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<meta name="keywords" content="C0338462, dementia, frontotemporal, dementia, frontotemporal, with or without parkinsonism, dementia, frontotemporal, with parkinsonism, dementia, semantic, dementias, semantic, disinhibition-dementia-parkinsonism-amyotrophy complex, frontotemporal dementia, frontotemporal dementia with parkinsonism, frontotemporal lobar degeneration with tau inclusions, frontotemporal lobe dementia, ftd, ftdp17, ftld with tau inclusions, mental or behavioral dysfunction, multiple system tauopathy with presenile dementia, pallidopontonigral degeneration, pick complex, semantic dementia, semantic dementias, semantic primary progressive aphasia, semantic variant ppa, trouble remembering words, wilhelmsen-lynch disease, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A progressive loss of the ability to remember the meaning of words, faces and objects." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=83268
ConceptID=C0338462
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Semantic dementia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83268</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0338462</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Dementia, Semantic; Dementias, Semantic; Semantic Dementia; Semantic Dementias</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Semantic dementia (230288001)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_109109"><div><strong>Non-Mendelian inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>109109</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0600599</a></dd><dt><span class="dotprefix"></span></dt><dd>Genetic Function</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">A mode of inheritance that depends on genetic determinants in more than one gene.</div></div>
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms&#10;that cannot be identified in NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">CN307044</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_109109" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Non-Mendelian inheritance</a><span> (Orphanet)</span></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030219">HP:0030219</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0010857" target="_blank">MONDO:0010857</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=100069">ORPHA100069</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A progressive loss of the ability to remember the meaning of words, faces and objects. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Semantic dementia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/14336" ref="tree=MeSH" title="MedGen record for Disorder of nervous system">Disorder of nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/3306" ref="tree=MeSH" title="MedGen record for Disorder of the central nervous system">Disorder of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/14214" ref="tree=MeSH" title="MedGen record for Brain disorder">Brain disorder</a></span><ul><li><span class="TLline"><a href="/medgen/99229" ref="tree=MeSH" title="MedGen record for Dementia">Dementia</a></span><ul><li><span class="TLline"><a href="/medgen/148228" ref="tree=MeSH" title="MedGen record for Degenerations, Frontotemporal Lobar">Degenerations, Frontotemporal Lobar</a></span><ul><li><span class="TLline"><a href="/medgen/83266" ref="tree=MeSH" title="MedGen record for Frontotemporal dementia">Frontotemporal dementia</a></span><ul><li><span class="matched_ds">Semantic dementia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=14642&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Semantic dementia</span> in Orphanet.</div></div></div>
</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/33543347">Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ruksenaite J,
Volkmer A,
Jiang J,
Johnson JC,
Marshall CR,
Warren JD,
Hardy CJ</span><br />
<span class="medgenPMjournal">Curr Neurol Neurosci Rep</span>
2021 Feb 4;21(3):7.
doi: 10.1007/s11910-021-01097-z.
<span class="bold">PMID: </span><a href="/pubmed/33543347" target="_blank">33543347</a><a href="/pmc/articles/PMC7861583" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22950490">Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seltman RE,
Matthews BR</span><br />
<span class="medgenPMjournal">CNS Drugs</span>
2012 Oct 1;26(10):841-70.
doi: 10.2165/11640070-000000000-00000.
<span class="bold">PMID: </span><a href="/pubmed/22950490" target="_blank">22950490</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11310619">Primary progressive aphasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mesulam MM</span><br />
<span class="medgenPMjournal">Ann Neurol</span>
2001 Apr;49(4):425-32.
<span class="bold">PMID: </span><a href="/pubmed/11310619" target="_blank">11310619</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22semantic%20dementia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (30)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35731122">Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Younes K,
Borghesani V,
Montembeault M,
Spina S,
Mandelli ML,
Welch AE,
Weis E,
Callahan P,
Elahi FM,
Hua AY,
Perry DC,
Karydas A,
Geschwind D,
Huang E,
Grinberg LT,
Kramer JH,
Boxer AL,
Rabinovici GD,
Rosen HJ,
Seeley WW,
Miller ZA,
Miller BL,
Sturm VE,
Rankin KP,
Gorno-Tempini ML</span><br />
<span class="medgenPMjournal">Brain</span>
2022 Nov 21;145(11):4080-4096.
doi: 10.1093/brain/awac217.
<span class="bold">PMID: </span><a href="/pubmed/35731122" target="_blank">35731122</a><a href="/pmc/articles/PMC10200288" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33543347">Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ruksenaite J,
Volkmer A,
Jiang J,
Johnson JC,
Marshall CR,
Warren JD,
Hardy CJ</span><br />
<span class="medgenPMjournal">Curr Neurol Neurosci Rep</span>
2021 Feb 4;21(3):7.
doi: 10.1007/s11910-021-01097-z.
<span class="bold">PMID: </span><a href="/pubmed/33543347" target="_blank">33543347</a><a href="/pmc/articles/PMC7861583" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29392464">Primary progressive aphasia: a clinical approach.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Marshall CR,
Hardy CJD,
Volkmer A,
Russell LL,
Bond RL,
Fletcher PD,
Clark CN,
Mummery CJ,
Schott JM,
Rossor MN,
Fox NC,
Crutch SJ,
Rohrer JD,
Warren JD</span><br />
<span class="medgenPMjournal">J Neurol</span>
2018 Jun;265(6):1474-1490.
Epub 2018 Feb 1
doi: 10.1007/s00415-018-8762-6.
<span class="bold">PMID: </span><a href="/pubmed/29392464" target="_blank">29392464</a><a href="/pmc/articles/PMC5990560" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24943344">Frontotemporal dementia and its subtypes: a genome-wide association study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ferrari R,
Hernandez DG,
Nalls MA,
Rohrer JD,
Ramasamy A,
Kwok JB,
Dobson-Stone C,
Brooks WS,
Schofield PR,
Halliday GM,
Hodges JR,
Piguet O,
Bartley L,
Thompson E,
Haan E,
Hernández I,
Ruiz A,
Boada M,
Borroni B,
Padovani A,
Cruchaga C,
Cairns NJ,
Benussi L,
Binetti G,
Ghidoni R,
Forloni G,
Galimberti D,
Fenoglio C,
Serpente M,
Scarpini E,
Clarimón J,
Lleó A,
Blesa R,
Waldö ML,
Nilsson K,
Nilsson C,
Mackenzie IR,
Hsiung GY,
Mann DM,
Grafman J,
Morris CM,
Attems J,
Griffiths TD,
McKeith IG,
Thomas AJ,
Pietrini P,
Huey ED,
Wassermann EM,
Baborie A,
Jaros E,
Tierney MC,
Pastor P,
Razquin C,
Ortega-Cubero S,
Alonso E,
Perneczky R,
Diehl-Schmid J,
Alexopoulos P,
Kurz A,
Rainero I,
Rubino E,
Pinessi L,
Rogaeva E,
St George-Hyslop P,
Rossi G,
Tagliavini F,
Giaccone G,
Rowe JB,
Schlachetzki JC,
Uphill J,
Collinge J,
Mead S,
Danek A,
Van Deerlin VM,
Grossman M,
Trojanowski JQ,
van der Zee J,
Deschamps W,
Van Langenhove T,
Cruts M,
Van Broeckhoven C,
Cappa SF,
Le Ber I,
Hannequin D,
Golfier V,
Vercelletto M,
Brice A,
Nacmias B,
Sorbi S,
Bagnoli S,
Piaceri I,
Nielsen JE,
Hjermind LE,
Riemenschneider M,
Mayhaus M,
Ibach B,
Gasparoni G,
Pichler S,
Gu W,
Rossor MN,
Fox NC,
Warren JD,
Spillantini MG,
Morris HR,
Rizzu P,
Heutink P,
Snowden JS,
Rollinson S,
Richardson A,
Gerhard A,
Bruni AC,
Maletta R,
Frangipane F,
Cupidi C,
Bernardi L,
Anfossi M,
Gallo M,
Conidi ME,
Smirne N,
Rademakers R,
Baker M,
Dickson DW,
Graff-Radford NR,
Petersen RC,
Knopman D,
Josephs KA,
Boeve BF,
Parisi JE,
Seeley WW,
Miller BL,
Karydas AM,
Rosen H,
van Swieten JC,
Dopper EG,
Seelaar H,
Pijnenburg YA,
Scheltens P,
Logroscino G,
Capozzo R,
Novelli V,
Puca AA,
Franceschi M,
Postiglione A,
Milan G,
Sorrentino P,
Kristiansen M,
Chiang HH,
Graff C,
Pasquier F,
Rollin A,
Deramecourt V,
Lebert F,
Kapogiannis D,
Ferrucci L,
Pickering-Brown S,
Singleton AB,
Hardy J,
Momeni P</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2014 Jul;13(7):686-99.
doi: 10.1016/S1474-4422(14)70065-1.
<span class="bold">PMID: </span><a href="/pubmed/24943344" target="_blank">24943344</a><a href="/pmc/articles/PMC4112126" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17992091">The genetics of frontotemporal lobar degeneration.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sikkink S,
Rollinson S,
Pickering-Brown SM</span><br />
<span class="medgenPMjournal">Curr Opin Neurol</span>
2007 Dec;20(6):693-8.
doi: 10.1097/WCO.0b013e3282f1c961.
<span class="bold">PMID: </span><a href="/pubmed/17992091" target="_blank">17992091</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (451)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37906327">Primary progressive aphasia: six questions in search of an answer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Belder CRS,
Marshall CR,
Jiang J,
Mazzeo S,
Chokesuwattanaskul A,
Rohrer JD,
Volkmer A,
Hardy CJD,
Warren JD</span><br />
<span class="medgenPMjournal">J Neurol</span>
2024 Feb;271(2):1028-1046.
Epub 2023 Oct 31
doi: 10.1007/s00415-023-12030-4.
<span class="bold">PMID: </span><a href="/pubmed/37906327" target="_blank">37906327</a><a href="/pmc/articles/PMC10827918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31753134">Neuroimaging in aging and neurologic diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Risacher SL,
Saykin AJ</span><br />
<span class="medgenPMjournal">Handb Clin Neurol</span>
2019;167:191-227.
doi: 10.1016/B978-0-12-804766-8.00012-1.
<span class="bold">PMID: </span><a href="/pubmed/31753134" target="_blank">31753134</a><a href="/pmc/articles/PMC9006168" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30707189">Primary Progressive Aphasias and Apraxia of Speech.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Botha H,
Josephs KA</span><br />
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
2019 Feb;25(1):101-127.
doi: 10.1212/CON.0000000000000699.
<span class="bold">PMID: </span><a href="/pubmed/30707189" target="_blank">30707189</a><a href="/pmc/articles/PMC6548538" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29478591">Frontotemporal dementia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Deleon J,
Miller BL</span><br />
<span class="medgenPMjournal">Handb Clin Neurol</span>
2018;148:409-430.
doi: 10.1016/B978-0-444-64076-5.00027-2.
<span class="bold">PMID: </span><a href="/pubmed/29478591" target="_blank">29478591</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29392464">Primary progressive aphasia: a clinical approach.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Marshall CR,
Hardy CJD,
Volkmer A,
Russell LL,
Bond RL,
Fletcher PD,
Clark CN,
Mummery CJ,
Schott JM,
Rossor MN,
Fox NC,
Crutch SJ,
Rohrer JD,
Warren JD</span><br />
<span class="medgenPMjournal">J Neurol</span>
2018 Jun;265(6):1474-1490.
Epub 2018 Feb 1
doi: 10.1007/s00415-018-8762-6.
<span class="bold">PMID: </span><a href="/pubmed/29392464" target="_blank">29392464</a><a href="/pmc/articles/PMC5990560" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (437)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/39385207">Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang D,
Hou J,
Nan H,
Yue A,
Chu M,
Wang Y,
Wang Y,
Wu L</span><br />
<span class="medgenPMjournal">Alzheimers Res Ther</span>
2024 Oct 9;16(1):215.
doi: 10.1186/s13195-024-01586-6.
<span class="bold">PMID: </span><a href="/pubmed/39385207" target="_blank">39385207</a><a href="/pmc/articles/PMC11462771" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25998110">The frontotemporal dementias.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Waldö ML</span><br />
<span class="medgenPMjournal">Psychiatr Clin North Am</span>
2015 Jun;38(2):193-209.
Epub 2015 Mar 18
doi: 10.1016/j.psc.2015.02.001.
<span class="bold">PMID: </span><a href="/pubmed/25998110" target="_blank">25998110</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24974082">Primary progressive aphasia: linguistic patterns and clinical variants.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Silveri MC,
Pravatà E,
Brita AC,
Improta E,
Ciccarelli N,
Rossi P,
Colosimo C</span><br />
<span class="medgenPMjournal">Brain Lang</span>
2014 Aug;135:57-65.
Epub 2014 Jun 27
doi: 10.1016/j.bandl.2014.05.004.
<span class="bold">PMID: </span><a href="/pubmed/24974082" target="_blank">24974082</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21710360">Semantic dementia: a specific network-opathy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fletcher PD,
Warren JD</span><br />
<span class="medgenPMjournal">J Mol Neurosci</span>
2011 Nov;45(3):629-36.
Epub 2011 Jun 29
doi: 10.1007/s12031-011-9586-3.
<span class="bold">PMID: </span><a href="/pubmed/21710360" target="_blank">21710360</a><a href="/pmc/articles/PMC3207124" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15174457">Retrieval of episodic and semantic autobiographical memories in early Alzheimer's disease and semantic dementia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ivanoiu A,
Cooper JM,
Shanks MF,
Venneri A</span><br />
<span class="medgenPMjournal">Cortex</span>
2004 Feb;40(1):173-5.
doi: 10.1016/s0010-9452(08)70939-0.
<span class="bold">PMID: </span><a href="/pubmed/15174457" target="_blank">15174457</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (61)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37906327">Primary progressive aphasia: six questions in search of an answer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Belder CRS,
Marshall CR,
Jiang J,
Mazzeo S,
Chokesuwattanaskul A,
Rohrer JD,
Volkmer A,
Hardy CJD,
Warren JD</span><br />
<span class="medgenPMjournal">J Neurol</span>
2024 Feb;271(2):1028-1046.
Epub 2023 Oct 31
doi: 10.1007/s00415-023-12030-4.
<span class="bold">PMID: </span><a href="/pubmed/37906327" target="_blank">37906327</a><a href="/pmc/articles/PMC10827918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35731122">Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Younes K,
Borghesani V,
Montembeault M,
Spina S,
Mandelli ML,
Welch AE,
Weis E,
Callahan P,
Elahi FM,
Hua AY,
Perry DC,
Karydas A,
Geschwind D,
Huang E,
Grinberg LT,
Kramer JH,
Boxer AL,
Rabinovici GD,
Rosen HJ,
Seeley WW,
Miller ZA,
Miller BL,
Sturm VE,
Rankin KP,
Gorno-Tempini ML</span><br />
<span class="medgenPMjournal">Brain</span>
2022 Nov 21;145(11):4080-4096.
doi: 10.1093/brain/awac217.
<span class="bold">PMID: </span><a href="/pubmed/35731122" target="_blank">35731122</a><a href="/pmc/articles/PMC10200288" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34242731">History of Magnetic Resonance Imaging: A Trip Down Memory Lane.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Viard A,
Eustache F,
Segobin S</span><br />
<span class="medgenPMjournal">Neuroscience</span>
2021 Oct 15;474:3-13.
Epub 2021 Jul 6
doi: 10.1016/j.neuroscience.2021.06.038.
<span class="bold">PMID: </span><a href="/pubmed/34242731" target="_blank">34242731</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30707189">Primary Progressive Aphasias and Apraxia of Speech.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Botha H,
Josephs KA</span><br />
<span class="medgenPMjournal">Continuum (Minneap Minn)</span>
2019 Feb;25(1):101-127.
doi: 10.1212/CON.0000000000000699.
<span class="bold">PMID: </span><a href="/pubmed/30707189" target="_blank">30707189</a><a href="/pmc/articles/PMC6548538" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21222601">Lobar atrophy in frontotemporal dementia: diagnostic and prognostic implications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Davies RR,
Kipps CM</span><br />
<span class="medgenPMjournal">Curr Alzheimer Res</span>
2011 May;8(3):261-5.
doi: 10.2174/156720511795563818.
<span class="bold">PMID: </span><a href="/pubmed/21222601" target="_blank">21222601</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (204)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/39385207">Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang D,
Hou J,
Nan H,
Yue A,
Chu M,
Wang Y,
Wang Y,
Wu L</span><br />
<span class="medgenPMjournal">Alzheimers Res Ther</span>
2024 Oct 9;16(1):215.
doi: 10.1186/s13195-024-01586-6.
<span class="bold">PMID: </span><a href="/pubmed/39385207" target="_blank">39385207</a><a href="/pmc/articles/PMC11462771" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37906327">Primary progressive aphasia: six questions in search of an answer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Belder CRS,
Marshall CR,
Jiang J,
Mazzeo S,
Chokesuwattanaskul A,
Rohrer JD,
Volkmer A,
Hardy CJD,
Warren JD</span><br />
<span class="medgenPMjournal">J Neurol</span>
2024 Feb;271(2):1028-1046.
Epub 2023 Oct 31
doi: 10.1007/s00415-023-12030-4.
<span class="bold">PMID: </span><a href="/pubmed/37906327" target="_blank">37906327</a><a href="/pmc/articles/PMC10827918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35731122">Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Younes K,
Borghesani V,
Montembeault M,
Spina S,
Mandelli ML,
Welch AE,
Weis E,
Callahan P,
Elahi FM,
Hua AY,
Perry DC,
Karydas A,
Geschwind D,
Huang E,
Grinberg LT,
Kramer JH,
Boxer AL,
Rabinovici GD,
Rosen HJ,
Seeley WW,
Miller ZA,
Miller BL,
Sturm VE,
Rankin KP,
Gorno-Tempini ML</span><br />
<span class="medgenPMjournal">Brain</span>
2022 Nov 21;145(11):4080-4096.
doi: 10.1093/brain/awac217.
<span class="bold">PMID: </span><a href="/pubmed/35731122" target="_blank">35731122</a><a href="/pmc/articles/PMC10200288" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35549825">Physical understanding in neurodegenerative diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baumard J,
Lesourd M,
Guézouli L,
Osiurak F</span><br />
<span class="medgenPMjournal">Cogn Neuropsychol</span>
2021 Oct-Dec;38(7-8):490-514.
Epub 2022 May 13
doi: 10.1080/02643294.2022.2071152.
<span class="bold">PMID: </span><a href="/pubmed/35549825" target="_blank">35549825</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34242731">History of Magnetic Resonance Imaging: A Trip Down Memory Lane.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Viard A,
Eustache F,
Segobin S</span><br />
<span class="medgenPMjournal">Neuroscience</span>
2021 Oct 15;474:3-13.
Epub 2021 Jul 6
doi: 10.1016/j.neuroscience.2021.06.038.
<span class="bold">PMID: </span><a href="/pubmed/34242731" target="_blank">34242731</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (353)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/39028529">FDG-PET in the diagnosis of primary progressive aphasia: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mirbod M,
Ayubcha C,
Redden HWK,
Teichner E,
Subtirelu RC,
Patel R,
Raynor W,
Werner T,
Alavi A,
Revheim ME</span><br />
<span class="medgenPMjournal">Ann Nucl Med</span>
2024 Sep;38(9):673-687.
Epub 2024 Jul 19
doi: 10.1007/s12149-024-01958-w.
<span class="bold">PMID: </span><a href="/pubmed/39028529" target="_blank">39028529</a><a href="/pmc/articles/PMC11339180" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35867973">Right Temporal Lobe Variant of Frontotemporal Dementia: Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Campos DF,
Rocca AR,
Caixeta LF</span><br />
<span class="medgenPMjournal">Alzheimer Dis Assoc Disord</span>
2022 Jul-Sep 01;36(3):272-279.
Epub 2022 Jul 21
doi: 10.1097/WAD.0000000000000511.
<span class="bold">PMID: </span><a href="/pubmed/35867973" target="_blank">35867973</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34344452">Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ulugut H,
Dijkstra AA,
Scarioni M;
Netherlands Brain Bank,
Barkhof F,
Scheltens P,
Rozemuller AJM,
Pijnenburg YAL</span><br />
<span class="medgenPMjournal">Acta Neuropathol Commun</span>
2021 Aug 3;9(1):131.
doi: 10.1186/s40478-021-01229-z.
<span class="bold">PMID: </span><a href="/pubmed/34344452" target="_blank">34344452</a><a href="/pmc/articles/PMC8330072" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27567843">Atrophy in Alzheimer's Disease and Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chapleau M,
Aldebert J,
Montembeault M,
Brambati SM</span><br />
<span class="medgenPMjournal">J Alzheimers Dis</span>
2016 Oct 4;54(3):941-955.
doi: 10.3233/JAD-160382.
<span class="bold">PMID: </span><a href="/pubmed/27567843" target="_blank">27567843</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21537725">Pharmacological treatment of frontotemporal lobar degeneration: systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Portugal Mda G,
Marinho V,
Laks J</span><br />
<span class="medgenPMjournal">Braz J Psychiatry</span>
2011 Mar;33(1):81-90.
doi: 10.1590/s1516-44462011000100016.
<span class="bold">PMID: </span><a href="/pubmed/21537725" target="_blank">21537725</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Semantic%20dementia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div></div>
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