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<meta name="keywords" content="C0541767, abnormal platelet aggregation, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=154224
|
||
ConceptID=C0541767
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormal platelet aggregation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>154224</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0541767</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030402">HP:0030402</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Abnormal platelet aggregation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/57492" ref="tree=MeSH" title="MedGen record for Abnormality of thrombocytes">Abnormality of thrombocytes</a></span><ul><li><span class="TLline"><a href="/medgen/488944" ref="tree=MeSH" title="MedGen record for Abnormal platelet function">Abnormal platelet function</a></span><ul><li><span class="matched_ds">Abnormal platelet aggregation</span><ul><li><span class="TLline"><a href="/medgen/383786" ref="tree=MeSH" title="MedGen record for Impaired platelet aggregation">Impaired platelet aggregation</a></span><ul><li><span class="TLline"><a href="/medgen/870824" ref="tree=MeSH" title="MedGen record for Impaired ADP-induced platelet aggregation">Impaired ADP-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/868750" ref="tree=MeSH" title="MedGen record for Impaired arachidonic acid-induced platelet aggregation">Impaired arachidonic acid-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/1386873" ref="tree=MeSH" title="MedGen record for Impaired calcium ionophore-induced platelet aggregation">Impaired calcium ionophore-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/870264" ref="tree=MeSH" title="MedGen record for Impaired collagen-induced platelet aggregation">Impaired collagen-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/1373790" ref="tree=MeSH" title="MedGen record for Impaired collagen-related peptide-induced platelet aggregation">Impaired collagen-related peptide-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/1381508" ref="tree=MeSH" title="MedGen record for Impaired convulxin-induced platelet aggregation">Impaired convulxin-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/870285" ref="tree=MeSH" title="MedGen record for Impaired epinephrine-induced platelet aggregation">Impaired epinephrine-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/1390659" ref="tree=MeSH" title="MedGen record for Impaired phorbol myristate acetate-induced platelet aggregation">Impaired phorbol myristate acetate-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/868748" ref="tree=MeSH" title="MedGen record for Impaired thrombin-induced platelet aggregation">Impaired thrombin-induced platelet aggregation</a></span></li><li><span class="TLline"><a href="/medgen/868736" ref="tree=MeSH" title="MedGen record for Impaired thromboxane A2 agonist-induced platelet aggregation">Impaired thromboxane A2 agonist-induced platelet aggregation</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/896447" ref="tree=MeSH" title="MedGen record for Increased RIPA">Increased RIPA</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_481656"><div><strong>Hermansky-Pudlak syndrome 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481656</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280026</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/481656">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1844414"><div><strong>Thrombocytopenia 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1844414</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882678</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Thrombocytopenia-9 (THC9) is an autosomal dominant condition characterized by low platelet counts in the absence of significant bleeding tendency. Some individuals may have mild mucocutaneous bleeding, whereas others do not show bleeding and thrombocytopenia may be an incidental finding. Platelets may show normal function and morphology or be slightly enlarged with platelet anisotropy (Noris et al., 2018; Cornish et al., 2020). For a discussion of genetic heterogeneity of thrombocytopenia, see 313900.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1844414">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481656" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1844414" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytopenia 9</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32562816">The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo BY,
|
||
Jiang JL,
|
||
Fang YF,
|
||
Yang F,
|
||
Yin MD,
|
||
Zhang BC,
|
||
Zhao RR,
|
||
Shao JW</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2020 Sep;159:105031.
|
||
Epub 2020 Jun 17
|
||
doi: 10.1016/j.phrs.2020.105031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32562816" target="_blank">32562816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3942696">Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruiz-Argüelles GJ,
|
||
Marín-Lopez A,
|
||
Lobato-Mendizábal E,
|
||
Ruiz-Argüelles A,
|
||
Nichols WL,
|
||
Katzman JA</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
1986 Jan;62(1):55-63.
|
||
doi: 10.1111/j.1365-2141.1986.tb02900.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3942696" target="_blank">3942696</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22abnormal%20platelet%20aggregation%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36169058">Platelet aggregation in normal pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Su X,
|
||
Zhao W</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2022 Nov 1;536:94-97.
|
||
Epub 2022 Sep 19
|
||
doi: 10.1016/j.cca.2022.09.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36169058" target="_blank">36169058</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32562816">The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo BY,
|
||
Jiang JL,
|
||
Fang YF,
|
||
Yang F,
|
||
Yin MD,
|
||
Zhang BC,
|
||
Zhao RR,
|
||
Shao JW</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2020 Sep;159:105031.
|
||
Epub 2020 Jun 17
|
||
doi: 10.1016/j.phrs.2020.105031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32562816" target="_blank">32562816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23746107">Garlic and cardioprotection: insights into the molecular mechanisms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khatua TN,
|
||
Adela R,
|
||
Banerjee SK</span><br />
|
||
<span class="medgenPMjournal">Can J Physiol Pharmacol</span>
|
||
2013 Jun;91(6):448-58.
|
||
Epub 2013 Mar 6
|
||
doi: 10.1139/cjpp-2012-0315.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23746107" target="_blank">23746107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3579263">Effect of Haemophilus influenzae infection and moxalactam on platelet function in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaplan SL,
|
||
Courtney JT,
|
||
Kenal KA</span><br />
|
||
<span class="medgenPMjournal">Antimicrob Agents Chemother</span>
|
||
1987 Mar;31(3):467-9.
|
||
doi: 10.1128/AAC.31.3.467.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3579263" target="_blank">3579263</a><a href="/pmc/articles/PMC174755" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6972134">Abnormal platelet aggregation measured by screen filtration pressure (sfp) in coronary heart disease: a new risk factor?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pagnan A,
|
||
Faggiotto A,
|
||
Bulian I,
|
||
Visoná A,
|
||
dal Palu C</span><br />
|
||
<span class="medgenPMjournal">Acta Cardiol</span>
|
||
1980;35(6):437-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6972134" target="_blank">6972134</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20platelet%20aggregation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (24)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32139434">Glanzmann thrombasthenia: genetic basis and clinical correlates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Botero JP,
|
||
Lee K,
|
||
Branchford BR,
|
||
Bray PF,
|
||
Freson K,
|
||
Lambert MP,
|
||
Luo M,
|
||
Mohan S,
|
||
Ross JE,
|
||
Bergmeier W,
|
||
Di Paola J;
|
||
ClinGen Platelet Disorder Variant Curation Expert Panel</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2020 Apr;105(4):888-894.
|
||
Epub 2020 Mar 5
|
||
doi: 10.3324/haematol.2018.214239.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32139434" target="_blank">32139434</a><a href="/pmc/articles/PMC7109743" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22460356">An update on pediatric bleeding disorders: bleeding scores, benign joint hypermobility, and platelet function testing in the evaluation of the child with bleeding symptoms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Brien SH</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2012 May;87 Suppl 1:S40-4.
|
||
Epub 2012 Mar 28
|
||
doi: 10.1002/ajh.23157.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22460356" target="_blank">22460356</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524447">Essential thrombocythemia in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dror Y,
|
||
Zipursky A,
|
||
Blanchette VS</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1999 Sep-Oct;21(5):356-63.
|
||
doi: 10.1097/00043426-199909000-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524447" target="_blank">10524447</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3953624">Familial essential thrombocythemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eyster ME,
|
||
Saletan SL,
|
||
Rabellino EM,
|
||
Karanas A,
|
||
McDonald TP,
|
||
Locke LA,
|
||
Luderer JR</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1986 Mar;80(3):497-502.
|
||
doi: 10.1016/0002-9343(86)90727-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3953624" target="_blank">3953624</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6972134">Abnormal platelet aggregation measured by screen filtration pressure (sfp) in coronary heart disease: a new risk factor?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pagnan A,
|
||
Faggiotto A,
|
||
Bulian I,
|
||
Visoná A,
|
||
dal Palu C</span><br />
|
||
<span class="medgenPMjournal">Acta Cardiol</span>
|
||
1980;35(6):437-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6972134" target="_blank">6972134</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20platelet%20aggregation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32562816">The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo BY,
|
||
Jiang JL,
|
||
Fang YF,
|
||
Yang F,
|
||
Yin MD,
|
||
Zhang BC,
|
||
Zhao RR,
|
||
Shao JW</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Res</span>
|
||
2020 Sep;159:105031.
|
||
Epub 2020 Jun 17
|
||
doi: 10.1016/j.phrs.2020.105031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32562816" target="_blank">32562816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23746107">Garlic and cardioprotection: insights into the molecular mechanisms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khatua TN,
|
||
Adela R,
|
||
Banerjee SK</span><br />
|
||
<span class="medgenPMjournal">Can J Physiol Pharmacol</span>
|
||
2013 Jun;91(6):448-58.
|
||
Epub 2013 Mar 6
|
||
doi: 10.1139/cjpp-2012-0315.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23746107" target="_blank">23746107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12672470">Antiphospholipid syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manson JJ,
|
||
Isenberg DA</span><br />
|
||
<span class="medgenPMjournal">Int J Biochem Cell Biol</span>
|
||
2003 Jul;35(7):1015-20.
|
||
doi: 10.1016/s1357-2725(02)00313-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12672470" target="_blank">12672470</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10431414">Priapism as a complication of heparin therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Siati M,
|
||
Chierigo P,
|
||
Contin F,
|
||
Lazzarotto M,
|
||
Rahmati M,
|
||
Franzolin N</span><br />
|
||
<span class="medgenPMjournal">Arch Ital Urol Androl</span>
|
||
1999 Jun;71(3):201-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10431414" target="_blank">10431414</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7111310">Platelet cancer cell interaction in metastasis formation. Platelet aggregation inhibitors: a possible approach to metastasis prevention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gastpar H,
|
||
Ambrus JL,
|
||
Ambrus CM</span><br />
|
||
<span class="medgenPMjournal">Prog Clin Biol Res</span>
|
||
1982;89:63-82.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7111310" target="_blank">7111310</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20platelet%20aggregation%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28181366">Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Badin MS,
|
||
Iyer JK,
|
||
Chong M,
|
||
Graf L,
|
||
Rivard GE,
|
||
Waye JS,
|
||
Paterson AD,
|
||
Pare G,
|
||
Hayward CPM</span><br />
|
||
<span class="medgenPMjournal">Haemophilia</span>
|
||
2017 May;23(3):e204-e213.
|
||
Epub 2017 Feb 8
|
||
doi: 10.1111/hae.13169.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28181366" target="_blank">28181366</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524447">Essential thrombocythemia in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dror Y,
|
||
Zipursky A,
|
||
Blanchette VS</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1999 Sep-Oct;21(5):356-63.
|
||
doi: 10.1097/00043426-199909000-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524447" target="_blank">10524447</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8556365">Glanzmann thrombasthenia in children from Argentina.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sassetti B,
|
||
Lajmanovich A,
|
||
Vázquez A,
|
||
Vizcarguénaga MI,
|
||
Berthier R,
|
||
Aversa L,
|
||
Bustelo P,
|
||
Kordich L</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1996 Feb;18(1):23-8.
|
||
doi: 10.1097/00043426-199602000-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8556365" target="_blank">8556365</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4084660">Blood coagulation and platelet profiles in persistent post-splenectomy thrombocytosis. The relationship to thromboembolism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Visudhiphan S,
|
||
Ketsa-Ard K,
|
||
Piankijagum A,
|
||
Tumliang S</span><br />
|
||
<span class="medgenPMjournal">Biomed Pharmacother</span>
|
||
1985;39(6):264-71.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4084660" target="_blank">4084660</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6298281">Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remuzzi G,
|
||
Benigni A,
|
||
Dodesini P,
|
||
Schieppati A,
|
||
Livio M,
|
||
De Gaetano G,
|
||
Day SS,
|
||
Smith WL,
|
||
Pinca E,
|
||
Patrignani P,
|
||
Patrono C</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
1983 Mar;71(3):762-8.
|
||
doi: 10.1172/jci110824.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6298281" target="_blank">6298281</a><a href="/pmc/articles/PMC436927" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20platelet%20aggregation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22460356">An update on pediatric bleeding disorders: bleeding scores, benign joint hypermobility, and platelet function testing in the evaluation of the child with bleeding symptoms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Brien SH</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2012 May;87 Suppl 1:S40-4.
|
||
Epub 2012 Mar 28
|
||
doi: 10.1002/ajh.23157.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22460356" target="_blank">22460356</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524447">Essential thrombocythemia in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dror Y,
|
||
Zipursky A,
|
||
Blanchette VS</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1999 Sep-Oct;21(5):356-63.
|
||
doi: 10.1097/00043426-199909000-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524447" target="_blank">10524447</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10431414">Priapism as a complication of heparin therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Siati M,
|
||
Chierigo P,
|
||
Contin F,
|
||
Lazzarotto M,
|
||
Rahmati M,
|
||
Franzolin N</span><br />
|
||
<span class="medgenPMjournal">Arch Ital Urol Androl</span>
|
||
1999 Jun;71(3):201-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10431414" target="_blank">10431414</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3953624">Familial essential thrombocythemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eyster ME,
|
||
Saletan SL,
|
||
Rabellino EM,
|
||
Karanas A,
|
||
McDonald TP,
|
||
Locke LA,
|
||
Luderer JR</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1986 Mar;80(3):497-502.
|
||
doi: 10.1016/0002-9343(86)90727-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3953624" target="_blank">3953624</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/678472">Abnormal platelet aggregation in severe combined immunodeficiency disease with adenosine deaminase deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schwartz AL,
|
||
Polmar SH,
|
||
Stern RC,
|
||
Cowan DH</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
1978 Jun;39(2):189-94.
|
||
doi: 10.1111/j.1365-2141.1978.tb01088.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/678472" target="_blank">678472</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20platelet%20aggregation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
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