023 Feb 23;13(1):69.
|
||
doi: 10.1038/s41398-023-02341-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36823209" target="_blank">36823209</a><a href="/pmc/articles/PMC9950421" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35567613">Dystonic motor and phonic tics in Tourette syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baizabal-Carvallo JF,
|
||
Alonso-Juarez M,
|
||
Jankovic J</span><br />
|
||
<span class="medgenPMjournal">J Neurol</span>
|
||
2022 Oct;269(10):5312-5318.
|
||
Epub 2022 May 14
|
||
doi: 10.1007/s00415-022-11174-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35567613" target="_blank">35567613</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29304272">Botulinum toxin for motor and phonic tics in Tourette's syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pandey S,
|
||
Srivanitchapoom P,
|
||
Kirubakaran R,
|
||
Berman BD</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2018 Jan 5;1(1):CD012285.
|
||
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<div class="nl"><a target="_blank" href="/pubmed/12210863">Adult-onset tic disorders.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/18350763">Tourette's syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kenney C,
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Kuo SH,
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Jimenez-Shahed J</span><br />
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<span class="medgenPMjournal">Am Fam Physician</span>
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2008 Mar 1;77(5):651-8.
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<span class="bold">PMID: </span><a href="/pubmed/18350763" target="_blank">18350763</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/10350221">Tourette's syndrome mimicking asthma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hogan MB,
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<div class="nl"><a target="_blank" href="/pubmed/39212585">Pharmacological Treatment of Tourette Disorder in Children.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Can A,
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<div class="nl"><a target="_blank" href="/pubmed/37620085">Tourette syndrome and other tic disorders of childhood.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Nilles C,
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Hartmann A,
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Roze E,
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Martino D,
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Pringsheim T</span><br />
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<span class="medgenPMjournal">Handb Clin Neurol</span>
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doi: 10.1016/B978-0-323-98817-9.00002-8.
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<span class="bold">PMID: </span><a href="/pubmed/37620085" target="_blank">37620085</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24633901">Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT).</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Saygi S,
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Ozkale Y,
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<div class="nl"><a target="_blank" href="/pubmed/36823209">Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jain P,
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Mueller N,
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Munchau A,
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Plessen KJ,
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Porcelli C,
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Walitza S,
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Schrag A,
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Martino D;
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Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS);
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EMTICS collaborative group,
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Dietrich A;
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TS-EUROTRAIN Network,
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Mathews CA,
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Scharf JM,
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<div class="nl"><a target="_blank" href="/pubmed/36182698">Systematic Review and Meta-Analysis of Tourette Syndrome Prevalence; 1986 to 2022.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jafari F,
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<div class="nl"><a target="_blank" href="/pubmed/35567613">Dystonic motor and phonic tics in Tourette syndrome.</a></div>
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Alonso-Juarez M,
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Jankovic J</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/34596744" target="_blank">34596744</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32174031">Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Inagawa T,
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Ueda N,
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Nakagome K,
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Sumiyoshi T</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/32174031" target="_blank">32174031</a><a href="/pmc/articles/PMC7722657" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Motor%20tics%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (101)</a></div></div>
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||
</div>
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|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36182698">Systematic Review and Meta-Analysis of Tourette Syndrome Prevalence; 1986 to 2022.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jafari F,
|
||
Abbasi P,
|
||
Rahmati M,
|
||
Hodhodi T,
|
||
Kazeminia M</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
2022 Dec;137:6-16.
|
||
Epub 2022 Sep 5
|
||
doi: 10.1016/j.pediatrneurol.2022.08.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36182698" target="_blank">36182698</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30121819">Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kim DD,
|
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Barr AM,
|
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Chung Y,
|
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Yuen JWY,
|
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Etminan M,
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Carleton BC,
|
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White RF,
|
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Honer WG,
|
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Procyshyn RM</span><br />
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<span class="medgenPMjournal">CNS Drugs</span>
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2018 Oct;32(10):917-938.
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doi: 10.1007/s40263-018-0559-8.
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<span class="bold">PMID: </span><a href="/pubmed/30121819" target="_blank">30121819</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/29304272">Botulinum toxin for motor and phonic tics in Tourette's syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pandey S,
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Srivanitchapoom P,
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Kirubakaran R,
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Berman BD</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2018 Jan 5;1(1):CD012285.
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<span class="bold">PMID: </span><a href="/pubmed/29304272" target="_blank">29304272</a><a href="/pmc/articles/PMC6491277" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22713420">Trials of pharmacological interventions for Tourette syndrome: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Waldon K,
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Hill J,
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<span class="bold">PMID: </span><a href="/pubmed/22713420" target="_blank">22713420</a><a href="/pmc/articles/PMC5215438" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Motor%20tics%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
|
||
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|
||
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|
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|
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|
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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|
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