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<meta name="keywords" content="C0699790, carcinoma of colon, carcinoma of the colon, colon cancer, colon carcinoma, colonic carcinoma, crc, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=147065
ConceptID=C0699790
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Carcinoma of colon<span class="h1sub">(CRC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>147065</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0699790</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Colon carcinoma; Colonic carcinoma; CRC</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Carcinoma of colon (269533000)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0002032" target="_blank">MONDO:0002032</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_101">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1211" target="_blank">Lynch Syndrome</a></div><div>Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Summary" target="NBK1211">Summary</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Diagnosis" target="NBK1211">Diagnosis</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Clinical_Characteristics" target="NBK1211">Clinical Characteristics</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Genetically_Related_Allelic_Disord" target="NBK1211">Genetically Related (Allelic) Disorders</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Differential_Diagnosis" target="NBK1211">Differential Diagnosis</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Management" target="NBK1211">Management</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Genetic_Counseling" target="NBK1211">Genetic Counseling</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Resources" target="NBK1211">Resources</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Molecular_Genetics" target="NBK1211">Molecular Genetics</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Chapter_Notes" target="NBK1211">Chapter Notes</a>  |  <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.References" target="NBK1211">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
Gregory Idos  |  Laura Valle   <a href="/books/NBK1211" target="NBK1211" title="NCBI Bookshelf: Lynch Syndrome">view full author information</a></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009404[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=3171">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=3171" ref="ncbi_uid=3171">V</a></span></span><span class="TLline"><a href="/medgen/3171" ref="tree=GTR&amp;ncbi_uid=3171&amp;link_uid=3171" title="View MedGen record for 'Neoplasm of the large intestine'">Neoplasm of the large intestine</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/91125" ref="tree=GTR&amp;ncbi_uid=91125&amp;link_uid=91125" title="View MedGen record for 'Benign neoplasm of large intestine'">Benign neoplasm of large intestine</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0346629[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=83428">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=83428">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=83428" ref="ncbi_uid=83428">V</a></span></span><span class="TLline"><a href="/medgen/83428" ref="tree=GTR&amp;ncbi_uid=83428&amp;link_uid=83428" title="View MedGen record for 'Colorectal cancer'">Colorectal cancer</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007102[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=2839">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=2839" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=2839" ref="ncbi_uid=2839">V</a></span></span><span class="TLline"><a href="/medgen/2839" ref="tree=GTR&amp;ncbi_uid=2839&amp;link_uid=2839" title="View MedGen record for 'Colon cancer'">Colon cancer</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=147065">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&amp;test_type=Research" ref="ncbi_uid=147065">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=147065">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=147065" ref="ncbi_uid=147065">V</a></span></span><span class="TLline">Carcinoma of colon</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/101033" ref="tree=GTR&amp;ncbi_uid=101033&amp;link_uid=101033" title="View MedGen record for 'Colon lymphoma'">Colon lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/272493" ref="tree=GTR&amp;ncbi_uid=272493&amp;link_uid=272493" title="View MedGen record for 'Colon sarcoma'">Colon sarcoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009402[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=3170">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=3170" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=3170" ref="ncbi_uid=3170">V</a></span></span><span class="TLline"><a href="/medgen/3170" ref="tree=GTR&amp;ncbi_uid=3170&amp;link_uid=3170" title="View MedGen record for 'Colorectal carcinoma'">Colorectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/474455" ref="tree=GTR&amp;ncbi_uid=474455&amp;link_uid=474455" title="View MedGen record for 'Colorectal lymphoma'">Colorectal lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=965772">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&amp;test_type=Research&amp;redirect=true" ref="ncbi_uid=965772">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=965772" ref="ncbi_uid=965772">V</a></span></span><span class="TLline"><a href="/medgen/965772" ref="tree=GTR&amp;ncbi_uid=965772&amp;link_uid=965772" title="View MedGen record for 'Familial colorectal cancer'">Familial colorectal cancer</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0949022[DISCUI]&amp;test_type=Clinical&amp;redirect=true" ref="ncbi_uid=181763">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/181763" ref="tree=GTR&amp;ncbi_uid=181763&amp;link_uid=181763" title="View MedGen record for 'Malignant tumor of rectum'">Malignant tumor of rectum</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007113[DISCUI]&amp;test_type=Clinical&amp;redirect=true" ref="ncbi_uid=40100">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/40100" ref="tree=GTR&amp;ncbi_uid=40100&amp;link_uid=40100" title="View MedGen record for 'Rectal carcinoma'">Rectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/233393" ref="tree=GTR&amp;ncbi_uid=233393&amp;link_uid=233393" title="View MedGen record for 'Rectum lymphoma'">Rectum lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/277577" ref="tree=GTR&amp;ncbi_uid=277577&amp;link_uid=277577" title="View MedGen record for 'Rectum sarcoma'">Rectum sarcoma</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/7130" ref="tree=MeSH" title="MedGen record for Intestinal disorder">Intestinal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1049" ref="tree=MeSH" title="MedGen record for Colonic disorder">Colonic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/3171" ref="tree=MeSH" title="MedGen record for Neoplasm of the large intestine">Neoplasm of the large intestine</a></span><ul><li><span class="TLline"><a href="/medgen/3165" ref="tree=MeSH" title="MedGen record for Colonic neoplasm">Colonic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2839" ref="tree=MeSH" title="MedGen record for Colon cancer">Colon cancer</a></span><ul><li><span class="matched_ds">Carcinoma of colon</span><ul><li><span class="TLline"><a href="/medgen/232083" ref="tree=MeSH" title="MedGen record for Adenosquamous colon carcinoma">Adenosquamous colon carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/101762" ref="tree=MeSH" title="MedGen record for Cecum carcinoma">Cecum carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/83854" ref="tree=MeSH" title="MedGen record for Carcinoma in situ of cecum">Carcinoma in situ of cecum</a></span></li><li><span class="TLline"><a href="/medgen/234098" ref="tree=MeSH" title="MedGen record for Cecum adenocarcinoma">Cecum adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/137834" ref="tree=MeSH" title="MedGen record for Colon adenocarcinoma">Colon adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/474446" ref="tree=MeSH" title="MedGen record for Colon Cribriform Comedo-Type Adenocarcinoma">Colon Cribriform Comedo-Type Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/310620" ref="tree=MeSH" title="MedGen record for Colon Intramucosal Adenocarcinoma">Colon Intramucosal Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272285" ref="tree=MeSH" title="MedGen record for Adenoma of the Colon with Intramucosal Adenocarcinoma">Adenoma of the Colon with Intramucosal Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/363630" ref="tree=MeSH" title="MedGen record for Colon medullary carcinoma">Colon medullary carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474449" ref="tree=MeSH" title="MedGen record for Colon Micropapillary Adenocarcinoma">Colon Micropapillary Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76007" ref="tree=MeSH" title="MedGen record for Colon mucinous adenocarcinoma">Colon mucinous adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474443" ref="tree=MeSH" title="MedGen record for Colon Serrated Adenocarcinoma">Colon Serrated Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/313039" ref="tree=MeSH" title="MedGen record for Colon signet ring cell adenocarcinoma">Colon signet ring cell adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272681" ref="tree=MeSH" title="MedGen record for Grade 1 Colon Adenocarcinoma">Grade 1 Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232252" ref="tree=MeSH" title="MedGen record for Grade 2 Colon Adenocarcinoma">Grade 2 Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234319" ref="tree=MeSH" title="MedGen record for Grade 3 Colon Adenocarcinoma">Grade 3 Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1685225" ref="tree=MeSH" title="MedGen record for Metastatic Colon Adenocarcinoma">Metastatic Colon Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1698076" ref="tree=MeSH" title="MedGen record for Advanced Colon Adenocarcinoma">Advanced Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1685944" ref="tree=MeSH" title="MedGen record for Locally Advanced Unresectable Colon Adenocarcinoma">Locally Advanced Unresectable Colon Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1687816" ref="tree=MeSH" title="MedGen record for Recurrent Colon Adenocarcinoma">Recurrent Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1707710" ref="tree=MeSH" title="MedGen record for Refractory Colon Adenocarcinoma">Refractory Colon Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/271523" ref="tree=MeSH" title="MedGen record for Submucosal invasive colon adenocarcinoma">Submucosal invasive colon adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1705920" ref="tree=MeSH" title="MedGen record for Unresectable Colon Adenocarcinoma">Unresectable Colon Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/455933" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v6 Stage">Colon Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/167826" ref="tree=MeSH" title="MedGen record for Carcinoma of colon, stage IV">Carcinoma of colon, stage IV</a></span></li><li><span class="TLline"><a href="/medgen/1620570" ref="tree=MeSH" title="MedGen record for Stage 0 Colon Cancer AJCC v6 and v7">Stage 0 Colon Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1614934" ref="tree=MeSH" title="MedGen record for Stage I Colon Cancer AJCC v6 and v7">Stage I Colon Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/78837" ref="tree=MeSH" title="MedGen record for Stage II Colon Cancer AJCC v6">Stage II Colon Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/75823" ref="tree=MeSH" title="MedGen record for Stage III Colon Cancer AJCC v6">Stage III Colon Cancer AJCC v6</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456315" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v7 Stage">Colon Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/459985" ref="tree=MeSH" title="MedGen record for Stage II Colon Cancer AJCC v7">Stage II Colon Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/853699" ref="tree=MeSH" title="MedGen record for Stage IIA Colon Cancer AJCC v7">Stage IIA Colon Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/853700" ref="tree=MeSH" title="MedGen record for Stage IIB Colon Cancer AJCC v7">Stage IIB Colon Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/856679" ref="tree=MeSH" title="MedGen record for Stage IIC Colon Cancer AJCC v7">Stage IIC Colon Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/459982" ref="tree=MeSH" title="MedGen record for Stage III Colon Cancer AJCC v7">Stage III Colon Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/853701" ref="tree=MeSH" title="MedGen record for Stage IIIA Colon Cancer AJCC v7">Stage IIIA Colon Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/853702" ref="tree=MeSH" title="MedGen record for Stage IIIB Colon Cancer AJCC v7">Stage IIIB Colon Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/853703" ref="tree=MeSH" title="MedGen record for Stage IIIC Colon Cancer AJCC v7">Stage IIIC Colon Cancer AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1619899" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v8 Stage">Colon Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1625268" ref="tree=MeSH" title="MedGen record for Stage 0 Colon Cancer AJCC v8">Stage 0 Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1626297" ref="tree=MeSH" title="MedGen record for Stage I Colon Cancer AJCC v8">Stage I Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1617457" ref="tree=MeSH" title="MedGen record for Stage II Colon Cancer AJCC v8">Stage II Colon Cancer AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1618261" ref="tree=MeSH" title="MedGen record for Stage IIA Colon Cancer AJCC v8">Stage IIA Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1613170" ref="tree=MeSH" title="MedGen record for Stage IIB Colon Cancer AJCC v8">Stage IIB Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1621622" ref="tree=MeSH" title="MedGen record for Stage IIC Colon Cancer AJCC v8">Stage IIC Colon Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1623702" ref="tree=MeSH" title="MedGen record for Stage III Colon Cancer AJCC v8">Stage III Colon Cancer AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1615425" ref="tree=MeSH" title="MedGen record for Stage IIIA Colon Cancer AJCC v8">Stage IIIA Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1624206" ref="tree=MeSH" title="MedGen record for Stage IIIB Colon Cancer AJCC v8">Stage IIIB Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622958" ref="tree=MeSH" title="MedGen record for Stage IIIC Colon Cancer AJCC v8">Stage IIIC Colon Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1620934" ref="tree=MeSH" title="MedGen record for Stage IV Colon Cancer AJCC v8">Stage IV Colon Cancer AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1624517" ref="tree=MeSH" title="MedGen record for Stage IVA Colon Cancer AJCC v8">Stage IVA Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1617458" ref="tree=MeSH" title="MedGen record for Stage IVB Colon Cancer AJCC v8">Stage IVB Colon Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1621408" ref="tree=MeSH" title="MedGen record for Stage IVC Colon Cancer AJCC v8">Stage IVC Colon Cancer AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1730673" ref="tree=MeSH" title="MedGen record for Colon Large Cell Neuroendocrine Carcinoma">Colon Large Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232087" ref="tree=MeSH" title="MedGen record for Colon small cell neuroendocrine carcinoma">Colon small cell neuroendocrine carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76008" ref="tree=MeSH" title="MedGen record for Colon Undifferentiated Carcinoma">Colon Undifferentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1717725" ref="tree=MeSH" title="MedGen record for Hereditary Colon Carcinoma">Hereditary Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649079" ref="tree=MeSH" title="MedGen record for Metastatic Colon Carcinoma">Metastatic Colon Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1712846" ref="tree=MeSH" title="MedGen record for Advanced Colon Carcinoma">Advanced Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234159" ref="tree=MeSH" title="MedGen record for Colon Carcinoma Metastatic in the Liver">Colon Carcinoma Metastatic in the Liver</a></span></li><li><span class="TLline"><a href="/medgen/455364" ref="tree=MeSH" title="MedGen record for Colon Carcinoma Metastatic in the Lung">Colon Carcinoma Metastatic in the Lung</a></span></li><li><span class="TLline"><a href="/medgen/1759831" ref="tree=MeSH" title="MedGen record for Locally Advanced Colon Carcinoma">Locally Advanced Colon Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1791351" ref="tree=MeSH" title="MedGen record for Locally Advanced Microsatellite Stable Colon Carcinoma">Locally Advanced Microsatellite Stable Colon Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1791350" ref="tree=MeSH" title="MedGen record for Metastatic Microsatellite Stable Colon Carcinoma">Metastatic Microsatellite Stable Colon Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1791055" ref="tree=MeSH" title="MedGen record for Microsatellite Stable Colon Carcinoma">Microsatellite Stable Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/82939" ref="tree=MeSH" title="MedGen record for Recurrent Colon Carcinoma">Recurrent Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1663185" ref="tree=MeSH" title="MedGen record for Refractory Colon Carcinoma">Refractory Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1710884" ref="tree=MeSH" title="MedGen record for Resectable Colon Carcinoma">Resectable Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/155572" ref="tree=MeSH" title="MedGen record for Sigmoid Colon Carcinoma">Sigmoid Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272494" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of colon">Squamous cell carcinoma of colon</a></span></li><li><span class="TLline"><a href="/medgen/1792785" ref="tree=MeSH" title="MedGen record for Unresectable Colon Carcinoma">Unresectable Colon Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/32106724">Colon carcinoma treatment using bispecific anti-GITR/CTLA-4 antibodies: a patent evaluation of WO2018091739.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Millán-Pérez Peña L,
Martin PS,
Herrera-Camacho I,
Bandala C,
Anaya-Ruiz M</span><br />
<span class="medgenPMjournal">Expert Opin Ther Pat</span>
2020 May;30(5):307-311.
Epub 2020 Feb 27
doi: 10.1080/13543776.2020.1732352.
<span class="bold">PMID: </span><a href="/pubmed/32106724" target="_blank">32106724</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19997551">Physical activity in the prevention and treatment of colorectal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Halle M,
Schoenberg MH</span><br />
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
2009 Oct;106(44):722-7.
Epub 2009 Oct 30
doi: 10.3238/arztebl.2009.0722.
<span class="bold">PMID: </span><a href="/pubmed/19997551" target="_blank">19997551</a><a href="/pmc/articles/PMC2788907" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4159261">Delay in treatment in carcinoma of colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rowejones DC,
Aylett SO</span><br />
<span class="medgenPMjournal">Lancet</span>
1965 Nov 13;2(7420):973-6.
doi: 10.1016/s0140-6736(65)92839-4.
<span class="bold">PMID: </span><a href="/pubmed/4159261" target="_blank">4159261</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22carcinoma%20of%20colon%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (17)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/22138009">NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Febbo PG,
Ladanyi M,
Aldape KD,
De Marzo AM,
Hammond ME,
Hayes DF,
Iafrate AJ,
Kelley RK,
Marcucci G,
Ogino S,
Pao W,
Sgroi DC,
Birkeland ML</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2011 Nov;9 Suppl 5:S1-32; quiz S33.
doi: 10.6004/jnccn.2011.0137.
<span class="bold">PMID: </span><a href="/pubmed/22138009" target="_blank">22138009</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2024</a></h3>
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng151" target="_blank">UK NICE Guideline NG151, Colorectal cancer, 2021</a></h3>
<h3 class="nl vspace"><a href="https://www.cms.gov/Medicare/Coverage/DeterminationProcess/downloads/id90TA.pdf" target="_blank">Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)</a></h3>
<h3 class="nl vspace"><a href="https://www.acmg.net/PDFLibrary/Colon-Cancer.pdf" target="_blank">American College of Medical Genetics and Genomics Family History ACT Sheet, Colon Cancer (Asymptomatic), 2012</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_114">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
<div class="nl"><a target="_blank" href="/pubmed/25006736">Multitarget stool DNA testing for colorectal-cancer screening.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Imperiale TF,
Ransohoff DF,
Itzkowitz SH</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2014 Jul 10;371(2):187-8.
doi: 10.1056/NEJMc1405215.
<span class="bold">PMID: </span><a href="/pubmed/25006736" target="_blank">25006736</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div><h3 class="subhead">External</h3><h3 class="nl vspace"><a href="http://www.nchpeg.org/documents/crc/11-0456%20Fact%20sheets%20(MSI%20and%20IHC%20testing).pdf" target="_blank">AMA/NCHPEG, 2012</a></h3>
</div>
</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35395754">Characteristics of primary signet ring cell carcinoma of colon and rectum: a case control study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weng MT,
Chao KH,
Tung CC,
Chang HC,
Shih IL,
Lin BR,
Shieh MJ,
Shun CT,
Wong JM,
Wei SC</span><br />
<span class="medgenPMjournal">BMC Gastroenterol</span>
2022 Apr 8;22(1):173.
doi: 10.1186/s12876-022-02258-1.
<span class="bold">PMID: </span><a href="/pubmed/35395754" target="_blank">35395754</a><a href="/pmc/articles/PMC8994381" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22513428">Population-based evaluation of adenosquamous carcinoma of the colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masoomi H,
Ziogas A,
Lin BS,
Barleben A,
Mills S,
Stamos MJ,
Zell JA</span><br />
<span class="medgenPMjournal">Dis Colon Rectum</span>
2012 May;55(5):509-14.
doi: 10.1097/DCR.0b013e3182420953.
<span class="bold">PMID: </span><a href="/pubmed/22513428" target="_blank">22513428</a><a href="/pmc/articles/PMC3330249" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7418585">Carcinoma of colon and appendix related to fecal stasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Annegers JF</span><br />
<span class="medgenPMjournal">Dis Colon Rectum</span>
1980 Sep;23(6):442.
doi: 10.1007/BF02586798.
<span class="bold">PMID: </span><a href="/pubmed/7418585" target="_blank">7418585</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4117277">Radiotherapy using hyperbaric oxygen in the palliation of carcinoma of colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dische S,
Senanayake F</span><br />
<span class="medgenPMjournal">Clin Radiol</span>
1972 Oct;23(4):512-8.
doi: 10.1016/s0009-9260(72)80032-1.
<span class="bold">PMID: </span><a href="/pubmed/4117277" target="_blank">4117277</a></div>
<div class="nl"><a target="_blank" href="/pubmed/5496538">Carcinoma of colon and rectum with reference to longterm survival.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thompson HL</span><br />
<span class="medgenPMjournal">Bull Soc Int Chir</span>
1970 Mar-Apr;29(2):81-4.
<span class="bold">PMID: </span><a href="/pubmed/5496538" target="_blank">5496538</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29417382">Squamous Cell Carcinoma of Colon-an Etiopathological Surprise.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dikshit V,
Ali I,
Patil C,
Manerikar K,
Mody P</span><br />
<span class="medgenPMjournal">J Gastrointest Cancer</span>
2019 Sep;50(3):604-608.
doi: 10.1007/s12029-018-0072-9.
<span class="bold">PMID: </span><a href="/pubmed/29417382" target="_blank">29417382</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28447224">Synchronous Neuroendocrine Carcinoma of Colon Presenting as Subacute Intestinal Obstruction-a Rare Case Report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Selvi SK,
Srinivas BH,
Badhe BA,
Dharanipragada K</span><br />
<span class="medgenPMjournal">J Gastrointest Cancer</span>
2018 Dec;49(4):525-527.
doi: 10.1007/s12029-017-9941-x.
<span class="bold">PMID: </span><a href="/pubmed/28447224" target="_blank">28447224</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4337947">Carcinoma of colon simulating Crohn's disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stoodley BJ,
Mann CV</span><br />
<span class="medgenPMjournal">Br J Surg</span>
1972 Jun;59(6):484-6.
doi: 10.1002/bjs.1800590619.
<span class="bold">PMID: </span><a href="/pubmed/4337947" target="_blank">4337947</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4872711">Crohn's disease and carcinoma of colon.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wyburn-Mason R</span><br />
<span class="medgenPMjournal">Br Med J</span>
1968 Jun 15;2(5606):697.
doi: 10.1136/bmj.2.5606.697-a.
<span class="bold">PMID: </span><a href="/pubmed/4872711" target="_blank">4872711</a><a href="/pmc/articles/PMC1991720" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4159261">Delay in treatment in carcinoma of colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rowejones DC,
Aylett SO</span><br />
<span class="medgenPMjournal">Lancet</span>
1965 Nov 13;2(7420):973-6.
doi: 10.1016/s0140-6736(65)92839-4.
<span class="bold">PMID: </span><a href="/pubmed/4159261" target="_blank">4159261</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/28447224">Synchronous Neuroendocrine Carcinoma of Colon Presenting as Subacute Intestinal Obstruction-a Rare Case Report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Selvi SK,
Srinivas BH,
Badhe BA,
Dharanipragada K</span><br />
<span class="medgenPMjournal">J Gastrointest Cancer</span>
2018 Dec;49(4):525-527.
doi: 10.1007/s12029-017-9941-x.
<span class="bold">PMID: </span><a href="/pubmed/28447224" target="_blank">28447224</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16174444">Radioimmunotherapy of carcinoma of colon with [131I]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lu QJ,
Bian GX,
Chen YY,
Zhang M,
Guo SM,
Wen LQ</span><br />
<span class="medgenPMjournal">Acta Pharmacol Sin</span>
2005 Oct;26(10):1259-64.
doi: 10.1111/j.1745-7254.2005.00177.x.
<span class="bold">PMID: </span><a href="/pubmed/16174444" target="_blank">16174444</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9727193">Amelogenin dosage compensation in carcinoma of colon, lung, liver and kidney, is not a marker of clonality in males.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zvejnieks PA,
Tellschow SR,
Gudlaugsson EG,
Markham N,
Shroyer KR</span><br />
<span class="medgenPMjournal">Mol Cell Probes</span>
1998 Aug;12(4):185-90.
doi: 10.1006/mcpr.1998.0172.
<span class="bold">PMID: </span><a href="/pubmed/9727193" target="_blank">9727193</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4057514">Asbestos bodies in carcinoma of colon in an insulation worker with asbestosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ehrlich A,
Rohl AN,
Holstein EC</span><br />
<span class="medgenPMjournal">JAMA</span>
1985 Nov 22-29;254(20):2932-3.
<span class="bold">PMID: </span><a href="/pubmed/4057514" target="_blank">4057514</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7363616">Invasive pulmonary aspergillosis after carcinoma of colon: report of a successfully treated case.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kiss GT,
Rao K,
Raju N</span><br />
<span class="medgenPMjournal">Conn Med</span>
1980 Mar;44(3):137-9.
<span class="bold">PMID: </span><a href="/pubmed/7363616" target="_blank">7363616</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (20)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/28447224">Synchronous Neuroendocrine Carcinoma of Colon Presenting as Subacute Intestinal Obstruction-a Rare Case Report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Selvi SK,
Srinivas BH,
Badhe BA,
Dharanipragada K</span><br />
<span class="medgenPMjournal">J Gastrointest Cancer</span>
2018 Dec;49(4):525-527.
doi: 10.1007/s12029-017-9941-x.
<span class="bold">PMID: </span><a href="/pubmed/28447224" target="_blank">28447224</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4175766">Carcinoma of colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cooper J,
Griffiths JD</span><br />
<span class="medgenPMjournal">Lancet</span>
1968 Oct 19;2(7573):873.
doi: 10.1016/s0140-6736(68)91033-7.
<span class="bold">PMID: </span><a href="/pubmed/4175766" target="_blank">4175766</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6026733">Necrotic carcinoma of colon.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tchang S</span><br />
<span class="medgenPMjournal">J Can Assoc Radiol</span>
1967 Jun;18(2):322-7.
<span class="bold">PMID: </span><a href="/pubmed/6026733" target="_blank">6026733</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4159261">Delay in treatment in carcinoma of colon and rectum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rowejones DC,
Aylett SO</span><br />
<span class="medgenPMjournal">Lancet</span>
1965 Nov 13;2(7420):973-6.
doi: 10.1016/s0140-6736(65)92839-4.
<span class="bold">PMID: </span><a href="/pubmed/4159261" target="_blank">4159261</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14186809">SURVIVAL RATE IN OBSTRUCTING CARCINOMA OF COLON.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">LOEFLER I,
HAFNER CD</span><br />
<span class="medgenPMjournal">Arch Surg</span>
1964 Oct;89:716-8.
doi: 10.1001/archsurg.1964.01320040132023.
<span class="bold">PMID: </span><a href="/pubmed/14186809" target="_blank">14186809</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (30)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/23436826">Evaluation of the growth pattern of carcinoma of colon and rectum by MDCT.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Choi SJ,
Kim HS,
Ahn SJ,
Jeong YM,
Choi HY</span><br />
<span class="medgenPMjournal">Acta Radiol</span>
2013 Jun;54(5):487-92.
Epub 2013 Apr 30
doi: 10.1177/0284185113475923.
<span class="bold">PMID: </span><a href="/pubmed/23436826" target="_blank">23436826</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16174444">Radioimmunotherapy of carcinoma of colon with [131I]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lu QJ,
Bian GX,
Chen YY,
Zhang M,
Guo SM,
Wen LQ</span><br />
<span class="medgenPMjournal">Acta Pharmacol Sin</span>
2005 Oct;26(10):1259-64.
doi: 10.1111/j.1745-7254.2005.00177.x.
<span class="bold">PMID: </span><a href="/pubmed/16174444" target="_blank">16174444</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10694641">Prognostic significance of mucinous carcinoma of colon and rectum: a prospective case-control study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Consorti F,
Lorenzotti A,
Midiri G,
Di Paola M</span><br />
<span class="medgenPMjournal">J Surg Oncol</span>
2000 Feb;73(2):70-4.
doi: 10.1002/(sici)1096-9098(200002)73:2&lt;70::aid-jso3&gt;3.0.co;2-j.
<span class="bold">PMID: </span><a href="/pubmed/10694641" target="_blank">10694641</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2404583">Clinical radioimmunodetection, 1978-1988: overview and suggestions for standardization of clinical trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Larson SM</span><br />
<span class="medgenPMjournal">Cancer Res</span>
1990 Feb 1;50(3 Suppl):892s-898s.
<span class="bold">PMID: </span><a href="/pubmed/2404583" target="_blank">2404583</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14843331">Carcinoma of colon and rectum; observations on Massachusetts General Hospital cases, 1937-1948.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">WELCH CE,
GIDDINGS WP</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
1951 Jun 7;244(23):859-67.
doi: 10.1056/NEJM195106072442301.
<span class="bold">PMID: </span><a href="/pubmed/14843331" target="_blank">14843331</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/33021125">Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schizas D,
Katsaros I,
Mastoraki A,
Karela NR,
Zampetaki D,
Lazaridis II,
Tsapralis D,
Theodoropoulos GE</span><br />
<span class="medgenPMjournal">J Invest Surg</span>
2022 Jan;35(1):151-156.
Epub 2020 Oct 6
doi: 10.1080/08941939.2020.1824044.
<span class="bold">PMID: </span><a href="/pubmed/33021125" target="_blank">33021125</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carcinoma%20of%20colon%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<div class="supplemental col three_col last">
<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="rightCol mgCol">
<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
</div>
<div class="portlet mgSection" id="ID_106">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (93)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A1%5F3" target="_blank">Immunohistochemistry (1)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F15" target="_blank">Methylation analysis (2)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (4)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (1)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;test_type=Research" target="_blank">Research (2)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F30" target="_blank">RNA analysis (5)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (18)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (108)</a></li>
<li><a href="/gtr/tests?term=C0699790%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (27)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0699790%5bDISCUI%5d" target="_blank">See all (154)</a></total></li>
</ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Carcinoma%20of%20colon" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22carcinoma%20of%20colon%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2024</div></li><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng151">NICE, 2021</a><div>UK NICE Guideline NG151, Colorectal cancer, 2021</div></li><li><a target="_blank" href="https://www.cms.gov/Medicare/Coverage/DeterminationProcess/downloads/id90TA.pdf">AHRQ, 2013</a><div>Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)</div></li><li><a target="_blank" href="https://www.acmg.net/PDFLibrary/Colon-Cancer.pdf">ACMG ACT, 2012</a><div>American College of Medical Genetics and Genomics Family History ACT Sheet, Colon Cancer (Asymptomatic), 2012</div></li><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov//22138009/">NCCN, 2011</a><div>NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.</div></li></ul></div>
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